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| science translational medicine journal impact factor: Regenerative Engineering Cato T. Laurencin, Yusuf Khan, 2013-06-20 Distinct from tissue engineering, which focuses primarily on the repair of tissues, regenerative engineering focuses on the regeneration of tissues: creating living, functional tissue that has the ability to replace organs that are dysfunctional. The challenge of working in an area like regenerative engineering lies, in part, in the breadth of info |
| science translational medicine journal impact factor: Principles of Translational Science in Medicine Martin Wehling, 2021-07-15 Principles of Translational Science in Medicine: From Bench to Bedside, Third Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing number of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. New chapters include: Translation in Oncology, Biologicals, and Orphan Drugs. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine and is written by worldwide experts in their respective fields. - Includes state-of-the-art principles, tools such as biomarkers and early clinical trials, algorithms of translational science in medicine - Provides in-depth description of special translational aspects in the currently most successful areas of clinical translation, namely oncology and immunology - Covers status of institutionalization of translational medicine, networking structures and outcomes at the level of marketing authorization |
| science translational medicine journal impact factor: Women in Science - Translational Medicine 2021 Victoria Bunik, Claudine Habak, 2022-10-25 |
| science translational medicine journal impact factor: The Journal of Laboratory and Clinical Medicine , 1916 |
| science translational medicine journal impact factor: Unreliable Csaba Szabo, 2025-03-11 Reproducibility is fundamental to the scientific method. After reading a paper describing research findings, a scientist should be able to repeat the experiment and obtain the same results. Yet an alarming number—perhaps as high as 90 percent—of published biomedical research papers face challenges in independent replication. Such issues range from honest mistakes to outright fraud. The scope of this crisis, however, underscores deeper systemic issues within the scientific community: its culture, incentives, and institutions. In Unreliable, the distinguished scientist Csaba Szabo examines the causes and consequences of the reproducibility crisis in biomedical research, showing why the factors that encourage misconduct stem from flaws in real-world science. There are many culprits, including commonplace research methods and dubious statistical techniques. Academic career incentives, hypercompetition for grant funding, and a bias toward publishing positive results have exacerbated the problem. Deliberate data manipulation and fabricated findings churned out by “paper mills” are disturbingly common. Academic institutions and publishers, for their part, have perpetuated a culture of impunity. Szabo explores how these failures have hindered scientific progress and impeded the development of new treatments, and he introduces readers to the “science sleuths” who tirelessly uncover misconduct. He proposes comprehensive reforms, from scientific training to the grant system through the publication process, to address the root causes of the crisis. Written in clear language and leavened with a keen sense of irony, Unreliable is an essential account of the reproducibility crisis that gives readers an inside look at how science is actually done. |
| science translational medicine journal impact factor: Cancer Immunotherapy Principles and Practice Lisa H. Butterfield, Howard L. Kaufman, Francesco M. Marincola, 2017 Part 1: Intratumoral Signatures Associated With Immune Responsiveness |
| science translational medicine journal impact factor: Sharing Publication-Related Data and Materials National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Responsibilities of Authorship in the Biological Sciences, 2003-04-17 Biologists communicate to the research community and document their scientific accomplishments by publishing in scholarly journals. This report explores the responsibilities of authors to share data, software, and materials related to their publications. In addition to describing the principles that support community standards for sharing different kinds of data and materials, the report makes recommendations for ways to facilitate sharing in the future. |
| science translational medicine journal impact factor: Biomaterials in Translational Medicine Lei Yang, Sarit Bhaduri, Thomas J. Webster, 2018-12-07 Biomaterials in Translational Medicine delivers timely and detailed information on the latest advances in biomaterials and their role and impact in translational medicine. Key topics addressed include the properties and functions of these materials and how they might be applied for clinical diagnosis and treatment. Particular emphasis is placed on basic fundamentals, biomaterial formulations, design principles, fabrication techniques and transitioning bench-to-bed clinical applications. The book is an essential reference resource for researchers, clinicians, materials scientists, engineers and anyone involved in the future development of innovative biomaterials that drive advancement in translational medicine. |
| science translational medicine journal impact factor: Reproducibility and Replicability in Science National Academies of Sciences, Engineering, and Medicine, Policy and Global Affairs, Committee on Science, Engineering, Medicine, and Public Policy, Board on Research Data and Information, Division on Engineering and Physical Sciences, Committee on Applied and Theoretical Statistics, Board on Mathematical Sciences and Analytics, Division on Earth and Life Studies, Nuclear and Radiation Studies Board, Division of Behavioral and Social Sciences and Education, Committee on National Statistics, Board on Behavioral, Cognitive, and Sensory Sciences, Committee on Reproducibility and Replicability in Science, 2019-10-20 One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science. |
| science translational medicine journal impact factor: The Science of Science Dashun Wang, Albert-László Barabási, 2021-03-25 This is the first comprehensive overview of the exciting field of the 'science of science'. With anecdotes and detailed, easy-to-follow explanations of the research, this book is accessible to all scientists, policy makers, and administrators with an interest in the wider scientific enterprise. |
| science translational medicine journal impact factor: Fritz Jahr and the Foundations of Global Bioethics Amir Muzur, Hans-Martin Sass, 2012 Leading bioethicists from America, Asia and Europe discuss Jahr's visionary concept of an ethics of 'bios', integrating the ethics of land, community, health, and culture in light of global challenges in the 21st century. |
| science translational medicine journal impact factor: How to Be a Scientist Roslyn A. Kemp, Deborah M. Brown, 2023-11-06 Many undergraduate students choose a science degree but are not aware of how science and research work in the real world. We explain the processes of collecting, sharing and, most importantly, critical analysis of scientific research, with a focus on the life sciences. This book explains how scientific research is conceived, carried out and analysed. It outlines how research findings are constantly evolving and why that is exciting and important. Students using this textbook will learn how to design experiments, explain their data and analyse and interpret the work of others. They will learn to think about broader aspects of science, such as bias and ethics. They will gain practical skills, including understanding the use of statistical tests and how to prepare an effective presentation. Active individual and class exercises provide opportunities for students to think about difficult concepts in science and research and to include their own perspectives. Key Features: Encourages discussion and critical thinking using individual and class exercises Provides real-world examples and context for difficult concepts Allows students to assess their understanding with practical exercises and examples Documents a variety of career options and opportunities from studying science Permits students to advocate for science with suggestions for creating and sharing research Related Titles: Barrass, R. Students Must Write: A Guide to Better Writing in Coursework and Examinations, 3rd ed. (ISBN 978-0-415-35826-2) Zlatanova, J. What Is Science?: Myths and Reality (ISBN 978-0-367-46523-0) Walters, D. E. & G. C. Walters. Scientists Must Speak, 2nd ed. (ISBN 978-1-4398-2603-4) Barrass, R. Scientists Must Write: A Guide to Better Writing for Scientists, Engineers and Students, 2nd ed. (ISBN 978-0-415-26996-4) |
| science translational medicine journal impact factor: Nourishment Fred Provenza, 2018-11-26 “Nourishment will change the way you eat and the way you think.”—Mark Schatzker, author of The Dorito Effect “[Provenza is] a wise observer of the land and the animals [and] becomes transformed to learn the meaning of life.”—Temple Grandin Reflections on feeding body and spirit in a world of change Animal scientists have long considered domestic livestock to be too dumb to know how to eat right, but the lifetime research of animal behaviorist Fred Provenza and his colleagues has debunked this myth. Their work shows that when given a choice of natural foods, livestock have an astoundingly refined palate, nibbling through the day on as many as fifty kinds of grasses, forbs, and shrubs to meet their nutritional needs with remarkable precision. In Nourishment Provenza presents his thesis of the wisdom body, a wisdom that links flavor-feedback relationships at a cellular level with biochemically rich foods to meet the body’s nutritional and medicinal needs. Provenza explores the fascinating complexity of these relationships as he raises and answers thought-provoking questions about what we can learn from animals about nutritional wisdom. What kinds of memories form the basis for how herbivores, and humans, recognize foods? Can a body develop nutritional and medicinal memories in utero and early in life? Do humans still possess the wisdom to select nourishing diets or has that ability been hijacked by nutritional “authorities”? Is taking supplements and enriching and fortifying foods helping us, or is it hurting us? On a broader scale Provenza explores the relationships among facets of complex, poorly understood, ever-changing ecological, social, and economic systems in light of an unpredictable future. To what degree do we lose contact with life-sustaining energies when the foods we eat come from anywhere but where we live? To what degree do we lose the mythological relationship that links us physically and spiritually with Mother Earth who nurtures our lives? Provenza’s paradigm-changing exploration of these questions has implications that could vastly improve our health through a simple change in the way we view our relationships with the plants and animals we eat. “Nourishment is a conversation between science, culture, and a greater spiritual or cosmological umbrella.”—Montana Public Radio |
| science translational medicine journal impact factor: Operative Techniques in Spine Surgery John Rhee, Scott D. Boden, 2015-12-07 Derived from Sam W. Wiesel’s four-volume Operative Techniques in Orthopaedic Surgery, this single-volume resource contains the user-friendly, step-by-step information you need to confidently perform the full range of operative techniques in spine surgery. In one convenient place, you’ll find the entire Spine section, as well as relevant chapters from the Oncology and Pediatrics sections of Operative Techniques in Orthopaedic Surgery. Superb full-color illustrations and step-by-step explanations help you master surgical techniques, select the best procedure, avoid complications, and anticipate outcomes. Written by global experts from leading institutions, Operative Techniques in Spine Surgery, 2nd Edition, provides authoritative, easy-to-follow guidance to both the novice trainee or experienced surgeon. |
| science translational medicine journal impact factor: Chasing My Cure David Fajgenbaum, 2019-09-10 LOS ANGELES TIMES AND PUBLISHERS WEEKLY BESTSELLER • The powerful memoir of a young doctor and former college athlete diagnosed with a rare disease who spearheaded the search for a cure—and became a champion for a new approach to medical research. “A wonderful and moving chronicle of a doctor’s relentless pursuit, this book serves both patients and physicians in demystifying the science that lies behind medicine.”—Siddhartha Mukherjee, New York Times bestselling author of The Emperor of All Maladies and The Gene David Fajgenbaum, a former Georgetown quarterback, was nicknamed the Beast in medical school, where he was also known for his unmatched mental stamina. But things changed dramatically when he began suffering from inexplicable fatigue. In a matter of weeks, his organs were failing and he was read his last rites. Doctors were baffled by his condition, which they had yet to even diagnose. Floating in and out of consciousness, Fajgenbaum prayed for a second chance, the equivalent of a dramatic play to second the game into overtime. Miraculously, Fajgenbaum survived—only to endure repeated near-death relapses from what would eventually be identified as a form of Castleman disease, an extremely deadly and rare condition that acts like a cross between cancer and an autoimmune disorder. When he relapsed while on the only drug in development and realized that the medical community was unlikely to make progress in time to save his life, Fajgenbaum turned his desperate hope for a cure into concrete action: Between hospitalizations he studied his own charts and tested his own blood samples, looking for clues that could unlock a new treatment. With the help of family, friends, and mentors, he also reached out to other Castleman disease patients and physicians, and eventually came up with an ambitious plan to crowdsource the most promising research questions and recruit world-class researchers to tackle them. Instead of waiting for the scientific stars to align, he would attempt to align them himself. More than five years later and now married to his college sweetheart, Fajgenbaum has seen his hard work pay off: A treatment he identified has induced a tentative remission and his novel approach to collaborative scientific inquiry has become a blueprint for advancing rare disease research. His incredible story demonstrates the potency of hope, and what can happen when the forces of determination, love, family, faith, and serendipity collide. Praise for Chasing My Cure “A page-turning chronicle of living, nearly dying, and discovering what it really means to be invincible in hope.”—Angela Duckworth, #1 New York Times bestselling author of Grit “[A] remarkable memoir . . . Fajgenbaum writes lucidly and movingly . . . Fajgenbaum’s stirring account of his illness will inspire readers.”—Publishers Weekly |
| science translational medicine journal impact factor: Science John Michels (Journalist), 2012 |
| science translational medicine journal impact factor: Altmetrics Andy Tattersall, 2016-06-21 This book gives an overview of altmetrics, its tools and how to implement them successfully to boost and measure research outputs. New methods of scholarly communication and dissemination of information are having a huge impact on how academics and researchers build profiles and share research. This groundbreaking and highly practical guide looks at the role that library and information professionals can play in facilitating these new ways of working and demonstrating impact and influence. Altmetrics focuses on research artefact level metrics that are not exclusive to traditional journal papers but also extend to book chapters, posters and data sets, among other items. This book explains the theory behind altmetrics, including how it came about, why it can help academics and where it sits amongst current measurements of impact. Editor Andy Tattersall draws on the expertise of leading altmetric innovators and practitioners, with chapters from Euan Adie, the founder of Altmetric.com; William Gunn, the Head of Academic Outreach at Mendeley and Ben Showers, author of the bestselling Facet title Library Analytics and Metrics. Readership: Altmetrics will empower library and information professionals working in higher education, researchers, academics and higher education leaders and strategists to develop the skills and knowledge needed to introduce and support altmetrics within their own institutions. |
| science translational medicine journal impact factor: Enhancing the Effectiveness of Team Science National Research Council, Division of Behavioral and Social Sciences and Education, Board on Behavioral, Cognitive, and Sensory Sciences, Committee on the Science of Team Science, 2015-07-15 The past half-century has witnessed a dramatic increase in the scale and complexity of scientific research. The growing scale of science has been accompanied by a shift toward collaborative research, referred to as team science. Scientific research is increasingly conducted by small teams and larger groups rather than individual investigators, but the challenges of collaboration can slow these teams' progress in achieving their scientific goals. How does a team-based approach work, and how can universities and research institutions support teams? Enhancing the Effectiveness of Team Science synthesizes and integrates the available research to provide guidance on assembling the science team; leadership, education and professional development for science teams and groups. It also examines institutional and organizational structures and policies to support science teams and identifies areas where further research is needed to help science teams and groups achieve their scientific and translational goals. This report offers major public policy recommendations for science research agencies and policymakers, as well as recommendations for individual scientists, disciplinary associations, and research universities. Enhancing the Effectiveness of Team Science will be of interest to university research administrators, team science leaders, science faculty, and graduate and postdoctoral students. |
| science translational medicine journal impact factor: Prebiotics and Probiotics in Human Milk Michelle McGuire, Mark A McGuire, Lars Bode, 2016-10-06 Prebiotics and Probiotics in Human Milk: Origins and Functions of Milk-Borne Oligosaccharides and Bacteria provides a comprehensive, yet approachable, treatise on what is currently known about the origins and functions of human milk oligosaccharides (HMO), the complex sugars in milk that are not digested by the infant. The book examines how HMOs and bacteria in human milk may function independently and coordinately to influence both maternal and infant health. Human milk is the only food designed specifically to nourish humans, indeed representing the essence of a perfect functional food. And although researchers have been studying its composition for decades, surprisingly little is really understood about the origins and functions of its myriad components, an area that is especially true for HMOs and bacteria. This book provides a thorough review of the newest research on these inter-related milk constituents as written by a team of experts from both academia and industry who actively conduct HMO and human milk microbiome research as they endeavor to apply this new knowledge to infant nutrition. Each chapter provides objective rationale for what research is still needed in this rapidly evolving area, also discussing the challenges and opportunities faced by the industry in adding HMO and microbes to infant food products. This book is a valuable resource for nutrition researchers focused on infant nutrition, food scientists and product developers working on infant formula, and clinicians interested in broadening their understanding of the benefits of human milk for infants. - Presents a reader-friendly, highly-curated text that includes a review of the literature related to origins, variability, metabolism, and functions of HMO and human milk bacteria - Discusses the potential implications of HMO and milk microbiota to industry – for instance, utilization in the dairy industry and infant formula - Consists of learning aids, such as pull quotes, critical summary statements, and an extensive list of published literature throughout |
| science translational medicine journal impact factor: Cancer on Trial Peter Keating, Alberto Cambrosio, 2014-04-18 There were no medical oncologists until a few decades ago. In the early 1960s, not only were there no such specialists, many practitioners regarded the treatment of terminally-ill cancer patients with heroic courses of chemotherapy as highly questionable. Physicians loath to assign patients randomly to competing treatments also expressed their outright opposition to the randomized clinical trials that were then relatively rare. And yet today these trials form the basis of medical oncology. How did such a spectacular change occur? How did medical oncology move from a non-entity and in some regards a reviled practice to the central position it now occupies in modern medicine?Cancer on Trialanswers these questions by exploring how practitioners established a new style of practice, at the center of which lies the cancer clinical trial. |
| science translational medicine journal impact factor: Evidence-based Advance and Management of Adverse Events of Immunotherapy for Cancer Yonggang Zhang, Xuelei Ma, Shuang Zhou, 2020-12-22 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| science translational medicine journal impact factor: Science with Impact Anne Helen Toomey, 2024-12-03 Will you please just listen to me? If you are a scientist, or a fan of science, have you ever wondered why your fact-based explanation of ground-breaking scientific research falls flat with family, friends, and the general public? Social science communicator Anne Helen Toomey argues that science today faces a public-relations crisis, and she calls for a whole-scale change in how scientists engage with the world. This practical, how-to guide will help scientists address public distrust, communicate about uncertainty, and engage with policymakers so that science can make a difference. Science with Impact argues that science can--and should--make a meaningful difference in society, and offers hope and guidance to those of us who wish to take the steps to make it so. |
| science translational medicine journal impact factor: Extracellular Targeting of Cell Signaling in Cancer James W. Janetka, Roseann M. Benson, 2018-05-10 International experts present innovative therapeutic strategies to treat cancer patients and prevent disease progression Extracellular Targeting of Cell Signaling in Cancer highlights innovative therapeutic strategies to treat cancer metastasis and prevent tumor progression. Currently, there are no drugs available to treat or prevent metastatic cancer other than non-selective, toxic chemotherapy. With contributions from an international panel of experts in the field, the book integrates diverse aspects of biochemistry, molecular biology, protein engineering, proteomics, cell biology, pharmacology, biophysics, structural biology, medicinal chemistry and drug development. A large class of proteins called kinases are enzymes required by cancer cells to grow, proliferate, and survive apoptosis (death) by the immune system. Two important kinases are MET and RON which are receptor tyrosine kinases (RTKs) that initiate cell signaling pathways outside the cell surface in response to extracellular ligands (growth factors.) Both kinases are oncogenes which are required by cancer cells to migrate away from the primary tumor, invade surrounding tissue and metastasize. MET and RON reside on both cancer cells and the support cells surrounding the tumor, called the microenvironment. MET and RON are activated by their particular ligands, the growth factors HGF and MSP, respectively. Blocking MET and RON kinase activation and downstream signaling is a promising therapeutic strategy for preventing tumor progression and metastasis. Written for cancer physicians and biologists as well as drug discovery and development teams in both industry and academia, this is the first book of its kind which explores novel approaches to inhibit MET and RON kinases other than traditional small molecule kinase inhibitors. These new strategies target key tumorigenic processes on the outside of the cell, such as growth factor activation by proteases. These unique strategies have promising potential as an improved alternative to kinase inhibitors, chemotherapy, or radiation treatment. |
| science translational medicine journal impact factor: The Immune System and Mental Health Hymie Anisman, Shawn Hayley, Alexander W. Kusnecov, 2018-07-19 The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson's and Alzheimer's-like dementia are explored. - Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan - Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences - Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health |
| science translational medicine journal impact factor: The Political Economy of COVID-19 Luke A. Amadi, Prince I. Igwe, Luke Amadi, 2024-12-15 Political Economy of COVID-19: Understanding the Dynamics of a Global Pandemic, illuminates intellectual discourse on the complex dimensions, effects and responses to the pandemic. The book offers fresh perspectives and new methodological insights to present and discuss COVID-19 research with an interdisciplinary approach. |
| science translational medicine journal impact factor: Futures Studies The Emirates Center for Strategic Studies and Research , 2020-06-18 Futures studies are particularly important in our contemporary world, indispensable for countries and institutions alike. Unprecedented rapid developments in all fields require continuous efforts, from countries and individuals, to explore the future and draw up plans to keep pace with the latest developments. Moreover, countries that aspire to strengthen their economic position, and see citizens reach their full potential by providing the highest standards of welfare, should base strategies for the future on rational, objective studies. In this context, The Emirates Center for Strategic Studies and Research’s (ECSSR) 23rd Annual Conference, ‘Futures Studies’, merits special attention, as it tackled a critical subject that is of great interest for strategic planners and decision-makers, particularly in the United Arab Emirates (UAE). This is especially significant as the UAE pursues future plans in accordance with its ambitious aspirations to become the best country in the world by its centennial in 2071. This book documents the key proceedings and discussions of the ECSSR’s 23rd Annual Conference. Through its seven chapters, researchers examine the most important areas pertaining to futures studies. The first chapter looks at the evolution of warfare over the last two centuries and discusses the ways these changes have impacted paradigms of political stability. The second chapter discusses international relations in the post-globalization era. The third chapter examines the Sapiens 5.0 (S5.0) manifesto, which includes advancing interdisciplinary and future-focused solutions. The fourth chapter reviews the revolutionary aspects of genomic medicine, while the fifth chapter discusses bacterial resistance to antibiotics, which has developed into a global crisis affecting the world’s health and economic well-being. The sixth chapter examines ageing communities and the need to redesign healthcare systems. Finally, the seventh chapter highlights social networking technology and the media of the future. |
| science translational medicine journal impact factor: Nutritional Psychiatry Ted Dinan, Timothy G. Dinan, 2023-08-31 The first book to provide a comprehensive overview of the relationship between nutrition and mental health for clinicians. |
| science translational medicine journal impact factor: The CTSA Program at NIH Institute of Medicine, Board on Health Sciences Policy, Committee to Review the Clinical and Translational Science Awards Program at the National Center for Advancing Translational Sciences, 2013-10-09 In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective. |
| science translational medicine journal impact factor: Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Neurodegenerative Disease Research and Commonalities with Metabolic Diseases , 2020-07-30 Metabolic Drivers and Bioenergetic Components of Neurodegenerative Disease summarizes recent developments in intervention trials in neurodegenerative diseases, particularly Alzheimer's and Parkinson's, as well as increasing evidence for the overlap between drivers of metabolic and neurodegenerative disease that impact mitochondrial function and bioenergetics, and subsequently cellular function and pathophysiology. Topics covered include Brain Glucose and Ketone Utilization in Brain Ageing and Neurodegenerative Diseases; the Mitochondrial Hypothesis: Dysfunction, Bioenergetic Defects, and the Metabolic Link to Alzheimer's Disease; the Metabolic Impact on Neuroinflammation and Microglial Modulation in Neurodegenerative Diseases, the Impact of Circadian and Diurnal Rhythms on Cellular Metabolic Function and Neurodegenerative Diseases, and much more. - Summarizes the current status of and future research in Alzheimer's and Parkinson's diseases - Reviews the impact of the metabolic hypothesis on underlying mechanisms of neurodegenerative diseases |
| science translational medicine journal impact factor: Biophysical Regulation of Vascular Differentiation and Assembly Sharon Gerecht, 2018-11-07 This book updates and expands on various aspects of the vasculature’s microenvironment and how these regulate differentiation and assembly. Discussed in this new edition are efforts to capitalize on combing engineering techniques, to study and manipulate various biophysical cues, including: endothelial cell- pericyte interactions (Davis), mechanical forces to regulate vascularization in three-dimensional constructs (Levenberg), how matrix properties and oxygen tension regulate vascular fate and assembly (Gerecht), biophysical cues in relation to vascular aging (Ferreira), 3D printing of complex vascularized tissue (Hibino), the harnessing of biophysical cues for therapeutic vasculature interfacing with the damaged brain (Segura) and finally, the infarcted heart (Grayson). This second edition of Biophysical Regulation of Vascular Differentiation and Assembly provides an interdisciplinary view of vasculature regulation thru various biophysical cues and presents recent advances in measuring and controlling such parameters. This book will be of interest to biologists, biophysicists and engineers who work with vascular differentiation and assembly. |
| science translational medicine journal impact factor: Inflammation in Cancellous and Cortical Bone Healing Love Tätting, 2019-04-09 Fractures in humans most commonly occur near the joints, in the metaphyseal bone area mainly consisting of cancellous bone. Despite this, mainly cortical fractures, located in the diaphyseal bone area, have been studied in experimental models of bone healing. It is known from previous studies that the diaphyseal fracture is sensitive to anti-inflammatory treatment, while metaphyseal bone healing is more resistant. The aim of this thesis is to study the inflammatory response to bone trauma in cancellous and cortical bone. A flow cytometric method was established for the purpose of examining the cellular composition of the inflammatory process in models of bone healing In paper I the cellular composition of metaphyseal bone healing was studied with flow cytometry. The proximal tibia was traumatized and then studied at day 1, 3, 5 and 10 afterwards and compared to healthy mice. The contralateral proximal tibia was also studied at the same time points to delineate the trauma site specific inflammation. A few changes could be noted that seemed specific to the trauma site in macrophage phenotype development. However, the cellular composition was similar at the trauma site and in the contralateral proximal tibia. This notion of a general skeletal response was confirmed with analysis of the humerus at day 5. In paper II a model of cortical bone healing apt for flow cytometry was developed and compared to cancellous bone healing. A furrow was milled along the femoral cortex and the healing bone tissue analyzed. The earliest time point that enough cells were present for flow cytometry was day 3. The cortical and cancellous model of bone healing was compared at day 3 and 5 to study how they evolve in comparison to each other. It was noted that they were similar in cellular composition at day 3, but had diverged at day 5. The cancellous model increased in neutrophilic granulocytes, whereas the cortical model increased in lymphocytes. In paper III the cancellous and cortical model were compared under experimental intervention of indomethacin. It is known that indomethacin leads to weakened biomechanical properties in cortical bone healing, but not in cancellous bone healing. The effect on cellular composition with indomethacin was studied with flow cytometry and the extracellular protein profile in the healing bone tissue with mass spectrometry. Unexpectedly, inflammatory monocytes were increased in the cortical model at day 3 with indomethacin, but otherwise the models were similar in cell composition at day 3 and 5. In mass spectrometry there was a large increase in detected proteins at day 3 in the indomethacin exposed cortical model, but otherwise the models were similar. This points to an early and model specific effect of indomethacin. The observed lack of indomethacin-induced effects in cancellous bone healing is in line with the previously noted lack of indomethacin-induced effects on bone weakening. The apparently increased inflammatory activity in the cortical model with indomethacin exposure at day 3 might indicate the healing process to be disturbed and not able to progress from the early proinflammatory state to a more anabolic, anti-inflammatory state. In paper IV the effect of macrophage depletion on healing of metaphyseal bone was studied. Clodronate was given for depletion at different time points prior to surgery and the pull-out force of a screw or tissue phenotyping of macrophages was performed a varying number of days after surgery. It was noted that metaphyseal bone healing was to a large extent inhibited by macrophage depletion up to two days after surgery, but not if depletion was done more than two days after surgery. Thus, macrophages seem to be most important during the first two days after trauma in cancellous bone healing. In summary this thesis provide insight to the natural development of bone healing. The findings emphasise that cancellous and cortical bone healing are different entities with differences in the inflammatory process leading to healing. |
| science translational medicine journal impact factor: Recent Advancements in Microbial Diversity Jae Youl Cho, 2022-03-18 In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study. - Outlines the role of macrophages in inflammation - Contains chapters by leading authors on the basic and translational aspects of macrophage biology - Deals with internal and external treats |
| science translational medicine journal impact factor: Entangled Life Merlin Sheldrake, 2021-04-13 NEW YORK TIMES BESTSELLER • A “brilliant [and] entrancing” (The Guardian) journey into the hidden lives of fungi—the great connectors of the living world—and their astonishing and intimate roles in human life, with the power to heal our bodies, expand our minds, and help us address our most urgent environmental problems. “Grand and dizzying in how thoroughly it recalibrates our understanding of the natural world.”—Ed Yong, author of An Immense World ONE OF PEOPLE’S BEST BOOKS OF THE 2020S • ONE OF THE BEST BOOKS OF THE YEAR: Time, BBC Science Focus, The Daily Mail, Geographical, The Times, The Telegraph, New Statesman, London Evening Standard, Science Friday When we think of fungi, we likely think of mushrooms. But mushrooms are only fruiting bodies, analogous to apples on a tree. Most fungi live out of sight, yet make up a massively diverse kingdom of organisms that supports and sustains nearly all living systems. Fungi provide a key to understanding the planet on which we live, and the ways we think, feel, and behave. In the first edition of this mind-bending book, Sheldrake introduced us to this mysterious but massively diverse kingdom of life. This exquisitely designed volume, abridged from the original, features more than one hundred full-color images that bring the spectacular variety, strangeness, and beauty of fungi to life as never before. Fungi throw our concepts of individuality and even intelligence into question. They are metabolic masters, earth makers, and key players in most of life’s processes. They can change our minds, heal our bodies, and even help us remediate environmental disaster. By examining fungi on their own terms, Sheldrake reveals how these extraordinary organisms—and our relationships with them—are changing our understanding of how life works. Winner of the Wainwright Prize, the Royal Society Science Book Prize, and the Guild of Food Writers Award • Shortlisted for the British Book Award • Longlisted for the Rathbones Folio Prize |
| science translational medicine journal impact factor: Breastfeeding and Human Lactation Karen Wambach, Becky Spencer, 2024-10-03 Breastfeeding and Human Lactation, Seventh Edition is the ultimate reference for the latest clinical techniques and research findings that direct evidence-based clinical practice and research for lactation consultants and specialists. It contains everything a nurse, lactation consultant, midwife, women’s health nurse practitioner, physician assistant, or Ob/Gyn needs to know about lactation care and science. Topics include placing breastfeeding in its historical context, workplace-related issues, anatomical and biological imperatives of lactation, the prenatal and perinatal periods and concerns during the postpartum period, the mother’s health, sociocultural issues, and more vital information. |
| science translational medicine journal impact factor: Psoriasis Wolfram Sterry, Robert Sabat, Sandra Philipp, 2014-12-15 Practical and user-friendly, this is the ideal guide to the diagnosis and treatment of psoriasis, helping you navigate a logical management pathway through a complex maze of possibilities. Psoriasis is a cruel disease that can seriously affect the sufferer’s quality and length of life. It is also highly idiosyncratic, with features that vary greatly from patient to patient; this being mirrored in the highly variable response to treatment. It is increasingly recognized that psoriasis is not a discrete disease and that many patients suffer two or three comorbid conditions that can complicate the efforts of doctors treating patients. Psoriasis: Diagnosis and Management will provide dermatologists of all levels with a practical, well-illustrated approach to fully understanding the disease, including clear, clinical guidance to enable best-practice and effective management of patients. In full color throughout and excellently illustrated, key highlights include: easily understandable description of the psoriasis pathogenesis; a strong emphasis on the clinical features of psoriasis; careful consideration of comorbid conditions as part of the psoriatic spectrum to be managed; coverage of both traditional and contemporary management approaches; plenty of diagnostic algorithms and management protocols to aid the daily practical care of patients. Brought to you by several of the world’s leading authorities on the subject, Psoriasis: Diagnosis and Management is an essential purchase for the dermatologist. |
| science translational medicine journal impact factor: Neurogenetics, Part I , 2018-01-08 Genetic methodologies are having a significant impact on the study of neurological and psychiatric disorders. Using genetic science, researchers have identified over 200 genes that cause or contribute to neurological disorders. Still an evolving field of study, defining the relationship between genes and neurological and psychiatric disorders is evolving rapidly and expected to grow in scope as more disorders are linked to specific genetic markers. Part I covers basic genetic concepts and recurring biological themes, and begins the discussion of movement disorders and neurodevelopmental disorders, leading the way for Part II to cover a combination of neurological, neuromuscular, cerebrovascular, and psychiatric disorders. This volume in the Handbook of Clinical Neurology will provide a comprehensive introduction and reference on neurogenetics for the clinical practitioner and the research neurologist. - Presents a comprehensive coverage of neurogenetics - Details the latest science and impact on our understanding of neurological psychiatric disorders - Provides a focused reference for clinical practitioners and the neuroscience/neurogenetics research community |
| science translational medicine journal impact factor: 21-Day Tummy Diet Cookbook Liz Vaccariello, 2014-12-22 Belly bulges plague millions of Americans. So does bloating, heartburn, and other tummy troubles. It’s no coincidence. As Reader's Digest editor-in-chief and weight loss expert Liz Vaccariello revealed in 21-Day Tummy Diet, the same foods can both pack on the pounds and lead to gastrointestinal problems—and the culprits may surprise you. Luckily, there are also foods that can help us both shrink and soothe our stomachs. In 21-Day Tummy Diet Cookbook, you’ll find 150 all-new quick and easy recipes featuring amazing Belly Buddies such as blueberries, potatoes, and tomatoes, including: • Fast and filling breakfasts such as Potato, Ham and Cheddar Hash and Blueberry Corn Muffins, plus all new variations on the Belly Soother Smoothie • Soothing and satisfying soups such as Italian Tomato and Meatball Soup and Chicken Chard Soup with Pasta • Nourishing entrees and one-dish mains such as Tex-Mex Cheeseburger, Hazelnut-Stuffed Pork Chops, and Chicken Mac and Cheese, • Simply delicious sides and salads such as Cherry Tomato and Forbidden Rice Salad, Tuscan Green Beans, and Home-Fries • Delectable desserts such as Chocolate-Chip Walnut Cookies, Blueberry Shortcakes, and Mochachino Cupcakes Plus you’ll find sample menus for each phase of the 21-Day Tummy Diet, easy-to-follow tips on how to create your own Belly Buddy recipes, and inspirational stories from the Tummy Testers, who collectively lost 90 pounds in 3 weeks, shed 29 inches from their waists, and all reported fewer digestive symptoms and happier tummies. |
| science translational medicine journal impact factor: Circadian Rhythms in Health and Disease , 2025-05-23 Circadian Rhythms in Health and Disease, Volume 393 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Chapters in this new release include Circadian Rhythms in Cardiac Health and Disease, Liver as a nexus of daily metabolic cross talk, Non-rhythmic modulators of the circadian system: A new class of circadian modulators, The emerging role of circadian rhythms in exosome-mediated cellular crosstalk, Circadian rhythms and muscle health, and Output circuits from the suprachiasmatic nucleus controlling diverse physiological functions. - Provides a thorough introduction to concepts surrounding circadian rhythms, including their biological basis - Incorporates insights from various disciplines, such as biology, medicines, Psychology, and Neuroscience - Addresses possible research directions and advancements in the field of circadian rhythms |
| science translational medicine journal impact factor: The Social Life of DNA Alondra Nelson, 2016-09-20 The unexpected story of how genetic testing is affecting race in America We know DNA is a master key that unlocks medical and forensic secrets, but its genealogical life is both revelatory and endlessly fascinating. Tracing genealogy is now the second-most popular hobby amongst Americans, as well as the second-most visited online category. This billion-dollar industry has spawned popular television shows, websites, and Internet communities, and a booming heritage tourism circuit. The tsunami of interest in genetic ancestry tracing from the African American community has been especially overwhelming. In The Social Life of DNA, Alondra Nelson takes us on an unprecedented journey into how the double helix has wound its way into the heart of the most urgent contemporary social issues around race. For over a decade, Nelson has deeply studied this phenomenon. Artfully weaving together keenly observed interactions with root-seekers alongside illuminating historical details and revealing personal narrative, she shows that genetic genealogy is a new tool for addressing old and enduring issues. In The Social Life of DNA, she explains how these cutting-edge DNA-based techniques are being used in myriad ways, including grappling with the unfinished business of slavery: to foster reconciliation, to establish ties with African ancestral homelands, to rethink and sometimes alter citizenship, and to make legal claims for slavery reparations specifically based on ancestry. Nelson incisively shows that DNA is a portal to the past that yields insight for the present and future, shining a light on social traumas and historical injustices that still resonate today. Science can be a crucial ally to activism to spur social change and transform twenty-first-century racial politics. But Nelson warns her readers to be discerning: for the social repair we seek can’t be found in even the most sophisticated science. Engrossing and highly original, The Social Life of DNA is a must-read for anyone interested in race, science, history and how our reckoning with the past may help us to chart a more just course for tomorrow. |
| science translational medicine journal impact factor: Metabolism and Medicine Brian Fertig, 2022-01-31 Chronic disease states of aging should be viewed through the prism of metabolism and biophysical processes at all levels of physiological organization present in the human body. This book connects these insights to what causes them to go awry in the context of unhealthy human behaviors and aging, aiming to buttress scientific creativity. It also provides links between the art and science of medicine that strengthens problem-solving in patient care. New and important discoveries in the area of metabolic health and metabolic diseases are discussed in exquisite detail. Key Features: Broad and up-to-date overview of the field of metabolic aspects of health and chronic disease development, especially connecting the spectrum of topics that range from molecular clocks to stress response to nuclear hormone receptors and the role of microbiota in human health Provides a deeper basic science and interdisciplinary understanding of biological systems that broaden the perspectives and therapeutic problem solving by elaborating on the usefulness of the Physiological Fitness Landscape Describes the importance of insulin resistance in metabolic disease, especially diabetes but also includes links to cancer and Alzheimer’s disease Examines the process of aging from the perspective of metabolic decline illustrating it with the Physiological Fitness Landscape This book, the second volume in a two-volume set, primarily targets an audience of clinical and science students, biomedical researchers and physicians who would benefit from understanding each other’s language. |
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