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| translocation definition biology: Molecular Biology of the Cell , 2002 |
| translocation definition biology: Encyclopedia of Cancer Manfred Schwab, 2008-09-23 This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely. |
| translocation definition biology: Reintroduction Biology John G. Ewen, Doug P. Armstrong, Kevin A. Parker, Philip J. Seddon, 2012-01-30 This book aims to further advance the field of reintroduction biology beyond the considerable progress made since the formation of the IUCN/SSC Re-introduction Specialist Group. Using an issue-based framework that purposely avoids a structure based on case studies the book's central theme is advocating a strategic approach to reintroduction where all actions are guided by explicit theoretical frameworks based on clearly defined objectives. Issues covered include husbandry and intensive management, monitoring, and genetic and health management. Although taxonomically neutral there is a recognised dominance of bird and mammal studies that reflects the published research in this field. The structure and content are designed for use by people wanting to bridge the research-management gap, such as conservation managers wanting to expand their thinking about reintroduction-related decisions, or researchers who seek to make useful applied contributions to reintroduction. |
| translocation definition biology: Abscisic Acid in Plants , 2019-11-21 Abscisic Acid in Plants, Volume 92, the latest release in the Advances in Botanical Research series, is a compilation of the current state-of-the-art on the topic. Chapters in this new release comprehensively describe latest knowledge on how ABA functions as a plant hormone. They cover topics related to molecular mechanisms as well as the biochemical and chemical aspects of ABA action: hormone biosynthesis, catabolism, transport, perception, signaling in plants, seeds and in response to biotic and abiotic stresses, hormone evolution and chemical biology, and much more. - Presents the latest release in the Advances in Botanical Research series - Provides an Ideal resource for post-graduates and researchers in the plant sciences, including plant physiology, plant genetics, plant biochemistry, plant pathology, and plant evolution - Contains contributions from internationally recognized authorities in their respective fields |
| translocation definition biology: Genetics for Surgeons Patrick John Morrison, Roy Archibald Joseph Spence, 2005 Morrison (human genetics, University of Ulster, UK) and Spence (biomedical science, University of Ulster, UK) offer an accessible reference on the genetic disorders that surgeons can expect to meet in general surgical practice. Written in non-technical language, with a glossary, list of abbreviations, and color and b&w photos and medical images, the book supplies an introduction to the nomenclature and technology of molecular biology, and will be a useful starting point for those who wish to extend their knowledge. Annotation :2005 Book News, Inc., Portland, OR (booknews.com). |
| translocation definition biology: Signal Transduction in Plants P. Aducci, 1997 The molecular aspects of recognition and transduction of different kinds of signals is a research area that is spawning increasing interest world-wide. Major advances have been made in animal systems but recently plants too, have become particularly attractive because of their promising role in biotechnology. The type of signals peculiar to the plant world and the similarity of plant transduction pathways investigated thus far to their animal counterparts are prompting more and more studies in this modern area of cell biology. The present book provides a comprehensive survey of all aspects of the recognition and transduction of plant signals of both chemical and physical origin such as hormones, light, toxins and elicitors. The contributing authors are drawn from diverse areas of plant physiology and plant molecular biology and present here different approaches to studying the recognition and transduction of different signals which specifically trigger molecular processes in plants. Recent advances in the field are reviewed, providing the reader with the current state of knowledge as well as insight into research perspectives and future developments. The book should interest a wide audience that includes not only researchers, advanced students, and teachers of plant biology, biochemistry and agriculture, but it has also significant implications for people working in related fields of animal systems. |
| translocation definition biology: Protein Transport into the Endoplasmic Reticulum Richard Zimmermann, 2009-08-31 Protein transport into the endoplasmic reticulum (ER) is just one aspect of the general cell biology topic of intracellular protein sorting. This larger picture also includes protein transport into other organelles of the eukaryotic cell (chloroplasts, mitochondria, nucleus, peroxisomes), protein export from bacteria, vesicular transport that deliv |
| translocation definition biology: Gene Therapy of Cancer Stanton L. Gerson, Edmund C. Lattime, 2002-04-04 The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. - Provides in-depth description of targeted systems and treatment strategies - Explains the underlying cancer biology necessary for understanding a given therapeutic approach - Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses - Presents translational focus with emphasis on requirements for clinical implementation - Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference |
| translocation definition biology: Polymer Translocation M. Muthukumar, 2016-04-19 Polymer translocation occurs in many biological and biotechnological phenomena where electrically charged polymer molecules move through narrow spaces in crowded environments. Unraveling the rich phenomenology of polymer translocation requires a grasp of modern concepts of polymer physics and polyelectrolyte behavior. Polymer Translocation discusse |
| translocation definition biology: Genetic Disorders and the Fetus Aubrey Milunsky, 2012-12-06 Technological advances continue to expand the number of genetic disorders that can be diagnosed in utero. Utilization of this new technology has de manded special expertise available in relatively few academic centers. As these new applications have become more widespread so have the realities of the medicolegal implications. Notwithstanding the laboratory challenges, most legal action, at least in the United States, has arisen from the physician's failure to inform a patient about the risks of a genetic disorder or the oppor tunities presented by prenatal diagnosis. Hence an extensive thorough reex amination of the subject seems appropriate and timely. The steady escalation in the number of prenatal genetic studies now being done in the western world makes it imperative for the physician to have a thorough comprehension of the subject in its entirety. I am, therefore, fortu nate in having colleagues who as acknowledged experts have shared their knowledge and experience in order to make this volume a major critical repository of facts and guidance about prenatal genetic diagnosis. The subject matter ranges from a consideration of required genetic counseling through the intricacies of establishing prenatal diagnoses. Special attention is focused on new advances using ultrasound, a-fetoprotein, fetoscopy, and first trimester diagnosis. Both ethical and legal implications are discussed in detail, as is the development of public policy. |
| translocation definition biology: Toward Precision Medicine National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on A Framework for Developing a New Taxonomy of Disease, 2012-01-16 Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for a new taxonomy of human disease based on molecular biology and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The new taxonomy that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy. |
| translocation definition biology: Exocytosis and Endocytosis Andrei I. Ivanov, 2008 In this book, skilled experts provide the most up-to-date, step-by-step laboratory protocols for examining molecular machinery and biological functions of exocytosis and endocytosis in vitro and in vivo. The book is insightful to both newcomers and seasoned professionals. It offers a unique and highly practical guide to versatile laboratory tools developed to study various aspects of intracellular vesicle trafficking in simple model systems and living organisms. |
| translocation definition biology: Chromosome Abnormalities and Genetic Counseling R.J.M McKinlay Gardner, Grant R Sutherland, Lisa G. Shaffer, 2011-11-11 Chromosome abnormalities have been known for over 50 years, though the methods of analysis have become increasing more sophisticated and precise. Surprisingly, the questions that parents and families raise in genetic counseling have changed little over that period. Questions like, Why did an abnormality happen? Why did it cause the problems we see in our child? Would it happen again in a future child? How could we avoid it happening again? are common concerns for families. This new edition of Chromosome Abnormalities and Genetic Counseling deals with these universal questions, and in the context of the recent developments in molecular cytogenetic analysis, but retaining always the major focus on the needs of the families in which these conditions occur. Thoroughly updated once again, this richly-illustrated text combines basic concepts of chromosomal analysis with practical applications of recent advances in molecular cytogentics. The book will give counselors the information that will enable them to help concerned parents accommodate and adapt to their particular chromosomal challenges and to determine what may be, for them, the best course of action. |
| translocation definition biology: Guidelines for the Translocation of Threatened Plants in Australia , 2018 The main objective of these guidelines is to demonstrate the degree of difficulty involved in translocations and to minimise inappropriate occurrence; highlight the expensiveness of the process; to help in correct decision-making; provide guidance for successful outcomes; to encourage better communication with interested parties. |
| translocation definition biology: The Sonoran Desert Tortoise Thomas R. Van Devender, 2006-09-01 One of the most recognizable animals of the Southwest, the desert tortoise (Gopherus agassizii) makes its home in both the Sonoran and Mohave Deserts, as well as in tropical areas to the south in Mexico. Called by Tohono O'odham people komik'c-ed, or shell with living thing inside, it is one of the few desert creatures kept as a domestic petÑas well as one of the most studied reptiles in the world. Most of our knowledge of desert tortoises comes from studies of Mohave Desert populations in California and Nevada. However, the ecology, physiology, and behavior of these northern populations are quite different from those of their southern, Sonoran Desert, and tropical cousins, which have been studied much less. Differences in climate and habitat have shaped the evolution of three races of desert tortoises as they have adapted to changes in heat, rainfall, and sources of food and shelter as the deserts developed in the last ten million years. This book presents the first comprehensive summary of the natural history, biology, and conservation of the Sonoran and Sinaloan desert tortoises, reviewing the current state of knowledge of these creatures with appropriate comparisons to Mohave tortoises. It condenses a vast amount of information on population ecology, activity, and behavior based on decades of studying tortoise populations in Arizona and Sonora, Mexico, and also includes important material on the care and protection of tortoises. Thirty-two contributors address such topics as tortoise fossil records, DNA analysis, and the mystery of secretive hatchlings and juveniles. Tortoise health is discussed in chapters on the care of captives, and original data are presented on the diets of wild and captive tortoises, the nutrient content of plant foods, and blood parameters of healthy tortoises. Coverage of conservation issues includes husbandry methods for captive tortoises, an overview of protective measures, and an evaluation of threats to tortoises from introduced grass and wildfires. A final chapter on cultural knowledge presents stories and songs from indigenous peoples and explores their understanding of tortoises. As the only comprehensive book on the desert tortoise, this volume gathers a vast amount of information for scientists, veterinarians, and resource managers while also remaining useful to general readers who keep desert tortoises as backyard pets. It will stand as an enduring reference on this endearing creature for years to come. |
| translocation definition biology: The Molecular Biology of Down Syndrome G. Lubec, 1999-12-02 This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology. |
| translocation definition biology: ISCN 2005 Lisa G. Shaffer, Niels Tommerup, 2005-01-01 This publication combines and extends the now classic system of human cytogenetic nomenclature prepared by expert committees and published in collaboration with Cytogenetic and Genome Research (formerly: Cytogenetics and Cell Genetics ) since 1963. Revised and finalized by the ISCN Committee and its advisors at a meeting in Vancouver, BC, in December 2004, it updates, corrects and incorporates all previous human cytogenetic nomenclature recommendations into one systematically organized publication. It thus supersedes the previous compilations in ISCN 1985 and its supplement, ISCN 1991 , the Guidelines for Cancer Cytogenetics , and ISCN 1995 . What s new in ISCN 2005? the G- and R-banded karyotypes have been replaced by new ones reflecting higher band-level resolutions new ideograms at the 300-band and 700-band level have been added the in situ hybridization nomenclature has been modernized, simplified, and expanded new examples reflecting unique situations are included a basic nomenclature for recording array comparative genomic hybridization results is introduced ISCN 2005 also contains a detachable fold-out of the normal human karyotype, consisting of photographs of G-banded and R-banded chromosomes at the commonly examined 550-band resolution stage and their diagrammatic representations a useful aid for human cytogeneticists, technicians, and students. |
| translocation definition biology: The Microbiota in Gastrointestinal Pathophysiology Martin H. Floch, Yehuda Ringel, W. Allen Walker, 2016-11-16 The Microbiota in Gastrointestinal Pathophysiology: Implications for Human Health, Prebiotics, Probiotics and Dysbiosis is a one-stop reference on the state-of-the-art research on gut microbial ecology in relation to human disease. This important resource starts with an overview of the normal microbiota of the gastrointestinal tract, including the esophagus, stomach, Ileum, and colon. The book then identifies what a healthy vs. unhealthy microbial community looks like, including methods of identification. Also included is insight into which features and contributions the microbiota make that are essential and useful to host physiology, as is information on how to promote appropriate mutualisms and prevent undesirable dysbioses. Through the power of synthesizing what is known by experienced researchers in the field, current gaps are closed, raising understanding of the role of the microbiome and allowing for further research. - Explains how to modify the gut microbiota and how the current strategies used to do this produce their effects - Explores the gut microbiota as a therapeutic target - Provides the synthesis of existing data from both mainstream and non-mainstream sources through experienced researchers in the field - Serves as a 'one-stop' shop for a topic that's currently spread across a number of various journals |
| translocation definition biology: Human Reproductive and Prenatal Genetics Peter C.K. Leung, Jie Qiao, 2018-08-28 Human Reproductive and Prenatal Genetics presents the latest material from a detailed molecular, cellular and translational perspective. Considering its timeliness and potential international impact, this all-inclusive and authoritative work is ideal for researchers, students, and clinicians worldwide. Currently, there are no comprehensive books covering the field of human reproductive and prenatal genetics. As such, this book aims to be among the largest and most useful references available. Named a Highly Commended book in the Basic and Clinical Sciences by the British Medical Association. - Features chapter contributions from leading international scientists and clinicians - Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization and implantation, in vitro culture of the human embryo for the study of post-implantation development, and more - Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics based approaches |
| translocation definition biology: Agrobacterium: From Biology to Biotechnology Tzvi Tzfira, Vitaly Citovsky, 2007-12-25 Agrobacterium is a plant pathogen which causes the “crown-gall” disease, a neoplastic growth that results from the transfer of a well-defined DNA segment (“transferred DNA”, or “T-DNA”) from the bacterial Ti (tumor-inducing) plasmid to the host cell, its integration into the host genome, and the expression of oncogenes contained on the T-DNA. The molecular machinery, needed for T-DNA generation and transport into the host cell and encoded by a series of chromosomal (chv) and Ti-plasmid virulence (vir) genes, has been the subject of numerous studies over the past several decades. Today, Agrobacterium is the tool of choice for plant genetic engineering with an ever expanding host range that includes many commercially important crops, flowers, and tree species. Furthermore, its recent application for the genetic transformation of non-plant species, from yeast to cultivated mushrooms and even to human cells, promises this bacterium a unique place in the future of biotechnological applications. The book is a comprehensive volume describing Agrobacterium's biology, interactions with host species, and uses for genetic engineering. |
| translocation definition biology: Human Genes and Genomes Leon E. Rosenberg, Diane Drobnis Rosenberg, 2012-05-21 In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor's office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines. - Bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease - Includes the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more - Explores ethical, legal, regulatory and economic aspects of genomics in medicine - Integrates historical (classical) genetics approach with the latest discoveries in structural and functional genomics |
| translocation definition biology: Molecular Diagnostics George P. Patrinos, Wilhelm Ansorge, 2005-06-06 Molecular Diagnostics covers current molecular biological techniques used to identify the underlying molecular defects in inherited disease. Although an increasing number of laboratories, both academic and private are moving in that direction, there are only a few books in the existing literature, and they deal only partly with diagnosis at the molecular level. Each chapter includes the principle and a brief description of the technique, followed by exmples from the authors' own epertise. Contributors are well-known experts in their field, and derive from a variety of disciplines, to ensure breadth and depth of coverage. - Examines widely used molecular biology techniques to screen for genetic defects causing inherited disorders - Includes state-of-the-art techniques for the detection of the underlying genetic heterogeneity leading to inherited disorders - Identification of genetically modified organisms (GMO's) - Forensic analysis and every-day issues in a diagnostic laboratory - Discusses ethics, genetic counselling and quality management |
| translocation definition biology: The Bacterial Phosphotransferase System Milton H. Saier, 2002-06-13 Following it's discovery in E.coli by Kundig, Ghosh and Rosema thirty seven years ago, a wealth of information has accumulated on the bacterial Phosphotransferase system (PTS). Since then the PTS has been found in a wide variety of different bacteria where it has been recognised to play a pivotal role in numerious aspects of bacterial cellular physiology. While the primary functions of this system involve sugar reception, transport and phosphorylation, the secondary functions include the regulation, both directly and indirectly, of important metabolic pathways. In this book, Internationally recognised authors review the current research on the PTS, discuss the multifaceted structural and functional aspects of the system and attempt to provide a realistic forecast of future discoveries. Study of this important system will contribute to our understanding of prokaryotic physiology and pathogenesis, will allow major advances in biotechnology, and will result in the development of agents capable of effectively combating harmful microorganisms. |
| translocation definition biology: Membrane Structural Biology Mary Luckey, 2014-02-24 This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field. |
| translocation definition biology: Global Re-introduction Perspectives Pritpal S. Soorae, 2010 This is the second issue in the Global Re-introduction Perspectives series and has been produced in the same standardized format as the previous one. The case-studies are arranged in the following order: Introduction, Goals, Success Indicators, Project Summary, Major Difficulties Faced, Major Lessons Learned, Success of Project with reasons for success or failure. For this second issue we received a total of 72 case-studies compared to 62 in the last issue. These case studies cover the following taxa as follows: invertebrates (9), fish (6), amphibians (5), reptiles (7), birds (13), mammals (20) and plants (12) ... We hope the information presented in this book will provide a broad global perspective on challenges facing re-introduction projects trying to restore biodiversity.--Pritpal S. Soorae. |
| translocation definition biology: Translational Biotechnology Yasha Hasija, 2021-01-21 Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field. |
| translocation definition biology: Molecular Cell Biology Harvey F. Lodish, 2008 The sixth edition provides an authoritative and comprehensive vision of molecular biology today. It presents developments in cell birth, lineage and death, expanded coverage of signaling systems and of metabolism and movement of lipids. |
| translocation definition biology: Anticancer Drug Development Bruce C. Baguley, David J. Kerr, 2001-11-17 Here in a single source is a complete spectrum of ideas on the development of new anticancer drugs. Containing concise reviews of multidisciplinary fields of research, this book offers a wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death. Detailed descriptions of sources for new drugs and methods for testing and clinical trial design are also provided. - One work that can be consulted for all aspects of anticancer drug development - Concise reviews of research fields, combined with practical scientific detail, written by internationally respected experts - A wealth of ideas on current and future molecular targets for drug design, including signal transduction, the cell division cycle, and programmed cell death - Detailed descriptions of the sources of new anticancer drugs, including combinatorial chemistry, phage display, and natural products - Discussion of how new drugs can be tested in preclinical systems, including the latest technology of robotic assay systems, cell culture, and experimental animal techniques - Hundreds of references that allow the reader to access relevant scientific and medical literature - Clear illustrations, some in color, that provide both understanding of the field and material for teaching |
| translocation definition biology: Molecular Biology of Photosynthesis Govindjee, Hans J. Bohnert, W. Bottomley, D.A. Bryant, John E. Mullet, W.L. Ogren, Himadri Pakrasi, C.R. Somerville, 2012-12-06 Molecular biology, particularly molecular genetics, is among the newest and most powerful approach in modern photosynthesis research. Development of molecular biology techniques has provided new methods to solve old problems in many biological disciplines. Molecular biology has its greatest potential for contribution when applied in combination with other disciplines, to focus not just on genes and molecules, but on the complex interaction between them and the biochemical pathways in the whole organism. Photosynthesis is surely the best studied research area in plant biology, making this field the foremost candidate for successfully employing molecular genetic techniques. Already, the success of molecular biology in photosynthesis has been nothing short of spectacular. Work performed over the last few years, much of which is sum marized in this volume, stands in evidence. Techniques such as site-specific mutagenesis have helped us in examining the roles of individual protein domains in the function of multiunit complexes such as the enzyme ribulose-l ,5-bisphos phate carboxylase/oxygenase (RUBISCO) and the oxygen evolving photo system (the photosystem II). The techniques of molecular biology have been very important in advancing the state of knowledge of the reaction center from the photosynthetic bacteria whose structure has been elegantly deduced by H. Michel and 1. Deisenhofer from the X-ray studies of its crystals. |
| translocation definition biology: The Enzymes , 2023-11-07 The Enzymes, Volume 54 highlights new advances in enzymes, with new chapters on a variety of topics, including the History of The Enzymes, Impact of The Enzymes in chronicling biochemical processes and pathways, Metabolism and Catalysis, Mitochondrial ATP synthase, The respiratory chain, A century of mitochondrial research, Five decades of metalloenzymology, Mechanisms of catalysis, Mitochondrial fatty acid synthesis and associated processes, Signaling, MAPK cascades: Origins, mechanisms and current status, Sphingolipids: From structural components to signaling hubs, Protein Homeostasis and Hydrolysis, Mitochondrial AAA+ proteases, Hsp70 and JDP proteins: structure-function perspective on molecular chaperone activity. Other sections cover DNA Replication and Repair, Structure-function studies of DNA replication proteins, and Helicases required for nucleotide excision repair. - Provides the authority and expertise of leading contributors from an international board of authors - Updated release includes the latest information on enzymes |
| translocation definition biology: Best practice guidelines for the rehabilitation and translocation of gibbons International Union for the Conservation of Nature and Natural Resources (IUCN), Clare O. Campbell, Susan M. Cheyne, Benjamin M. Rawson, 2015-05-28 Rehabilitation and translocation programmes are increasingly becoming an important component of conservation action plans for threatened species. Translocation can help address gibbon conservation issues (gibbons are recognized as one of the most threatened primate families globally) by allowing gibbons held in captivity to be rescued, rehabilitated and then returned to the wild. These guidelines for the translocation of gibbons have been developed in collaboration with stakeholders in hylobatid conservation. This process was initiated druing a workshop on gibbon rehabilitation, reintroduction and translocation, facilitated by the IUCN SSC PSG Section on Small Apes (SSA), and the result of this process is the current document, which is based on shared knowledge and experience to date. The guidelines are designed to be a practical and useful document available for all stakeholders, with the aim of equipping field projects and decision makers with the tools for scientifically sound practice in gibbon rehabilitation and translocation. |
| translocation definition biology: Morrey's the Elbow and Its Disorders Bernard F. Morrey, Joaquin Sanchez Sotelo, Mark E. Morrey, 2017-06-30 Preceded by Elbow and its disorders / [edited by] Bernard F. Morrey, Joaquin Sanchez-Sotelo. 4th ed. c2009. |
| translocation definition biology: Genomics of Rare Diseases Claudia Gonzaga-Jauregui, James R. Lupski, 2021-06-12 Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. - Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes - Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions - Explores opportunities for novel therapeutics - Features chapter contributions from leading researchers and clinicians |
| translocation definition biology: The Use of CRISPR/Cas9, ZFNs, and TALENs in Generating Site-specific Genome Alterations Jennifer A. Doudna, Erik J. Sontheimer, 2014 This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Contains sections on such topics as genome editing, genome engineering, CRISPR, Cas9, TALEN and zinc finger nuclease |
| translocation definition biology: Pediatric Cancer Genetics Nathaniel H. Robin, Meagan Farmer, 2017-08-22 Get a quick, expert overview of the many key facets of pediatric cancer genetics with this concise, practical resource by Dr. Nathaniel H. Robin and Meagan Farmer, MS, CGC, MBA. Ideal for pediatric oncologists and all providers who care for children, this easy-to-read reference addresses the remarkable potential of genetic testing as well as the complexities of choosing the correct test, understanding the results, and counseling the family. - Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counsellors - Highlights examples of syndromes that present in childhood and increase susceptibility to cancer - Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer - Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples - Consolidates today's available information and guidance in this timely area into one convenient resource - Features a wealth of information on pediatric cancer genetics, including the epidemiology and biology of cancer and the genetic evaluation process and role of genetic counselors. - Highlights examples of syndromes that present in childhood and increase susceptibility to cancer. - Discusses the genetic evaluation process in context of the multidisciplinary care of children with cancer. - Considers the ethical and legal issues of genetic testing in children and provides illustrative case examples. - Consolidates today's available information and guidance in this timely area into one convenient resource. |
| translocation definition biology: Epigenetic Technological Applications Yujun George Zheng, 2015-05-30 Epigenetic Technological Applications is a compilation of state-of-the-art technologies involved in epigenetic research. Epigenetics is an exciting new field of biology research, and many technologies are invented and developed specifically for epigenetics study. With chapters covering the latest developments in crystallography, computational modeling, the uses of histones, and more, Epigenetic Technological Applications addresses the question of how these new ideas, procedures, and innovations can be applied to current epigenetics research, and how they can keep pushing discovery forward and beyond the epigenetic realm. - Discusses technologies that are critical for epigenetic research and application - Includes epigenetic applications for state-of-the-art technologies - Contains a global perspective on the future of epigenetics |
| translocation definition biology: Physical Biology of the Cell Rob Phillips, Jane Kondev, Julie Theriot, Hernan Garcia, 2012-10-29 Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics for undergraduate or graduate students. It maps the huge and complex landscape of cell and molecular biology from the distinct perspective of physical biology. As a key organizing principle, the proximity of topics is based on the physical concepts that |
| translocation definition biology: Desk Encyclopedia of Microbiology Moselio Schaechter, 2003-12-11 The Desk Encyclopedia of Microbiology aims to provide an affordable and ready access to a large variety of microbiological topics within one set of covers. This handy desk-top reference brings together an outstanding collection of work by the top scientists in the field. Covering topics ranging from the basic science of microbiology to the current hot topics in the field.* Provides a broad, easily accessible perspective on a wide range of microbiological topics* A synthesis of the broadest topics from the comprehensive and multi-volumed Encyclopedia of Microbiology, Second Edition * Helpful resource in preparing for lectures, writing reports, or drafting grant applications |
| translocation definition biology: Introduction to Tumor Biology I. De Wever, 1999 This book offers clinical oncologists an introduction to some selected topics of tumor biology where important progress has been made during the last decade. The concept is rather unique because it combines advances in clinical pathology, genetics, molecular oncology and immunology.The first two chapters deal with the genetic and molecular basis of malignant transformation on cellular level: DNA damage, mutations and repair mechanisms, oncogenes and tumor suppressor genes. The growth of a tumor cell population depends not only on cell division, but also on deregulation of apoptosis (chapter 3). Most clinical tumors are charcterised by heterogeneity caused by different degrees of differentiation in different cell clones as illustrated for soft tissue tumors in chapter 4. The following chapters explain the multistep process of local tumor progression in gastro-intestinal cancers and malignant melanoma. Cellular and molucular aspects of metastases are dealt with in chapter 7. But host cells react to tumor cells and specific T-cell defined antigens offer a perspective for cancer vaccine development as reviewed in the last chatper.The book is timely because new diagnostic and therapeutic applications based on molecular oncology will reach the clinic at ever increasing pace. |
| translocation definition biology: Encyclopedia of Astrobiology Muriel Gargaud, William M. Irvine, Ricardo Amils, Philippe Claeys, Henderson James Cleaves, Maryvonne Gerin, Daniel Rouan, Tilman Spohn, Stéphane Tirard, Michel Viso, 2023-07-27 Now in its third edition the Encyclopedia of Astrobiology serves as the key to a common understanding in the extremely interdisciplinary community of astrobiologists. Each new or experienced researcher and graduate student in adjacent fields of astrobiology will appreciate this reference work in the quest to understand the big picture. The carefully selected group of active researchers contributing to this work are aiming to give a comprehensive international perspective on and to accelerate the interdisciplinary advance of astrobiology. The interdisciplinary field of astrobiology constitutes a joint arena where provocative discoveries are coalescing concerning, e.g. the prevalence of exoplanets, the diversity and hardiness of life, and its chances for emergence. Biologists, astrophysicists, (bio)-chemists, geoscientists and space scientists share this exciting mission of revealing the origin and commonality of life in the Universe. With its overview articles and its definitions the Encyclopedia of Astrobiology not only provides a common language and understanding for the members of the different disciplines but also serves for educating a new generation of young astrobiologists who are no longer separated by the jargon of individual scientific disciplines. This new edition offers ~170 new entries. More than half of the existing entries were updated, expanded or supplemented with figures supporting the understanding of the text. Especially in the fields of astrochemistry and terrestrial extremophiles but also in exoplanets and space sciences in general there is a huge body of new results that have been taken into account in this new edition. Because the entries in the Encyclopedia are in alphabetical order without regard for scientific field, this edition includes a section “Astrobiology by Discipline” which lists the entries by scientific field and subfield. This should be particularly helpful to those enquiring about astrobiology, as it illustrates the broad and detailed nature of the field. |
Chromosomal translocation - Wikipedia
Chromosomal translocation Chromosomal reciprocal translocation of the 4th and 20th chromosome. In genetics, chromosome translocation is a phenomenon that results in unusual …
What Are Translocations? What Disorders Do They Cause? - WebMD
Dec 2, 2024 · In a reciprocal translocation, two different chromosomes have exchanged pieces with each other. In a Robertsonian translocation, an entire chromosome attaches to another at …
Translocation - National Human Genome Research Institute
3 days ago · A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. The detection of …
The biogenesis of chromosome translocations - PMC
A chromosome translocation is defined as a genome abnormality in which a chromosome breaks and either the whole or a portion of it reattaches to a different chromosome (Fig. 1a).
Translocation: MedlinePlus Medical Encyclopedia
Translocation means a change in location. It often refers to genetics, when part of a chromosome is transferred to another chromosome. Chromosomes are structures that carry genes, our …
Translocation: Origin, Types and Effects | Genetics
Translocations originate through chromosome breakage and reunion. It can also be interpreted on the basis of exchange model. The unit of translocation may be a chromosome (chromosomal …
Translocation – MyPathologyReport
A translocation is a specific type of genetic change where a piece of one chromosome breaks off and attaches to another chromosome. Chromosomes are structures inside your cells that carry …
What Are Translocations? - iCliniq
Feb 26, 2024 · Translocation is a key biological process that influences the genetic landscape, cellular function, and disease development. Translocation is a dynamic mechanism with …
Overview of Genetics Translocation
Dec 20, 2023 · Learn about genetics translocation, a chromosomal abnormality that occurs when a segment of one chromosome breaks off and attaches to another chromosome, and its …
Translocation in Genetics | Definition, Types & Examples
Nov 21, 2023 · What are translocations in genetics? A translocation in genetics occurs when a segment of one chromosome breaks and attaches to a new locus on the same chromosome …
Chromosomal translocation - Wikipedia
Chromosomal translocation Chromosomal reciprocal translocation of the 4th and 20th chromosome. In genetics, chromosome translocation is a phenomenon that results in unusual …
What Are Translocations? What Disorders Do They Cause? - WebMD
Dec 2, 2024 · In a reciprocal translocation, two different chromosomes have exchanged pieces with each other. In a Robertsonian translocation, an entire chromosome attaches to another at …
Translocation - National Human Genome Research Institute
3 days ago · A translocation, as related to genetics, occurs when a chromosome breaks and the (typically two) fragmented pieces re-attach to different chromosomes. The detection of …
The biogenesis of chromosome translocations - PMC
A chromosome translocation is defined as a genome abnormality in which a chromosome breaks and either the whole or a portion of it reattaches to a different chromosome (Fig. 1a).
Translocation: MedlinePlus Medical Encyclopedia
Translocation means a change in location. It often refers to genetics, when part of a chromosome is transferred to another chromosome. Chromosomes are structures that carry genes, our …
Translocation: Origin, Types and Effects | Genetics
Translocations originate through chromosome breakage and reunion. It can also be interpreted on the basis of exchange model. The unit of translocation may be a chromosome (chromosomal …
Translocation – MyPathologyReport
A translocation is a specific type of genetic change where a piece of one chromosome breaks off and attaches to another chromosome. Chromosomes are structures inside your cells that carry …
What Are Translocations? - iCliniq
Feb 26, 2024 · Translocation is a key biological process that influences the genetic landscape, cellular function, and disease development. Translocation is a dynamic mechanism with …
Overview of Genetics Translocation
Dec 20, 2023 · Learn about genetics translocation, a chromosomal abnormality that occurs when a segment of one chromosome breaks off and attaches to another chromosome, and its …
Translocation in Genetics | Definition, Types & Examples
Nov 21, 2023 · What are translocations in genetics? A translocation in genetics occurs when a segment of one chromosome breaks and attaches to a new locus on the same chromosome …
