Advertisement
| quest calprotectin: Inflammatory Bowel Disease M. Campieri, 2002-03-31 This book is the proceedings of the Falk Symposium No. 122 on Inflammatory Bowel Disease - A Clinical Case Approach to Pathophysiology, Diagnosis, and Treatment, held in Bologna, Italy, on June 22-23, 2001, and deals with some major issues concerning Genetics of IBD, Pediatrics in IBD, Early vs Late IBD, Bacteria and Gut Inflammation, Refractory CD, Fistulizing CD, Refractory Distal Colitis, and Complications of Ileal-Pouch Anastomosis. The main aim of the meeting was to highlight the value of an integrated clinical approach and the importance of clinical research in developing innovative methods of treatment. |
| quest calprotectin: Enteroimmunology Dr. Charles Lewis, 2023-11-26 Enteroimmunology is the emerging field of medicine that studies the enteric immune system and microbial biome of the digestive system, and their interaction with diet, digestion, the enteric and central nervous systems and endocrine functions. It explores and elucidates how these systems affect each other, impacting health and disease. Enteroimmune disease is not limited to diseases such as irritable bowel syndrome and inflammatory bowel diseases but also cause systemic and neurological diseases. Neurological diseases discussed include autism, migraine, chronic fatigue syndrome, multiple sclerosis, bipolar and rage disorders. The gastrointestinal mucosa is predominantly lined with enterocytes that form a continuous barrier throughout the digestive path. These cells absorb nutrients while excluding the trillions of bacteria and other microbes that inhabit the gut. Just below the enterocytes, the mucosa contains over half of the body’s immune cells. These cells effect immune activity that protect the body from infection. However, they can also promote chronic inflammation, not just in the intestines, but in any organ system of the body. This book details the physiologic functions of the digestive and immune cells; their reactions to proteins, antigens and nutrients in the diet; the role of bacterial toxins and immune mediators; and the hormones that mediate appetite, GI motility and digestion. It explores the mechanisms occurring in immune dysfunction; when the immune response, rather than protect health, promotes chronic inflammation, responsible for depression, obesity, diabetes, acne, Alzheimer’s disease, cancer, migraines, fibromyalgia, IBS, osteoporosis, schizophrenia, and many other chronic inflammatory diseases. Understanding the immune system of the gut, provides insight to how these mechanisms impact both the enteric and central nervous systems. Dr. Lewis elucidates the physiology and pathophysiology of the intestinal and immune cells with clarity and humor that makes reading this book a pleasure. Enteroimmunology describes how various types of food sensitivities, including IgG antergies, which are analogous to IgE allergies, cause a wide array of chronic disease. This book explains mast cell activation syndrome, leaky gut syndrome, small bowel overgrowth, dysbiosis, metabolic syndrome and describes how to achieve long-term effective resolution of these conditions through diet. The book provides examples of a variety of conditions and the pathological processes that underlie them and then acts a guide to the tertiary treatment for the condition. There are chapters on obesity and metabolic syndrome, mood and thought disorders, fibromyalgia, autoimmune diseases, interstitial cystitis, sexual dysfunction, acne and other diseases. A chapter is dedicated to traumatic brain injury and its secondary prevention. Another chapter focuses on cancer prevention and explains the dietary factors responsible for the majority of human cancers, and provides practical, evidenced-based advice for cancer prevention. There is a chapter explaining how the mitochondria and aging, detailing of how individuals can maintain vibrant, healthy, mitochondria. There are chapters on the role of sleep disorders in enteroimmune disease, explaining the role osteoimmunity in osteoporosis and on prevention of hearing loss. Enteroimmunology is a guide to the prevention and the reversal of chronic disease by first understanding, and then using diet and nutrition to reverse the underlying causation of these diseases. Enteroimmunology explains the emerging understanding of the ecology of the gut and its relationship with diet, food and nutrition. This highly acclaimed book, now in its 3rd edition, has been extensively updated and expanded. It provides citations to National Library of Medicine PMID numbers that link to over a thousand free, full-length scientific |
| quest calprotectin: Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases Honghui Zhou, Diane R. Mould, 2019-02-14 Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders. |
| quest calprotectin: Boundless Ben Greenfield, 2020-01-21 What if the ability to look, feel, and perform at peak capacity wasn’t the stuff of lore but instead was within easy reach? In a perfect world, you would be able to have it all: complete optimization of mind, body, and spirit. In Boundless, the New York Times bestselling author of Beyond Training and health and fitness leader Ben Greenfield offers a first-of-its-kind blueprint for total human optimization. To catapult you down the path of maximizing cognition, mental clarity, and IQ, you will discover: • How to rewire your skull’s supercomputer (and nine ways to fix your neurotransmitters) • The twelve best ways to heal a leaky brain • Eight proven methods to banish stress and kiss high cortisol goodbye • Ten foods that break your brain, and how to eat yourself smart • How to safely utilize nootropics and smart drugs, along with eight of the best brain-boosting supplement stacks and psychedelics • The top nutrient for brain health that you probably aren’t getting enough of • Six ways to upgrade your brain using biohacking gear, games, and tools • How to exercise the cells of your nervous system using technology and modern science • Easy ways to train your brain for power, speed, and longevity • The ultimate guide to optimizing your sleep, maximizing mental recovery, and stopping jet lag To ensure that you look good naked and live a long time, you will learn: • Sic ways to get quick, powerful muscles (and why bigger muscles aren’t better) • How to burn fat fast without destroying your body • The fitness secrets of sic of the fittest old people on the planet • The best training program for maximizing muscle gain and fat loss at the same time • One simple tactic for staying lean year-round with minimal effort • A step-by-step system for figuring out exactly which foods to eat • Fourteen ways to build an unstoppable immune system • Little-known tactics, tips, and tricks for recovering from workouts with lightning speed • The best tools for biohacking your body at home and on the road • How to eat, train, and live for optimal symmetry and beauty (and how to raise kids with superhuman bodies and brains) And to help you live a fulfilling and happy life, you will learn: • Twelve techniques to heal your body using your own internal pharmacy • What the single most powerful emotion is and how to tap into it every day • Four of the best ways to heal your body and spirit using sounds and vibrations • Six ways to enhance your life and longevity with love, friendships, and lasting relationships • How to biohack the bedroom for better sex and longer orgasms, and the top libido-enhancing herbs, supplements, and strategies • The perfect morning, afternoon, and evening routines for enhancing sleep, productivity, and overall happiness • Twenty-eight ways to combine ancestral wisdom and modern science to enhance longevity, including the best foods, herbs, supplements, injections, medical treatments, biohacks, fasting strategies, and much more • The four hidden variables that can make or break your mind, body, and spirit • The exercise that will change your life forever (and how to reverse-engineer your perfect day) Boundless guides you every step of the way to becoming an expert in what makes your brain tick, your body work, and your spirit happy. You can flip open the book to any chapter and discover research-proven, trench-tested techniques to build muscle, burn fat, live longer, have mind-blowing sex, raise robust children, and much, much more! |
| quest calprotectin: In The Belly of Darkness Fernando Bernall, AP, CFMP, 2025-02-07 Prepare to embark on a captivating exploration of the most enigmatic system in the human body—the gut. In this groundbreaking book, Fernando Bernall takes you on a journey into the depths of the gut’s microbiome, unlocking its secrets and revealing its profound influence on every aspect of human health. From the bacteria that call our bodies home to the intricate relationship between hormones, mitochondria, and the gut, this book sheds light on the interconnected systems that sustain us. Through expertly crafted chapters, Bernall examines the surprising role of the oral microbiome, the delicate balance between beneficial and harmful bacteria like H. pylori, and the far-reaching effects of medications and dysbiosis. Drawing on cutting-edge science and historical insights, In the Belly of Darkness offers a fresh perspective on the microbiome’s pivotal role in digestion, immunity, and even mental health. You’ll uncover the mystery behind fiber, the dance between hormones and gut health, and the mechanisms of prebiotics, probiotics, and their emerging counterparts. This is not a how-to book—it is a what and why book, answering the essential questions that will leave you in awe of the microbiome’s complexity. Whether you’re a curious reader or a health professional, this book will challenge your understanding of health and inspire a deeper appreciation for the ecosystems within us. Dive into the belly of darkness and discover a world within—a world that holds the key to so much more than digestion. |
| quest calprotectin: Genetic markers identification for animal production and disease resistance Hongyu Liu, Ibrar Muhammad Khan, Muhammad Zahoor Khan, Adnan Khan, 2023-08-01 |
| quest calprotectin: Translational Gastroenterology Adam E.M. Eltorai, Tao Liu, Devendra Mehta, Karoly Horvath, 2025-04-18 Translational Gastroenterology covers the principles of evidence-based medicine and applies these principles to the design of translational investigations. Readers will learn important concepts, including case-control study, prospective cohort study, randomized trials, and reliability study. Medical researchers will benefit from greater confidence in their ability to initiate and execute their own investigations, avoid common pitfalls in gastroenterology, and know what is needed in collaboration. Further, this title is an indispensable tool in grant writing and funding efforts. The practical, straightforward approach helps the aspiring investigator navigate challenging considerations in study design and implementation.The book provides valuable discussions of the critical appraisal of published studies in gastroenterology, allowing the reader to learn how to evaluate the quality of such studies with respect to measuring outcomes and to make effective use of all types of evidence in patient care. In short, this practical guidebook will be of interest to every medical researcher or gastroenterologist who has ever had a good clinical idea but not the knowledge of how to test it. - Provides a clear process for understanding, designing, executing, and analyzing translational and clinical research - Presents practical and step-by-step guidance to help readers take ideas from the lab to the bedside - Written by a team of experts who cover the breadth of translational research in Gastroenterology |
| quest calprotectin: Digestive Wellness: Strengthen the Immune System and Prevent Disease Through Healthy Digestion, Fifth Edition Elizabeth Lipski, 2019-11-22 Optimize your overall health through digestive wellness! Fewer antacids and less bloating aren’t the only benefits of good digestion. When your digestive system is healthy and balanced, you sleep better, have more energy, think more clearly, experience less pain, and combat disease more effectively. Digestive Health shows how everything from migraines to skin disease to arthritis are connected to your digestive system. And now, this go-to guide has been updated with critical new research and developments, including late-breaking information on: • Probiotics and Prebiotics • Celiac Disease • The Gut-Brain Connection • Carbohydrates • Leaky Gut Syndrome • Auto-Immune Conditions • Kidney and Bone Health • Cancer Prevention • Alzheimer’s Disease You’ll find practical solutions to numerous conditions and disorders, along with expert guidance on the newest advances in testing and diagnosis, nutrition, and natural therapies. A perfect balance of science and practical advice, Digestive Health explains how your digestive system works and what to do when it doesn’t function properly. It provides everything you need to take control of your overall health through close, careful attention to your digestive system. |
| quest calprotectin: NETosis 2: The Excitement Continues Mariana J. Kaplan, Marko Radic, Martin Herrmann, 2017-12-28 NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nuclear chromatin following certain kinds of stimulation. Variations of NETosis were noted with cells that remain temporarily motile after the release of chromatin. Numerous stimuli for NETosis were discovered, including bacterial breakdown products, inflammatory stimuli, particulate matter, certain crystals, immune complexes and activated thrombocytes. Fundamental explorations into the mechanisms of NETosis observed that neutrophil enzyme activity (PAD4, neutrophil elastase, proteinase 3 and myeloperoxidase) and signal transduction pathways contribute to the regulation of NETosis. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases, leading to extensive chromatin externalization. In addition, NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. NETs are decorated with proteases and may thus contribute to tissue destruction. However, the attachment of these enzymes to NET-associated supramolecular structures restricts systemic spread of the proteolytic activity. While the benefit of NETs in an infection appears obvious, NETs also participate as key protagonists in various pathologic states. Therefore, it is essential for NETs to be efficiently cleared; otherwise digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions, serve as antigen for nuclear autoantibodies and foster DNA immune complex-related inflammation. Neutrophil products and deiminated proteins comprise an important group of autoantigens in musculoskeletal disorders. Aberrant NET synthesis and/or clearance are often associated with inflammatory and autoimmune conditions. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. Intravital microscopy provides evidence for conditions that induce NETosis in vivo. Furthermore, NETs can easily be detected in synovial fluid and tissue sections of patients with arthritis and gout. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we enter the second decade of research on NETosis, it is useful and timely to review the mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their importance as inducers of autoimmune responses. |
| quest calprotectin: An A-Z of Genetic Factors in Autism Kenneth Aitken, 2011-01-15 The book covers the main genetic disorders associated with autism, including those linked to growth differences, neurodevelopmental problems, gastrointestinal disturbances epilepsy and many others. It alphabetically lists the conditions next to information about how common they are, causes, signs, symptoms, and methods of treatment and management. |
| quest calprotectin: Index Medicus , 2004 Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings. |
| quest calprotectin: Virulence Mechanisms of Bacterial Pathogens Indira T. Kudva, Nancy A. Cornick, Paul J. Plummer, Qijing Zhang, Tracy L. Nicholson, John P. Bannantine, Bryan H. Bellaire, 2020-07-10 Ground-breaking overview of an enduring topic Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies. A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including how metabolism shapes the host-pathogen interface interactions across species and genera mechanisms of the secretion systems evasion, survival, and persistence mechanisms new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians. |
| quest calprotectin: Prosthetic Joint Infections Trisha Peel, 2017-11-28 This book outlines the most updated clinical guidelines that are vital for the prevention infections and care of patients with joint infections following a replacement surgery, one of the highest volume medical interventions globally. Sections address the diagnosis, management approaches and prevention of prosthetic joint infections. Written by experts in the field, this text provides a brief overview of the literature and current recommendations in each of the specified areas. Given the rapidly evolving state-of-play in this clinical area, this compendium grows increasingly important to clinicians in their management decisions. Prosthetic Joint Infections is a valuable resource for infectious disease specialists, epidemiologists, surgeons, and orthopedic specialists who may work with patients with prosthetic joint infections. |
| quest calprotectin: Immunity to Parasitic Infections in Pregnancy Justin Yai Alamou Doritchamou, Adrian John Frederick Luty, Elizabeth Helen Aitken, 2022-01-31 |
| quest calprotectin: Healthy Gut, Healthy You Michael Ruscio, 2018-02-06 Thousands of years ago, Hippocrates said that all disease begins in the gut. Scientific research has proven this idea to be true. In Healthy Gut, Healthy You, clinician and researcher Dr. Michael Ruscio shows how modern lifestyle changes and the widespread use of antibiotics have made our guts more vulnerable than ever before. |
| quest calprotectin: Immune-boosting Effects of Dietary Bioactive Polysaccharides Baojun Xu, Ammad Ahmad Farooqi, Bin Du, 2023-01-05 |
| quest calprotectin: Trace Metals and Infectious Diseases Jerome O. Nriagu, Eric P. Skaar, 2015-05-08 Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang |
| quest calprotectin: Sjögren's Syndrome and Oral Health Seunghee Cha, 2021-05-29 This book provides a thorough update on Sjögren’s syndrome (SS) and its adverse impacts on oral health. The opening section focuses on the clinical and laboratory characteristics of SS and its current management. Here, readers will find information on diagnostic criteria, pharmacotherapy, dental management, and the importance of saliva in oral health and SS. Attention then turns to the immunopathogenesis of SS, which includes the mechanisms of secretory dysfunction, myoepithelial cell functions in salivary gland physiology and disease, dysregulated innate and adaptive immunity, and B-cell expansion and neoplasia. The final section details important advances in SS diagnosis and therapy. The differential diagnoses of recurrent glandular swelling, glandular irrigation and sialendoscopy, and salivary gland ultrasound for SS in children are explained, along with the pharmacological management for SS, clinical care for dry eyes, and gene therapy. This book will be of interest to not only dental practitioners and researchers but also rheumatologists and pathologists. |
| quest calprotectin: Host and Microbe Adaptations in the Evolution of Immunity Larry J. Dishaw, Gary W. Litman, 2019-12-31 The evolution of metazoans has been accompanied by new interfaces with the microbial environment that include biological barriers and surveillance by specialized cell types. Increasingly complex organisms require increased capacities to confront pathogens, achieved by co-evolution of recognition mechanisms and regulatory pathways. Two distinct but interactive forms of immunity have evolved. Innate immunity, shared by all metazoans, is traditionally viewed as simple and non-specific. Adaptive immunity possesses the capacity to anticipate new infectious challenges and recall previous exposures; the most well-understood example of such a system, exhibited by lymphocytes of vertebrates, is based on somatic gene alterations that generate extraordinary specificity in discrimination of molecular structures. Our understanding of immune phylogeny over the past decades has tried to reconcile immunity from a vertebrate standpoint. While informative, such approaches cannot completely address the complex nature of selective pressures brought to bear by the complex microbiota (including pathogens) that co-exist with all metazoans. In recent years, comparative studies (and new technologies) have broadened our concepts of immunity from a systems-wide perspective. Unexpected findings, e.g., genetic expansions of innate receptors, high levels of polymorphism, RNA-based forms of generating diversity, adaptive evolution and functional divergence of gene families and the recognition of novel mediators of adaptive immunity, prompt us to reconsider the very nature of immunity. Even fundamental paradigms as to how the jawed vertebrate adaptive immune system should be structured for “optimal” recognition potential have been disrupted more than once (e.g., the discovery of the multicluster organization and germline joining of immunoglobulin genes in sharks, gene conversion as a mechanism of somatic diversification, absence of IgM or MHC II in certain teleost fishes). Mechanistically, concepts of innate immune memory, often referred to as “trained memory,” have been realized further, with the development of new discoveries in studies of epigenetic regulation of somatic lineages. Immune systems innovate and adapt in a taxon-specific manner, driven by the complexity of interactions with microbial symbionts (commensals, mutualists and pathogens). Immune systems are shaped by selective forces that reflect consequences of dynamic interactions with microbial environments as well as a capacity for rapid change that can be facilitated by genomic instabilities. We have learned that characterizing receptors and receptor interactions is not necessarily the most significant component in understanding the evolution of immunity. Rather, such a subject needs to be understood from a more global perspective and will necessitate re-consideration of the physical barriers that afford protection and the developmental processes that create them. By far, the most significant paradigm shifts in our understanding of immunity and the infection process has been that microbes no longer are considered to be an automatic cause or consequence of illness, but rather integral components of normal physiology and homeostasis. Immune phylogeny has been shaped not only by an arms race with pathogens but also perhaps by mutualistic interactions with resident microbes. This Research Topic updates and extends the previous eBook on Changing Views of the Evolution of Immunity and contains peer-reviewed submissions of original research, reviews and opinions. |
| quest calprotectin: Nutrition in Immune Balance (NIMBAL) Therapy David L Suskind, 2015-06 We are what we eat. Each year in America thousands of kids and adults are diagnosed with inflammatory bowel disease (IBD) in the form of ulcerative colitis and Crohn's disease. The incidence of IBD continues to rise, and a major culprit is our food environment. Our diets affect our microbiomes and our natural digestive bacteria. What we war can cause these bacteria to get out of balance and trigger our immune systems to attack our bowels. But nutrition and diet are frequently overlooked in medicine and sciences. Nutrition in immune Balance (NIMBAL) therapy is a standardized method to incorporate dietary therapy into current medical practices. With friendly, practical advice, tips, and recipes, this groundbreaking book supports IBD patients, families and healthcare providers alike who want to pursue dietary interventions. Book jacket. |
| quest calprotectin: Cancer Research , 2004 |
| quest calprotectin: Biosensor Based Advanced Cancer Diagnostics Raju Khan, Arpana Parihar, S.K. Sanghi, 2021-08-25 Early diagnosis of cancer and other non-oncological disorders gives a significant advantage for curing the disease and improving patient's life expectancy. Recent advances in biosensor-based techniques which are designed for specific biomarkers can be exploited for early diagnosis of diseases. Biosensor Based Advanced Cancer Diagnostics covers all available biosensor-based approaches and comprehensive technologies; along with their application in diagnosis, prognosis and therapeutic management of various oncological disorders. Besides this, current challenges and future aspects of these diagnostic approaches have also been discussed. This book offers a view of recent advances and is also helpful for designing new biosensor-based technologies in the field of medical science, engineering and biomedical technology. Biosensor Based Advanced Cancer Diagnostics helps biomedical engineers, researchers, molecular biologists, oncologists and clinicians with the development of point of care devices for disease diagnostics and prognostics. It also provides information on developing user friendly, sensitive, stable, accurate, low cost and minimally invasive modalities which can be adopted from lab to clinics. This book covers in-depth knowledge of disease biomarkers that can be exploited for designing and development of a range of biosensors. The editors have summarized the potential cancer biomarkers and methodology for their detection, plus transferring the developed system to clinical application by miniaturization and required integration with microfluidic systems. - Covers design and development of advanced platforms for rapid diagnosis of cancerous biomarkers - Takes a multidisciplinary approach to sensitive transducers development, nano-enabled advanced imaging, miniaturized analytical systems, and device packaging for point-of-care applications - Offers an insight into how to develop cost-effective diagnostics for early detection of cancer |
| quest calprotectin: Inflammation-Associated Depression: Evidence, Mechanisms and Implications Robert Dantzer, Lucile Capuron, 2016-12-28 Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level. |
| quest calprotectin: Animal Clinical Chemistry G.O. Evans, 1996-04-29 By presenting background information on the selection and application of biochemical tests in safety assessment studies, this text seeks to provide a basis for improving the knowledge required to interpret data from toxicological studies. In addition to chapters which discuss the assessment of specific organ toxicity (such as the liver, kidney and thyroid), the book also covers pre-analytical variables, regulatory requirements and statistical approaches, and highlights some of the major differences between man and different laboratory animals. The editor and contributor are all members of the Animal Clinical Chemistry Association, a group formed to advance the science of animal clinical chemistry in safety evaluation, toxicology and veterinary science. |
| quest calprotectin: Inflammatory Bowel Disease Nursing Manual Andreas Sturm, Lydia White, 2019-01-24 This comprehensive manual discusses the many aspects of inflammatory bowel disease (IBD), providing relevant information along with practical guidance. The reader is also directed to additional resources for extra and current information. This book comes at a time when the number of people suffering from the two major forms of IBD, ulcerative colitis (UC) and Crohn’s disease (CD), is rising around the globe. Despite their huge impact on daily life and health economics, these diseases are not fully understood, and diagnosis and treatment remains a significant challenge. IBD nurses are increasingly recognised as key clinicians within the multidisciplinary team caring for people with IBD. Through experience and specialist knowledge IBD nurses provide timely support, advice, and treatment for people living with this unpredictable condition. IBD nurses are also well placed to liaise with the wider team, developing patient centred services which best fit their local health framework. The combined international expertise and accessible guidance here will equip nurses, or any clinician wanting to increase their competence in IBD management. Thereby this manual aims to contribute to the optimisation of IBD care throughout the world. |
| quest calprotectin: Inflammatory Bowel Disease Ramona Rajapakse, 2022-09-25 This book uses new thinking on precision medicine and the interplay of genetic factors, the microbiome, and external triggers to build on the core concepts of inflammatory bowel disease. It outlines the latest findings in targeting therapies to the individual patient with Crohn’s and colitis, management of chronic infections in the setting of immunomodulators and biologics, non-surgical therapy of dysplasia in colitis patients, and redefining and structuring the problematic pouch. In addition, this book features useful chapters dedicated to the economic aspects of IBD in an increasingly constrained healthcare system, as well as the patient experience and the role of subspecialist telemedicine care. Written by specialists and thought leaders in the field, Inflammatory Bowel Disease: Pathogenesis, Diagnosis and Management provides a concise but highly relevant account of the latest thinking and concepts in IBD. |
| quest calprotectin: Biomarkers in Inflammatory Bowel Diseases Nik Sheng Ding, Peter De Cruz, 2019-05-13 This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice. The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice. This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline. The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future. |
| quest calprotectin: Handbook of Immunoassay Technologies Sandeep K. Vashist, John H.T. Luong, 2025-02-04 Handbook of Immunoassay Technologies: Approaches, Performances, and Applications, Second Edition unravels the role of immunoassays in the biochemical sciences. During the last four decades, a wide range of immunoassays has been developed, ranging from the conventional enzyme-linked immunosorbent assays to the smartphone-based point-of-care formats. The book discusses how advances in rapid biochemical procedures, novel biosensing schemes, fully integrated lab-on-a-chip platforms, prolonged biomolecular storage strategies, device miniaturization and interfacing, and emerging smart system technologies that have paved the way for next-generation immunoassays.Revised and updated, the second edition of Handbook of Immunoassay Technologies: Approaches, Performances, and Applications covers all the relevant, timely, and important developments in the field. This edition offers new content on topics such as antibody production for immunodiagnostics, multiplex immunoassays, chemiluminescent immunoassays, immunoassays for newborn screening, and immunoassays of viruses like SARS-CoV-2, HIV, Ebola, and Hepatitis C. The addition of these new topics as well as up-to-date content make the second edition a valuable and comprehensive resource on immunoassays. - Provides comprehensive details of various types of immunoassays utilized in healthcare as well as industrial, environmental, and other biochemical settings - Offers extensive knowledge and guided insights on multifarious aspects of immunoassays and types of immunoassays developed to date. - Comprehensively describes immunoassay formats along with their principles of operation, characteristics, pros and cons, and potential biochemical and bioanalytical applications - Provides technical know-how as it is written by renowned experts and key opinion leaders in the field of immunoassays with decades of experience. |
| quest calprotectin: Models of Protection Against HIV/SIV Gianfranco Pancino, Guido Silvestri, Keith Fowke, 2011-12-02 A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike. Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS Comprehensive writing and illustrations Contributors are among the most eminent specialists in the field |
| quest calprotectin: Proteases and Their Receptors in Inflammation Nathalie Vergnolle, Michel Chignard, 2011-08-03 Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response. This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.). |
| quest calprotectin: The Psychiatric Hospitalist Michael D. Jibson, M.D., Ph.D., 2021-10-07 Until recently, the hospital care of patients with mental disorders was overseen by either rotating faculty at an academic hospital or a private psychiatrist who would manage both a clinic and an inpatient caseload. When one considers, however, that working in a hospital setting means treating acutely agitated or even violent patients, or individuals who have seriously harmed themselves, it's clear that a dedicated, focused approach is needed. In The Psychiatric Hospitalist, Michael D. Jibson, M.D., Ph.D., and a cadre of experts make the case for hospital-based psychiatry, comprehensively describing not only its structure but also the qualities and skills needed to succeed in this setting. The book leverages vignettes and the insights of its contributors to examine the effects of background and training on a hospitalist career, opportunities for teaching and supervising in a hospital setting, diagnostic and treatment modalities, legal and ethical issues, and numerous other topics. Both novice and experienced clinicians will find the tools they need in this volume to flourish professionally, even as they make a notable impact on their patients' lives. |
| quest calprotectin: Sexually Transmitted Infections Antonio Cristaudo, Massimo Giuliani, 2020-05-30 This comprehensive, well-illustrated, and easily accessible book documents the latest research outcomes concerning sexually transmitted infections (STIs) and describes important advances in their prevention, diagnosis and treatment. The changes in the epidemiology and clinical aspects of STIs that have occurred over the past decade are fully explored, with special attention to core groups and patients with immunological disorders. The emerging challenges associated with particular sexually transmitted pathogens, including C. trachomatis, N. gonorrhoeae, HPV, and HIV, are identified and discussed. Readers will find detailed information on modern preventive strategies, new laboratory and diagnostic techniques, and a range of innovative treatments, including vaccines, continuous antiretroviral therapy, and new drugs against hepatitis viruses. Attention is also drawn to new directions in biomedical research that promise clinical benefits for the patients and communities. The combination of a detailed clinical and research approach, with emphasis on new knowledge and innovative aspects, ensures that the book will be of value to a wide readership comprising both clinicians and researchers. |
| quest calprotectin: Nutrition and Immunity Maryam Mahmoudi, Nima Rezaei, 2019-07-30 This volume provides readers with a systematic assessment of current literature on the link between nutrition and immunity. Chapters cover immunonutrition topics such as child development, cancer, aging, allergic asthma, food intolerance, obesity, and chronic critical illness. It also presents a thorough review of microflora of the gut and the essential role it plays in regulating the balance between immune tolerance and inflammation. Written by experts in the field, Nutrition and Immunity helps readers to further understand the importance of healthy dietary patterns in relation to providing immunity against disorders and offering readily available immunonutritional programming in clinical care. It will be a valuable resource for dietitians, immunologists, endocrinologists and other healthcare professionals. |
| quest calprotectin: Gut-brain Connection, Myth Or Reality?: Role Of The Microbiome In Health And Diseases Adrien A Eshraghi, 2021-11-03 In this book the recent advancements in understanding the gut-brain interaction as well as gut microbiome and how this interaction plays a vital role in human health and disease are discussed. Each chapter gives an analysis of questions, research directions, and methods within the field of gut-brain axis. The readers will benefit from the latest knowledge about our understanding about how gut-brain axis and modulation of gut microbiome determines predisposition to neurological disorders. The multidisciplinary book is essential reading for anyone interested in the field of gut-brain axis and gut microbiome: from undergraduates to graduate students as well as scientists and physicians having an interest in the new exciting field of gut microbiome and its relationship with brain function. |
| quest calprotectin: Gastroenterology, An Issue of Primary Care: Clinics in Office Practice Rick Kellerman, Laura Mayans, 2017-11-20 This issue of Primary Care: Clinics in Office Practice, guest edited by Drs. Rick Kellerman and Laura Mayans, is devoted to Gastroenterology. Articles in this issue include: Peptic Ulcer Disease, Gastritis and GERD; Gallbladder Dysfunction; Non Alcoholic Fatty Liver Disease (NAFLD); Pancreatic Cancer and Pancreatitis; Hepatitis A and Hepatitis B; Hepatitis C; Diverticular Disease; Irritable Bowel Syndrome; Inflammatory Bowel Disease; Celiac Disease and Gluten Sensitivity; Anorectal Disease and Hemorrhoids; Cancers of the Alimentary Tract - Esophagus, Stomach and Colon; and Emerging Concepts in GI Disease. |
| quest calprotectin: Mindfulness-Based Compassionate Living Erik van den Brink, Frits Koster, 2015-05-08 Mindfulness involves learning to be more aware of life as it unfolds moment by moment, even if these moments bring us difficulty, pain or suffering. This is a challenge we will all face at some time in our lives, and which health professionals face every day in their work. The Mindfulness-Based Compassionate Living programme presents a new way of learning how to face the pressures of modern living by providing an antidote which teaches us how to cultivate kindness and compassion – starting with being kind to ourselves. Compassion involves both sensitivity to our own and others’ suffering and the courage to deal with it. Integrating the work of experts in the field such as Paul Gilbert, Kristin Neff, Christopher Germer and Tara Brach, Erik van den Brink and Frits Koster have established an eight stage step-by-step compassion training programme, supported by practical exercises and free audio downloads, which builds on basic mindfulness skills. Grounded in ancient wisdom and modern science, they demonstrate how being compassionate shapes our minds and brains, and benefits our health and relationships. The programme will be helpful to many, including people with various types of chronic or recurring mental health problems, and can be an effective means of coping better with low self-esteem, self-reproach or shame, enabling participants to experience more warmth, safeness, acceptance and connection with themselves and others. Mindfulness-Based Compassionate Living will be an invaluable manual for mindfulness teachers, therapists and counsellors wishing to bring the ‘care’ back into healthcare, both for their clients and themselves. It can also be used as a self-help guide for personal practice. |
| quest calprotectin: Bacterial Virulence Anthony William Maresso, 2019-09-05 This textbook introduces in an engaging way the fundamentals of how pathogenic bacteria interact with, and are virulent within, the human host. To inspire and educate the next generation of microbe hunters, the author, Microbiologist and Scientist Anthony William Maresso, integrates the major findings of the field into a single, easy-to-understand volume emphasizing a molecular appreciation of the concepts underlying bacterial infectious diseases. The work explores such themes as the history of Microbiology, bacterial structure and physiology, bacterial toxins, secretion systems, and adhesins, the host immune system and its battle with bacteria, biofilms, sepsis, and technologies/techniques to the present day. Fully illustrated in concept and packed with idea-provoking challenges highlighting “out-of-the-box” thinking, the work moves beyond being just a review of the scientific literature intent on equipping the next generation of Microbiologists and their teachers with the knowledge to confront, and hopefully one day defeat, the insidious microbes which undermine human health. This textbook is a resource for undergraduate, graduate, and medical students, as well as other health-oriented learners, postdoctoral scholars, basic scientists, and professors intent on expanding their knowledge of bacterial infection and virulence mechanisms. |
| quest calprotectin: Kidney Biomarkers Seema S. Ahuja, Brian Castillo, 2020-07-17 Since laboratory testing and biomarkers are an integral part in the diagnosis and treatment of kidney disease, Kidney Biomarkers: Clinical Aspects and Laboratory Determination covers currently used biomarkers as well as markers that are in development. Laboratories are increasingly more involved in the follow-up confirmatory laboratory testing and this unique volume showcases the collaboration needed to solve diagnostic clinical puzzles between the laboratory and clinician. This volume provides guidance on laboratory test selection and results interpretation in patients. Sources of inaccurate results in the measurement of kidney biomarkers are discussed along with possibility of eliminating such interferences. Each chapter is organized with a uniform easy-to-follow format with insightful case examples highlighting the collaboration between clinical laboratorians and clinicians. |
| quest calprotectin: CDC Health Information for International Travel 2010 Gary W. Brunette, Phyllis E. Kozarsky, M.D., Alan J. Magill, David R. Shlim, M.D., 2009 The 2009-2010 edition of the this guide presents dependable advice on any travel health issue, including vaccinations, essential trip planning and safety tips, prevention of an expanded list of travel-related infectious diseases, altitude illness, motion sickness, sunburn, medical tourism, and much more. This official publication is filled with valuable information not only for healthcare providers and travelers, but also for anyone interested in travel health. |
| quest calprotectin: A Manual of Laboratory and Diagnostic Tests Frances Talaska Fischbach, RN, Bsn, Msn, Marshall B. Dunning, 2015-04-27 Now in its Eighth Edition, this leading comprehensive manual helps nurses deliver safe, effective, and informed care for patients undergoing diagnostic tests and procedures. The book covers a broad range of laboratory and diagnostic tests and studies that are delivered to varied patient populations in varied settings. Tests are grouped according to specimen and function/test type (e.g. blood, urine, stool, cerebrospinal fluid, etc.). Each test is described in detail, with step-by-step guidance on correct procedure, tips for accurate interpretation, and instructions for patient preparation and aftercare. Clinical Alerts highlight critical safety information. |
Meta 官宣 Quest 3，如何评价该款产品？ - 知乎
Quest 3 提供水平 110 度、垂直 96 度的视野，比 Quest 2 扩大了约 15%。同时，比较重要的是，新一代的 Quest 3 终于提供了瞳距调节功能，可以通过头显外部的滚轮来进行调节。在外观 …
知乎 - 有问题，就会有答案
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
2025年全球XR眼镜（AR，VR，MR）科普，推荐，视频，配件，游 …
May 17, 2025 · 其它品牌还有Magic Leap，Meta Quest Pro，Apple Vision Pro等。 从技术的实现难易来讲MR难度>VR难度>AR难度，从市场的角度来讲往往最先能普及的就是技术难度较 …
Quest Mobile 的报告中的数据来源是哪里，数据是否准确？ - 知乎
基于以上两点，Quest Mobile提供的服务对于投资或者敌情监控，已经很有价值了。 做过技术的同学就知道，找两个团队来做不同的统计服务，搞出来的统计结果往往还有百分之几的误差，更 …
魔兽世界单机版求推荐？ - 知乎
魔兽世界单机版目前主要是使用开源的TrinityCore和Azerothcore架设的服务器，因为开源，所以所有人都可以在自己电脑上架起单机版，所以如果需要单机版，也不用求什么推荐，直接用开源 …
有没有单机打怪升级爆装备的无限刷刷刷类游戏？ - 知乎
泰坦之旅十周年纪念版（Titan Quest Anniversary Edition） 泰坦之旅怎么说呢，属于小众经典的老游戏，但是绝对耐玩。 游戏发行于2006年，在2016年的时候发售了十周年纪念版。
2025年，还有适合入坑的端游mmorpg吗？ - 知乎
2025年是否还有适合入坑的端游MMORPG？本页面探讨了点卡和免费模式的可能性，月卡不被接受。
你认为 PC 上最好用的 PDF 阅读器是哪一种？ - 知乎
PDF-XChange Viewer效果. 总之，PDF-XChange Viewer兼顾较强的注释功能和极快的启动速度，即使在性能羸弱的PC上也能顺畅运行，适合需要快速浏览文档并做少量笔记的同学。
什么是 CRPG？有哪些游戏可以被分类至 CRPG？ - 知乎
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
如何在word中插入类似CSDN中代码块？ - 知乎
Jan 12, 2016 · 如何在word中插入类似CSDN中代码块？ - 知乎 ... 如图。
Meta 官宣 Quest 3，如何评价该款产品？ - 知乎
Quest 3 提供水平 110 度、垂直 96 度的视野，比 Quest 2 扩大了约 15%。同时，比较重要的是，新一代的 Quest 3 终于提供了瞳距调节功能，可以通过头显外部的滚轮来进行调节。在外观 …
知乎 - 有问题，就会有答案
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
2025年全球XR眼镜（AR，VR，MR）科普，推荐，视频，配件， …
May 17, 2025 · 其它品牌还有Magic Leap，Meta Quest Pro，Apple Vision Pro等。 从技术的实现难易来讲MR难度>VR难度>AR难度，从市场的角度来讲往往最先能普及的就是技术难度较 …
Quest Mobile 的报告中的数据来源是哪里，数据是否准确？ - 知乎
基于以上两点，Quest Mobile提供的服务对于投资或者敌情监控，已经很有价值了。 做过技术的同学就知道，找两个团队来做不同的统计服务，搞出来的统计结果往往还有百分之几的误差，更 …
魔兽世界单机版求推荐？ - 知乎
魔兽世界单机版目前主要是使用开源的TrinityCore和Azerothcore架设的服务器，因为开源，所以所有人都可以在自己电脑上架起单机版，所以如果需要单机版，也不用求什么推荐，直接用开源 …
有没有单机打怪升级爆装备的无限刷刷刷类游戏？ - 知乎
泰坦之旅十周年纪念版（Titan Quest Anniversary Edition） 泰坦之旅怎么说呢，属于小众经典的老游戏，但是绝对耐玩。 游戏发行于2006年，在2016年的时候发售了十周年纪念版。
2025年，还有适合入坑的端游mmorpg吗？ - 知乎
2025年是否还有适合入坑的端游MMORPG？本页面探讨了点卡和免费模式的可能性，月卡不被接受。
你认为 PC 上最好用的 PDF 阅读器是哪一种？ - 知乎
PDF-XChange Viewer效果. 总之，PDF-XChange Viewer兼顾较强的注释功能和极快的启动速度，即使在性能羸弱的PC上也能顺畅运行，适合需要快速浏览文档并做少量笔记的同学。
什么是 CRPG？有哪些游戏可以被分类至 CRPG？ - 知乎
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
如何在word中插入类似CSDN中代码块？ - 知乎
Jan 12, 2016 · 如何在word中插入类似CSDN中代码块？ - 知乎 ... 如图。
