Advertisement
| siphox health review: Cross-Coupling Reactions S.L. Buchwald, 2002-01-11 In 1972, a very powerful catalytic cycle for carbon-carbon bond formation was 2 first discovered by the coupling reaction of Grignard reagents at the sp -carbon. Over the past 30 years, the protocol has been substantially improved and expanded to other coupling reactions of Li,B,N,O,Al,Si,P,S,Cu,Mn,Zn,In,Sn, and Hg compounds. These reactions provided an indispensable and simple methodology for preparative organic chemists. Due to the simplicity and rel- bility in the carbon-carbon, carbon-heteroatom, and carbon-metalloid bo- formations,as well as high efficiency of the catalytic process,the reactions have been widely employed by organic chemists in various fields. Application of the protocol ranges from various syntheses of complex natural products to the preparation of biologically relevant molecules including drugs, and of sup- molecules, and to functional materials. The reactions on solid surfaces allow robot synthesis and combinatorial synthesis. Now, many organic chemists do not hesitate to use transition metal complexes for the transformation of org- ic molecules. Indeed, innumerable organic syntheses have been realized by the catalyzed reactions of transition metal complexes that are not achievable by t- ditional synthetic methods. Among these, the metal-catalyzed cross-coupling reactions have undoubtedly contributed greatly to the development of such a new area of “metal-catalyzed organic syntheses”. An excellent monograph for the cross-coupling reactions and other met- catalyzed C-C bond-forming reactions recently appeared in Metal-catalyzed Cross-coupling Reactions (Wiley-VCH,1998). |
| siphox health review: Pharmaceutical Process Chemistry Takayuki Shioiri, Kunisuke Izawa, Toshiro Konoike, 2010-12-09 Covering the whole area of process chemistry in the pharmaceutical industry, this monograph provides the essential knowledge on the basic chemistry needed for future development and key industrial techniques, as well as morphology, engineering and regulatory compliances. Application-oriented and well structured, the authors include recent examples of excellent industrial production of active pharmaceutical ingredients. |
| siphox health review: Age Later Nir Barzilai, 2020-06-16 |
| siphox health review: Facilitating Treatment Adherence Donald Meichenbaum, D.C. Turk, 2012-11-17 |
| siphox health review: Putting Knowledge to Use Edward Maynard Glaser, Harold Herbert Abelson, Kathalee N. Garrison, 1983 |
| siphox health review: Synthesis of Best-Seller Drugs Ruben Vardanyan, Victor Hruby, 2016-01-07 Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation |
| siphox health review: Bifunctional Molecular Catalysis Takao Ikariya, Masakatsu Shibasaki, 2011-06-26 Masakatsu Shibasaki, Motomu Kanai, Shigeki Matsunaga, and Naoya Kumagai: Multimetallic Multifunctional Catalysts for Asymmetric Reactions.- Takao Ikariya: Bifunctional transition metal-based molecular catalysts for asymmetric syntheses.- Chidambaram Gunanathan and David Milstein: Bond Activation by Metal-Ligand Cooperation: Design of ”Green” Catalytic Reactions Based on Aromatization-Dearomatization of Pincer Complexes.- Madeleine C. Warner, Charles P. Casey, and Jan-E. Bäckvall: Shvo’s Catalyst in Hydrogen Transfer Reactions.- Noritaka Mizuno, Keigo Kamata, and Kazuya Yamaguchi: Liquid-Phase Selective Oxidation by Multimetallic Active Sites of Polyoxometalate-Based Molecular Catalysts.- Pingfan Li and Hisashi Yamamoto: Bifunctional Acid Catalysts for Organic Synthesis.- Jun-ichi Ito, Hisao Nishiyama: Bifunctional Phebox Complexes for Asymmetric Catalysis. |
| siphox health review: Comprehensive Sampling and Sample Preparation Josep M. Bayona, Paola Dugo, X. Chris Le, Hian Kee Lee, Xing-Fang Li, Heather Lord, 2012-12-31 Comprehensive Sampling and Sample Preparation is a complete treatment of the theory and methodology of sampling in all physical phases and the theory of sample preparation for all major extraction techniques. It is the perfect starting point for researchers and students to design and implement their experiments and support those experiments with quality-reviewed background information. In its four volumes, fundamentals of sampling and sample preparation are reinforced through broad and detailed sections dealing with Biological and Medical, Environmental and Forensic, and Food and Beverage applications. The contributions are organized to reflect the way in which analytical chemists approach a problem. It is intended for a broad audience of analytical chemists, both educators and practitioners of the art and can assist in the preparation of courses as well in the selection of sampling and sample preparation techniques to address the challenges at hand. Above all, it is designed to be helpful in learning more about these topics, as well as to encourage an interest in sampling and sample preparation by outlining the present practice of the technology and by indicating research opportunities. Sampling and Sample preparation is a large and well-defined field in Analytical Chemistry, relevant for many application areas such as medicine, environmental science, biochemistry, pharmacology, geology, and food science. This work covers all these aspects and will be extremely useful to researchers and students, who can use it as a starting point to design and implement their experiments and for quality-reviewed background information There are limited resources that Educators can use to effectively teach the fundamental aspects of modern sample preparation technology. Comprehensive Sampling and Sample Preparation addresses this need, but focuses on the common principles of new developments in extraction technologies rather than the differences between techniques thus facilitating a more thorough understanding Provides a complete overview of the field. Not only will help to save time, it will also help to make correct assessments and avoid costly mistakes in sampling in the process Sample and sample preparation are integral parts of the analytical process but are often less considered and sometimes even completely disregarded in the available literature. To fill this gap, leading scientists have contributed 130 chapters, organized in 4 volumes, covering all modern aspects of sampling and liquid, solid phase and membrane extractions, as well as the challenges associated with different types of matrices in relevant application areas |
| siphox health review: Clinical Challenges in Therapeutic Drug Monitoring William Clarke, Amitava Dasgupta, 2016-05-17 Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. |
| siphox health review: Applied Homogeneous Catalysis with Organometallic Compounds Boy Cornils, Wolfgang A. Herrmann, Matthias Beller, Rocco Paciello, 2017-09-05 The completely revised third edition of this four-volume classic is fully updated and now includes such topics as as CH-activation and multicomponent reactions. It describes the most important reaction types, new methods and recent developments in catalysis. The internationally renowned editors and a plethora of international authors (including Nobel laureate R. Noyori) guarantee high quality content throughout the book. A must read for everyone in academia and industry working in this field. |
| siphox health review: Encyclopedia of Forensic Sciences , 2012-12-28 Forensic science includes all aspects of investigating a crime, including: chemistry, biology and physics, and also incorporates countless other specialties. Today, the service offered under the guise of forensic science’ includes specialties from virtually all aspects of modern science, medicine, engineering, mathematics and technology. The Encyclopedia of Forensic Sciences, Second Edition, Four Volume Set is a reference source that will inform both the crime scene worker and the laboratory worker of each other’s protocols, procedures and limitations. Written by leading scientists in each area, every article is peer reviewed to establish clarity, accuracy, and comprehensiveness. As reflected in the specialties of its Editorial Board, the contents covers the core theories, methods and techniques employed by forensic scientists – and applications of these that are used in forensic analysis. This 4-volume set represents a 30% growth in articles from the first edition, with a particular increase in coverage of DNA and digital forensics Includes an international collection of contributors The second edition features a new 21-member editorial board, half of which are internationally based Includes over 300 articles, approximately 10pp on average Each article features a) suggested readings which point readers to additional sources for more information, b) a list of related Web sites, c) a 5-10 word glossary and definition paragraph, and d) cross-references to related articles in the encyclopedia Available online via SciVerse ScienceDirect. Please visit www.info.sciencedirect.com for more information This new edition continues the reputation of the first edition, which was awarded an Honorable Mention in the prestigious Dartmouth Medal competition for 2001. This award honors the creation of reference works of outstanding quality and significance, and is sponsored by the RUSA Committee of the American Library Association |
| siphox health review: Blanco's Overview of Alpha-1 Antitrypsin Deficiency Ignacio Blanco, 2017-05-03 Blanco's Overview of Alpha-1 Antitrypsin Deficiency: History, Biology, Pathophysiology, Related Diseases, Diagnosis, and Treatment is a robust introduction to topics associated with Alpha-1 Antitrypsin Deficiency (AATD). Included are topics ranging from the history of the disease, biology, pathophysiology, related diseases, including the two major manifestations of the disease (liver disease and lung disease), and diagnosis and treatment. The book addresses the need for the amalgamation of current and novel concepts and practices in the field of AATD. AATD is under-recognized in the medical community and, as a result, it is underdiagnosed. The book provides increased awareness and understanding of the condition to improve diagnosis rates and enhance patient care. This book is an essential tool and reference, beneficial to clinicians who screen and treat AATD patients, as well as research scientists working in the AATD field at junior and senior levels. |
| siphox health review: Ligand Design in Metal Chemistry Mark Stradiotto, Rylan J. Lundgren, 2016-09-01 The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales. Ligand Design in Metal Chemistry presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include: Key concepts in ligand design Redox non-innocent ligands Ligands for selective alkene metathesis Ligands in cross-coupling Ligand design in polymerization Ligand design in modern lanthanide chemistry Cooperative metal-ligand reactivity P,N Ligands for enantioselective hydrogenation Spiro-cyclic ligands in asymmetric catalysis This book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry, polymer science and materials chemistry. |
| siphox health review: Practical Synthetic Organic Chemistry Stéphane Caron, 2020-02-05 Diese Publikation ist ein Praktikerbuch für Organiker. Der Schwerpunkt liegt auf den Reaktionen, die am verlässlichsten und nützlichsten sind. Die Autoren der einzelnen Kapitel stellen Chemiker die Informationen zur Verfügung, die für die strategische Planung einer Synthese und Wiederholung der Verfahren im Labor notwendig sind. - Fasst alle wesentlichen Entwicklungen und Konzepte in einer Publikation zusammen und deckt die meisten der wichtigen Reaktionen in der organischen Chemie ab, u. a. Substitutions-, Additions-, Eliminierungsreaktionen, Umlagerung, Oxidation, Reduktion. - Behandelt die wichtigsten Reaktionen ausführlicher und zeigt die grundlegenden Prinzipien, Vor- und Nachteile der Methoden, Mechanismen und Techniken, um Reaktionen im Labor erfolgreich durchzuführen. - Mit neuen Inhalten zu den jüngsten Fortschritten in den Bereichen CH-Aktivierung, Photoredox-Katalyse und Elektrochemie, kontinuierliche chemische Prozesse und Anwendung der Biokatalyse in der Synthese. - Bietet überarbeitete Kapitel mit neuen und zusätzlichen chemischen Beispielen aus der Praxis. |
| siphox health review: P-stereogenic Ligands in Enantioselective Catalysis Arnald Grabulosa, 2011 P-stereogenic ligands were among the first to be used in asymmetric catalysis but synthetic difficulties and prejudices have hampered their development. However, continuous screening for new chiral ligands means that they can no longer be ignored and this rigorous reference source reflects their renaissance.The book is filled with many examples from recent primary literature. The synthetic chemist will easily be able to follow the preparation methods which are accompanied by a description of the challenges and limitations. Those working in homogenous catalysis, and wanting to increase their repertoire of ligands, will be able to establish which have already been used in each reaction and their performance.This book provides comprehensive coverage of the application of P-stereogenic ligands in homogeneous catalysis. It begins with a brief chapter on generalities of P-stereogenic compounds: history, configurational stability, and interconversions among them.The book then goes on to describe the main preparative methods, from resolution of racemates to enantioselective catalysis, before focusing on the catalytic applications of P-stereogenic ligands. Chapter 7 describes the use of the ligands in catalytic hydrogenation and related reactions whereas chapter 8 deals with other reactions, mainly C-C bond forming reactions. The aim of these two final chapters is to give an outline of the usefulness of the ligands in homogeneous catalysis. |
| siphox health review: Metabolomics for Biomedical Research Jerzy Adamski, 2020-03-21 Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. |
| siphox health review: Medical Applications of Mass Spectrometry Karoly Vekey, Andreas Telekes, Akos Vertes, 2011-08-11 Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging.* Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.* Guides the reader from basic principles and methods to cutting edge applications.* There is NO comparable book on the market to fill this fast growing field. |
| siphox health review: Get Off Your Sugar Dr. Daryl Gioffre, 2021-01-05 In his first book, Dr. Daryl Gioffre taught us how to fight inflammation by getting off unhealthy, highly acidic foods. Now, he’s targeted sugar—because when you break your sugar addiction, you cut out a major contributor to inflammation, brain fog, aging, and chronic disease. You’ll go from stress eating to strength eating with Dr. Gioffre’s life-changing plan: Phase 1: Weed—7 days to detox your mind, body, and diet Phase 2: Seed—21 days to crush your cravings Phase 3: Feed—A lifetime of satisfying, strengthening eating With tips for customizing the plan, including using clean keto and intermittent fasting to tune up your metabolism, and sixty-five craving-stopping recipes, Get Off Your Sugar is your guide to turning your body into a strength-eating, energy-filled, acid-kicking machine. |
| siphox health review: Contemporary Drug Synthesis Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth, 2004-12-27 An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis Organizes the drugs into fourteen therapeutic areas for clarity and ease of use Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students. |
| siphox health review: Eat Rich, Live Long Ivor Cummins, 2018-02-27 You can take control of your health, lose weight, prevent disease, and enjoy a long and healthy life. The unique nutritional program outlined in Eat Rich, Live Long is designed by experts to help you feel great while you eat delicious and satisfying foods. Millions of people have gotten healthy through low-carb plans over the years—and a growing number have discovered the wonderful benefits of ketogenic (Keto) nutrition. Many are confused, though, about how low-carb they should go. Now, Eat Rich, Live Long reveals how mastering the low-carb/Keto spectrum can maximize your weight loss and optimize your health for the long term. In this book, Ivor Cummins, a world-class engineer and technical master for a huge global tech corporation, and Dr. Jeff Gerber, a family doctor who is widely regarded as a global leader in low-carb nutrition, team up to present their unique perspectives from their extensive clinical, medical, and scientific/research experience. Together, Cummins and Gerber crack the code that shows you how to eat the foods you enjoy, lose weight, and regain robust health. They reveal how the nutritional “experts” have gotten it so wrong for so long by demonizing healthy natural fats in our diets and focusing on cholesterol and LDL as the villains. In fact, as the authors reveal by drawing on the latest peer-reviewed global research, eating a high percentage of natural fats, a moderate amount of protein, and a low percentage of carbs can help you lose weight, prevent disease, satisfy your appetite, turn off your food cravings, and live longer. The heart of Eat Rich, Live Long is the book’s prescriptive program, which includes a 7-day eating plan, a 14-day eating plan, and more than 50 gourmet-quality low-carb high-fat recipes –illustrated with gorgeous full-color photographs -- for breakfasts, lunches, appetizers, snacks, dinners, drinks, and desserts. Low-carb never tasted so good! Nutritional sacred cows are constantly being challenged in the media. How much fat should we eat -- and which kinds of fats are best? Which fats can contribute to diabetes, heart disease, and early mortality? Does a high-protein diet increase muscle mass and lead to vigorous health – or can it promote aging, cancer, and early mortality? Which vitamins and minerals should we be taking, if any? How do we change our metabolism so that our bodies burn fat instead of all the sugars we consume? Does intermittent fasting really work? Eat Rich, Live Long lays out the truth based on the latest scientific research. Eat Rich, Live Long will change the way you look at eating. Meanwhile you will lose weight – and look and feel great. |
| siphox health review: Electroorganic Reduction Synthesis Shigeru Torii, 2006 Publisher Description |
| siphox health review: Green Chemistry in the Pharmaceutical Industry Peter J. Dunn, Andrew Wells, Michael T. Williams, 2010-02-02 Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry. |
| siphox health review: Privileged Structures in Drug Discovery Larry Yet, 2018-03-07 A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that reviews privileged structures from the point of view of medicinal chemistry and contains the synthetic routes to these structures. In this text, the author—a noted expert in the field—includes an historical perspective on the topic, presents a practical compendium to privileged structures, and offers an informed perspective on the future direction for the field. The book describes the up-to-date and state-of-the-art methods of organic synthesis that describe the use of privileged structures that are of most interest. Chapters included information on benzodiazepines, 1,4-dihydropyridines, biaryls, 4-(hetero)arylpiperidines, spiropiperidines, 2-aminopyrimidines, 2-aminothiazoles, 2-(hetero)arylindoles, tetrahydroisoquinolines, 2,2-dimethylbenzopyrans, hydroxamates, and bicyclic pyridines containing ring-junction nitrogen as privileged scaffolds in medicinal chemistry. Numerous, illustrative case studies document the current use of the privileged structures in the discovery of drugs. This important volume: Describes the drug compounds that have successfully made it to the marketplace and the chemistry associated with them Offers the experience from an author who has worked in many therapeutic areas of medicinal chemistry Details many of the recent developments in organic chemistry that prepare target molecules Includes a wealth of medicinal chemistry case studies that clearly illustrate the use of privileged structures Designed for use by industrial medicinal chemists and process chemists, academic organic and medicinal chemists, as well as chemistry students and faculty, Privileged Structures in Drug Discovery offers a current guide to organic synthesis methods to access the privileged structures of interest, and contains medicinal chemistry case studies that document their application. |
| siphox health review: Asymmetric Organocatalysis Combined with Metal Catalysis Bruce A. Arndtsen, Liu-Zhu Gong, 2020-04-24 The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience.Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.The chapter Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates is available open access under a CC BY 4.0 License via link.springer.com. |
| siphox health review: Catalytic Asymmetric Synthesis Takahiko Akiyama, Iwao Ojima, 2022-05-27 Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia. |
| siphox health review: The Chemical Transformations of C1 Compounds Xiao-Feng Wu, Buxing Han, Kuiling Ding, Zhongmin Liu, 2022-01-14 The Chemical Transformations of C1 Compounds A comprehensive exploration of one-carbon molecule transformations The chemistry of one-carbon molecules has recently gained significant prominence as the world transitions away from a petroleum-based economy to a more sustainable one. In The Chemical Transformations of C1 Compounds, an accomplished team of chemists delivers an in-depth overview of recent developments in the field of single-carbon chemistry. The three-volume book covers all major C1 sources, including carbon monoxide, carbon dioxide, methane, methanol, formic acid, formaldehyde, carbenes, C1 halides, and organometallics. The editors have included resources discussing the main reactions and transformations into feedstock chemicals of each of the major C1 compounds reviewed in dedicated chapters. Readers will discover cutting-edge material on organic transformations with MeNO2, DMF, DCM, methyl organometallic reagents, CCl4, CHCl3, and CHBr3, as well as recent achievements in cyanation reactions via cross-coupling. The book also offers: Thorough introductions to chemical transformations of CH4, methods of CH4 activation, chemical transformations of CH3OH and synthesis alkenes from CH3OH Comprehensive explorations of the carbonylation of MeOH, CH2O in organic synthesis, organic transformations of HCO2H, and hydrogen generation from HCO2H Practical discussions of the carbonylation of unsaturated bonds with heterogeneous and homogeneous catalysts, as well as the carbonylation of C(sp2)-X bonds and C(sp3)-X bonds In-depth examinations of carbonylative C-H bond activation and radical carbonylation Perfect for organic and catalytic chemists, The Chemical Transformations of C1 Compounds is also an ideal resource for industrial chemists, chemical engineers, and practitioners at energy supply companies. |
| siphox health review: Sulfur Ylides: Emerging Synthetic Intermediates Barry M. Trost, Lawrence S. Melvin, 1975 |
| siphox health review: Process Chemistry in the Pharmaceutical Industry Kumar Gadamasetti, 1999-05-06 Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers-offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various special |
| siphox health review: The Social Psychology of Telecommunications John Short, Ederyn Williams, Bruce Christie, 1976 |
| siphox health review: Conjugate Addition Reactions in Organic Synthesis P. Perlmutter, 1992 This book provides an introduction to the chemistry of conjugate reactions, a group of reactions that constitute one of the most important classes of chemical reactions in organic synthesis. The book is organised in terms of the major classes of conjugate acceptors. Within each of these classes, the chemistry and applications of conjugate additions with several different categories of nucleophiles have been examined. Where several different nucleophiles achieve the same synthetic transformation, they are cross-referenced within the book and qualitative comparisons offered where appropriate. Examples of the use of conjugate additions in total synthesis of important molecules are included, with a special emphasis throughout the book on stereoselectivity. This will be a useful main text for graduate and postgraduate courses on conjugate addition reactions or the Michael reaction. It could also serve as a supplementary text for courses on topics such as the chemistry of organocopper reagents, enamines and carbanion chemistry. |
| siphox health review: Challenges in Synthetic Organic Chemistry Teruaki Mukaiyama, 1994 This volume describes the life's work of Professor Teruaki Mukaiyama, one of Japan's most important and respected synthetic organic chemists. It includes information on his early research into a wide range of reactions, including dehydration reactions, the use of organosulfur compounds, and oxidation-reduction condensations in peptide and nucleotide synthesis reagents, as well as an account of Mukaiyama's important work on the applications of titanium compounds in organic synthesis. Three final chapters review Mukaiyama's work in synthetic control, stereoselective synthesis of carbohydrates, the stereoselective aldol, and Michael reactions. This unique book makes accessible much research that has only been available in Japanese, and provides a rare account of the contributions of one of the world's leading chemists. |
| siphox health review: Organometallics as Catalysts in the Fine Chemical Industry Matthias Beller, Hans-Ulrich Blaser, 2012-08-30 Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor. |
| siphox health review: Asymmetric catalysis Michael P. Doyle, 1997 This is the second volume in a series covering research advances in the field of catalytic processes. |
| siphox health review: The Art of Drug Synthesis Douglas S. Johnson, Jie Jack Li, 2007-07-09 The Art of Drug Synthesis illustrates how chemistry, biology, pharmacokinetics, and a host of other disciplines come together to produce successful medicines. The authors have compiled a collection of 21 representative categories of drugs, from which they have selected as examples many of the best-selling drugs on the market today. An introduction to each drug is provided, as well as background to the biology, pharmacology, pharmacokinetics, and drug metabolism, followed by a detailed account of the drug synthesis. Edited by prominent scientists working in drug discovery for Pfizer Meets the needs of a growing community of researchers in pharmaceutical R&D Provides a useful guide for practicing pharmaceutical scientists as well as a text for medicinal chemistry students An excellent follow-up to the very successful first book by these editors, Contemporary Drug Synthesis, but with all new therapeutic categories and drugs discussed. |
| siphox health review: Bioactive Heterocycles III Mahmud Tareq Hassan Khan, 2007 |
| siphox health review: Systematic Reviews to Answer Health Care Questions Heidi D. Nelson, 2014-05-29 Systematic Evidence Reviews to Answer Health Care Questions is your most effective, A-to-Z guide to conducting thorough, comprehensive systematic reviews. By breaking down topics and essential steps, this volume teaches you how to form key questions, select evidence, and perform illuminating review not just in predictable circumstances, but when basic rules don’t apply—honing your ability to think critically and solve problems. You’ll learn how to define a review’s purpose and scope, develop research questions, build a team, and even manage your project to maximize efficacy. If you’re looking to refine your approach to systematic reviews, don’t just catalog and collect; use this powerful text to evaluate, synthesize, and deliver results that will help shape the health care industry. FEATURES Presented in standard format throughout to allow for more practical, easy to read approach Provides useful instruction on how to conduct a high-quality systematic review that meets the recent standards of the Institute of Medicine Accessible, concise information about the state-of-the-art methods of systematic review, from key question formulation to assessing the quality of included studies and reporting results Illustrated throughout with real-world examples from systematic reviews that have been used to inform practice guidelines and health policy |
| siphox health review: Finding What Works in Health Care Institute of Medicine, Board on Health Care Services, Committee on Standards for Systematic Reviews of Comparative Effectiveness Research, 2011-06-20 Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research. |
SiPhox Health Reviews | Read Customer Service Reviews of …
May 19, 2025 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 283 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
May 31, 2025 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 280 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Dec 23, 2024 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 278 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 266 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 276 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 278 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Apr 1, 2025 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 243 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 249 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 127 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 194 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
May 19, 2025 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 283 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
May 31, 2025 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 280 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Dec 23, 2024 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 278 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 266 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 276 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 278 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Apr 1, 2025 · Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 243 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 249 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 127 customers have already said.
SiPhox Health Reviews | Read Customer Service Reviews of …
Do you agree with SiPhox Health's TrustScore? Voice your opinion today and hear what 194 customers have already said.
