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| vl rust repair: Pharmacology of Itch Alan Cowan, Gil Yosipovitch, 2015-04-10 Basic research on the pharmacology of itch has exploded in the wake of two very influential papers that were published in Nature (2007) and Science (2009). Long overlooked as a milder form of pain, itching has rapidly gained a new appreciation in both research and clinical communities because of its complexity and its negative effects on the quality of life of the distressed patients. Like pain, not all itches are the same. Unlike pain, there are no standard drugs equivalent to aspirin and morphine. Epidemiological studies emphasize the high incidence and economic costs of itch (pruritus). It is the most prevalent symptom of a wide variety of allergic and inflammatory skin conditions (e.g., psoriasis, atopic dermatitis), is associated with several systemic diseases (e.g., chronic kidney and liver disease), and occurs in patients undergoing hemodialysis, spinal administration of opioids, and in those suffering from AIDS. The reader will learn about the multiple pathways for itch and their interactions with pain. The relationship between these closely related, yet distinct sensory phenomena, will be emphasized. Both itch and pain use several common molecules to send signals to the brain. Thus, drugs that have been, and are being, developed as analgesics may also attenuate intractable itch. This has been an exciting and very necessary turn of events since traditional H-1 receptor antagonists are ineffective in blocking the pruritus associated with kidney failure and cholestasis. The clinical chapters will provide insights into contemporary treatment regimens for pruritus in different human scenarios. |
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| vl rust repair: Handbook of Chemical Risk Assessment Ronald Eisler, 2000-04-12 Written over a period of 17 years, the Handbook of Chemical Risk Assessment exhaustively examines and analyzes the world literature on chemicals entering the environment from human activities. The three volumes cover chemicals recommended by environmental specialists of the U.S. Fish and Wildlife Service and other resource managers. The choices were based on the real or potential impact of each contaminant and on the knowledge available about their mitigation. The information for each chemical includes source and use; physical, chemical, and metabolic properties; concentrations in field collections of abiotic materials and living organisms; deficiency effects; lethal and sublethal effects; and proposed regulatory criteria for the protection of human health and sensitive natural resources. Each chapter selectively reviews and synthesizes the technical literature on a specific priority contaminant and its effects on the environment. Successful risk assessment relies heavily on extensive and well-documented databases. They often include too much - or too little - information about too many chemicals. Of the hundreds of thousands of chemicals discharged into the environment, only a small number have sufficient information to attempt preliminary risk assessment. Sold only as a three volume set, the Handbook of Chemical Risk Assessment provides you with the exact amount of information you need in a single resource. |
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| vl rust repair: Digital and Information Technologies in Economics and Management Arthur Gibadullin, 2023-04-15 This book covers the II International Scientific and Practical Conference Digital and Information Technologies in Economics and Management (DITEM2022), which was held on November 21–23, 2022. The conference addressed issues of information, digital and intellectual technologies in economics and management. A distinctive feature of the conference is that it presented reports of authors from China, Saudi Arabia, Tunisia, Uzbekistan, Tajikistan, Angola, Kazakhstan, India and Russia. Researchers from different countries presented the process of transition of economic activities to the information and digital path of development and presented the main directions and developments that can improve the efficiency and development of the economy and management. The materials of the conference may be useful to state and regional authorities, international and supranational organizations, the scientific and professional community. |
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VLADIVOSTOK | Projects & Construction - SkyscraperCity Forum
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Feb 20, 2006 · some news, shortly Inteko announced project of business complex on west of Moscow. Setun' Hills is 24 hectares area where will be build 570 thousand sq m business center.
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