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| phage and the origins of molecular biology: Phage and the Origins of Molecular Biology John Cairns, Gunther Siegmund Stent, James D. Watson, 2007 First published in 1966 as a 60th birthday tribute to Max Delbrck, this influential work is republished as The Centennial Edition. The book was hailed as [introducing] into the literature of science, for the first time, a self-conscious historical element in which the participants in scientific discovery engage in writing their own chronicle (Journal of History of Biology). |
| phage and the origins of molecular biology: Phage and the Origins of Molecular Biology, the Centennial Edition John Cairns, Gunther S. Stent, James D. Watson, 2017-10-02 This hugely influential book, published in 1966 as a 60th birthday tribute to Max Delbrück, is now republished as The Centennial Edition. On first publication, the book was hailed as [introducing] into the literature of science, for the first time, a selfDSconscious historical element in which the participants in scientific discovery engage in writing their own chronicle. As such, it is an important document in the history of biology... (Journal of History of Biology). And in another review it was described as required reading for every student of experimental biology...[who] will sense the smell and rattle of the laboratory (Bioscience). The book was a formative influence on many of today's leading scientists. |
| phage and the origins of molecular biology: Phage and the Origins of Molecular Biology John Cairns, Gunther Siegmund Stent, James D. Watson, 1966 This is an expanded edition of the landmark collection of 35 essays by pioneers of molecular biology that was first published in 1966 as a 60th birthday tribute to Max Delbruck. The book was hailed as [introducing] into the literature of science, for the first time, a self-conscious historical element in which the participants in scientific discovery engage in writing their own chronicle. As such, it is an important document in the history of biology... (Journal of History of Biology). This new edition includes Gunther Stent's obituary of Max Delbruck, two commentaries on issues raised in the book reprinted from Scientific American and Science, and a new preface in which John Cairns reflects on the book's creation and molecular biology's age of innocence. |
| phage and the origins of molecular biology: Félix d`Herelle and the Origins of Molecular Biology William C. Summers, 1999-06-10 A self-taught scientist determined to bring science out of the laboratory and into the practical arena, French-Canadian Felix d’Herelle (1873-1949) made history in two different fields of biology. Not only was he first to demonstrate the use and application of bacteria for biological control of insect pests, he also became a seminal figure in the history of molecular biology. This engaging book is the first full biography of d’Herelle, a complex figure who emulated Louis Pasteur and influenced the course of twentieth-century biology, yet remained a controversial outsider to the scientific community. Drawing on family papers, archival sources, interviews, and d’Herelle’s published and unpublished writings, Dr. William C. Summers tells the fascinating story of the scientist’s life and the work that took him around the globe. In 1917, d’Herelle published the first paper describing the phenomenon of the bacteriophage and its biological nature. A series of more than 110 articles and 6 major books followed, in which d’Herelle established the foundation for the later work of the Phage Group in molecular biology. Yet d’Herelle sometimes inspired animosity in others--he was drummed out of the Pasteur Institute, he held only one brief permanent position in the scientific establishment (at Yale University from 1928 to 1933), and he was bewildered by the social nuances of the world of international science. His story is more than the biography of a single brilliant scientist; it is also a fascinating chapter in the history of biology. |
| phage and the origins of molecular biology: Phage and the origins of molecular biology Richard C. Lewontin, 1968 |
| phage and the origins of molecular biology: A History of Molecular Biology Michel Morange, 2000 Every day it seems the media focus on yet another new development in biology--gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology. A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries--the double helix, messenger RNA, oncogenes, DNA polymerase--but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg. This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry. An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research. |
| phage and the origins of molecular biology: Landmark Experiments in Molecular Biology Michael Fry, 2016-06-10 Landmark Experiments in Molecular Biology critically considers breakthrough experiments that have constituted major turning points in the birth and evolution of molecular biology. These experiments laid the foundations to molecular biology by uncovering the major players in the machinery of inheritance and biological information handling such as DNA, RNA, ribosomes, and proteins. Landmark Experiments in Molecular Biology combines an historical survey of the development of ideas, theories, and profiles of leading scientists with detailed scientific and technical analysis. - Includes detailed analysis of classically designed and executed experiments - Incorporates technical and scientific analysis along with historical background for a robust understanding of molecular biology discoveries - Provides critical analysis of the history of molecular biology to inform the future of scientific discovery - Examines the machinery of inheritance and biological information handling |
| phage and the origins of molecular biology: Single-stranded RNA phages Paul Pumpens, 2020-02-03 This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies |
| phage and the origins of molecular biology: We Can Sleep Later Alfred Day Hershey, 2000 An absorbing portrait of the pioneering molecular biologist best known for demonstrating that DNA is the genetic component of phages, through essays and reminiscences from twenty–three distinguished scientists whose work and careers were influenced by the man and his science. |
| phage and the origins of molecular biology: The American Phage Group William C. Summers, 2023-01-10 A fascinating historical account of the American Phage Group and how its new research framework became the foundation for molecular biology This book is the first critical and analytical study of the American Phage Group--a small group of scientists who gathered around Max Delbrück, Salvador Luria, and Alfred Hershey between 1940 and 1960--and how this novel research program became the foundation of the field of molecular biology. These three young, charismatic, and iconoclastic scientists were convinced of the importance of bacterial viruses (bacteriophages) to the study of the gene and of heredity in general. Based on substantial archival research, numerous participant interviews collected over the past thirty years, and an intimate knowledge of the relevant scientific literature in the field, William C. Summers has written a fascinating new history of the American Phage Group. Rather than a linear narrative of progress by past heroes, this book emphasizes the diversity and historical contingencies in the group's development. |
| phage and the origins of molecular biology: Who Wrote the Book of Life? Lily E. Kay, 2000 This is a detailed history of one of the most important and dramatic episodes in modern science, recounted from the novel vantage point of the dawn of the information age and its impact on representations of nature, heredity, and society. Drawing on archives, published sources, and interviews, the author situates the work on the genetic code (1953-70) within the history of life science, the rise of communication technosciences (cybernetics, information theory, and computers), the intersection of molecular biology with cryptanalysis and linguistics, and the social history of postwar Europe and the United States. --COVER. |
| phage and the origins of molecular biology: The Early Days of Yeast Genetics Michael N. Hall, Patrick Linder, 1993-01-01 Hall and Linder have assembled the reminiscences of many early investigators whose pioneering studies in the years before 1975 brought yeast biology to its current maturity. These illustrated essays about the science, the events and the personalities involved capture a fascinating era, in the informal style made famous by Phage and the Origins of Molecular Biology. |
| phage and the origins of molecular biology: Phages and the Origins of Molecular Biology John Cairns, Max Delbrück, 1966 |
| phage and the origins of molecular biology: Bacteriophage Ecology Stephen T. Abedon, 2008-05-01 Bacteriophages, or phages, are viruses that infect bacteria and are believed to be the most abundant and genetically diverse organisms on Earth. As such, their ecology is vast both in quantitative and qualitative terms. Their abundance makes an understanding of phage ecology increasingly relevant to bacterial ecosystem ecology, bacterial genomics and bacterial pathology. Abedon provides the first text on phage ecology for almost 20 years. Written by leading experts, synthesizing the three key approaches to studying phage ecology, namely studying them in natural environments (in situ), experimentally in the lab, or theoretically using mathematical or computer models. With strong emphasis on microbial population biology and distilling cutting-edge research into basic principles, this book will complement other currently available volumes. It will therefore serve as an essential resource for graduate students and researchers, particularly those with an interest in phage ecology and evolutionary biology. |
| phage and the origins of molecular biology: The Evolution of Molecular Biology Kensal Van Holde, Jordanka Zlatanova, 2018-02-20 The Evolution of Molecular Biology: The Search for the Secrets of Life provides the historical knowledge behind techniques founded in molecular biology, also presenting an appreciation of how, and by whom, these discoveries were made. It deals with the evolution of intellectual concepts in the context of active research in an approachable language that accommodates readers from a variety of backgrounds. Each chapter contains a prologue and epilogue to create continuity and provide a complete framework of molecular biology. This foundational work also functions as a historical and conceptual supplement to many related courses in biochemistry, biology, chemistry, genetics and history of science. In addition, the book demonstrates how the roots of discovery and advances–and an individual's own research–have grown out of the history of the field, presenting a more complete understanding and context for scientific discovery. - Expands on the development of molecular biology from the convergence of two independent disciplines, biochemistry and genetics - Discusses the value of molecular biology in a variety of applications - Includes research ethics and the societal implications of research - Emphasizes the human aspects of research and the consequences of such advances to society |
| phage and the origins of molecular biology: Origin and Evolution of Viruses Esteban Domingo, Colin R. Parrish, John J. Holland, 2008-06-23 New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. - NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution - UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups - SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts |
| phage and the origins of molecular biology: A Tale of Two Viruses Neeraja Sankaran, 2021-03-09 In 1965, French microbiologist André Lwoff was awarded the Nobel Prize in Physiology or Medicine for his work on lysogeny—one of the two types of viral life cycles—which resolved a contentious debate among scientists about the nature of viruses. A Tale of Two Viruses is the first study of medical virology to compare the history of two groups of medically important viruses—bacteriophages, which infect bacteria, and sarcoma agents, which cause cancer—and the importance of Lwoff’s discovery to our modern understanding of what a virus is. Although these two groups of viruses may at first glance appear to have little in common, they share uniquely parallel histories. The lysogenic cycle, unlike the lytic, enables viruses to replicate in the host cell without destroying it and to remain dormant in a cell’s genetic material indefinitely, or until induced by UV radiation. But until Lwoff’s discovery of the mechanism of lysogeny, microbiologist Félix d’Herelle and pathologist Peyton Rous, who themselves first discovered and argued for the viral identity of bacteriophages and certain types of cancer, respectively, faced opposition from contemporary researchers who would not accept their findings. By following the research trajectories of the two virus groups, Sankaran takes a novel approach to the history of the development of the field of medical virology, considering both the flux in scientific concepts over time and the broader scientific landscapes or styles that shaped those ideas and practices. |
| phage and the origins of molecular biology: Fundamental Molecular Biology Lizabeth A. Allison, 2011-10-18 Unique in in its focus on eukaryotic molecular biology, this textbook provides a distillation of the essential concepts of molecular biology, supported by current examples, experimental evidence, and boxes that address related diseases, methods, and techniques. End-of-chapter analytical questions are well designed and will enable students to apply the information they learned in the chapter. A supplementary website include self-tests for students, resources for instructors, as well as figures and animations for classroom use. |
| phage and the origins of molecular biology: Time, Love , Memory Jonathan Weiner, 2014-05-14 The story of Nobel Prize–winning discoveries regarding the molecular mechanisms controlling the body’s circadian rhythm. How much of our fate is decided before we are born? Which of our characteristics is inscribed in our DNA? Weiner brings us into Benzer's Fly Rooms at the California Institute of Technology, where Benzer, and his asssociates are in the process of finding answers, often astonishing ones, to these questions. Part biography, part thrilling scientific detective story, Time, Love, Memory forcefully demonstrates how Benzer's studies are changing our world view--and even our lives. Jonathan Weiner, winner of the Pulitzer Prize for The Beak of the Finch, brings his brilliant reporting skills to the story of Seymour Benzer, the Brooklyn-born maverick scientist whose study of genetics and experiments with fruit fly genes has helped revolutionize or knowledge of the connections between DNA and behavior both animal and human. |
| phage and the origins of molecular biology: Genetics and Molecular Biology Robert F. Schleif, 1993 In the first edition of Genetics and Molecular Biology, renowned researcher and award-winning teacher Robert Schleif produced a unique and stimulating text that was a notable departure from the standard compendia of facts and observations. Schleif's strategy was to present the underlying fundamental concepts of molecular biology with clear explanations and critical analysis of well-chosen experiments. The result was a concise and practical approach that offered students a real understanding of the subject. This second edition retains that valuable approach--with material thoroughly updated to include an integrated treatment of prokaryotic and eukaryotic molecular biology. Genetics and Molecular Biology is copiously illustrated with two-color line art. Each chapter includes an extensive list of important references to the primary literature, as well as many innovative and thought-provoking problems on material covered in the text or on related topics. These help focus the student's attention of a variety of critical issues. Solutions are provided for half of the problems. Praise for the first edition: Schleif's Genetics and Molecular Biology... is a remarkable achievement. It is an advanced text, derived from material taught largely to postgraduates, and will probably be thought best suited to budding professionals in molecular genetics. In some ways this would be a pity, because there is also gold here for the rest of us... The lessons here in dealing with the information explosion in biology are that an ounce of rationale is worth a pound of facts and that, for educational value, there is nothing to beat an author writing about stuff he knows from theinside.--Nature. Schleif presents a quantitative, chemically rigorous approach to analyzing problems in molecular biology. The text is unique and clearly superior to any currently available.--R.L. Bernstein, San Francisco State University. The greatest strength is the author's ability to challenge the student to become involved and get below the surface.--Clifford Brunk, UCLA |
| phage and the origins of molecular biology: Molecular Biology of the Cell , 2002 |
| phage and the origins of molecular biology: Molecular Evolution Roderick D.M. Page, Edward C. Holmes, 2009-07-14 The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility. |
| phage and the origins of molecular biology: Bacteriophages David R. Harper, Stephen T. Abedon, Benjamin H. Burrowes, Malcolm L. McConville, 2021-01-31 This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology. The book introduces to bacteriophage biology, ecology and history and reviews the latest technologies and tools in bacteriophage detection, strain optimization and nanotechnology. Usage of bacteriophages in food safety, agriculture, and different therapeutic areas is discussed in detail. This book serves as essential guide for researchers in applied microbiology, biotechnology and medicine coming from both academia and industry. |
| phage and the origins of molecular biology: Clostridia Holger Brüggemann, Gerhard Gottschalk, 2009 In this book internationally recognized Clostridium experts critically review the most important aspects of clostridial research, providing the first coherent picture of the organism's molecular and cellular biology in this post-genomic era. Essential reading for every clostridia researcher, from the PhD student to the experienced scientist, as it provides a timely review of current research. --Book Jacket. |
| phage and the origins of molecular biology: A History of Genetics Alfred Henry Sturtevant, 2001 In the small “Fly Room†at Columbia University, T.H. Morgan and his students, A.H. Sturtevant, C.B. Bridges, and H.J. Muller, carried out the work that laid the foundations of modern, chromosomal genetics. The excitement of those times, when the whole field of genetics was being created, is captured in this book, written in 1965 by one of those present at the beginning. His account is one of the few authoritative, analytic works on the early history of genetics. This attractive reprint is accompanied by a website, http://www.esp.org/books/sturt/history/ offering full-text versions of the key papers discussed in the book, including the world's first genetic map. |
| phage and the origins of molecular biology: Phage Display Carlos F. Barbas, 2001 Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application. |
| phage and the origins of molecular biology: Scientific Establishments and Hierarchies N. Elias, H. Martins, Richard P. Whitley, 2012-12-06 In recent years sociologists of sciences have become more interested in scien tific elites, in the way they direct and control the development of sciences and, beyond that, in which the organization of research facilities and resources generally affects research strategies and goals. In this volume we focus on scientific establishments and hierarchies as a means of bringing aspects of these concerns together in their historical and comparative contexts. These terms draw attention to the fact that much scientific work has been pursued within a highly specific organizational setting, that of universities and aca demic research institutes. The effects of this organizational setting as well as its power relations, and its resources in relation to governmental and other non-scientific establishments in society at large, deserve closer attention. One significant aspect of scientific establishments and hierarchies and of the power relations impinging upon scientific research, is the fact that the bulk of leading scientists have the professional career, qualifications and status of a professor. As heads or senior members of departments, institutes and laboratories, professors form the ruling groups of scientific work. They are the main defenders of scientific - or departmental - autonomy, accept or resist innovations in their field, play a leading part in fighting scientific controversies or establishing consensus. Even where research units are not directly controlled by professors, authority structures usually remain strongly hierarchical. These hierarchies too deserve attention in any explora tion of the social characteristics of scientific knowledge and its production. |
| phage and the origins of molecular biology: A Guinea Pig's History of Biology Jim Endersby, 2007 Biology today promises everything from better foods or cures For common diseases to the alarming prospect of redesigning life itself Looking at the organisms that have made all this possible gives us a new way of understanding how we got here - and perhaps of thinking about where we're going. Instead of a history of which great scientists had which great ideas, this story of passionflowers and hawkweeds, of zebra fish and viruses, oilers a bird's (or rodent's) eye view of the work that makes science possible. --Book Jacket. |
| phage and the origins of molecular biology: The Perfect Predator Steffanie Strathdee, Thomas Patterson, 2019-02-26 An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. A memoir that reads like a thriller. -New York Times Book Review A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short. -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka the perfect predator, can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis. |
| phage and the origins of molecular biology: The Eighth Day of Creation Horace Freeland Judson, 2004-01-01 |
| phage and the origins of molecular biology: Physics in Molecular Biology Kim Sneppen, Giovanni Zocchi, 2005-08-25 This book, first published in 2005, is a discussion for advanced physics students of how to use physics to model biological systems. |
| phage and the origins of molecular biology: Undisciplining Knowledge Harvey J. Graff, 2015-08-01 The first critical history of interdisciplinary efforts and movements in the modern university. Interdisciplinarity—or the interrelationships among distinct fields, disciplines, or branches of knowledge in pursuit of new answers to pressing problems—is one of the most contested topics in higher education today. Some see it as a way to break down the silos of academic departments and foster creative interchange, while others view it as a destructive force that will diminish academic quality and destroy the university as we know it. In Undisciplining Knowledge, acclaimed scholar Harvey J. Graff presents readers with the first comparative and critical history of interdisciplinary initiatives in the modern university. Arranged chronologically, the book tells the engaging story of how various academic fields both embraced and fought off efforts to share knowledge with other scholars. It is a story of myths, exaggerations, and misunderstandings, on all sides. Touching on a wide variety of disciplines—including genetic biology, sociology, the humanities, communications, social relations, operations research, cognitive science, materials science, nanotechnology, cultural studies, literacy studies, and biosciences—the book examines the ideals, theories, and practices of interdisciplinarity through comparative case studies. Graff interweaves this narrative with a social, institutional, and intellectual history of interdisciplinary efforts over the 140 years of the modern university, focusing on both its implementation and evolution while exploring substantial differences in definitions, goals, institutional locations, and modes of organization across different areas of focus. Scholars across the disciplines, specialists in higher education, administrators, and interested readers will find the book’s multiple perspectives and practical advice on building and operating—and avoiding fallacies and errors—in interdisciplinary research and education invaluable. |
| phage and the origins of molecular biology: Bacteriophages Renos Savva, 2020 |
| phage and the origins of molecular biology: Phage Display Tim Clackson, Henry B. Lowman, 2004-03-04 This new book is designed to enable researchers to design and undertake all aspects of a phage display project, from designing an experimental strategy and constructing a library to performing selections and analyzing the results.All of the protocols and chapters are extensively cross-referenced, allowing readers to move beyond the specific examples provided in order to customize the procedures for their own protein or selection system of interest. Phage Display is an up-to-date, comprehensive and integrated experimental guide to the technique, which is essential reading for anyone currently using, or wishing to use the technique for basic research and drug discovery. |
| phage and the origins of molecular biology: Practical Handbook of Microbiology Emanuel Goldman, Lorrence H Green, 2008-08-29 The field of microbiology has developed considerably in the last 20 years, building exponentially on its own discoveries and growing to encompass many other disciplines. Unfortunately, the literature in the field tends to be either encyclopedic in scope or presented as a textbook and oriented for the student. Finding its niche between these two pol |
| phage and the origins of molecular biology: The Great Manchurian Plague of 1910-1911 William C. Summers, 2012-12-11 When plague broke out in Manchuria in 1910 as a result of transmission from marmots to humans, it struck a region struggling with the introduction of Western medicine, as well as with the interactions of three different national powers: Chinese, Japanese, and Russian. In this fascinating case history, William Summers relates how this plague killed as many as 60,000 people in less than a year, and uses the analysis to examine the actions and interactions of the multinational doctors, politicians, and ordinary residents who responded to it.Summers covers the complex political and economic background of early twentieth-century Manchuria and then moves on to the plague itself, addressing the various contested stories of the plague's origins, development, and ecological ties. Ultimately, Summers shows how, because of Manchuria's importance to the world powers of its day, the plague brought together resources, knowledge, and people in ways that enacted in miniature the triumphs and challenges of transnational medical projects such as the World Health Organization. |
| phage and the origins of molecular biology: The Genetic Code and the Origin of Life Lluis Ribas de Pouplana, 2007-04-03 Early Thoughts on RNA and the Origin of Life The full impact of the essential role of the nucleic acids in biological systems was forcefully demonstrated by the research community in the 1950s. Although Avery and his collaborators had identified DNA as the genetic material responsible for the transformation of bacteria in 1944, it was not until the early 1950s that the Hershey-Chase experiments provided a more direct demonstration of this role. Finally, the structural DNA double helix proposed by Watson and Crick in 1953 clearly created a structural frame work for the role of DNA as both information carrier and as a molecule that could undergo the necessary replication needed for daughter cells. Research continued by Kornberg and his colleagues in the mid-1950s emphasized the biochemistry and enzymology of DNA replication. At the same time, there was a growing interest in the role of RNA. The 1956 dis covery by David Davies and myself showed that polyadenylic acid and polyuridylic acid could form a double-helical RNA molecule but that it differed somewhat from DN A A large number of experiments were subsequendy carried out with synthetic polyribonucleotides which illustrated that RNA could form even more complicated helical structures in which the specificity of hydrogen bonding was the key element in determining the molecular conformation. Finally, in I960,1 could show that it was possible to make a hybrid helix. |
| phage and the origins of molecular biology: The Forgotten Cure Anna Kuchment, 2011-12-09 This book fills a void. Never before has a comprehensive history of phage therapy—a once-neglected, now resurgent field—been written. Kuchment writes from the perspective of the eager student of history for the common reader. |
| phage and the origins of molecular biology: Using The Biological Literature Diane Schmidt, Elisabeth B. Davis, 2001-12-06 Provides an in-depth review of current print and electronic tools for research in numerous disciplines of biology, including dictionaries and encyclopedias, method guides, handbooks, on-line directories, and periodicals. Directs readers to an associated Web page that maintains the URLs and annotations of all major Inernet resources discussed in th |
Mayo patient with life-threatening multidrug-resistant infection ...
May 9, 2022 · Mayo Clinic has established partnerships with several entities for phage biomanufacturing, with ultimate plans to establish phage biomanufacturing on site. "Mark’s …
In a first, Mayo Clinic treats cardiology patient with phage therapy
Mar 8, 2023 · Next steps for phage therapy. Dr. Suh is working to make phage therapy more broadly applicable, including plans to treat more cardiology patients. She also is launching two …
Phage therapy shows potential for treating prosthetic joint infections
Jul 23, 2020 · ROCHESTER, Minn. — Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic …
7 ways Mayo Clinic is leading to cure, connect and transform …
Feb 11, 2020 · Mayo is also supporting a new phage therapy program to offer a potential life-saving alternative to antibiotics. Phages are naturally occurring viruses that target and kill …
Mayo Clinic Q and A: Understanding sepsis and septic shock
Dec 7, 2018 · DEAR MAYO CLINIC: Who’s most at risk for developing sepsis, and what are the symptoms to watch for? What’s the difference between sepsis and septic shock? ANSWER: …
Scientists discover autoimmune disease associated with testicular ...
Jul 3, 2019 · A UCSF team led by Joe DeRisi, Ph.D., a biochemist and co-president of Chan Zuckerberg Biohub, and Michael Wilson, M.D., neurologist and member of the UCSF Weill …
A new name for Center for Regenerative Medicine
Aug 30, 2022 · Mayo Clinic's Center for Regenerative Medicine has been renamed the Center for Regenerative Biotherapeutics. The name change reflects Mayo's new strategic focus: …
Mayo patient with life-threatening multidrug-resistant infection ...
May 9, 2022 · Mayo Clinic has established partnerships with several entities for phage biomanufacturing, with ultimate plans to establish phage biomanufacturing on site. "Mark’s …
In a first, Mayo Clinic treats cardiology patient with phage therapy
Mar 8, 2023 · Next steps for phage therapy. Dr. Suh is working to make phage therapy more broadly applicable, including plans to treat more cardiology patients. She also is launching two …
Phage therapy shows potential for treating prosthetic joint infections
Jul 23, 2020 · ROCHESTER, Minn. — Bacteriophages, or phages, may play a significant role in treating complex bacterial infections in prosthetic joints, according to new Mayo Clinic …
7 ways Mayo Clinic is leading to cure, connect and transform …
Feb 11, 2020 · Mayo is also supporting a new phage therapy program to offer a potential life-saving alternative to antibiotics. Phages are naturally occurring viruses that target and kill …
Mayo Clinic Q and A: Understanding sepsis and septic shock
Dec 7, 2018 · DEAR MAYO CLINIC: Who’s most at risk for developing sepsis, and what are the symptoms to watch for? What’s the difference between sepsis and septic shock? ANSWER: …
Scientists discover autoimmune disease associated with testicular ...
Jul 3, 2019 · A UCSF team led by Joe DeRisi, Ph.D., a biochemist and co-president of Chan Zuckerberg Biohub, and Michael Wilson, M.D., neurologist and member of the UCSF Weill …
A new name for Center for Regenerative Medicine
Aug 30, 2022 · Mayo Clinic's Center for Regenerative Medicine has been renamed the Center for Regenerative Biotherapeutics. The name change reflects Mayo's new strategic focus: …
