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| stem cell stroke clinical trial 2022: Cell Therapy Against Cerebral Stroke Kiyohiro Houkin, Koji Abe, Satoshi Kuroda, 2017-03-05 This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan. |
| stem cell stroke clinical trial 2022: Stem Cell Transplantation , 2025-03-26 Stem Cell Transplantation is a comprehensive guide to the latest regenerative medicine and transplantation science advancements. This book investigates the critical role of stem cell therapies in treating a wide range of diseases, from hematological disorders to autoimmune conditions. Explore pioneering research and innovative techniques that reshape patient care and improve outcomes. Key topics include the integration of gene editing technologies, advancements in donor matching, and novel approaches to minimize transplant-related complications. This book also emphasizes stem cell research's ethical considerations and future directions. An essential resource for clinicians, researchers, and students, Stem Cell Transplantation equips readers with practical insights and inspires groundbreaking approaches in the field. This book will help the readers stay at the forefront of medical innovation, giving them the knowledge to improve treatments and drive scientific progress. |
| stem cell stroke clinical trial 2022: Vascular Immunity and Ischemic Stroke Yanlin Zhang, Xia Wang , Jie Lu, 2024-11-18 Ischemic stroke is among the most severe diseases threatening human health, of which atherosclerosis is the main pathophysiological basis. In recent years, both basic and clinical studies have confirmed that the immune system plays a core regulatory role in the occurrence and development of atherosclerosis. Some patients with systemic immune diseases are more likely to develop atherosclerosis, and its severity is higher than in patients without systemic immune disorders. Immune cells are also involved in brain tissue damage and repair after ischemic stroke. The clinical application of monoclonal antibodies targeting B cell surface molecules (such as CD20) and survival factors (such as BAFF) in some chronic inflammatory diseases such as rheumatoid arthritis and psoriasis also provides new directions for the immunotherapy in ischemic stroke. However, finding the best target for drug intervention remains the biggest challenge and an attractive target for new strategies for ischemic stroke. |
| stem cell stroke clinical trial 2022: Cell and Gene Therapies for Neurologic Diseases , 2024-10-02 Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson's, Huntington's, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs. - Summarizes advances in cell and gene therapy for neurological diseases - Describes the therapies available and in development - Includes surgical, ethical, and manufacturing considerations - Identifies best practices for specific neurological diseases - Covers Huntington's, Parkinson's, ALS, Stroke, Demyelination, epilepsy, and more |
| stem cell stroke clinical trial 2022: Pharmaceutical Strategies to Prevent, Treat, and Recover: Advances and Challenges in Ischemic Stroke and Hemorrhagic Stroke Yuwen Li, Gang-Min Hur, Tiejun Zhang, 2024-03-01 Stroke is one of the leading causes of death and disability worldwide. Among them, ischemic stroke is attributed to an abrupt blockage of blood flow to brain, while hemorrhagic stroke is caused by bleeding into brain. The principal aim of stroke therapy is to decrease mortality and reduce persistent neurologic injury and long-term disability. It also targets to prevent complications and recurrence after stroke as well as minimize the brain function loss caused by the cerebral damage. Fortunately, many strokes could be prevented through healthy lifestyle changes and controlling stroke risk factors, such as cigarette or tobacco smoking, high blood pressure, diabetes, and heart disease. Carotid endarterectomy and stenting of the cervical and intracranial vessels may help reduce recurrent stroke in some cases. Advanced treatments and rehabilitation are helping many stroke patients return to society and their families. |
| stem cell stroke clinical trial 2022: Application of Innovative Techniques in Genetic and Cellular Therapies Yuan Xiong, Jingfeng Li, Yori Endo, 2023-12-27 Tightly linked to tissue engineering and regenerative medicine, genetic and cellular therapies have drawn universal attention. Since genetic sequencing is critical for precision medicine, the combination of bioinformatics and therapies is important to conduct prescriptive and predictive analytics based on genetic sequencing data. Bioinformatics and computational approaches have been widely considered for the development of genetic and cellular therapies. Therefore, the current research topic aims to cover recent advances in studies such as functional genomics, proteomics, metabolomics, and bioinformatics that bring in new perspectives on genetic therapies. The central goal of regenerative medicine is to replace damaged or diseased tissue with cells that are integrated and functioning optimally. Stem cell-based therapy is restricted by the limited availability of cell sources, the excessive cost, and the anticipated difficulties of clinical translation and ethical approval. Some promising alternatives are to incite the patient's innate ability of tissue repairs such as in situ tissue regeneration, which has the potential to provide new therapeutic options for tissue engineering and regenerative medicine. These innovative cellular therapies are also contained in our research topic. |
| stem cell stroke clinical trial 2022: Computational Biology for Stem Cell Research Pawan Raghav, Rajesh Kumar, Anjali Lathwal, Navneet Sharma, 2024-01-12 Computational Biology for Stem Cell Research is an invaluable guide for researchers as they explore HSCs and MSCs in computational biology. With the growing advancement of technology in the field of biomedical sciences, computational approaches have reduced the financial and experimental burden of the experimental process. In the shortest span, it has established itself as an integral component of any biological research activity. HSC informatics (in silico) techniques such as machine learning, genome network analysis, data mining, complex genome structures, docking, system biology, mathematical modeling, programming (R, Python, Perl, etc.) help to analyze, visualize, network constructions, and protein-ligand or protein-protein interactions. This book is aimed at beginners with an exact correlation between the biomedical sciences and in silico computational methods for HSCs transplantation and translational research and provides insights into methods targeting HSCs properties like proliferation, self-renewal, differentiation, and apoptosis. - Modeling Stem Cell Behavior: Explore stem cell behavior through animal models, bridging laboratory studies to real-world clinical allogeneic HSC transplantation (HSCT) scenarios. - Bioinformatics-Driven Translational Research: Navigate a path from bench to bedside with cutting-edge bioinformatics approaches, translating computational insights into tangible advancements in stem cell research and medical applications. - Interdisciplinary Resource: Discover a single comprehensive resource catering to biomedical sciences, life sciences, and chemistry fields, offering essential insights into computational tools vital for modern research. |
| stem cell stroke clinical trial 2022: Stem Cell Therapy for Vascular Diseases Tulio Pinho Navarro, Lara Lellis Navarro Minchillo Lopes, Alan Dardik, 2020-11-05 Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers. |
| stem cell stroke clinical trial 2022: Essentials of Regenerative Medicine in Interventional Pain Management Annu Navani, Sairam Atluri, Mahendra Sanapati, 2024-05-02 Regenerative medicine is an emerging and integral part of interventional pain management and meets definitions of interventional pain management and interventional techniques. Interventional techniques are defined as minimally invasive procedures including, percutaneous precision needle placement, with placement of drugs in targeted areas or ablation of targeted nerves; and some surgical techniques such as laser or endoscopic diskectomy, intrathecal infusion pumps, and spinal cord stimulators, for the diagnosis and management of chronic, persistent, or intractable pain. On the same token, interventional pain management is defined as the discipline of medicine devoted to the diagnosis and treatment of pain related disorders principally with the application of interventional techniques in managing subacute, chronic, persistent, and intractable pain, independently or in conjunction with other modalities of treatment. This new edition brings a wide array of information for interventional pain physicians and other physicians practicing regenerative medicine with its applications in managing chronic pain and other disorders. The structure of the book begins with an introduction of the subject, followed by sections on historical context, pathophysiology, applicability of regenerative medicine with its evidence base, anatomy, technical aspects, complications, and precautions for each topic when available and applicable. From across the globe, leading experts in their respective fields contributed chapters on specific topics to present a cogent and integrative understanding of the field of regenerative medicine as applicable for interventional pain physicians. This comprehensive text achieves its goal of providing an evidence-based approach to application of principles of regenerative medicine in managing chronic pain of spinal, neurological, and musculoskeletal origins. |
| stem cell stroke clinical trial 2022: Guidelines for Human Embryonic Stem Cell Research National Research Council, Institute of Medicine, Board on Health Sciences Policy, Division on Earth and Life Studies, Board on Life Sciences, Committee on Guidelines for Human Embryonic Stem Cell Research, 2005-08-15 Since 1998, the volume of research being conducted using human embryonic stem (hES) cells has expanded primarily using private funds because of restrictions on the use of federal funds for such research. Given limited federal involvement, privately funded hES cell research has thus far been carried out under a patchwork of existing regulations, many of which were not designed with this research specifically in mind. In addition, hES cell research touches on many ethical, legal, scientific, and policy issues that are of concern to the public. This report provides guidelines for the conduct of hES cell research to address both ethical and scientific concerns. The guidelines are intended to enhance the integrity of privately funded hES cell research by encouraging responsible practices in the conduct of that research. |
| stem cell stroke clinical trial 2022: Ethics of Modern Stem Cell Research and Therapy Ernst R. von Schwarz, 2024-08-05 This book provides an authoritative and comprehensive overview on the ethical issues surrounding the most promising and most controversially discussed topic in modern biotechnology and medicine, stem cell therapy. It is written by a scientist who has been involved in the basic research of stem cell therapy for over 20 years and was part of the initial experimental studies demonstrating benefits and damage repair using stem cells, and who also is a clinical cardiologist involved in the clinical studies of stem cell therapy in patients with mainly cardiovascular and neurodegenerative diseases from its early stage until now. The book starts with a brief overview of the history of stem cell research, the administrative and regulatory aspects including the federal governmental changes with every political administration over the last 20 years, and the stand of the FDA on research and therapy. It also discusses the issues of medical tourism, patient funded studies, false marketing claims, and the ethical and religious aspects of stem cell research, anti aging research, and immortality research including the Roman Catholic Churches view on embryonic stem cells. Ethics of Modern Stem Cell Research and Therapy will be a valuable resource for clinicians, physicians, and researchers who are looking to either conduct or use stem cell therapies. It offers a one-stop guide to the current regulations of the FDA as well as the potential that stem cell therapies have on many degenerative diseases. |
| stem cell stroke clinical trial 2022: Arterial Treatment of Neurological Diseases Shailendra Joshi, 2025-05-06 Drug delivery by injecting them through arteries poses unique challenges. The first attempts to treat malignant brain tumors by arterial injections were undertaken soon after World War II. Yet, the applications of arterial delivery in treating neurological diseases have not advanced significantly over the last seventy years. Although arterial drug delivery is used to treat several neurological conditions, its applications, other than for localization of brain functions, remain experimental and are unproven in robust scientific studies. Over the last two decades, interventional radiology has significantly advanced by developing catheter-based devices, but arterial drug development has largely been ignored. This book makes the case for arterial drug development. Unless drugs are developed explicitly for arterial injections, the vast potential of arterial treatments of neurological diseases will remain untapped. This multi-author book brings together experienced researchers and clinicians to investigate various applications of arterial drug delivery for treating neurological diseases. It’s an essential resource for various medical subspecialties related to the field and to advance pharmacological and clinical research with this mode of drug delivery. |
| stem cell stroke clinical trial 2022: Cheating Death Rand McClain, 2023-03-07 For the first time outside his private clinic, medical practitioner and pioneer Dr. Rand McClain shares what you can start doing today to increase longevity and better your health—at home or at your doctor’s office. In this golden age of medical discovery, cutting-edge treatments are emerging that increase longevity, stave off disease, and enhance our appearance and quality of life—our “healthspan.” But chances are, these advances are not readily available at most doctor’s offices, in stores, or easy to find online. Dr. Rand McClain takes a fresh approach to genetics, natural aging, and proactive medical treatments. He is the founder and head of the renowned Regenerative and Sports Medicine Clinic in Santa Monica, a leading practitioner of alternative and cutting-edge treatments. In Cheating Death, McClain shares the best drugs and supplements, treatment methods, and devices—approaches that are backed by extensive research as well as Dr. McClain’s own work with his patients—including: Little-known treatments that can reverse the effects of new and old injuries Emergent diagnostic and screening technologies that detect early onset disease sooner Breakthrough methods (some DIY) to slow down or reverse aging in the body Steps you can take now to enhance gene expression and side-step your “sins of the past” and poor family genetics Best of all, McClain shows how you can get access to these therapies and jumpstart your body’s regenerative processes—everything from stabilizing mood swings, relieving depression and anxiety, extending hormone balance and sexual function, improving muscle strength and stamina, relieving debilitating pain, and restoring a youthful appearance. Bolstered with research and recovery stories from real people, Cheating Death gives readers the tools to live healthier, longer lives. |
| stem cell stroke clinical trial 2022: Neuroinflammation in Stroke Ulrich Dirnagl, Bernd Elger, 2013-04-17 The successful treatment of acute stroke remains one of the major challenges in clinical medicine. Over the last decades, the understanding of stroke pathophysiology has greatly improved, while the therapeutic options in stroke therapy remain very limited. Today, hyperacute mechanisms of damage, such as excitotoxicity, can be discriminated from delayed ones, such as inflammation and apoptosis. Targeting of inflammation has already been successfully applied in various stroke models, but translation into a clinically efficacious strategy has not been achieved so far. In this book, leading experts in basic cerebrovascular research as well as stroke treatment review the current evidence for and against an important role for inflammation in stroke, and explore the potential of treating or modulating inflammation in stroke therapy. |
| stem cell stroke clinical trial 2022: Cardiovascular Applications of Stem Cells Khawaja H. Haider, 2023-07-05 The book covers multifarious aspects of stem cell-based therapy for cardiovascular diseases. In addition to stem cells from different sources for cell-based therapy, it covers stem cell organoids and stem cell-derived exosomes in regenerative medicine. The book also encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of mesenchymal stem cells, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, the book also reviews the stem cell-derived exosomes, their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models. Additionally, the book also discusses the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protects the cells and their retention post-engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy. |
| stem cell stroke clinical trial 2022: The Mind Unlocked Marc Arginteanu, M.D., 2023-11-21 A popular claim in recent years is that a person only uses 10% of their brain, and while this is not remotely true, it is accurate that the human brain contains massive untapped capabilities. Brains remain the most magnificent biological machines, and the latest neurobiological research on nutrition, sleep, music and exercise aims to help people keep theirs in top shape. The human mind is more than just electrochemical signals--it's a fountain of consciousness, transcending physicality. This work, backed by decades of experience, includes the latest neuroscience research and vignettes based on the author's actual patients. Containing mental hacks to explain how to overcome mental limitations, it explores how simple changes like breaking bad habits, having a better work-life balance, and more could help the human mind go from being just fine-tuned to being enlightened and limitless. With these hacks, a designer brain is just around the corner. |
| stem cell stroke clinical trial 2022: Cottrell and Patel's Neuroanesthesia E-Book James E. Cottrell, Piyush Patel, 2023-12-29 **Selected for Doody's Core Titles® 2024 in Anesthesiology & Pain Medicine**Balancing must-know scientific knowledge with clinical applications, Cottrell and Patel's Neuroanesthesia, 7th Edition, reflects the latest developments in neurosurgical anesthesia, providing a comprehensive, authoritative overview of this challenging field. Clinically oriented chapters offer key clinical points, case presentations, and discussions, delivering the complete and authoritative guidance you need to ensure optimal perioperative care and safety for neurosurgical patients. Broad, clearly organized coverage of all important aspects of neuroanesthesia enables you to find reliable answers to any clinical question. - Integrates current scientific principles with the newest clinical applications, including current clinical management guidelines for neurosurgical patients. - Provides expert guidance on what to do under a variety of circumstances, the logic behind why it should be done, and tips for avoiding complications. - Includes clear, conceptual illustrations throughout, along with neuroimaging, clinical photos, charts and graphs, and clinical algorithms, making complex concepts easier to understand at a glance. - Covers the latest advancements in the field including cerebrospinal fluid hemodynamics and physiology, minimally invasive techniques, brain tissue oxygenation oximetry, microdialysis, neuroimaging and neurointerventional radiology, traumatic brain injury, pediatric neuroanesthesia, and acute treatment of depression. - Any additional digital ancillary content may publish up to 6 weeks following the publication date. |
| stem cell stroke clinical trial 2022: Machine Learning-Assisted Diagnosis and Treatment of Endocrine-Related Diseases Qiuming Yao, Prem Prakash Kushwaha, Wenjie Shi, 2023-12-27 |
| stem cell stroke clinical trial 2022: Mesenchymal Stem Cell Therapy Lucas G. Chase, Mohan C Vemuri, 2012-12-11 Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field. |
| stem cell stroke clinical trial 2022: Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation Fawaz Alzaid, Mohammed Al-Onaizi, Ayman ElAli, 2024-09-05 Neuroinflammation manifests as changes to cognition or behavior, or as altered function in peripheral tissues. Patients with metabolic diseases (e.g., diabetes, obesity) are more likely to suffer with neuroinflammation since the disrupted metabolism and chronic low-grade inflammation that accompany metabolic diseases extends to the nervous system. Neuroinflammation will then lead to functional impairment and progressive loss of neuronal structure, with neurodegeneration being the end result. Factors like chronic hyperglycemia, dyslipidemia and insulin resistance are candidate drivers of neuroinflammation and neurodegeneration. The effects on the nervous system also contribute to worsening insulin resistance and a further loss of metabolic function and homeostasis in innervated peripheral tissues (e.g., liver, adipose tissue). Persistent metabolic stress predisposes patients to peripheral neuropathies, cognitive dysfunction, and development of neurodegenerative diseases (e.g., Alzheimer’s disease). Multiple associations link metabolic disease to neuropathology, targeting neuroinflammation to preserve neuronal integrity holds promise for managing metabolic diseases and associated neurological complications. Research on Neuroinflammation, Neurodegeneration and Metabolic Disease: From Molecular Mechanisms to Therapeutic Innovation is necessary to address several critical gaps in our understanding and treatment of metabolic diseases and of neuropathology. Firstly, while the role of systemic inflammation in metabolic diseases has been extensively studied, the specific impact of nervous system inflammation – neuroinflammation – and resulting neurodegeneration on these conditions is still an emerging field. Investigating the mechanisms by which neuroinflammation and neurodegeneration contribute to metabolic diseases can provide valuable insights into the pathogenesis and progression of these conditions. |
| stem cell stroke clinical trial 2022: Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-morbidity Factors Part A , 2023-10-03 Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-morbidity Factors, Volume 171 in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on Neurodegenerative diseases, Stress induced exacerbation of Alzheimer's disease brain pathology is thwarted by co-administration of nanowired cerebrolysin and amyloid beta peptide antibodies with serotonin 5-HT6 receptor antagonist SB-39988, Nanowired delivery of dl-3-n-butylphthalide with antibodies to alpha synuclein potentiated neuroprotection in Parkinson's disease with emotional stress, Efficacy of invasive and non-invasive methods for the treatment of Parkinson ́s disease: nanodelivery and enriched environment, and much more. Other sections cover Sleep deprivation induced exacerbation of Parkinson's disease pathophysiology is attenuated by co-administration of nanowired cerebrolysin and serotonin-3 receptor antagonist ondansetron, Co-administration of DL-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with brain injury, Stress and brain diseases, Pathophysiology of sleep deprivation enhances amyloid beta peptide and p-tau in the CSF and brain, Neuroprotective effects of nanowired delivery of multimodal drug cerebrolysin and monoclonal 5-HT antibodies, Prior heat exposure exacerbates brain blast injury, Neuroprotection by nanodelivery of cerebrolysin with serotonin 6 receptor antagonist SB-399885, the Effects of curcumin nanodelivery on several brain pathologies, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in Internation Review on Neurobiology series Updated release includes the latest information on Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-Morbidity Factors |
| stem cell stroke clinical trial 2022: Drug Discovery and Antiaging Approaches for Human Longevity Chen, Jen-Tsung, 2025-05-23 For years, antiaging biology and genetics have been advanced through approaches of molecular biology, particularly the technologies of high-throughput multiple omics, AI- and accelerated-computational biology, and RNA-based tools, such as epigenetic regulation and CRISPR technology. It has led to dramatic progress in drug discovery and the development of antiaging medicines and medical strategies. The field of research on lifespan-extending agents and their underlying molecular mechanisms remains minimal. Traditional herbal medicines, natural compounds, antioxidants, metabolites, kinase inhibitors, nuclear hormone receptors, and G protein-coupled receptor ligands, present promising medical strategies for antiaging involving CRISPR-based therapy, gene therapy, stem-cell therapy, and epigenetic drugs. Further research into ethical and social issues may reveal effective strategies for antiaging medicines in medical practice. Drug Discovery and Antiaging Approaches for Human Longevity explores antiaging biology and technical advancements in drug development for extending the human lifespan. It discusses the progress of clinical trials and ethical and social issues in antiaging medicines. This book covers topics such as genetics, human lifespan, and natural medicine, and is a useful resource for medical professionals, engineers, biologists, nutritionists, academicians, researchers, and scientists. |
| stem cell stroke clinical trial 2022: Neurobiological and Psychological Aspects of Brain Recovery Laura Petrosini, 2023-06-06 The importance of this unique book's approach lies in addressing the impact of neurobiological factors as well as psychological influences on brain recovery following injury. There is growing evidence that emotional, motivational, and cognitive factors along with personality traits play a crucial role in brain plasticity, resilience, and recovery. Topics include synaptic and neuronal plasticity, development of brain reserves, biological markers, environmental factors, emotional resilience, and personality traits. By combining the latest research on neural mechanisms and psychological resilience the authors present a book that will help lead to the development of better treatment strategies for functional recovery from brain damage. The new edition is fully updated throughout and contains completely new chapters on brain recovery in childhood, epigenetic aspects of brain recovery, and artificial intelligence techniques in traumatic brain injury research. |
| stem cell stroke clinical trial 2022: Principles and Practice of Neurocritical Care Hemanshu Prabhakar, Vasudha Singhal, Kapil G Zirpe, Harsh Sapra, 2024-05-31 This official textbook of the Society of Neurocritical Care (SNCC) comprises a comprehensive review of all possible neurologic conditions that one may encounter in the practice of neuro-intensive care. It covers various topics, from the history and origin of neuro-intensive care to psychological and nursing care. Neurocritical care is the intensive care management of patients with life-threatening neurological and neurosurgical illnesses such as massive stroke, bleeding in or around the brain (subarachnoid hemorrhage, intracerebral hemorrhage, subdural hemorrhage, intraventricular hemorrhage), brain tumors, brain trauma, status epilepticus, nerve and muscle diseases (myasthenia gravis, Guillain-Barre Syndrome), spinal cord disorders and the cardiopulmonary complications of brain injury. Neurocritical care units specialize in managing the unique needs of such critically ill patients. The textbook is divided into many sections. Chapters discuss issues related to palliative care and describe some of the commonly performed procedures in the neuro-intensive care unit as well. It provides a straightforward and systematic approach to various clinical problems encountered during intensive care management of neurologic patients. It includes a separate section on special considerations in neurocritical care. The book includes ample figures, flowcharts and algorithms. The textbook is a valuable resource for residents, fellows and trainees in neuroanesthesia, neurointensive care, critical care, and anesthesia. It serves as a quick guide to all intensivists managing neurosurgical patients. It is also helpful for general intensivists who occasionally manages neurologic patients. |
| stem cell stroke clinical trial 2022: Crosstalk in Ferroptosis, Immunity & Inflammation Qi Feng, Hua Zhong, Yu’e Liu, 2025-04-17 Ferroptosis represents a critical form of regulated cell death, notable for its reliance on iron and its triggering by lipid peroxidation. The process becomes particularly significant in the context of inflammation, a crucial bodily response intended to tackle various threats and ensure tissue equilibrium. Issues arise when inflammation is uncontrolled, leading towards immune dysfunction and cellular demise. Current studies have further postulated that inflammation may instigate ferroptosis, releasing damage-associated molecular patterns (DAMPs) that activate the immune response and exacerbate inflammation. This bi-directional relationship highlights a complex interplay where ferroptosis and inflammation are both cause and consequence. This Research Topic aims to delineate the complex interactions between ferroptosis and inflammation, uncovering how this nexus influences disease treatment, particularly in inflammatory diseases and cancers. We intend to dissect the interaction between ferroptosis and various immune cells and assess ferroptosis's role in conditions like infection, inflammation, and cancer. These insights are anticipated to reveal novel therapeutic avenues and advance the development of targeted medicinal interventions. |
| stem cell stroke clinical trial 2022: Mitochondrial Transplantation and Transfer Gokhan Burcin Kubat, Oner Ulger, Serdar Gunaydin, 2024-08-03 Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases, among other disease types. Step-by-step instruction is provided around research protocols and methods discussed, along with careful attention to the ethical implications of mitochondrial transplantation research and application. - Provides an in-depth discussion of mitochondrial transplantation, considering fundamental biology, disease implications, research methods and applications - Discusses recent advances in the field and their meaning for future research and clinical utility - Considers ethical dimensions of mitochondrial transplantation research and use in therapeutics - Examines mitochondrial transplantation across a range of disease types, from neurological to cardiovascular disease and ischemia |
| stem cell stroke clinical trial 2022: Fighting for recovery on multiple fronts in spinal cord injury Jacob Kjell, Jennifer Dulin, Philippa Warren, 2023-04-11 |
| stem cell stroke clinical trial 2022: The Study Skills Handbook Stella Cottrell, 2024-06-13 This is the ultimate guide to study skills, written by million copy bestselling author Stella Cottrell. Her tried and tested approach, based on over 20 years' experience of working with students, has helped over a million students to achieve their potential. When it comes to studying, there is no one-size-fits-all approach. This engaging and accessible guide shows students how to tailor their learning to their individual needs in order to boost their grades, build their confidence and increase their employability. Fully revised for the sixth edition, it contains everything students need to succeed. This is an invaluable resource for undergraduate students of all disciplines, and is also ideal for postgraduates, mature students and international students. It prepares students for what to expect before, during and after their studies at university. New content in this edition helps students make the most of online learning, with a new self-evaluation page and more on working collaboratively online. This edition includes support tailored for students on hybrid, asynchronous or distance learning courses as well as more material on building study stamina and improving concentration. |
| stem cell stroke clinical trial 2022: Mechanisms, imaging techniques, and therapies for acute ischemic stroke and related neuroprotective strategies Xunming Ji, Yuchuan Ding, Jie Lu, Lingling Zhu, Lian Duan, Geng Xiao Kun, Wenbo Zhao, 2023-10-03 |
| stem cell stroke clinical trial 2022: In Celebration of Women in Molecular and Cellular Reproduction Dolores Busso , Vanina Gabriela Da Ros , Patricia S. Cuasnicu, 2024-05-09 At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. |
| stem cell stroke clinical trial 2022: Medical Nanobiotechnology Sougata Ghosh, Thomas J. Webster, 2024-11-26 Medical Nanobiotechnology: Nanomedicine for Repair, Regeneration, Remodelling, and Recovery thoroughly reviews the potential of functionalized biomaterials as ideal candidates for nanomedicine. This book covers advances in the development of nanotheranostic agents that can simultaneously help in both effective therapy and rapid diagnosis. A range of materials is covered, including their fabrication, characterization, and assessment, as well as their functionalization and incorporation into implants and medical devices. Clinical aspects and challenges are discussed, helping bridge the gap between laboratory research and the translational impact as nanomedicine begins to develop point-of-care customized therapy. This book is an interdisciplinary reference for researchers and R&D groups interested in the development of novel nanobiomaterials for therapeutic applications. - Explores a wide range of regenerative, reparative, and therapeutic applications for novel nanobiomaterials and technologies, including biosensing, drug delivery, wound healing, cell remodeling, tissue engineering, and more - Discusses the clinical challenges and commercialization of nanomedicine in regenerative medicine, while also offering potential solutions - Utilizes case studies and flow charts to provide clearer understanding of the development techniques and therapeutic applications described |
| stem cell stroke clinical trial 2022: Next generation MSC therapy manufacturing, potency and mechanism of action analysis Raghavan Chinnadurai, Guido Moll, Sowmya Viswanathan, 2023-05-17 |
| stem cell stroke clinical trial 2022: Pediatric Neurovascular Disorders, An Issue of Neuroimaging Clinics of North America Prakash Muthusami, Todd Abruzzo, 2024-10-30 In this issue of Neuroimaging Clinics, guest editors Drs. Prakash Muthusami and Todd Abruzzo bring their considerable expertise to the topic of Pediatric Neurovascular Disorders. Top experts in the field discuss catheter-directed cerebral and spinal angiography in children; fetal neurovascular malformations; intracranial arterial aneurysms in childhood; neurovascular trauma in children; spinal vascular malformations of childhood; and more. - Contains 11 relevant, practice-oriented topics including special considerations for cross-sectional imaging in the child with neurovascular disease; pediatric intracranial vascular malformations; arterial ischemic stroke in children; hemorrhagic stroke in children; neurovascular diseases across the pediatric age spectrum; and more. - Provides in-depth clinical reviews on pediatric neurovascular disorders, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews. |
| stem cell stroke clinical trial 2022: Neuroprotection Swapan K. Ray, 2024-03-01 This volume contains cutting-edge molecular biology methods on neuroprotective mechanisms and specific preclinical models of the CNS injury, iseases and planning translation. Chapters guide readers through neuropathology, neuroprotection, Alzheimer’s disease, amyotrophic lateral sclerosis, ALS, Huntington’s disease , multiple sclerosis, Parkinson’s disease, spinal cord injury, traumatic brain injury, and ischemic brain injury. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neuroprotection: Methods and Protocols aims to ensure successful results in the further study of this vital field. |
| stem cell stroke clinical trial 2022: Therapeutic Relevance and Mechanisms of Neuro-Immune Communication in Brain Injury Zhang Pengyue, Xiangjian Zhang, Yunping Deng, Yuchuan Ding, Yulong Bai, Feng Zhang, 2023-08-25 The brain is a critical organ with neuro-immune communication. The nervous system and immune system evolved to provide regulation of physiological homeostasis and protect against threats. Neuro-immune communication is correlated with physiological functions of various tissues and organs, and the internal environment balance. In brain trauma, the neural network is destroyed and the neuro-immune communication process is impaired. However, the research on this process is insufficient and limited. A thorough clarification of the cellular and molecular mechanisms of neuro-immune communication in brain injury is an essential necessary endeavor in the search for new therapeutic targets for brain injury. This Research Topic is devoted to the cellular and molecular mechanisms of neuro-immune communication in brain injury and on the meaningful exploration of how the nervous system regulates the immune system to promote neurofunctional recovery after brain injury. |
| stem cell stroke clinical trial 2022: Extracellular Vesicles in Human Health and Diseases Asit Ranjan Ghosh, 2024-08-01 This book reviews the physiological and therapeutic applications of extracellular vesicles (EV) of different cell types. The initial chapter of the book focuses on their evolution, physiological functions, inter- and intra-cellular communication, and their strategic applications in defining different health disorders including aging, pathogenicity, toxicity, and drug delivery. The chapter also provides an overview of recent technologies for EV isolation, analysis, and quantification. The chapter also examines the role of EVs in viral and bacterial pathogenesis and discusses the emerging potential of EVs as diagnostic and therapeutic tools. It also discusses the emerging role of EVs including endosome-derived exosomes and fragments of the cellular plasma membrane in intercellular communication by transporting messenger RNA, microRNA (miRNA), and proteins. The book further explores the potential of membrane vesicles in the prevention, diagnosis, and treatment of inflammatory diseases,metabolic disorders, cardiovascular diseases, and neurodegenerative disorders. This book address researchers, clinicians, and doctoral and graduate students working in cellular molecular biology, cancer biology, infectious diseases, molecular medicine, biomedicine, neurobiology, microbiology, and translational medicine. |
| stem cell stroke clinical trial 2022: Bioactive Materials for Disease Diagnosis and Therapy Dan Shao, Mingqiang Li, Jie Tang, Yuce Li, 2024-04-16 With their advantages of controlled delivery and modular flexibility, biomaterials have fundamentally revolutionized disease diagnosis and therapy. Bioactive nanomaterials are not simple miniaturizations of macroscopic materials. They exhibit unique and intrinsic bioactivities as they readily acquire a precise structure upon interaction with the biological environment. Nowadays, bioactive materials offer great potential in eliciting specific responses and regulations of living tissues for diagnostics, therapeutics, and regenerative medicine. We are optimistic that the increasing innovations and advances in bioactive and biomimetic materials with sophisticated bioactivities and controllable responsiveness will make an important contribution to the next generation of biomaterials and biomedical engineering. |
| stem cell stroke clinical trial 2022: Omics-Based Approaches in Stroke Research Shubham Misra , Pradeep Kumar, 2024-08-23 Omics-based approaches have emerged as powerful tools in stroke research, revolutionizing our understanding of the underlying molecular mechanisms and potential therapeutic targets. These approaches encompass various disciplines such as genomics, transcriptomics, proteomics, metabolomics, radiomics, and epigenomics, enabling comprehensive analysis of biological and imaging markers and their interactions. Through genomics, researchers can identify genetic variants associated with stroke susceptibility, offering insights into individual risk factors and personalized medicine. Transcriptomics allows the investigation of gene expression patterns, highlighting key molecular pathways involved in stroke pathology and providing potential targets for intervention. Proteomics aids in the identification and quantification of proteins associated with stroke, aiding in the discovery of novel biomarkers and therapeutic targets. Metabolomics explores the metabolites involved in stroke pathophysiology, shedding light on metabolic alterations and potential therapeutic strategies. Radiomics involves the extraction and analysis of a multitude of quantitative features from medical imaging data, such as CT or MRI scans serving as potential imaging biomarkers, contributing to risk stratification and the identification of novel insights into stroke pathophysiology. Finally, epigenomics investigates modifications in gene expression without changing the DNA sequence, uncovering epigenetic mechanisms underlying stroke susceptibility and recovery. By integrating and analyzing data from these omics platforms, researchers can gain a comprehensive understanding of stroke pathogenesis, paving the way for the development of innovative diagnostic tools and effective therapeutic interventions. |
| stem cell stroke clinical trial 2022: Nutrition and Stroke Wael Mohamed, Mohd Basri Mat-Nor, 2024-12-27 This book provides a thorough examination of the correlation between nutrition and stroke. It delves into the interplay between nutrition and brain functions, neurogenesis, and cognitive functions. Additionally, it investigates how various types of nutrition relate to stroke. Moreover, it discusses recent progress in recognizing the significant therapeutic role of different nutrients in addressing stroke. Finally, it offers an overview of nutrients as neuroprotective agents and outlines the fundamental principles of nutrigenomics. |
| stem cell stroke clinical trial 2022: Volpe's Neurology of the Newborn E-Book Joseph J. Volpe, Terrie E. Inder, 2024-01-08 **Selected for Doody's Core Titles® 2024 in Neurology**Stay up to date with today's latest advances in diagnosis and management, as well as the many scientific and technological advances that are revolutionizing neonatal neurology, with the definitive text in the field. Volpe's Neurology of the Newborn, 7th Edition, shares the knowledge and expertise of world authority Dr. Joseph Volpe, who, along with Dr. Terrie E. Inder of Children's Hospital of Orange County and other distinguished editors, brings a wealth of insight to this classic text. Known for its clear, engaging writing style, vibrant, full-color illustrations, and authoritative information throughout, this reference is an indispensable resource for those who provide care for neonates with neurological conditions. - Provides clear, comprehensive coverage of neonatal neurology in Dr. Joseph Volpe's own legendary, readable manner—for a masterful, cohesive source of answers to any question that arises in your practice - Brings the latest science into the clinical setting, with an emphasis on translating new knowledge to the infant's bedside - Offers comprehensive updates with summary tables and text to reflect major advances in the study of hemorrhage; new insights into molecular genetics and molecular characterization of brain tumors; significant advances in drugs and the developing nervous system; and much more - Includes new chapters on fetal neurology which address the importance of understanding and investigating the maternal-fetal origins of neonatal disease, as well as new chapters on neurodevelopmental follow-up, inflammation, and neurology in low-resource settings - Contains more than 1,000 illustrations: clinical and pathological specimens, key experimental findings, schematics, algorithms, anatomical drawings, and neuroimaging throughout, as well as numerous tables and boxes that synthesize key points - Any additional digital ancillary content may publish up to 6 weeks following the publication date |
YOU Belong in STEM | U.S. Department of Education
Apr 10, 2025 · YOU Belong in STEM is an initiative designed to strengthen and increase Science, Technology, Engineering and Mathematics (STEM) education nationwide. Partnered with …
SCIENCE, TECHNOLOGY, ENGINEERING AND MATH:
STEM education. The Department of . Education will lead several new initiatives, including: • STEM Innovation Networks ($150 million): These networks of school districts, colleges, and …
Science, Technology, Engineering, and Mathematics (STEM)
High-quality STEM education provides students with the knowledge and skills to solve problems, gather and evaluate evidence, and make sense of information. STEM initiatives at IES …
STEM 2026: A Vision for Innovation in STEM Education - U.S.
STEM education disparities threaten the nation’s ability to close education and poverty gaps, meet the demands of a technology-driven economy, ensure national security, and maintain …
Resources for STEM Education - U.S. Department of Education
STEM concepts and approaches, including those in computer science; Title III funds to provide access to STEM resources specifically developed for English learners; and Perkins funds to …
Enhancing Students’ Abilities and Skills through Science …
The STEM-integrated approach will help students develop analytical and problem-solving skills in the world of work. Based on research conducted by (Samsudin et al., 2020), STEM integrated …
EJ821633 - STEM, STEM Education, STEMmania, Technology …
In this article, the author introduces integrative STEM (science, technology, engineering, and/or mathematics) education and discusses the importance of the program. The notion of …
Fast Facts: Science, Technology, Engineering, and Mathematics …
STEM fields include biological and biomedical sciences, computer and information sciences, engineering and engineering technologies, mathematics and statistics, and physical sciences …
STEM Education in the STEM Centers in Ethiopia: …
In Ethiopia, STEM education has been regarded as a corner stone for the economic and social transformations, and thus, the quest for STEM education for primary, secondary and tertiary …
The Role of Mathematics in STEM Activities: Syntheses and a …
STEM approaches described in the literature, it is common to find STEM activities in which the focus is on using STEM as a context for learning mathematics, while the other approach, with …
YOU Belong in STEM | U.S. Department of Education
Apr 10, 2025 · YOU Belong in STEM is an initiative designed to strengthen and increase Science, Technology, Engineering and Mathematics (STEM) education nationwide. Partnered with …
SCIENCE, TECHNOLOGY, ENGINEERING AND MATH:
STEM education. The Department of . Education will lead several new initiatives, including: • STEM Innovation Networks ($150 million): These networks of school districts, colleges, and …
Science, Technology, Engineering, and Mathematics (STEM)
High-quality STEM education provides students with the knowledge and skills to solve problems, gather and evaluate evidence, and make sense of information. STEM initiatives at IES …
STEM 2026: A Vision for Innovation in STEM Education - U.S.
STEM education disparities threaten the nation’s ability to close education and poverty gaps, meet the demands of a technology-driven economy, ensure national security, and maintain …
Resources for STEM Education - U.S. Department of Education
STEM concepts and approaches, including those in computer science; Title III funds to provide access to STEM resources specifically developed for English learners; and Perkins funds to …
Enhancing Students’ Abilities and Skills through Science …
The STEM-integrated approach will help students develop analytical and problem-solving skills in the world of work. Based on research conducted by (Samsudin et al., 2020), STEM integrated …
EJ821633 - STEM, STEM Education, STEMmania, Technology …
In this article, the author introduces integrative STEM (science, technology, engineering, and/or mathematics) education and discusses the importance of the program. The notion of …
Fast Facts: Science, Technology, Engineering, and Mathematics …
STEM fields include biological and biomedical sciences, computer and information sciences, engineering and engineering technologies, mathematics and statistics, and physical sciences …
STEM Education in the STEM Centers in Ethiopia: …
In Ethiopia, STEM education has been regarded as a corner stone for the economic and social transformations, and thus, the quest for STEM education for primary, secondary and tertiary …
The Role of Mathematics in STEM Activities: Syntheses and a …
STEM approaches described in the literature, it is common to find STEM activities in which the focus is on using STEM as a context for learning mathematics, while the other approach, with …
