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| renal and adrenal tumors biology and management: Renal and Adrenal Tumors Arie Belldegrun, 2003 In the past decade there has been an explosion of far-reaching developments in the biological and physical sciences relevant to cancer. The incidence and mortality from renal cell carcinoma has continuouly risen over the past 50 years. Despite this, survival for patients has notably improved and great strides have been made in the management of patients with renal cell carcinoma. Our understanding of the natural history of renal cell carcinoma, the role of nephrectomy, the benefits of immunotherapy and the possibilities of new technologies are evolving and are being integrated with advances in classification and staging. This book provides a comprehensive source of information on renal and adrenal tumors that will be of practical interest for students, residents, physicians, and researchers alike. It reviews comprehensively the current understanding of the biology, pathophysiology and urological oncology of the disease, looking at the clinical problems and potential solutions including chapters on both the scientific and clinical principles. Fully illustrated, the book emphasises new advances in molecular biology, pathogenesis, detection and experimental therapeutics and focuses on new developments in clinical research. An international team of recognized of experts have been brought together to provide historical perspectives, an overview of basic facts, and an assessment and exploration of the newer developments in our understanding of the clinical, genetic, and molecular aspects of these diseases. The book clearly distinguishes what is generally agreed upon from what is still controversial, giving both sides equal treatment. The primary market will include medical and clinical oncologists, urologists and trainee urologists, clinical pathologists, nephrologists and research workers in renal cancer. Also published by Oxford Univeristy Press Oxford Textbook of Oncology, Second Edition Robert Souhami, Ian Tannock, Peter Hohenberger and Jean-Claude Horiot Prostate Cancer - biology, diagnosis and management K Syrigos Oncology - an Oxford Core Text RAJ Spence OBE and P Johnston |
| renal and adrenal tumors biology and management: Cancer Nursing Connie Henke Yarbro, Michelle Goodman, Margaret Hansen Frogge, 2005 Rapid changes in oncology necessitate a comprehensive, up-to-date reference for oncology nurses. For seventeen years, best-selling Cancer Nursing: Principles and Practice has filled this need, supplying oncology nurses with cutting-edge, current information. Now, in its Sixth Edition, Cancer Nursing reflects the constantly shifting progress in the science of oncology, as well as emerging new therapies, new treatment modalities, the latest results from clinical trials, updates on new chemotherapeutic agents and targeted therapies, and new perspectives on supportive care. |
| renal and adrenal tumors biology and management: Epidemiology of Endocrine Tumors Jahangir Moini, Craig Badolato, Raheleh Ahangari, 2021-03-03 Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. - Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals - Focuses on the impact upon costs and patient deaths due to complications of these tumors - Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors - Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors - Provides review questions with an answer key and detailed glossary |
| renal and adrenal tumors biology and management: Cancer Nursing Connie Yarbro, Debra Wujcik, Barbara Holmes Gobel, 2011 A new and revised version of this best-selling reference! For over eighteen years, best-selling Cancer Nursing: Principles and Practice has provided oncology nurses with the latest information on new trends in the rapidly changing science of oncology. Now, in its Seventh Edition, Cancer Nursing has been completely revised and updated to reflect key new developments. New topics covered include targeted therapy, hypersensitivity reactions, mucositis, and family and caregiver issues. With 27 new chapters featuring insights from key authors, the Seventh Edition is a must-have resource for every oncology nurse. |
| renal and adrenal tumors biology and management: Manual of Clinical Oncology Dennis Albert Casciato, Mary C. Territo, 2009 Updated for its Sixth Edition, this pocket manual is a practical, accessible, comprehensive guide to the management of patients with cancer. In an outline format designed for rapid reference, the book provides the essential information needed for fast, effective clinical decision-making at the bedside. Coverage begins with principles of cancer management, proceeds through the specific malignancies, and then focuses on the organ-specific complications of cancer, whether due to the disease or its treatments. The unique appendices permit better readability within the chapters by placing frequently referenced, large, complex, and detailed tables at the end of the book. The appendices present cytogenetic nomenclature, toxicity of chemotherapy, critical tumor identifiers, and combination chemotherapy regimens for lymphomas. |
| renal and adrenal tumors biology and management: Manual of Clinical Oncology Casciato, Mary C. Territo, 2012 Manual of Clinical Oncology is a concise pocket manual that incorporates basic science, clinical findings, and available technology into the diagnosis and management of cancer. It focuses on information useful for participating in rounds and for making diagnostic and therapeutic decisions at the bedside of cancer patients. The seventh edition is a practical, accessible, comprehensive guide to the management of patients with cancer. |
| renal and adrenal tumors biology and management: Pheochromocytoma (PHEO) and Paraganglioma (PGL) Karel Pacak, David Taïeb, 2019-11-20 This book outlines some new advances in genetics, clinical evaluation, localization, therapy (newly including immunotherapy) of pheochromocytoma and paraganglioma including their metastatic counterparts. Well-known and experienced clinicians and scientists contributed to this book to include some novel approaches to these tumors. This book will serve to various health care professionals from different subspecialties, but mainly oncologists, endocrinologists, endocrine surgeons, pediatricians, and radiologists. This book shows that the field of pheochromocytoma/paraganglioma is evolving and a significant progress has been made in last 5 years requiring that health care professionals and scientists will learns new information and implement it in their clinical practice or scientific work, respectively. This book should not be missed by anybody who is focusing on neuroendocrine tumors, their newest evaluation and treatment. |
| renal and adrenal tumors biology and management: Journal of the National Cancer Institute , 1996 |
| renal and adrenal tumors biology and management: Diagnostic Landscape in Cancer Research Ranjita Shegokar, Yashwant Pathak, 2025-04-02 Diagnostic Landscape in Cancer Landscape examines the combined impact of prevention, diagnosis, and treatment of cancer. With a strong focus on the status, challenges, and prospects of diagnostic tools and technology, the book also examines the clinical translation-related knowledge and prognosis of different organ related cancers. In 22 chapters, the book describes current and new diagnostic tools in twenty different cancers and explores how innovations in the cancer diagnostic space could make cancer screening and early detection more straightforward.This book is a timely and valuable resource for health professionals, scientists, researchers, health practitioners, students, and all those who wish to broaden their knowledge in the allied field. - Provides essential information on the most recent developments in the diagnostic landscape of different cancer types - Explains current technology and its applications in the diagnostic cancer research landscape - Includes contributions from oncologists, biomedical engineers, pharmaceutical scientists, and manufacturers |
| renal and adrenal tumors biology and management: Nephron-Sparing Surgery Krishna Sasidharan, Mark Soloway, 2007-10-18 Despite the rising popularity of the minimally invasive laparoscopic option, open nephron-sparing surgery is still seen by many experts as the 'gold standard' for open surgery for kidney tumors and should remain the first choice for many patients. This challenges the idea that less-invasive therapies are always more desirable than open surgery. Whi |
| renal and adrenal tumors biology and management: Evolving Treatment Paradigms in Renal Cancer, An Issue of Urologic Clinics William C. Huang, Samir S. Taneja, 2012-05-28 This issue of the Urologic Clinics provides a timely update on Renal Cancer and the evolving treatment standards in urology. Articles include Contemporary Imaging of the Renal Mass, Surgical Approach to Multifocal Renal Cancers, and Systemic Therapy Prior to Surgery. Effects of the various existing surgical approaches on long-term renal function is also discussed, along with a review of the current trends in surgical management of renal cancers with specific attention to utilization of laparoscopic approach, partial nephrectomy, ablative technologies and observation. |
| renal and adrenal tumors biology and management: Urology & Nephrology Bernard L Schwartz, 2002-05 PDR eMedguides are clear and concise internet navigational directories designed to lead physicians directly to websites that have been reviewed by peer leaders and professionals in various medical specialties. Each guide focuses on a single specialty and reviews over 1600 related websites. Unlike search engines, eMedguides list only authoritative sites that offer useful professional content. eMedguides reviews are posted and continuously updated at www.emedguides.com, where you can easily click directly to any website reviewed. |
| renal and adrenal tumors biology and management: Index Medicus , 2004 Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings. |
| renal and adrenal tumors biology and management: Research Awards Index , |
| renal and adrenal tumors biology and management: Practical Algorithms in Pediatric Hematology and Oncology R. H. Sills, 2003-02-04 This is the only comprehensive collection of algorithms which exclusively addresses hematologic and oncologic problems affecting neonates, children and adolescents. Examining clinical problems which challenge the pediatrician, general practitioner and family practice physician, each algorithm utilizes a concise, step-by-step approach based upon clues from the history, physical examination and laboratory studies. The algorithms addressing differential diagnosis clearly distinguish between the most common etiologies, those that are less frequent, and finally some that are rare but important to recognize. The 51 topics include evaluation of anemia, sickle cell anemia, thalassemia, hemolytic anemia, the bleeding child, thrombocytopenia and other platelet disorders, hemophilia, leukocyte disorders, leukemias, lymphadenopathy, splenomegaly, approaches to mass lesions in the mediastinum, abdomen, pelvis, bones and soft tissues as well as approaches to potential emergencies such as tumor lysis and superior vena cava syndromes. The oncology topics emphasize diagnostic approach and management of complications, and not the details of chemotherapy. All algorithms are presented with a page of explanatory notes and a list of selected reading. Pediatricians, family physicians and general practitioners will find this book very helpful in managing problems in their practices. Trainees in pediatric hematology will find it a useful tool in developing approaches to solve the problems they will encounter, and pediatric hematologists/oncologists will find it useful as a teaching tool. |
| renal and adrenal tumors biology and management: Renal Cell Cancer Jean J. M. C. H. Rosette, Cora N. Sternberg, Hein P. van Poppel, 2008-07-10 This book is a state-of-the-art reference work covering every aspect of the field of renal cell cancer, from diagnostics to clinical management. It provides an overview of new information concerning epidemiology, molecular and immunologic characteristics, as well as surgical therapy. Particular focus is given to the latest diagnostic tests and genetic counseling. Associated topics such as pain management and palliative care are also covered. It is a vital reference tool for urologists, oncologists and radiologists alike, being the most comprehensive volume available on the subject. |
| renal and adrenal tumors biology and management: Urological Pathology David J. Grignon, John R. Srigley, 2013-12-18 Urological Pathology Knowledge in the field of urologic pathology is growing at an explosive pace. Today's pathologists, specialists, and residents require a comprehensive and authoritative text that examines the full range of urological diseases and their diagnosis. Written by recognized leaders and educators in the field, the text provides readers with a detailed understanding of all diagnostic aspects of urological disease. Inside this unique resource, readers will explore a broad spectrum of practical information—including etiology, diagnostic criteria, molecular markers, differential diagnosis, ancillary tests, and clinical management. This is sure to be the new definitive text for urological pathology! Features: Practical organization presents discussions by organ and by neoplastic/non-neoplastic nature of diseases to help readers access and retrieve essential facts quickly. Expert editors are highly respected academic urologic pathologists. Detailed guidance helps readers identify a range of pathologic entities, recognize typical and atypical presentations, refine diagnosis, and make sound treatment choices. Accompanying website with image bank and fully searchable text allows readers to view critical pathologic features and related discussions at a glance. |
| renal and adrenal tumors biology and management: Cumulated Index Medicus , 1982 |
| renal and adrenal tumors biology and management: WHO Classification of Tumours of the Urinary System and Male Genital Organs International Agency for Research on Cancer, 2016-02-02 WHO Classification of Tumours of the Urinary System and Male Genital Organs is the eighth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. It contains numerous color photographs, MRIs, ultrasound images, CT scans, charts and references. |
| renal and adrenal tumors biology and management: Urology Michael T. Macfarlane, 2013-06-07 The Fifth Edition of Urology in the House Officer Series creates a concise source of clinical information on urology for medical students and residents that can be easily carried for quick reference. Concentrating on the non-surgical aspects of urology, this pocket guide provides the information needed for making a diagnosis and deciding on the proper treatment course. This compact book is separated into two sections, the first, entitled Chief Presentations, covers the most common presenting complaints in the general urology clinic. The second section, entitled, Selected Topics, covers the major areas of urology in greater detail. Covering all diagnostic and treatment approaches for all urologic diseases, this pocket guide is also ideal for family practitioners, physician assistants, nurse practitioners, and emergency room physicians who wish to quickly review a specific urologic presentation. |
| renal and adrenal tumors biology and management: Biomedical Index to PHS-supported Research , |
| renal and adrenal tumors biology and management: Endocrinology and Metabolism Paul W. Ladenson, John Eager Howard, 2004-03 PDR eMedguides are clear and concise internet navigational directories designed to lead physicians directly to websites that have been reviewed by peer leaders and professionals in various medical specialties;each guide focuses on a single specialty and reviews over 1600 related websites. Unlike search engines, eMedguides list only authoritative sites that offer useful professional content;eMedguides reviews are posted and continuously updated at www.emedguides.com, where you can easily click directly to any website reviewed. |
| renal and adrenal tumors biology and management: Nelson Textbook of Pediatrics E-Book Robert Kliegman, Bonita F. Stanton, Joseph W. St. Geme III, Nina F Schor, Richard E. Behrman, 2011-06-10 Nelson Textbook of Pediatrics has been the world’s most trusted pediatrics resource for nearly 75 years. Drs. Robert Kliegman, Bonita Stanton, Richard Behrman, and two new editors—Drs. Joseph St. Geme and Nina Schor—continue to provide the most authoritative coverage of the best approaches to care. This streamlined new edition covers the latest on genetics, neurology, infectious disease, melamine poisoning, sexual identity and adolescent homosexuality, psychosis associated with epilepsy, and more. Understand the principles of therapy and which drugs and dosages to prescribe for every disease. Locate key content easily and identify clinical conditions quickly thanks to a full-color design and full-color photographs. Access the fully searchable text online at www.expertconsult.com, along with abundant case studies, new references and journal articles, Clinics articles, and exclusive web-only content. Stay current on recent developments and hot topics such as melamine poisoning, long-term mechanical ventilation in the acutely ill child, sexual identity and adolescent homosexuality, age-specific behavior disturbances, and psychosis associated with epilepsy. Tap into substantially enhanced content with world-leading clinical and research expertise from two new editors—Joseph St. Geme, III, MD and Nina Schor, MD—who contribute on the key subspecialties, including pediatric infectious disease and pediatric neurology. Manage the transition to adult healthcare for children with chronic diseases through discussions of the overall health needs of patients with congenital heart defects, diabetes, and cystic fibrosis. Recognize, diagnose, and manage genetic conditions more effectively using an expanded section that covers these diseases, disorders, and syndromes extensively. Find information on chronic and common dermatologic problems more easily with a more intuitive reorganization of the section. |
| renal and adrenal tumors biology and management: Subject Index of Current Extramural Research Administered by the National Cancer Institute , 1978 |
| renal and adrenal tumors biology and management: Algorithms in Pediatrics Nitin K Shah, 2017-03-31 Algorithms in Pediatrics uses an algorithm-based approach to various paediatric disorders. The book is divided into nineteen sections covering all paediatric specialties and sub-specialties, from neonatology, through to haematology and oncology. Later sections focus on other important topics in paediatrics including emergencies in office practice, intensive care, and a final section on paediatric surgery. Every section presents algorithms based on patient history, physical examination, and laboratory studies, using a step-by-step approach. Clinical evaluation, diagnosis, treatment and management are also included, with clinical pearls throughout and key points at the end of each section, making this an ideal resource for post-graduates and paediatricians. Key Points Comprehensive, step-by-step guide to a range of paediatric disorders Nineteen sections covering all paediatric specialities and sub-specialities Clinical pearls and key points summary in each section |
| renal and adrenal tumors biology and management: Subject Index of Extramural Research Administered by the National Cancer Institute , 1979 Current information about research grants and contracts supported by the National Cancer Institute. Subject listing gives contract or grant number and topic. Investigator, grant number, and contract number indexes. |
| renal and adrenal tumors biology and management: Biomedical Index to PHS-supported Research: Project number listing, investigator listing , 1989 |
| renal and adrenal tumors biology and management: Subject Index of Current Extramural Research Administered by the National Cancer Institute National Cancer Institute (U.S.), 1974 |
| renal and adrenal tumors biology and management: A Practice of Anesthesia for Infants and Children E-Book Charles J. Cote, Jerrold Lerman, I. David Todres, 2012-12-07 Provide optimal anesthetic care to your young patients with A Practice of Anesthesia in Infants and Children, 5th Edition, by Drs. Charles J. Cote, Jerrold Lerman, and Brian J. Anderson. 110 experts representing 10 different countries on 6 continents bring you complete coverage of the safe, effective administration of general and regional anesthesia to infants and children - covering standard techniques as well as the very latest advances. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Find authoritative answers on everything from preoperative evaluation through neonatal emergencies to the PACU. Get a free laminated pocket reference guide inside the book! Quickly review underlying scientific concepts and benefit from expert information on preoperative assessment and anesthesia management, postoperative care, emergencies, and special procedures. Stay on the cutting edge of management of emergence agitation, sleep-disordered breathing and postoperative vomiting; the use of new devices such as cuffed endotracheal tubes and new airway devices; and much more. Familiarize yourself with the full range of available new drugs, including those used for premedication and emergence from anesthesia. Benefit from numerous new figures and tables that facilitate easier retention of the material; new insights from neonatologists and neonatal pharmacologists; quick summaries of each chapter; and more than 1,000 illustrations that clarify key concepts. Access the entire text online, fully searchable, at www.expertconsult.com, plus an extensive video library covering simulation, pediatric airway management, burn injuries, ultra-sound guided regional anesthesia, and much more; and new online-only sections, tables and figures. |
| renal and adrenal tumors biology and management: Campbell Walsh Wein Urology, E-Book Alan W. Partin, Roger R. Dmochowski, Louis R. Kavoussi, Craig A. Peters, Alan J. Wein, 2020-01-21 From the basic science underpinnings to the most recent developments in medical and surgical care, Campbell-Walsh-Wein Urology offers a depth and breadth of coverage you won't find in any other urology reference. Now in three manageable volumes, the revised 12th Edition is a must-have text for students, residents, and seasoned practitioners, with authoritative, up-to-date content in an intuitively organized, easy-to-read format featuring key points, quick-reference tables, and handy algorithms throughout. - Features shorter, more practical chapters that help you find key information quickly. - Includes new chapters on Urinary Tract Imaging: Basic Principles of Nuclear Medicine · Ethics and Informed Consent · Incisions and Access · Complications of Urologic Surgery · Urologic Considerations in Pregnancy · Intraoperative Consultation · Special Urologic Considerations in Transgender Individuals · and more. - Covers hot topics such as minimally invasive and robotic surgery; advancements in urologic oncology, including innovative therapeutics for personalized medicine; new approaches to male infertility; technological advances for the treatment of stones; and advances in imaging modalities. - Incorporates current AUA/EAU guidelines in each chapter as appropriate - Updates all chapters with new content, new advances, and current references and best practices. Extensively updated chapters include Urological Immunotherapy, Minimally Invasive Urinary Diversion, and Updated Focal Therapy for Prostate Cancer. - Features more than 175 video clips, including all-new videos on perineal ultrasound, abdominoplasty in prune belly syndrome, partial penectomy, low dose rate brachytherapy, and many more. - Written and edited by key opinion leaders, reflecting essential changes and controversies in the field. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. |
| renal and adrenal tumors biology and management: Renal Tumors of Childhood Kathy Pritchard-Jones, Jeffrey S. Dome, 2016-10-06 This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. All of the authors are experts from Europe and North America and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases. |
| renal and adrenal tumors biology and management: Pediatric Surgical Oncology Paul D. Losty, Michael La Quaglia, Sabine Sarnacki, Jörg Fuchs, Tomoaki Taguchi, 2022-02-17 A new, definitive, state-of-the-art reference in the specialist field of paediatric surgical oncology. Key points and informative guidance on all aspects of cancer surgery for children make this a vital textbook for the surgery resident, surgical oncology specialist, nursing staff and cancer health care teams. The editorial team of world experts and international guest authorship listings guarantees that the textbook content provides a definitive treatise for a global audience of pediatric surgeons. Textbook coverage includes chapters on pediatric cancer epidemiology, chemotherapy, immunotherapy, radiotherapy, pathology, radiology and vascular access, following which the main theme sections feature all of the major pediatric solid tumours in a system-based chronology. A section devoted to rare tumours provides useful and pragmatic information for the oncology surgeon. Minimally invasive surgery is covered highlighting current concepts and clinical outcome(s) by leading experts in the field. Nutritional considerations for the pediatric cancer patient undergoing surgery are all discussed. Management of surgical complications, fertility considerations and long-term outcomes are an invaluable vital resource for the reader. Final sections look to the future by focusing on surgical innovation, including key chapters on navigational surgery and surgical robotics. • Includes all the latest developments in pediatric surgical oncology ensuring the reader is kept fully up to date. • Multi-disciplinary content reflects current best practice. • Comprehensive coverage provides a definitive reference guide. An authoritative seminal reference work for surgical residents in training, surgeons working in the field of pediatric oncology, medical oncologists, intensive care specialists, nursing staff and allied health care professionals. |
| renal and adrenal tumors biology and management: Textbook of Uncommon Cancer Derek Raghavan, Manmeet S. Ahluwalia, Charles D. Blanke, Jubilee Brown, Edward S. Kim, Gregory H. Reaman, Mikkael A. Sekeres, 2017-05-08 The fifth edition of the only comprehensive text dealing exclusively with rare or infrequently encountered malignancies in adults and children is an essential resource for any clinical oncologist. Encompasses all the information needed to diagnose and manage uncommon cancers, an area where advice and guidance is typically scarce Fully revised with new material and an evidence-based, teach-by-example approach Provides insight on real-world decision making in the clinical setting Edited and authored by a highly experienced and senior team of medical oncologists, radiation oncologists, and other specialists, giving a balanced and complete overview Extensively illustrated in full color throughout, including heat maps to show gene expression |
| renal and adrenal tumors biology and management: ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology Nicole Gallo-Payet, Antoine Martinez, André Lacroix, 2017-07-27 By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies. |
| renal and adrenal tumors biology and management: Annals of Saudi Medicine , 1997 |
| renal and adrenal tumors biology and management: Research Grants Index National Institutes of Health (U.S.). Division of Research Grants, 1975 |
| renal and adrenal tumors biology and management: The British National Bibliography Arthur James Wells, 2003 |
| renal and adrenal tumors biology and management: American Book Publishing Record , 2003 |
| renal and adrenal tumors biology and management: Biology and Diseases of the Ferret James G. Fox, Robert P. Marini, 2014-03-26 Biology and Diseases of the Ferret, Third Edition has been thoroughly revised and updated to provide a current, comprehensive reference on the ferret. Encyclopedic in scope, it is the only book to focus on the characteristics that make the ferret an important research animal, with detailed information on conditions, procedures, and treatments. Offering basic information on biology, husbandry, clinical medicine, and surgery, as well as unique information on the use of ferrets in biomedical research, Biology and Diseases of the Ferret is an essential resource for investigators using ferrets in the laboratory and for companion animal and comparative medicine veterinarians. The Third Edition adds ten completely new chapters, covering regulatory considerations, black-footed ferret recovery, diseases of the cardiovascular system, viral respiratory disease research, morbillivirus research, genetic engineering, hearing and auditory function, vision and neuroplasticity research, nausea and vomiting research, and lung carcinogenesis research. Additionally, the anesthesia, surgery, and biomethodology chapter has been subdivided into three and thoroughly expanded. The book also highlights the ferret genome project, along with the emerging technology of genetically engineered ferrets, which is of particular importance to the future of the ferret as an animal model in research and will allow the investigation of diseases and their genetic basis in a small, easily maintained, non-rodent species. |
| renal and adrenal tumors biology and management: Renal Mass Biopsy Raymond J. Leveillee, Merce Jorda, 2020-02-26 This text presents a comprehensive and state-of-the-art approach to renal mass biopsy, and reviews current techniques for obtaining samples, proper tissues processing, indications for biopsy, and treatment outcomes. Sections address preliminary issues faced by urologists, pathologists, interventional radiologists, oncologists, and nephrologists who may be initially reconsidering the role for RMB including clinical decision making, financial considerations, misconceptions, sampling errors, and understanding limitations. Basic techniques and set-up, navigational tools, and tips and tricks to maximize sampling and avoid complications is also included. Sections also address patient selection, pre-biopsy considerations, technical aspects of the most common techniques and equipment, and image guidance systems. Pathological considerations include role of fine needle aspirations, touch preparation, core biopsies, immunohistochemistry, and classification schemata. The text concludes with chapters on future directions and improvements in diagnostic imaging, future developments in optical biopsies (confocal microscopy), and ancillary studies on renal masses. Written by experts in the field of urology and pathology, Renal Mass Biopsy is your go to resource for techniques and outcomes for the treatment of renal masses. |
End-stage renal disease - Symptoms and causes - Mayo Clinic
Oct 10, 2023 · End-stage renal disease, also called end-stage kidney disease or kidney failure, occurs when chronic kidney disease — the gradual loss of kidney function — reaches an …
Renal system | Definition, Function, Diagram, & Facts | Britannica
Renal system, in humans, organ system that includes the kidneys, where urine is produced, and the ureters, bladder, and urethra for the passage, storage, and voiding of urine.
Kidney Failure: Stages, ESRD, Causes, Symptoms & Treatment
Kidney failure (renal failure) means one or both of your kidneys no longer function well on their own. Kidney failure is sometimes temporary and develops quickly (acute kidney failure).
Kidney Disease: Causes, Symptoms, Treatment, and Prevention
Oct 24, 2023 · Kidney disease can affect your body’s ability to clean your blood, filter extra water out of your blood, and help control your blood pressure. It can also affect red blood cell …
Kidney failure (ESRD) - Symptoms, stages, & treatment | National …
Sep 5, 2023 · Kidney failure, or end-stage renal disease (ESRD), is the last stage of chronic kidney disease. When kidneys fail, they can be treated with dialysis or kidney transplant.
Kidney Diseases | Renal Disease | MedlinePlus
Nov 18, 2020 · Properly functioning kidneys are critical for maintaining good health. Diabetes, high blood pressure, or family history can increase risk of kidney disease.
Physiology, Renal - StatPearls - NCBI Bookshelf
Jul 24, 2023 · The renal system consists of the kidney, ureters, and the urethra. The overall function of the system filters approximately 200 liters of fluid a day from renal blood flow which …
Renal system anatomy and physiology - Osmosis
Review renal, kidney, and urinary system anatomy. Learn with illustrated videos and quizzes. Cover filtration, nephrons, and blood flow to prep fast.
Your Kidneys & How They Work - NIDDK
Each of your kidneys is made up of about a million filtering units called nephrons. Each nephron includes a filter, called the glomerulus, and a tubule. The nephrons work through a two-step …
Kidney (Renal) Failure - Urology Care Foundation
Kidney (renal) failure is when kidneys don't work as well as they should, to the point where kidney replacement is required. Kidney replacement can be accomplished by different kinds of …
End-stage renal disease - Symptoms and causes - May…
Oct 10, 2023 · End-stage renal disease, also called end-stage kidney disease or kidney failure, occurs when chronic kidney disease — the gradual loss of …
Renal system | Definition, Function, Diagram, & Facts …
Renal system, in humans, organ system that includes the kidneys, where urine is produced, and the ureters, bladder, and urethra for the passage, …
Kidney Failure: Stages, ESRD, Causes, Symptoms & Treatme…
Kidney failure (renal failure) means one or both of your kidneys no longer function well on their own. Kidney failure is sometimes temporary and …
Kidney Disease: Causes, Symptoms, Treatment, and Pr…
Oct 24, 2023 · Kidney disease can affect your body’s ability to clean your blood, filter extra water out of your blood, and help control your blood pressure. It …
Kidney failure (ESRD) - Symptoms, stages, & treatme…
Sep 5, 2023 · Kidney failure, or end-stage renal disease (ESRD), is the last stage of chronic kidney disease. When kidneys fail, they can be treated with …
