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| xpharm the comprehensive pharmacology reference: XPharm , 2008 Consisting of more than 3,700 articles, all xPharm content is commissioned by an outstanding editorial board led by past Presidents of ASPET, S.J. Enna and David B. Bylund, Ph. D. and contributed by nearly 600 experts. |
| xpharm the comprehensive pharmacology reference: Privileged Scaffolds in Drug Discovery Bin Yu, Ning Li, Caiyun Fu, 2023-07-19 Privileged Scaffolds in Drug Discovery is the most complete and up-to-date work in the area. Covering a wide range of privileged structures, it is a perfect reference for scientists involved in targeted drug development. The editors recruited epserts from several prestigious Chinese institutions to cover the areas of antiviral drugs, chalcone, pyrimidine, (benz)imidazoles, natural product-derived privileged scaffolds, N-Sulfonyl carboxamides, kinase inhibitors, antitumor molecules, antineurodegenerative drugs, triazoles, oxazolidinone, indole and indoline scaffolds, tigliane diterpenoids, peptide and peptide-based drugs, quassinoids, and others including pseudonatural products, macrocycles, stable peptides and peptidomimetics. The book also explores scaffolds in drug molecules approved in recent years. Privileged Scaffolds in Drug Discovery is a complete reference for researchers in drug discovery and organic synthesis, in academic and corporate settings, who are investigating privileged structures upon which to base new drugs. Researchers in medicinal chemistry and chemical biology will also find the contents of this book valuable. - Provides wide coverage of privileged scaffolds in new drug discovery - Includes complex and diverse natural product scaffolds - Covers applications to peptides and peptide-based drugs |
| xpharm the comprehensive pharmacology reference: Handbook of Polymers for Pharmaceutical Technologies, Structure and Chemistry Vijay Kumar Thakur, Manju Kumari Thakur, 2015-06-19 Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe. This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated. Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers |
| xpharm the comprehensive pharmacology reference: Biopharmaceutical Processing Gunter Jagschies, Eva Lindskog, Karol Lacki, Parrish M. Galliher, 2018-01-18 Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. - Offers a comprehensive, go-to reference for daily work decisions - Covers both upstream and downstream processes - Includes case studies that emphasize financial outcomes - Presents summaries, decision grids, graphs and overviews for quick reference |
| xpharm the comprehensive pharmacology reference: Handbook of Oncobiology: From Basic to Clinical Sciences R. C. Sobti, Nirmal K. Ganguly, Rakesh Kumar, 2024-05-14 This Handbook on cancer biology comprehensively reviews the current status of the oncobiology of major cancer types, cancer detection and treatment strategies, principles and processes of cancer drug development, and nanomedicine and other emerging cancer medicine applications to cancer diagnosis and treatment. The book also provides practical and implementable nutritional guidance in cancer prevention, treatment, and quality of life for cancer survivors. It discusses pharmacogenetics strategies for predicting cancer prognosis and treatment exposure, response, and toxicity. Further, it presents bioinformatics approaches for predicting anti-cancer drugs and drug combinations based on the multi-omic data, including transcriptomics, toxicogenomics, functional genomics, and biological networks. The Handbook also examines major factors and pathways that regulate cancer stem cells development and discusses potential targeted therapy for cancer stem cells. The book explores the application of the CRISPR/Cas9-based gene-editing technique in basic cancer research, diagnosis, and treatment of cancer. This Handbook is an invaluable source for oncologists, researchers, public health specialists, epidemiologists, and policy makers. |
| xpharm the comprehensive pharmacology reference: Recent Advances in Phytochemical Research , 2025-04-10 The phytochemicals, particularly bioactive compounds such as alkaloids, flavonoids, terpenoids, and polyphenols, have revealed their diverse roles in human health, from antioxidant and anti-inflammatory properties to anticancer and antimicrobial effects. This book explores how the latest genomics, metabolomics, and bioinformatics methodologies enhance our understanding of plant secondary metabolites and their pharmacological potential. Through these technological innovations, researchers can now identify new bioactive molecules more efficiently and accurately than ever before. This volume highlights the intersections between traditional knowledge and modern scientific advancements. Many of the discoveries discussed here build upon ancient wisdom, validating the therapeutic potential of plants used for centuries in indigenous and folk medicine. |
| xpharm the comprehensive pharmacology reference: Frontiers in Clinical Drug Research - Anti Infectives: Volume 8 Atta-ur-Rahman, 2021-12-07 Frontiers in Clinical Drug Research – Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. The eighth volume of this series presents comprehensive reviews of interest to readers interested in the treatment of inflammatory diseases, new antiviral agents and strategies, specific antiprotozoal drugs that work against leishmania and helminths, and a study on potential agents against American foulbrood in honey bees. The 7 reviews included in this volume are: - Monoclonal antibodies as therapeutic agents for inflammatory diseases - Pharmacotherapy of emerging antiviral agents - Antiviral activity of vitamin D and COVID-19: current understanding - Anti-infectives to combat leishmaniasis - Anthelmintic drug discovery: current situation and future perspectives - Therapeutic targets for emerging Zika virus infection and vaccines in clinical trials - Agro-industrial waste: new source of raw material for the control of American foulbrood in honey bees. |
| xpharm the comprehensive pharmacology reference: Enzyme Inhibitors in Pharmacotherapy Dr Bukata B. Bukar, Enzyme Inhibitors in Pharmacotherapy explores the role of enzyme inhibitors in treating chronic diseases and infections. It covers enzyme biology, inhibition mechanisms, and pharmacological applications. Featuring detailed discussions and illustrations, the book offers valuable insights for students and practitioners. Written for a global audience, it combines theoretical knowledge with practical drug development advancements. |
| xpharm the comprehensive pharmacology reference: Bioactive Nutrients as Dietary Supplements and Therapeutic Agents Asma Saeed, Saeed Iqbal Zafar, 2024-03-18 Nutraceutical, during recent decades, has emerged as a new term in the scientific literature. Synonymously used to the term nutraceuticals in literature are dietary supplements, bioactive nutrients, functional foods, etc. This book considers how nutraceutical substances are regulated in different countries; the physiological role of dietary fibers in relation to their claimed health benefits within the scope of functional foods, dietary supplements, and nutraceuticals; prebiotics, probiotics, and synbiotics as nutraceuticals; and the nature of a large number of phytochemicals as nutraceuticals. The book also touts fruits and vegetables as Nature’s multinutraceutical capsules, as evidenced from their beneficial health effects emerging from epidemiological studies on such diseases as diabetes, hypertension, cardiovascular, cancer, osteoporosis, rheumatism, diverticulitis, etc. In light of this, international launching of campaigns on health benefits as “go for 2-5” daily servings of fruits and vegetables is also considered. |
| xpharm the comprehensive pharmacology reference: Innovative Approaches for Nanobiotechnology in Healthcare Systems Amna, Touseef, Hassan, M. Shamshi, 2021-09-17 Innovative and fusion technologies have shown an incredible ability to improve various aspects of society, such as healthcare systems. Nanobiotechnology is one such technology that is being applied to medical equipment and treatment approaches. Many pharmaceutical and medical companies have begun to count on medical nanotechnology due to its abundant applications and practical uses. Innovative Approaches for Nanobiotechnology in Healthcare Systems is a pivotal reference source that provides insights into a comprehensive collection of novel techniques used for the development of safe drugs using the available resources for diverse deadly diseases. This book discusses the various platforms of nanobiotechnology that are utilized in various fields. It is expected that bionanosytems will play a crucial role in the treatment of human diseases and the improvement of existing healthcare systems. This book is ideal for scientists, biotechnologists, microbiologists, medical professionals, entrepreneurs, policymakers, researchers, academicians, and students. |
| xpharm the comprehensive pharmacology reference: Sustainable Nanomaterials for Treatment and Diagnosis of Infectious Diseases Rajasekhar Chokkareddy, Suvardhan Kanchi, Gan G. Redhi, 2025-02-26 The book focuses on the design and novel synthetic routes of sustainable nanomaterials in diagnosing and treating infectious diseases offering potential benefits in terms of efficiency, biocompatibility, and environmental impact. The fifteen chapters in this book provide a comprehensive exploration of how sustainable nanotechnology can revolutionize infectious disease management and bridge the gap between the fundamental principles of nanotechnology and their practical applications in combating infectious diseases. Subjects covered include: the rise of multidrug-resistant pathogens and the limitations of existing therapies; the challenges of infectious disease management including the rise of multidrug-resistant pathogens and the limitations of existing therapies; nano-pharmacology and pharmacotherapeutics in the treatment of infectious diseases; the advancements in nanomaterial-based drug delivery systems, vaccines, and diagnostic tools, and the future of personalized medicine; nanotheranostic mechanisms outlining how nanomaterials can be engineered to simultaneously diagnose and treat infections; nano drug delivery systems that contribute to enhancing the efficacy and precision of treatment modalities; biocompatibility and toxicity of nanomaterials in the diagnosis and treatment of infectious diseases; regulatory perspectives of nanomaterials ensuring they meet safety and efficacy standards; green synthesis of reduced graphene oxide, carbon dots, and its composites for infectious diseases and biosurfactants; nanomaterials of polymeric design underscoring their potential to create more effective and sustainable therapeutic options; how nanomaterials can be engineered to simultaneously diagnose and treat infections. Audience The book targets nanotechnology researchers, scientists, and healthcare professionals interested in understanding nanotechnology’s critical role in sustainable healthcare solutions. |
| xpharm the comprehensive pharmacology reference: Medicinal Chemistry A.K. Ganguly, Sesha Sridevi Alluri, 2021-09-12 Medicinal Chemistry: A Look at How Drugs Are Discovered is written for those who are interested in learning how drugs are discovered. Compared to other books on the market, this text takes a different approach by presenting the subject on chemical reaction mechanism terms, which ideally makes the subject matter more interesting and easier to comprehend. The authors describe the drug discovery process, from advancing an initial lead to the approval process, and include drug discovery sources. Additional features: Explains medicinal chemistry on chemical mechanism terms, allowing for a more interesting and easier to comprehend text Includes valuable insights toward the various pathways taken at pharmaceutical industries in drug discoveries Improved by including questions raised and suggestions made from students in the authors’ medicinal chemistry classes This book will benefit both upper level undergraduates and graduates studying in the fields of medicinal chemistry and drug discovery, as well as scientists working in the pharmaceutical industry. |
| xpharm the comprehensive pharmacology reference: Technology in Forensic Science Deepak Rawtani, Chaudhery Mustansar Hussain, 2020-11-02 The book Technology in Forensic Science provides an integrated approach by reviewing the usage of modern forensic tools as well as the methods for interpretation of the results. Starting with best practices on sample taking, the book then reviews analytical methods such as high-resolution microscopy and chromatography, biometric approaches, and advanced sensor technology as well as emerging technologies such as nanotechnology and taggant technology. It concludes with an outlook to emerging methods such as AI-based approaches to forensic investigations. |
| xpharm the comprehensive pharmacology reference: The Maudsley Deprescribing Guidelines Mark Horowitz, David M. Taylor, 2024-01-04 The Maudsley® Deprescribing Guidelines Comprehensive resource describing guidelines for safely reducing or stopping (deprescribing) antidepressants, benzodiazepines, gabapentinoids and z-drugs for patients, including step-by-step guidance for all commonly used medications, covering common pitfalls, troubleshooting, supportive strategies, and more. Most formal guidance on psychiatric medication relates to starting or switching medications with minimal guidance on deprescribing medication. In 2023, the World Health Organisation and the United Nations called for patients, as a human right, to be informed of their right to discontinue treatment and to receive support to do so. The Maudsley Deprescribing Guidelines fills a significant gap in guidance for clinicians by providing comprehensive and authoritative information on this important aspect of treatment. This evidence-based handbook provides an overview of principles to be used in deprescribing. This is derived from fundamental scientific principles and the latest research on this topic, combined with emerging insights from clinical practice (including from patient experts). Building on the recognised brand of The Maudsley Prescribing Guidelines, and the prominence of the authors’ work, including in The Lancet Psychiatry on tapering antidepressants (the most read article across all Lancet titles when it was released). The Maudsley Deprescribing Guidelines covers topics such as: Why and when to deprescribe antidepressants, benzodiazepines, gabapentinoids and z-drugs Barriers and enablers to deprescribing including physical dependence, social circumstances, and knowledge about the discontinuation process Distinguishing withdrawal symptoms, such as poor mood, anxiety, insomnia, and a variety of physical symptoms from symptoms of the underlying disorder that medication was intended to treat The difference between physical dependence and addiction/substance use disorder Explanation of why and how to implement hyperbolic tapering in clinical practice Specific guidance on formulations of medication and techniques for making gradual reductions, including using liquid forms of medication, and other approaches Step-by-step guidance for safely stopping all commonly used antidepressants, benzodiazepines, gabapentinoids and z-drugs, including fast, moderate and slow tapering regimens or schedules for each drug, and guidance on how to tailor these to an individual Troubleshooting issues which can arise on stopping these medications, including akathisia, withdrawal symptoms, acute or protracted, and relapse. Written for anyone interested in safe deprescribing of psychiatric medications including psychiatrists, GPs, pharmacists, nurses, medical trainees, and interested members of the public. The Maudsley Deprescribing Guidelines is an essential resource on the subject that provides practical guidance on how to improve patient outcomes in this field of medicine. |
| xpharm the comprehensive pharmacology reference: Current and Future Aspects of Nanomedicine Islam Khalil, 2020-05-06 Nanomedicine refers to the use of nanotechnological applications in biomedical fields such as therapeutics, diagnostics, monitoring, visualization, tissue engineering and even surgery. This book presents recent updates in the nanomedicine market and discusses several aspects of drug delivery and tissue regeneration using different platforms and devices. |
| xpharm the comprehensive pharmacology reference: Advanced Pharmaceutical and Herbal Nanoscience for Targeted Drug Delivery Systems Part I Swarnlata Saraf, Ram Kumar Sahu, Vivek Dave, 2022-05-26 This 2-part reference informs readers about the application of drug delivery technologies to herbal medicines. Chapters cover a broad range of major topics on the subject of targeted drug delivery systems. These topics include the application of drug delivery systems for herbal nanomedicines, drug development issues, emerging technologies, adaptations for clinical use, market prospects and challenges of industrial commercialization. Chapters have been contributed by several experts in pharmaceutical chemistry and blend theoretical knowledge with practical aspects of drug delivery. Part I covers the following topics: - Introduction to nanotechnology and herbal-based nanoparticulate systems - Nucleic acid-based therapeutic drug delivery systems - Herbal bioactives: a booster dose for advanced pharmaceutical nanoscience - Pulmonary nano-drug delivery systems - Application of nano-drug delivery systems in improving the therapeutic efficacy of bioactive natural products - PEGylated liposomes - Insulin liposomes - Aquasomes: a promising novel drug carrier - Nanoparticle-aided herbal drugs: therapeutic implications on cholinergic dysfunction with relevance to Alzheimer’s disease - Vitamins based nanomedicine approach - Recent advances in tumor targeting drug delivery systems: fundamentals of advanced pharmaceutical nanoscience - Niosomes: a revolutionary progress in the field of pharmaceutical sciences - Infectious diseases: pharmaceutical nanoscience for targeted drug delivery This reference is a valuable resource for scholars that creates awareness of novel drug delivery systems as well as their promising applications in drug targeting, and nanotherapeutics for specific diseases. |
| xpharm the comprehensive pharmacology reference: Prospective Life Cycle Assessment of High-Temperature Superconductors for Future Grid Applications Buchholz, Alexander, 2022-07-27 High-temperature superconductors have distinct advantages compared to conventional conductors. Below their critical temperature, superconductors have immeasurably low ohmic losses. To maintain the superconducting state, superconductors require constant cooling. This study aims at identifying the environmental impacts of the application of superconductors in future grid technologies such as superconducting power cables. |
| xpharm the comprehensive pharmacology reference: From Anatomy to Function of the Central Nervous System Brandon Matteo Ascenzi, 2024-08-25 From Anatomy to Function of the Central Nervous System: Clinical and Neurosurgical Applications features neuroradiologic images that represent today, one of the most effective resources able to detect the anatomy of the nerve structures. Simultaneously featuring neuroimages, readers can study the functional aspects of the entire central nervous system with detailed captions that describe in detail how to use and interpret them. This book includes images of the brain dissected with the Klingler's method and white matter fiber dissection. By integrating the anatomo-functional description with the synaptic organization of the CNS, this reference is useful for anyone who wants to understand how the activity of a nerve structure arises, describing its microstructure, neurotransmitter phenotype, and neural activity. It also features descriptions of pathologic conditions which result from neuroanatomical and/or neurofunctional alterations and includes neurosurgical aspects. - Integrates anatomo-functional descriptions with the synaptic and neurochemical organization of the CNS - Allows readers to better understand the morphology and topography of encephalic structures - Features neuroradiological images and human brain dissections using the Klingler's method - Chapters have references (key article, book, and protocols) for additional detailed studies |
| xpharm the comprehensive pharmacology reference: Clinical Nuclear Medicine Physics with MATLAB® Maria Lyra Georgosopoulou, 2021-09-30 The use of MATLAB® in clinical Medical Physics is continuously increasing, thanks to new technologies and developments in the field. However, there is a lack of practical guidance for students, researchers, and medical professionals on how to incorporate it into their work. Focusing on the areas of diagnostic Nuclear Medicine and Radiation Oncology Imaging, this book provides a comprehensive treatment of the use of MATLAB in clinical Medical Physics, in Nuclear Medicine. It is an invaluable guide for medical physicists and researchers, in addition to postgraduates in medical physics or biomedical engineering, preparing for a career in the field. In the field of Nuclear Medicine, MATLAB enables quantitative analysis and the visualization of nuclear medical images of several modalities, such as Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), or a hybrid system where a Computed Tomography system is incorporated into a SPECT or PET system or similarly, a Magnetic Resonance Imaging system (MRI) into a SPECT or PET system. Through a high-performance interactive software, MATLAB also allows matrix computation, simulation, quantitative analysis, image processing, and algorithm implementation. MATLAB can provide medical physicists with the necessary tools for analyzing and visualizing medical images. It is useful in creating imaging algorithms for diagnostic and therapeutic purposes, solving problems of image reconstruction, processing, and calculating absorbed doses with accuracy. An important feature of this application of MATLAB is that the results are completely reliable and are not dependent on any specific γ-cameras and workstations. The use of MATLAB algorithms can greatly assist in the exploration of the anatomy and functions of the human body, offering accurate and precise results in Nuclear Medicine studies. KEY FEATURES Presents a practical, case-based approach whilst remaining accessible to students Contains chapter contributions from subject area specialists across the field Includes real clinical problems and examples, with worked through solutions Maria Lyra Georgosopoulou, PhD, is a Medical Physicist and Associate Professor at the National and Kapodistrian University of Athens, Greece. Photo credit: The Antikythera Mechanism is the world’s oldest known analog computer. It consisted of many wheels and discs that could be placed onto the mechanism for calculations. It is possible that the first algorithms and analog calculations in mathematics were implemented with this mechanism, invented in the early first centuries BC. It has been selected for the cover to demonstrate the importance of calculations in science. |
| xpharm the comprehensive pharmacology reference: Clinical Aromatherapy - E-Book Jane Buckle, 2014-11-14 Enhance patient care with the help of aromatherapy! Clinical Aromatherapy: Essential Oils in Healthcare is the first and only peer-reviewed clinical aromatherapy book in the world and features a foreword by Dr. Oz. Each chapter is written by a PhD nurse with post-doctoral training in research and then peer reviewed by named experts in their field. This clinical text is the must-have resource for learning how to effectively incorporate aromatherapy into clinical practice. This new third edition takes a holistic approach as it examines key facts and topical issues in aromatherapy practice and applies them within a variety of contexts and conditions. This edition also features updated information on aromatherapy treatments, aromatherapy organizations, essential oil providers, and more to ensure you are fully equipped to provide patients with the best complementary therapy available. - Expert peer-reviewed information spans the entire book. All chapters have been written by a PhD nurse with post-doctoral training in research and then peer reviewed by named experts in their field. - Introduction to the principles and practice of aromatherapy covers contraindications, toxicity, safe applications, and more. - Descriptions of real-world applications illustrate how aromatherapy works in various clinical specialties. - Coverage of aromatherapy in psychiatric nursing provides important information on depression, psychosis, bipolar, compulsive addictive, addiction and withdrawal. - In-depth clinical section deals with the management of common problems, such as infection and pain, that may frequently be encountered on the job. - Examples of specific oils in specific treatments helps readers directly apply book content to everyday practice. - Evidence-based content draws from thousands of references. - NEW! First and only totally peer-reviewed, evidence-based, clinical aromatherapy book in the world. - NEW Chapter on integrative Healthcare documenting how clinical aromatherapy has been integrated into hospitals and healthcare in USA, UK and elsewhere. - NEW Chapter on the M Technique: the highly successful method of gentle structured touch pioneered by Jane Buckle that is used in hospitals worldwide. - All chapters updated with substantial additional references and tables. |
| xpharm the comprehensive pharmacology reference: Advances in Antiparasitic Therapies and Drug Delivery Prashant Kesharwani, Neelima Gupta, 2023-11-21 Higee Chemical Reaction Engineering systematically discusses the fundamentals, principles and methods of molecular mixing and reaction process intensification. The book demonstrates in detail the implementation approach, process and effectiveness of Higee chemical reaction engineering through novel industrial case studies that help industrial technicians to select reaction intensification technology route more scientifically. The book covers the innovation and development process of Higee chemical reaction engineering, hydrodynamics behavior in Higee reactors, equipment design principles and methods, multiphase reaction of liquid-liquid, gas-liquid, gas-solid, gas-liquid-solid and reactive crystallization process intensification principles and effectiveness. It also prospects the future development direction and hot application fields of Higee chemical reaction process intensification. Higee Chemical Reaction Engineering is a systematic summary of several national award and key projects, such as the State Technological Innovation Award, State Science and Technology Advancement Award, National Natural Science Foundation of China, National key R&D Program of China, National ''863'' Program of China, National ''973'' Program of China and also some international cooperation. - Handles high gravity process intensification technology - Covers theoretical innovation in multiphase reaction intensified by high gravity - Presents engineering application cases in chemical engineering, materials science, ocean engineering, and environmental engineering - Provides systematic understanding of high gravity process intensification through theories and industrial applications |
| xpharm the comprehensive pharmacology reference: Gastrointestinal Physiology Menizibeya Osain Welcome, 2018-06-20 This book offers one of the most comprehensive reviews in the field of gastrointestinal (GI) physiology, guiding readers on a journey through the complete digestive tract, while also highlighting related organs and glandular systems. It is not solely limited to organ system physiology, and related disciplines like anatomy and histology, but also examines the molecular and cellular processes that keep the digestive system running. As such, the book provides extensive information on the molecular, cellular, tissue, organ, and system levels of functions in the GI system. Chapters on the roles of the gut as an endocrine, exocrine and neural organ, as well as its microbiome functions, broaden readers’ understanding of the multi-organ networks in the human body. To help illustrate the interconnections between the physiological concepts, principles and clinical presentations, it outlines clinical examples such as pathologies that link basic science with clinical practice in special “clinical correlates” sections. Covering both traditional and contemporary topics, it is a valuable resource for biomedical students, as well as healthcare and scientific professionals. |
| xpharm the comprehensive pharmacology reference: Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases Reza Heidari, M. Mehdi Ommati, 2023-03-31 Taurine, or 2aminoethanesulfonic acid, is one of the most abundant sulfurcontaining amino acids in the human body. It is found in the heart, brain, retina, and skeletal muscles, and is synthesized in the pancreas. Studies have revealed that taurine is of high physiological importance: it protects against pathologies associated with mitochondrial diseases, and linked processes like aging, metabolic syndrome, cancer, cardiovascular diseases, and neurological disorders. It is also used as a nutritional supplement. Taurine and the Mitochondrion: Applications in the Pharmacotherapy of Human Diseases explores the significance of taurine in the biology of mitochondria. It also explains its role as a pharmacological agent for treating different diseases. Readers will gain an insight into the crucial role it plays in human physiology and the benefits of taurine supplements. Topics covered in this reference include Synthesis of taurine and its dietary sources The Role of taurine in mitochondrial health Taurine as a neurotransmitter Beneficial effects of taurine in physiological systems such as the reproductive system, renal system, and the gastrointestinal tract Hepatoprotective and antiinflammatory properties of taurine The antiaging promise of taurine supplementation Role of taurine supplementation in obesity |
| xpharm the comprehensive pharmacology reference: Gaps and the Creation of Ideas Judith Seligson, 2021-03-08 Gaps and the Creation of Ideas: An Artist’s Book is a portrait of the space between things, whether they be neurons, quotations, comic-book frames, or fragments in a collage. This twenty-year project is an artist’s book that juxtaposes quotations and images from hundreds of artists and writers with the author’s own thoughts. Using Adobe InDesign® for composition and layout, the author has structured the book to show analogies among disparate texts and images. There have always been gaps, but a focus on the space between things is virtually synonymous with modernity. Often characterized as a break, modernity is a story of gaps. Around 1900, many independent strands of gap thought and experience interacted and interwove more intricately. Atoms, textiles, theories, women, Jews, collage, poetry, patchwork, and music figure prominently in these strands. The gap is a ubiquitous phenomenon that crosses the boundaries of neuroscience, rabbinic thinking, modern literary criticism, art, popular culture, and the structure of matter. This book explores many subjects, but it is ultimately a work of art. |
| xpharm the comprehensive pharmacology reference: Industrial Biotechnology Christoph Wittmann, James C. Liao, 2017-03-06 The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries. |
| xpharm the comprehensive pharmacology reference: Viral Infections and Antiviral Therapies Amal Kumar Dhara, Amit Kumar Nayak, 2022-11-10 Viral Infections and Antiviral Therapies provides comprehensive coverage of viral infections and their transmission. Coverage includes antiviral agents, therapeutics, their mechanisms and treatment strategies. The book is organized into four sections, including an introduction to antiviral therapies, viral infections and their transmission, antiviral agents and therapeutics, and a market overview and future developments. The chapters in each section of the book discuss various key topics that are contributed to by an international group of leading experts. - Covers emerging and sexually transmitted viruses, including mode of transmission and pathophysiology of viral infections - Describes antiviral agents and therapeutics for viruses such as rotaviruses, enteroviruses and coronaviruses - Discusses strategies for the delivery of antiviral agents and vaccinations |
| xpharm the comprehensive pharmacology reference: Nanotechnology-Based Sensing Platforms for Illicit Drugs Sayan Ganguly, Poushali Das, Amin Reza Rajabzadeh, Seshasai Srinivasan, 2025-04-11 Nanotechnology-Based Sensing Platforms for Illicit Drugs reviews different types of sensors that detect illicit drugs, with a special focus on the advantages provided by incorporating nanotechnology in their design. The book starts with the fundamentals, classification, progress, the current state of research on nanotechnology-based sensors, and an overview of materials commonly used. Subsequent chapters focus on the chemical interactive behaviors of drugs and their detection methods. It includes a thorough discussion on the design, fabrication, and characterization of sensors for illicit drug detection. Final sections provide an overall outlook on recent technological advances in drug detection devices and future research.This book is a valuable resource for researchers, scientists, and professionals interested in biosensors, nanotechnology, and their applications in illicit drug detection. - Reviews cutting-edge research in the fabrication, characterization, properties, and application of sensors for illicit drugs - Presents a wide range of applications for nanomaterials in sensor-based technologies - Highlights sensing mechanisms and their behavior against different molecules |
| xpharm the comprehensive pharmacology reference: Principles of Tumors Leon P. Bignold, 2019-11-01 Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine. - Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compounds - Presents translational approaches for every topic to improve conceptual insights for new research projects - Covers a broad range of subjects, making it easier for the reader to understand related fields - Includes diagrams for complex topics to aid in understanding for non-specialists |
| xpharm the comprehensive pharmacology reference: Handbook of Microbial Nanotechnology Chaudhery Mustansar Hussain, 2022-03-13 Handbook of Microbial Nanotechnology is a collection of the most recent scientific advancements in the fundamental application of microbial nanotechnology across various sectors. This comprehensive handbook highlights the vast subject areas of microbial nanotechnology and its potential applications in food, pharmacology, water, environmental remediation, etc. This book will serve as an excellent reference handbook for researchers and students in the food sciences, materials sciences, biotechnology, microbiology and in the pharmaceutical fields.Microbial nanotechnology is taking part in creating development and innovation in various sectors. Despite the participation of microbial nanotechnology in modern development, there are some hindrances. The lack of information, the possibility of adverse impacts on the environment, human health, safety and sustainability are still a challenge. This handbook addresses these challenges. - Offers up-to-date, scientific information on the integration of microbiology and nanotechnology - Explores how nanotechnology can improve the detection of trace chemical contaminants, viruses and bacteria in food and other industry applications - Provides readers with a fundamental understanding of microbial nanotechnology and its challenges - Includes real-time applications with case studies to illustrate how microbial nanotechnology influences modern sciences and technologies |
| xpharm the comprehensive pharmacology reference: Hayes' Principles and Methods of Toxicology A. Wallace Hayes, Tetyana Kobets, 2023-07-03 Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. Principles of Toxicology), major classes of established chemical hazards (Section II. Agents), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. Methods), as well as toxicology of specific target systems and organs (Section IV. Organ- and System-Specific Toxicology). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment. |
| xpharm the comprehensive pharmacology reference: Wild Mushrooms Sanju Bala Dhull, Aarti Bains, Prince Chawla, Pardeep Kumar Sadh, 2022-08-10 Many wild varieties of mushrooms are consumed by people around the world, yet many species remain unexplored, their nutritional as well as pharmacological significance yet to be discovered for many of them. Wild Mushrooms: Characteristics, Nutrition, and Processing informs readers about different unexplored wild mushrooms, their methods of cultivation, nutritional values, pharmaceutical values, and possible utilization for human wellbeing. The book represents a comprehensive assessement of current knowledge about the edible mushrooms commercialization, especially as nutraceuticals and dietary supplement formulation, mineral supplementation and source of quality proteins in foods and diet. The health benefits of edible mushrooms, nature and chemistry of bioactive components and in-vitro and in-vivo bioactivity of edible mushrooms are also highlighted in different chapters. By bringing diverse areas such as oxidative stress and longevity, techniques of mushroom analysis, toxicology and extracellular enzymes of wild mushrooms, it lays the groundwork for striking expansion in our understanding of these important biochemicals and their role in health and disease prevention. Key Features: Explores major preservation and processing technologies for wild mushrooms and their effects on bioavailability and nutritional value of mushrooms Presents the classical taxonomy and genetic classification of mushrooms Discusses the different components present in mushrooms and their biological activities and the health attribute of mushrooms due to these bioactive components Reviews the applications of mushrooms in environmental pollution reduction Covers different cultivation strategies of edible and medicinal mushrooms The book also explores the role of mushrooms in the degradation of harmful xenobiotic compounds as well as reduction of pesticides. It discusses the utilization of wild mushrooms in waste management and cultivation of wild mushroom using lignocellulosic biomass-based residue as a substrate. This book should be of interest to a large and varied audience of researchers in academia, industry, nutritionists, dietitian, food scientists, agriculturists and regulators. |
| xpharm the comprehensive pharmacology reference: Algal Biorefinery Sanjeet Mehariya, Bikash Kumar, Shashi Kant Bhatia, Obulisamy Parthiba Karthikeyan, 2025-03-21 Algal Biorefinery: A Sustainable Solution for Environmental Applications focuses on algae's possibilities, assets, and functions as a renewable and sustainable resource that can act as an excellent alternative to withstand adverse environmental conditions to generate useful products. Thus, apart from helping reduce environmental pollution and the carbon footprint, algae can help mitigate factors causing rapid climate change via concurrent bioremediation, resource recovery, and environmental sustainability.This comprehensive book will examine dedicated state-of-the-art information on the topic of how algae can act as a cushion against climate change. It will also explain how algal-based biorefineries can act as a potential solution to climate change, lack of natural resources, and environmental pollution - Elucidates algal biorefinery as a sustainable solution for carbon emission reduction and fossil fuels alternatives. - Offers up-to-date information on algal-based wastewater treatment and resource recovery to assist in climate change. - Provides flowcharts, schematic diagrams, and figures showing mechanisms and processes for the depiction of strategies for algal-based technologies. - Examines the environmental impact assessment of existing and developing algal-based technologies for future environmental sustainability. |
| xpharm the comprehensive pharmacology reference: Heart Failure: A Companion to Braunwald's Heart Disease E-Book G. Michael Felker, Douglas L. Mann, 2019-02-06 Up-to-date, authoritative and comprehensive, Heart Failure, 4th Edition, provides the clinically relevant information you need to effectively manage and treat patients with this complex cardiovascular problem. This fully revised companion to Braunwald's Heart Disease helps you make the most of new drug therapies such as angiotensin receptor neprilysin inhibitors (ARNIs), recently improved implantable devices, and innovative patient management strategies. Led by internationally recognized heart failure experts Dr. G. Michael Felker and Dr. Douglas Mann, this outstanding reference gives health care providers the knowledge to improve clinical outcomes in heart failure patients. - Focuses on a clinical approach to treating heart failure, resulting from a broad variety of cardiovascular problems. - Covers the most recent guidelines and protocols, including significant new updates to ACC, AHA, and HFSA guidelines. - Covers key topics such as biomarkers and precision medicine in heart failure and new data on angiotensin receptor neprilysin inhibitors (ARNIs). - Contains four new chapters: Natriuretic Peptides in Heart Failure; Amyloidosis as a Cause of Heart Failure; HIV and Heart Failure; and Neuromodulation in Heart Failure. - Covers the pathophysiological basis for the development and progression of heart failure. - Serves as a definitive resource to prepare for the ABIM's Heart Failure board exam. - 2016 British Medical Association Award: First Prize, Cardiology (3rd Edition). |
| xpharm the comprehensive pharmacology reference: Convergence of Population Health Management, Pharmacogenomics, and Patient-Centered Care Moumtzoglou, Anastasius S., 2024-09-27 The current healthcare framework, often characterized by standardized treatments and one-size-fits-all approaches, falls short in addressing the unique genetic compositions, lifestyles, and environmental factors that influence individual patient outcomes. This gap necessitates a radical reevaluation of healthcare practices, from reshaping infrastructure to redefining the roles of patients and doctors. The challenges are formidable, requiring critical reflection and bold initiatives to overcome obstacles and pave the way for a future where patient-centered care seamlessly integrates with population health management, leveraging data, technology, ethics, and collaboration for a global healthcare revolution. Convergence of Population Health Management, Pharmacogenomics, and Patient-Centered Care is a book that unveils a comprehensive exploration of solutions and pathways towards this transformative vision. This comprehensive guide is tailored for academic scholars, healthcare professionals, and students navigating the landscape of personalized medicine, population health management, and the digitalization of healthcare. Authored by leading experts, the book aims to serve as a compendium of terms, definitions, and in-depth explanations of key concepts. Its objectives include supporting students in understanding healthcare domains, aiding healthcare professionals in meeting patient needs, assisting patients in deriving more benefits from their healthcare, and guiding e-health systems' designers and managers in grounding practices on the science of individuality. |
| xpharm the comprehensive pharmacology reference: Wealth out of Food Processing Waste M. Selvamuthukumaran, 2024-04-01 High amounts of waste are generated daily in various food processing industries including seed, pomace, pit, peel, germ, husk, broken pulses, sludge, skin, bones, blood, feathers, wash water, and spent residue, among others. Several tons of generated waste can be effectively used to manufacture or recover such value-added by-products as fibers, antioxidants, proteins, vitamins and minerals, biofilms, fertilizers, and animal feed. While food processing- generated waste may lead to health and environmental hazards, it is critical to identify proper protocols to recover valuable ingredients from waste, thereby creating wealth in the society. Wealth out of Food Processing Waste identifies and describes the proper protocols to recover valuable ingredients from waste, thereby creating wealth in society. The effective utilization of waste can generate income for the entrepreneur, lead to more employment for society, enhance fertility of soil, reduce environmental pollution, conserve resources, and help augment national economies to a greater extent. Key Features: Provides in-depth knowledge about conversion of waste derived from various food processing industries into various value-added products Highlights the extraction of antioxidants and functional food ingredients from industrial food waste Presents current and emerging trends using biotechnological approaches for conversion of waste into various value-added products This book provides food industry personnel, scientists, food engineers, biotechnologists, research scholars, and students with strategies for effective utilization of waste from various food processing industries. |
| xpharm the comprehensive pharmacology reference: Biopolymer-Based Formulations Kunal Pal, Indranil Banerjee, Preetam Sarkar, Doman Kim, Win-Ping Deng, Navneet Kumar Dubey, Kaustav Majumder, 2020-01-18 Biopolymer-Based Formulations: Biomedical and Food Applications presents the latest advances in the synthesis and characterization of advanced biopolymeric formulations and their state-of-the-art applications across biomedicine and food science. Sections cover the fundamentals, applications, future trends, environmental, ethical and medical considerations, and biopolymeric architectures that are organized in nano, micro and macro scales. The final section of the book focuses on novel applications and recent developments. This book is an essential resource for researchers, scientists and advanced students in biopolymer science, polymer science, polymer chemistry, polymer composites, plastics engineering, biomaterials, materials science, biomedical engineering, and more. It will also be of interest to R&D professionals, scientists and engineers across the plastics, food, biomedical and pharmaceutical industries. - Provides in-depth coverage of methods for the characterization of the physical properties of biopolymeric architectures - Supports a range of novel applications, including scaffolds, implant coatings, drug delivery, and nutraceutical encapsulation systems - Includes the use of experimental data and mathematical modeling, thus enabling the reader to analyze and compare the properties of different polymeric gels |
| xpharm the comprehensive pharmacology reference: Phytochemical Drug Discovery for Central Nervous System Disorders Chukwuebuka Egbuna, Mithun Rudrapal, 2023-07-13 PHYTOCHEMICAL DRUG DISCOVERY FOR CENTRAL NERVOUS SYSTEM DISORDERS Understand herbal and plant-based treatments for chronic disorders with this groundbreaking work Due in part to the aging of the global population, disorders of the central nervous system have become an increasingly grave public health concern in recent years. Demand for pharmaceutical treatments has been correspondingly high, but there are many barriers to the successful development of effective synthetic drugs. Phytomedicines, or plant-based and herbal medicines, have proven to be an effective alternative, boasting lower toxicity and cost and higher efficacy, and one that demands greater research and broader-based practitioner knowledge. Phytochemical Drug Discovery for Central Nervous System Disorders meets this demand with a timely, clearly-structured guide. It thorough coverage presents a wide range of phytochemicals with potential as candidates for drug discovery, describing their sources, properties, and therapeutic efficacy. The result is a vital contribution to the ongoing fight against central nervous system (CNS) disorders. Phytochemical Drug Discovery for Central Nervous System Disorders readers will also find: Detailed treatment of CNS-active plant products, neuroprotective chemicals, plant-based nutraceutical products, and more Up-to-date information on FDA-approved drugs and existing plant-based products used to treat CNS disorders An authorial team featuring experts from across the globe Phytochemical Drug Discovery for Central Nervous System Disorders is essential for drug discovery scientists, drug developers, medicinal chemists, biochemists, and any researchers and professionals in the health care or pharmaceutical industries. |
| xpharm the comprehensive pharmacology reference: Dynamics and Control of Energy Systems Achintya Mukhopadhyay, Swarnendu Sen, Dipankar Narayan Basu, Sirshendu Mondal, 2019-10-14 This book presents recent advances in dynamics and control of different types of energy systems. It covers research on dynamics and control in energy systems from different aspects, namely, combustion, multiphase flow, nuclear, chemical and thermal. The chapters start from the basic concepts so that this book can be useful even for researchers with very little background in the area. A dedicated chapter provides an overview on the fundamental aspects of the dynamical systems approach. The book will be of use to researchers and professionals alike. |
| xpharm the comprehensive pharmacology reference: Ways of Nature Pany Decossard, 2023-12-13 In Ways of Nature, Dr. Décossard articulates the first theory of evolution since Darwin. By his own account, he stumbled upon his proposed mechanism of eukaryogenesis using a process worthy of the three princes of Serendip. From there, he succeeded in establishing a comprehensive theory of life and the universe. For instance, we learn that a new paradigm, called “ the seeds-first theory,” explains biodiversity among eukaryotic species, such as those of plants and animals. It is interesting to discover what contributions, if any, the theory of natural selection provided to the new model. Nevertheless, the modern version of Darwinism, or neo-Darwinism, has long been engaged in a major antagonism with the theory of Intelligent Design (ID), which holds that the living world emanated from the conscious choice of a designer rather than chance events. In any case, the author will be the first one to admit that the new model of evolution delineated in this opus is not born out of the crisis that is currently rocking neo-Darwinism, a crisis sparked by the assaults of many thinkers and scientists, including those of the ID movement. He is also quick to reveal how little he knew about the standoff between the two main protagonists in the crisis of the theory of natural selection before he began work on this book, cloistered as he was both literally and figuratively within the confines of emergency rooms caring for the sick and injured. In Ways of Nature, Dr. Décossard explores the paths taken by life since its apparition and shines a bright spotlight on its destiny and the fate of the universe. In so doing, he also identifies the connections between the living and the nonliving and opens our eyes to novel ideas about physical phenomena whose conventional descriptions we thought were settled. Ways of Nature is undoubtedly a landmark publication. It is indeed a paradigm shift à la Kuhn in our understanding of life and its evolution. |
| xpharm the comprehensive pharmacology reference: Role of Microbes in Industrial Products and Processes Sanjay Kumar, Narendra Kumar, Shahid Ul Islam, 2022-11-01 ROLE OF MICROBES IN INDUSTRIAL PRODUCTS AND PROCESSES The book covers recent breakthroughs and highlights the major role microbes play in industrial products and processes. With the advent of industrial biotechnology, microbes became popular as cell factories, and with the recent advancements in recombinant DNA technology, the application of microorganisms in various sectors has increased enormously for the development of various processes and products. Role of Microbes in Industrial Products and Processes covers recent breakthroughs and highlights the major role microbes play in industrial products and processes. It mainly focuses on the bio-refinery concept where bio-energy production and wastewater treatment are done simultaneously using micro-algae. Additionally, this book describes the role of microbes involved in the production of various enzymes, organic acids, and bio-polymers. It also provides detailed insight on modeling and simulation of bioprocess for the production of sugar alcohol; recovery of value-added products from organic waste using microbes is also reported. Detailed insights into the treatment of wastewater released from various industries, especially pharmaceutical wastewater, are given. Audience The book is intended for researchers, scientists, and postgraduates in chemical/biochemical engineering and bioprocess engineering, and others working in the domain of food microbiology, bioenergy/refinery, waste valorization to value-added products, and microbial production of bioplastics, sugar alcohols, enzymes, and organic acids. |
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