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| phage therapy prostatitis: Phage Therapy: A Practical Approach Andrzej Górski, Ryszard Międzybrodzki, Jan Borysowski, 2019-10-25 This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies. |
| phage therapy prostatitis: Phage Therapy: Past, Present and Future Stephen T. Abedon, Pilar García, Peter Mullany, Rustam Aminov, 2017-09-05 Historically, the first observation of a transmissible lytic agent that is specifically active against a bacterium (Bacillus anthracis) was by a Russian microbiologist Nikolay Gamaleya in 1898. At that time, however, it was too early to make a connection to another discovery made by Dmitri Ivanovsky in 1892 and Martinus Beijerinck in 1898 on a non-bacterial pathogen infecting tobacco plants. Thus the viral world was discovered in two of the three domains of life, and our current understanding is that viruses represent the most abundant biological entities on the planet. The potential of bacteriophages for infection treatment have been recognized after the discoveries by Frederick Twort and Felix d’Hérelle in 1915 and 1917. Subsequent phage therapy developments, however, have been overshadowed by the remarkable success of antibiotics in infection control and treatment, and phage therapy research and development persisted mostly in the former Soviet Union countries, Russia and Georgia, as well as in France and Poland. The dramatic rise of antibiotic resistance and especially of multi-drug resistance among human and animal bacterial pathogens, however, challenged the position of antibiotics as a single most important pillar for infection control and treatment. Thus there is a renewed interest in phage therapy as a possible additive/alternative therapy, especially for the infections that resist routine antibiotic treatment. The basis for the revival of phage therapy is affected by a number of issues that need to be resolved before it can enter the arena, which is traditionally reserved for antibiotics. Probably the most important is the regulatory issue: How should phage therapy be regulated? Similarly to drugs? Then the co-evolving nature of phage-bacterial host relationship will be a major hurdle for the production of consistent phage formulae. Or should we resort to the phage products such as lysins and the corresponding engineered versions in order to have accurate and consistent delivery doses? We still have very limited knowledge about the pharmacodynamics of phage therapy. More data, obtained in animal models, are necessary to evaluate the phage therapy efficiency compared, for example, to antibiotics. Another aspect is the safety of phage therapy. How do phages interact with the immune system and to what costs, or benefits? What are the risks, in the course of phage therapy, of transduction of undesirable properties such as virulence or antibiotic resistance genes? How frequent is the development of bacterial host resistance during phage therapy? Understanding these and many other aspects of phage therapy, basic and applied, is the main subject of this Topic. |
| phage therapy prostatitis: Hurdles for Phage Therapy (PT) to Become a Reality Harald Brüssow, 2019-08-20 Alternative treatment modes for antibiotic-resistant bacterial pathogens have become a public health priority. Bacteriophages are bacterial viruses that infect and lyse bacterial cells. Since bacteriophages are frequently bacterial host species-specific and can often also infect antibiotic-resistant bacterial cells, they could represent ideal antimicrobials for fighting the antibiotic resistance crisis. The medical use of bacteriophages has become known as phage therapy. It is widely used in Russia, where phage cocktails are sold in pharmacies as an over-the-counter drug. However, no phage product has been registered for medical purposes outside of the former Soviet Union. The current Special Issue of Viruses contains a collection of papers from opinion leaders in the field who explore hurdles to the introduction of phage therapy in western countries. The articles cover diverse topics ranging from patent to regulatory issues, the targeting of suitable bacterial infections, and the selection and characterization of safe and efficient phage cocktails. Phage resistance is discussed, and gaps in our knowledge of phage–bacterium interactions in the mammalian body are revealed, while other articles explore the use of phages in food production and processing. |
| phage therapy prostatitis: Bacteriophages to treat infections with multidrug resistant pathogens Dinesh Subedi, Mark Willcox, Tang Fang, Ram Bhusal, 2024-01-18 |
| phage therapy prostatitis: Phage Therapy - Part B , 2023-09-29 Phage Therapy - Part B, Volume 201 covers bacteriophage and their isolation, screening, synthetic phage, diagnostics, directed evolution, host interaction, and more. The book's aim is to highlight a number of aspects of phage in a way that can help students, researchers, clinicians, entrepreneurs and stakeholders perform research. Sections cover Phages for the treatment of Pseudomonas aeruginosa infection, Phage for the treatment of Vibrio cholerae infection, Phages for the treatment of Mycobacterium species, Phage therapy for gut microbiome, Phages as delivery vehicles, Phage display, Unlocking the potential of Phages: Innovative Approaches to harnessing Bacteriophages as Diagnostic Tools for Human Diseases, and more. Other sections explore Phage display and human disease detection, Bacteriophage as Cargo and its application in nanomedicine, Phage for drug delivery vehicles, Genome editing for phage design and uses for therapeutic applications, Phage for cancer therapy, and Phage for regenerative medicine and cosmetics. - Includes sections on phage isolation, screening and characterization - Covers synthetic phage, phage for diagnostic, directed evolution, and host interaction - Explores Phage for the treatment of bacterial infections |
| phage therapy prostatitis: Bacteriophages Wacław T. Szybalski, Malgorzata Łobocka, 2012 This volume, the first of a two-part series, covers topics including historical, ecological and evolutionary considerations, genomics and molecular biology, and interaction of phages with their hosts. |
| phage therapy prostatitis: Challenging Cases in Urological Surgery Karl Pang, James Catto, 2023 From challenges presented in everyday clinical practice to complex cases without simple answers, this is a highly-valuable reference and revision aid. This book is split into 15 comprehensive sections, including Emergency Urology and Trauma, with each chapter offering practical advice on management of urological surgery cases. |
| phage therapy prostatitis: Antimicrobials—Advances in Research and Application: 2012 Edition , 2012-12-26 Antimicrobials—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Antimicrobials. The editors have built Antimicrobials—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Antimicrobials in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antimicrobials—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| phage therapy prostatitis: Bugs as Drugs Robert A. Britton, Patrice D. Cani, 2020-07-02 Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted. If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow. |
| phage therapy prostatitis: Phage Therapy: A Practical Approach Andrzej Górski, Ryszard Międzybrodzki, Jan Borysowski, 2020-11-11 This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies. |
| phage therapy prostatitis: Biofilm Associated Antimicrobial Resistance and Its Recovery Dibyajit Lahiri, Moupriya Nag, Rina Rani Ray, Sougata Ghosh, 2023-12-01 A biofilm is a collection of microbial cells that have adhered to biotic surfaces such as plant cuticles or animal epithelia, as well as abiotic surfaces such as rocky substratum or catheter exteriors. The life cycle of a microorganism includes the fundamental process of biofilm formation for survival in diverse and harsh environments since it is a protected mode of growth allowing colonisation of new habitats by dispersal of microbes from the microbial clusters. The biofilm bound microorganisms remain embedded in an extracellular polymeric matrix that protects the indwelling cells from surfactants, biocides, several invaders like protozoans, and defences offered by the hosts like phagocytic cells. The biofilm bound recalcitrant microbes induce chronic and nosocomial diseases, posing a serious threat to public health. It has been observed that various antimicrobial drugs are able to successfully remove the planktonic (freely suspended) states of microbes as compared to the sessile (substrate-bound) forms, thus resulting in the development of antimicrobial resistance. Modern pharmacological strategies targeting the biofilm matrix differ from the conventional methods of antibiotic usage. This includes the use of natural compounds such as plant bioactive molecules, antimicrobial peptides, green synthesised nanoparticles, or secondary metabolites from other organisms that not only prevent the rise of antimicrobial resistance but are also safe for the host tissues. Biofilm Associated Antimicrobial Resistance and Its Recovery provides a detailed and systematic review of alternative pharmacological developments in the field of biofilm research. Features: A narrative overview of the mechanism of biofilm formation and its role in the emergence of antimicrobial resistance Recent research in the development of antibiofilm remedies involving biogenic compounds Advancements in biofilm detection methodologies with cutting-edge technologies This book serves as a resource for researchers who need to understand and analyze the progression of events during microbial biofilm formation, as well as design safer methodologies for its successful eradication. It may also be used as a textbook for a graduate level course in microbiology or microbial biotechnology. |
| phage therapy prostatitis: Advances in Phage Therapy: Present Challenges and Future Perspectives Andrzej Gorski, Petar Knezevic, Naomi Sulinger Hoyle, Shigenobu Matsuzaki, 2021-08-02 This Research Topic is dedicated to Prof. Elisabeth Kutter on the occasion of her 80th birthday. Dr. Kutter’s career as a phage scientist has extended nearly 60 years. She has been a pioneer as a woman in science. She started to work with phage at the University of Rochester, New York working with Dr. Wiberg on radioisotopes making excellent progress in the field – progress which was even cited in Luria’s 1969 Nobel Prize talk. Betty first encountered phage therapy during a visit to Georgia in 1990 which was part of a longer stay in the former Soviet Union under a US-USSR research exchange program. Dr. Kutter was one of the first Americans to advocate for phage therapy in the post antibiotic era. Betty started hosting the Evergreen International Phage meetings in Olympia, Washington, from 1975 onward, which helped to develop a strong phage community with participation increasing over the years to 350 at the 23 rd biannual last year. Betty continues to be an active member in the phage community, sharing her experience and working with all of us toward her ultimate goal of making phage therapy available worldwide thus reducing the burden caused by antibiotic resistant bacterial infections. |
| phage therapy prostatitis: Antibiotic Drug Resistance José-Luis Capelo-Martínez, Gilberto Igrejas, 2019-08-20 This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies |
| phage therapy prostatitis: Alternatives to Antibiotics Tilak Saha, Manab Deb Adhikari, Bipransh Kumar Tiwary, 2022-08-08 This book discusses prospective alternative approaches to fight bacterial infections to minimize the indiscriminate use of conventional antibiotics. It offers the current knowledge on research and development of alternative antibacterial agents such as probiotics, nanobiotics etc. while it also discusses newly emerging trends such as phage therapy, antibody therapy etc. The book highlights on the phytochemicals with potent antibacterial activities as alternatives to conventional antibiotics. Chemical modification to develop next generation antibiotics with enhanced efficacy has also been included. Such modifications are reported to overcome the inherent resistance of the parent antibiotics. Phage therapy and targeted antibodies are considered as potential alternative approaches to treat bacterial ailments and represent areas of cutting-edge research and have therefore been discussed with sufficient care. Mainly, the book highlights various approaches other than conventional antibiotics in treating bacterial infections. The scientific advancements in these areas will strengthen the ‘One Health’ approach benefiting human beings, animals and environment as well. This book is a comprehensive resource to cater researchers, biological scientists, herbalists and clinical practitioners with up-to-date information on antibacterials other than antibiotics. |
| phage therapy prostatitis: Bacteriophages David R. Harper, Stephen T. Abedon, Benjamin H. Burrowes, Malcolm L. McConville, 2021-01-30 This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology. The book introduces to bacteriophage biology, ecology and history and reviews the latest technologies and tools in bacteriophage detection, strain optimization and nanotechnology. Usage of bacteriophages in food safety, agriculture, and different therapeutic areas is discussed in detail. This book serves as essential guide for researchers in applied microbiology, biotechnology and medicine coming from both academia and industry. |
| phage therapy prostatitis: Biocommunication of Phages Guenther Witzany, 2020-06-29 This is the first book to systemize all levels of communicative behavior of phages. Phages represent the most diverse inhabitants on this planet. Until today they are completely underestimated in their number, skills and competences and still remain the dark matter of biology. Phages have serious effects on global energy and nutrient cycles. Phages actively compete for host. They can distinguish between ‘self’ and ‘non-self’ (complement same, preclude others). They process and evaluate available information and then modify their behaviour accordingly. These diverse competences show us that this capacity to evaluate information is possible owing to communication processes within phages (intra-organismic), between the same, related and different phage species (interorganismic), and between phages and non-phage organisms (transorganismic). This is crucial in coordinating infection strategies (lytic vs. lysogenic) and recombination in phage genomes. In 22 chapters, expert contributors review current research into the varying forms of phage biocommunication and Phagetherapy. Biocommunication of Phages aims to assess the current state of research, to orient further investigations on how phages communicate with each other to coordinate their behavioral patterns, and to inspire further investigation of the role of non-phage viruses (non-lytic, non-prokaryotic) in these highly dynamic interactional networks. |
| phage therapy prostatitis: Bacteriophages Pilar García Suárez, Lucía Fernández, 2020-11-24 There is talk of an upcoming antibiotic armageddon, with untreatable post-operative infections, and similarly untreatable complications after chemotherapy. Indeed, the now famous “O’Neill Report” (https://amr-review.org/) suggests that, by 2050, more people might die from antibiotic-resistant bacterial infections than from cancer. While we are still learning all the subtle drivers of antibiotic resistance, it seems increasingly clear that we need to take a “one health” approach, curtailing the use of antibiotics in both human and veterinary medicine. However, there are no new classes of antibiotics on our horizon. Maybe something that has been around “forever” can come to our rescue—bacteriophages! Nevertheless, it is also necessary to do things differently, and use these new antimicrobials appropriately. Therefore, an in-depth study of bacteriophage biology and case-by-case applications might be required. Whilst by no means comprehensive, this book does cover some of the many topics related to bacteriophages as antimicrobials, including their use in human therapy and aquaculture. It also explores the potential use of phage endolysins as substitutes of antibiotics in two sectors where there is an urgent need—human therapy and the agro-food industry. Last but not least, there is an excellent perspective article on phage therapy implementation. |
| phage therapy prostatitis: Handbook of Molecular Biotechnology Dongyou Liu, 2024-09-05 With a history that likely dates back to the dawn of human civilization more than 10,000 years ago, and a record that includes the domestication and selective breeding of plants and animals, the harnessing of fermentation process for bread, cheese, and brewage production, and the development of vaccines against infectious diseases, biotechnology has acquired a molecular focus during the 20th century, particularly following the resolution of DNA double helix in 1953, and the publication of DNA cloning protocol in 1973, and transformed our concepts and practices in disease diagnosis, treatment and prevention, pharmaceutical and industrial manufacturing, animal and plant industry, and food processing. While molecular biotechnology offers unlimited opportunities for improving human health and well-being, animal welfare, agricultural innovation and environmental conservation, a dearth of high quality books that have the clarity of laboratory manuals without distractive procedural details and the thoroughness of well-conversed textbooks appears to dampen the enthusiasm of aspiring students. In attempt to fill this glaring gap, Handbook of Molecular Biotechnology includes four sections, with the first three presenting in-depth coverage on DNA, RNA and protein technologies, and the fourth highlighting their utility in biotechnology. Recognizing the importance of logical reasoning and experimental verification over direct observation and simple description in biotechnological research and development, the Introduction provides pertinent discussions on key strategies (i.e., be first, be better, and be different), effective thinking (lateral, parallel, causal, reverse, and random), and experimental execution, which have proven invaluable in helping advance research projects, evaluate and prepare research reports, and enhance other scientific endeavors. Key features Presents state-of-the-art reviews on DNA, RNA and protein technologies and their biotechnological applications Discusses key strategies, effective thinking, and experimental execution for scientific research and development Fills the gap left by detailed-ridden laboratory manuals and insight-lacking standard textbooks Includes expert contributions from international scientists at the forefront of molecular biotechnology research and development Written by international scientists at the forefront of molecular biotechnology research and development, chapters in this volume cover the histories, principles, and applications of individual techniques/technologies, and constitute stand-alone, yet interlinked lectures that strive to educate as well as to entertain. Besides providing an informative textbook for tertiary students in molecular biotechnology and related fields, this volume serves as an indispensable roadmap for novice scientists in their efforts to acquire innovative skills and establish solid track records in molecular biotechnology, and offers a contemporary reference for scholars, educators, and policymakers wishing to keep in touch with recent developments in molecular biotechnology. |
| phage therapy prostatitis: Antibacterial Drug Discovery to Combat MDR Iqbal Ahmad, Shamim Ahmad, Kendra P. Rumbaugh, 2019-11-09 This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry. |
| phage therapy prostatitis: Last Help: Phage Therapy? Paul Enders, 2020-09-21 When the first antibiotic was discovered, it revolutionized medicine, and in many ways, the world. Illnesses that had previously decimated countless suddenly had a treatment, and those antibiotics were used judiciously - and have been ever since. Our Modern Medicine is so inundated with antibiotics that the bacteria and micro-organisms they were first created to destroy have found their own defense, a resistance to these duper drugs that have made them super bugs... and we need a way to fight back. While many look to the future creation of new, stronger antibiotics, the answer may very well lie in our own medical past. In 1915, two enterprising scientists discovered that bacteriophages were present in the stools and bodies of sick patients right before they began to recover. When they found that bacteriophages were also present wherever bacteria grew, it prompted a new line of thought - and the formation of Phage Therapy. This insightful and scientifically accurate book takes us on a journey 100 + years in the making, from the very beginnings of Phage Therapy, through its many varieties and applications and then on to the future of this medical practice - and how the medical breakthrough we have all been waiting for may have already happened. |
| phage therapy prostatitis: Maciocia La pratique de la médecine chinoise Giovanni Maciocia, Sylviane Burner, 2023-02-28 La nouvelle édition de La pratique de la médecine chinoise décrit les applications de la médecine chinoise traditionnelle. De la théorie au diagnostic, en passant par les différents traitements possibles, c'est plus de 48 maladies qui sont étudiées dans le présent volume. S'appuyant sur les textes fondateurs chinois, classiques et modernes, l'auteur expose avec le soin qui a fait sa réputation les concepts de la pratique de l'acupuncture et de la phytothérapie. Cette seconde édition pensée comme une encyclopédie a été enrichie de nombreuses illustrations et de 14 pathologies comme l'anxiété, l'hypertension ou encore la fibromyalgie. Faisant suite aux Principes fondamentaux de la médecine chinoise, cet ouvrage apportera aux étudiants et aux cliniciens des réponses concrètes à leurs questionnements. Chaque chapitre présente : • L'étiologie et la pathologie ; • Une sélection de traitements utilisant l'acupuncture et les plantes médicinales ; • Une liste de publications contemporaines chinoises ; • Les différences entre les diagnostics traditionnels chinois et occidentaux ; • De nombreuses illustrations, cas cliniques et résumés qui viennent éclairer et faciliter la lecture. |
| phage therapy prostatitis: Advances in Virus Research , 2013-12-26 The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field. - Contributions from leading authorities - Comprehensive reviews for general and specialist use - First and longest-running review series in virology |
| phage therapy prostatitis: The Forgotten Cure Anna Kuchment, 2011-12-09 This book fills a void. Never before has a comprehensive history of phage therapy—a once-neglected, now resurgent field—been written. Kuchment writes from the perspective of the eager student of history for the common reader. |
| phage therapy prostatitis: Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill Mayank Gangwar, Gopal Nath, 2024-11-18 This book delves into antibiotic resistance, offering insights into its emergence, mechanisms, and impact on global health. The book also scrutinizes over-prescription, agricultural use, and the scarcity of new drug development, while spotlighting the role of globalization in its propagation. It moves beyond conventional approaches, examining alternative strategies like phage therapy, immunotherapy, and nanotechnology. Highlighting precision diagnostics and the importance of policy implications, it navigates through public health strategies, surveillance, and international collaborations. Finally, it glimpses into the future, delineating the challenges, opportunities, and the urgency of action required to steer away from a post-antibiotic era. This book serves as an invaluable resource for students, researchers, and scientists in the fields of medicine, pharmacy, microbiology, and public health. |
| phage therapy prostatitis: The Quinolones Vincent T. Andriole, 2013-10-22 The Quinolones covers reviews on the history, chemistry and mechanism of action, in vitro properties, pharmacokinetics, clinical overview, toxicity, adverse effects and drug interactions, and future prospects of the 4-quinolones. The book discusses the microbiology of quinolones, particularly with consideration of the development of resistance, pharmacology, toxicology, and clinical uses. Chemists, microbiologists, pharmacologists and clinicians will find the book useful. |
| phage therapy prostatitis: The Bacteriophages Richard Calendar, 2006 This authoritative, timely, and comprehensively referenced compendium on the bacteriophages explores current views of how viruses infect bacteria. In combination with classical phage molecular genetics, new structural, genomic, and single-molecule technologies have rendered an explosion in our knowledge of phages. Bacteriophages, the most abundant and genetically diverse type of organism in the biosphere, were discovered at the beginning of the 20th century and enjoyed decades of used as anti-bacterial agents before being eclipsed by the antibiotic era. Since 1988, phages have come back into the spotlight as major factors in pathogenesis, bacterial evolution, and ecology. This book reveals their compelling elegence of function and their almost inconceivable diversity.Much of the founding work in molecular biology and structural biology was done on bacteriophages. These are widely used in molecular biology research and in biotechnology, as probes and markers, and in the popular method of assesing gene expression. |
| phage therapy prostatitis: Virome: Diversity, Function and Ecology Tao Jin, Mao Ye, Jingzhe Jiang, Pingfeng Yu, Minh-Thu Nguyen, 2022-11-04 |
| phage therapy prostatitis: Textbook of Natural Medicine Joseph E. Pizzorno, Jr. ND, Michael T. Murray, ND, 2012-09-14 Covering preventive, non-invasive, and natural treatments, Textbook of Natural Medicine, 4th Edition offers more than just alternative medicine. It promotes an integrated practice that can utilize natural medicine, traditional Western medicine, or a combination of both in a comprehensive, scientific treatment plan. Based on a combination of philosophy and clinical studies, Textbook of Natural Medicine helps you provide health care that identifies and controls the underlying causes of disease, is supportive of the body's own healing processes, and is considerate of each patient's unique biochemistry. Internationally known authors Joseph Pizzorno and Michael Murray include detailed pharmacologic information on herbs and supplements, plus evidence-based coverage of diseases and conditions to help you make accurate diagnoses and provide effective therapy. Comprehensive, unique coverage makes this book the gold standard in natural medicine. A scientific presentation includes the science behind concepts and treatments, and discusses Western medical treatments and how they can work with natural medicine in a comprehensive treatment plan; if natural medicine is not effective, this book recommends the Western treatment. Coverage of pharmacology of natural medicines includes the uses and potential dangers of nearly 80 herbal medicines, special nutrients, and other natural agents, addressing topics such as general information, chemical composition, history, pharmacology, clinical applications dosage, and toxicology. In-depth, evidence-based coverage of 73 diseases and conditions includes key diagnostic criteria, pathophysiology of diseases, and therapeutic rationales. Coverage of potential interactions between drugs, herbs, and supplements ensures the safest possible use for each of 79 herbs and supplements. Diagnostic procedures include practical, easy-to-follow descriptions of evidence-based techniques plus discussions of clinical application of diet analysis, food allergy testing, immune function assessment, fatty acid profiling, hair mineral analysis, and other diagnostic approaches. Common therapeutic modalities are described and reviewed, including botanical medicine, nutritional therapy, therapeutic fasting, exercise therapy, hydrotherapy, counseling, acupuncture, homeopathy, and soft tissue manipulation. Coverage of syndromes and therapies helps in understanding the underlying causes of diseases by discussing topics such as food reactions, functional toxicology, sports nutrition, stress management, and breathing pattern disorders. Coverage of the philosophy of natural medicine includes its history and background, with discussions of toxicity, detoxification, and scientific documentation of the healing actions of nature and natural substances. Internationally known authors Joseph Pizzorno and Michael Murray and more than 90 expert contributors provide material that is up to date, accurate, and informed. More than 10,000 research literature citations show that the content is based on science rather than opinions or anecdotes. 13 useful appendices offer quick lookup of frequently used charts, handouts, and information. New chapters are included on hot topics such as female infertility, medicinal mushrooms, natural products and quality control, pregnancy health and primary prevention, and Vitamin K; new appendices include a supplier certification questionnaire and cervical escharotics treatment. Thorough updates ensure that you use only the most current research and provide the most effective treatment of patients. Tabs in Specific Health Problems section separate more than 70 alphabetized diseases/conditions. One convenient volume replaces the cumbersome two-volume set for easy, convenient reference. Electronic access is available via Pageburst, making it easy to search topics, drugs, herbs and supplements, and diseases and conditions. Sold separately. |
| phage therapy prostatitis: Practical Handbook of Microbiology Lorrence H Green, Emanuel Goldman, 2021-05-04 Practical Handbook of Microbiology, 4th edition provides basic, clear and concise knowledge and practical information about working with microorganisms. Useful to anyone interested in microbes, the book is intended to especially benefit four groups: trained microbiologists working within one specific area of microbiology; people with training in other disciplines, and use microorganisms as a tool or chemical reagent; business people evaluating investments in microbiology focused companies; and an emerging group, people in occupations and trades that might have limited training in microbiology, but who require specific practical information. Key Features Provides a comprehensive compendium of basic information on microorganisms—from classical microbiology to genomics. Includes coverage of disease-causing bacteria, bacterial viruses (phage), and the use of phage for treating diseases, and added coverage of extremophiles. Features comprehensive coverage of antimicrobial agents, including chapters on anti-fungals and anti-virals. Covers the Microbiome, gene editing with CRISPR, Parasites, Fungi, and Animal Viruses. Adds numerous chapters especially intended for professionals such as healthcare and industrial professionals, environmental scientists and ecologists, teachers, and businesspeople. Includes comprehensive survey table of Clinical, Commercial, and Research-Model bacteria. The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license. Chapter 21, Archaea, of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license available at http://www.taylorfrancis.com See Emanuel Goldman's Open Access article: Lamarck redux and other false arguments against SARS-CoV-2 vaccination, https://www.embopress.org/doi/full/10.15252/embr.202254675 |
| phage therapy prostatitis: Textbook of Natural Medicine - E-Book Joseph E. Pizzorno, Michael T. Murray, 2020-06-26 **Selected for Doody's Core Titles® 2024 with Essential Purchase designation in Complementary & Integrative Health** |
| phage therapy prostatitis: Current Developments in Biotechnology and Bioengineering R. D. Tyagi, Balasubramanian Sellamuthu, Bhagyashree Tiwari, Song Yan, Patrick Drogui, Xiaolei Zhang, Ashok Pandey, 2020-04-01 Current Developments in Biotechnology and Bioengineering: Environmental and Health Impact of Hospital Wastewater narrates the origin (history) of pharmaceuticals discoveries, hospital wastewater and its environmental and health impacts. It covers microbiology of hospital wastewater (pathogens, multi-drug resistance development, microbial evolution and impacts on humans, animals, fish), advanced treatment options (including biological, physical and chemical methods), and highlights aspects required during hospital wastewater treatment processes. This book provides an amalgamation of all recent scientific information on hospital wastewater which is not available in the current literature. |
| phage therapy prostatitis: Biotherapy - History, Principles and Practice Martin Grassberger, Ronald A. Sherman, Olga S. Gileva, Christopher Kim, Kosta Mumcuoglu, 2013-06-04 Biotherapy is defined as the use of living organisms in the treatment and diagnosis of human and animal diseases. This volume is an evocative exploration of the history, scientific basis and practical use of the major biotherapy modalities. The authors provide researchers and practitioners interested in this field, with cutting-edge material on the latest key advances in the following fields of biotherapy: Maggot Therapy, Hirudotherapy, Bee Venom Therapy, Apitherapy, Ichthyotherapy, Helminth Therapy, Phage Therapy, Animal Assisted Therapy, Canine Olfactory Detection. In addition, the authors provide with their chapters an extensive bibliography that represents a state-of-the-art survey of the literature. Comprehensive and current, this fresh volume of reviews is an essential resource for professionals who need to stay ahead of the game in the exciting field of biotherapy. |
| phage therapy prostatitis: Nanotechnology to Aid Chemical and Biological Defense Terri A. Camesano, 2015-10-13 This book presents research into chemical, biological, radiological and nuclear (CBRN) defense and environmental security, exploring practical implications of the research. Contributions from a diverse group of international civilian researchers present the latest work on nanotechnology problems in this area, looking at detection, protective technologies, decontamination and threats to environmental security due to bacteriophages and nanomaterials. Highlights include the potential of Atomic Force Microscopy (AFM) to characterize the nanoscale properties of microbial pathogens, the development of bacteriophage-based therapeutics, prophylactic and diagnostic preparations and their uses in different fields, such as medicine, veterinary, agriculture, food and water safety, amongst others. Readers may also consider an inexpensive bioassay suited for assessing chemical poisoning in the environment such as the presence of pesticides, sensors to detect ultra-trace quantities of the explosive Pentaerythritol tetranitrate (PETN) using nanotubes and electrochemical sensors to simultaneously detect and reduce the explosive trinitrotoluene (TNT) to 2,4,6-triaminotoluene (TAT) in solution. This book shows how cooperative research among NATO countries and NATO partners can make a critical contribution to meeting the opportunities and challenges of nanotechnology problems relevant to chemical and biological defense needs. The papers presented here are representative of contributions made to the Advanced Research Workshop (ARW) on September 22-26, 2014 in Antalya, Turkey, to address the NATO SPS Key Priority of Defense against CBRN Agents and Environmental Security. |
| phage therapy prostatitis: Environmental and Food Virology Gislaine Fongaro, David Rodriguez LAZARO, Doris Sobral Marques Souza, 2023-06-23 Enteric pathogenic viruses are a major challenge in public health, as they represent a major concern with a severe global impact to the economy, commerce, and health systems. Consequently, their active monitoring can allow preventive surveillance and the discovery of new viruses, exemplifying an important epidemiological and health control tool. In an unprecedented way, this book addresses the general characteristics of enteric viruses and their environmental transmission, with a particular emphasis on their structures, stability, routes of transmission and the use of bioindicators for epidemiological monitoring and control. In addition, this book will also address the recent developments for viral concentration and detection in environmental and food samples and the challenges for the control of environmental and food viruses to reduce microbiological risk for final consumers. |
| phage therapy prostatitis: Guide to Antibiotics in Urology Truls E. Bjerklund Johansen, Tommaso Cai, 2024-06-07 This book provides a comprehensive analysis of the use of antibiotics in the urological setting. It is the first work to focus exclusively on the treatment of urinary tract infections, starting from the recent epidemiological and microbiological acquisitions in terms of bacterial resistance. The structure of the book reflects everyday clinical practice, and the sections are divided in line with the level of clinical severity, starting from the uncomplicated lower urinary tract infections and continuing to severe uro-sepsis. Particular emphasis has been given to patient-related risk factors, to the role of antibiotic prophylaxis in urological surgical procedures, and to the treatment of male associated gland infections. The final section offers a dedicated tool for easy and rapid consultation, helping physicians in the everyday clinical practice setting. The book offers the first practical guide for physicians who treat patients affectedby urological infections. Further, it offers a simple guide to consulting for all physicians who occasionally care for these patients. |
| phage therapy prostatitis: Surveying Antimicrobial Resistance: Approaches, Issues, and Challenges to Overcome Gilberto Igrejas, José Luis Capelo, Alexandre Gonçalves, Patrícia Poeta, 2017-03-29 Why Antibiotic Resistance? The use of antibiotics in human and veterinary medicine may have consequences beyond their intended applications. The “One Health” concept recognizes that the health of humans is connected to the health of animals and the environment. Progress in molecular genetics is facilitating the rapid evaluation of the essentiality of these targets on a genomic scale. In 2015, a group of researchers established the International Conference on Antibiotic Resistance (IC2AR).The primary objective of this meeting is to bring together scientists involved in antibiotic resistance prevention and control. The IC2AR conducted its inaugural world congress in January 2015 at Caparica (Portugal). Antimicrobial resistance presents a significant challenge to scientists in the field of infectious diseases. The full knowledge of how antibiotics resistance is evolving and being transmitted between hosts in different ecosystems is taking on great importance. Necessary action includes research to define the scope of the problem including its various sources. This eBook comprises a series of original research and review articles dealing with the epidemiology of resistance in animal and zoonotic pathogens, mobile elements containing resistance genes, the omics of antimicrobial resistance, emerging antimicrobial resistance mechanisms, control of resistant infections, establishing antimicrobial use and resistance surveillance systems, and alternatives strategies to overcome the problem of antimicrobial resistance worldwide. Gilberto Igrejas, José Luis Capelo and Patrícia Poeta Scientific Committee of IC2AR, February 20th, 2017 |
| phage therapy prostatitis: Güncel Üroloji Çalışmaları I Zeynel CANOĞULLARI, 2019-05-27 |
| phage therapy prostatitis: Praxis der chinesischen Medizin Giovanni Maciocia, 2024-04-09 Beschrieben wird die Anwendung der TCM für mehr als 50 Krankheiten. Zahlreiche Fallstudien vertiefen das Wissen. Einprägsame Grafiken, Tabellen und Abbildungen erleichtern Ihnen den Zugang zu Diagnostik und Therapie. Jedes Kapitel enthält: Ätiologie und Pathologie / Differenzialdiagnose in der TCM / Ausgewählte Behandlungen mit Akupunktur und Kräutern – jeweils mit Erläuterungen / Zusammenfassung der westlichen Differenzialdiagnose / Diskussion über Prognose und Prävention / Überprüfung der modernen chinesischen Literatur. Neu in der 3. Auflage - Sexualität in der chinesischen Medizin, Kombination von Arzneimittelmedizin und Akupunktur, Erörterung des Dreierwärmers - Zungengalerie - Aktualisierung der westlichen Differenzialdiagnosen - Red Flags in der westlichen Medizin - Klinische Studien erstmals übersetzt - Therapieprinzipien von Akupunktur und Arzneimitteltherapie in Übersichtskästen - Alphabetische Sortierung der KrankheitsbilderDas Buch eignet sich für: - Ärzt*innen mit Schwerpunkt TCM - Heilpraktiker*innen mit Schwerpunkt TCM |
| phage therapy prostatitis: USAMRIID's Medical Management of Biological Casualties Handbook U.S. Army Medical Research Institute of Infectious Diseases, 2001 The purpose for this handbook is to serve as a concise pocket-sized manual that will guide medical personnel in the prophylaxis and management of biological casulties. It is designed as a quick reference and overview, and is not intended as a definitive text on the medical management of biological casualties. |
| phage therapy prostatitis: Biofilm-Mediated Diseases: Causes and Controls Rina Rani Ray, Moupriya Nag, Dibyajit Lahiri, 2021-05-05 This book reviews the current concepts in biofilm formation and its implications in human health and disease. The initial chapters introduce the mechanisms of biofilm formation and its composition. Subsequently, the chapters discuss the role of biofilm in acute and chronic infections. It also explores the pivotal role of both innate and adaptive immunity on the course of biofilm infection. In addition, the book elucidates the bacterial biofilm formation on implantable devices and the current approaches to its treatment and prevention. It analyzes the possible relationship between antimicrobial resistance and biofilm formation. Finally, the book also summarizes the current state-of-the-art therapeutic approaches for preventing and treating biofilms. This book is a useful resource for researchers in the field of microbiology, clinical microbiology, and also medical practitioners. |
Mayo patient with life-threatening multidrug-resistant infection ...
May 9, 2022 · Mayo Clinic has established partnerships with several entities for phage biomanufacturing, with ultimate plans to establish phage biomanufacturing on site. "Mark’s …
In a first, Mayo Clinic treats cardiology patient with phage therapy
Mar 8, 2023 · Next steps for phage therapy. Dr. Suh is working to make phage therapy more broadly applicable, including plans to treat more cardiology patients. She also is launching two …
Phage therapy shows potential for treating prosthetic joint infections
Jul 23, 2020 · ROCHESTER, Minn. — Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic …
7 ways Mayo Clinic is leading to cure, connect and transform …
Feb 11, 2020 · Mayo is also supporting a new phage therapy program to offer a potential life-saving alternative to antibiotics. Phages are naturally occurring viruses that target and kill …
Mayo Clinic Q and A: Understanding sepsis and septic shock
Dec 7, 2018 · DEAR MAYO CLINIC: Who’s most at risk for developing sepsis, and what are the symptoms to watch for? What’s the difference between sepsis and septic shock? ANSWER: …
Scientists discover autoimmune disease associated with testicular ...
Jul 3, 2019 · A UCSF team led by Joe DeRisi, Ph.D., a biochemist and co-president of Chan Zuckerberg Biohub, and Michael Wilson, M.D., neurologist and member of the UCSF Weill …
A new name for Center for Regenerative Medicine
Aug 30, 2022 · Mayo Clinic's Center for Regenerative Medicine has been renamed the Center for Regenerative Biotherapeutics. The name change reflects Mayo's new strategic focus: …
Mayo patient with life-threatening multidrug-resistant infection ...
May 9, 2022 · Mayo Clinic has established partnerships with several entities for phage biomanufacturing, with ultimate plans to establish phage biomanufacturing on site. "Mark’s case …
In a first, Mayo Clinic treats cardiology patient with phage therapy
Mar 8, 2023 · Next steps for phage therapy. Dr. Suh is working to make phage therapy more broadly applicable, including plans to treat more cardiology patients. She also is launching two …
Phage therapy shows potential for treating prosthetic joint infections
Jul 23, 2020 · ROCHESTER, Minn. — Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic research. …
7 ways Mayo Clinic is leading to cure, connect and transform health ...
Feb 11, 2020 · Mayo is also supporting a new phage therapy program to offer a potential life-saving alternative to antibiotics. Phages are naturally occurring viruses that target and kill specific …
Mayo Clinic Q and A: Understanding sepsis and septic shock
Dec 7, 2018 · DEAR MAYO CLINIC: Who’s most at risk for developing sepsis, and what are the symptoms to watch for? What’s the difference between sepsis and septic shock? ANSWER: …
Scientists discover autoimmune disease associated with testicular ...
Jul 3, 2019 · A UCSF team led by Joe DeRisi, Ph.D., a biochemist and co-president of Chan Zuckerberg Biohub, and Michael Wilson, M.D., neurologist and member of the UCSF Weill …
A new name for Center for Regenerative Medicine
Aug 30, 2022 · Mayo Clinic's Center for Regenerative Medicine has been renamed the Center for Regenerative Biotherapeutics. The name change reflects Mayo's new strategic focus: …
