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| plos one computational biology: The Science of Stories M. Jones, E. Shanahan, M. McBeth, 2014-12-03 The study of narratives in a variety of disciplines has grown in recent years as a method of better explaining underlying concepts in their respective fields. Through the use of Narrative Policy Framework (NPF), political scientists can analyze the role narrative plays in political discourse. |
| plos one computational biology: Handbook of Research on Computational and Systems Biology Limin Angela Liu, Dongqing Wei, Yixue Li, 2011 This book offers information on the state-of-the-art development in the fields of computational biology and systems biology, presenting methods, tools, and applications of these fields by many leading experts around the globe--Provided by publisher. |
| plos one computational biology: Blue Marble Health Peter J. Hotez, 2016-09 Why do diseases of poverty afflict more people in wealthy countries than in the developing world? In 2011, Dr. Peter J. Hotez relocated to Houston to launch Baylor’s National School of Tropical Medicine. He was shocked to discover that a number of neglected diseases often associated with developing countries were widespread in impoverished Texas communities. Despite the United States’ economic prowess and first-world status, an estimated 12 million Americans living at the poverty level currently suffer from at least one neglected tropical disease, or NTD. Hotez concluded that the world’s neglected diseases—which include tuberculosis, hookworm infection, lymphatic filariasis, Chagas disease, and leishmaniasis—are born first and foremost of extreme poverty. In this book, Hotez describes a new global paradigm known as “blue marble health,” through which he asserts that poor people living in wealthy countries account for most of the world’s poverty-related illness. He explores the current state of neglected diseases in such disparate countries as Mexico, South Korea, Argentina, Australia, the United States, Japan, and Nigeria. By crafting public policy and relying on global partnerships to control or eliminate some of the world’s worst poverty-related illnesses, Hotez believes, it is possible to eliminate life-threatening disease while at the same time creating unprecedented opportunities for science and diplomacy. Clear, compassionate, and timely, Blue Marble Health is a must-read for leaders in global health, tropical medicine, and international development, along with anyone committed to helping the millions of people who are caught in the desperate cycle of poverty and disease. |
| plos one computational biology: Fostering Integrity in Research National Academies of Sciences, Engineering, and Medicine, Policy and Global Affairs, Committee on Science, Engineering, Medicine, and Public Policy, Committee on Responsible Science, 2018-01-13 The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support †or distort †practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices. |
| plos one computational biology: Fundamentals of Bioinformatics and Computational Biology Gautam B. Singh, 2014-09-24 This book offers comprehensive coverage of all the core topics of bioinformatics, and includes practical examples completed using the MATLAB bioinformatics toolboxTM. It is primarily intended as a textbook for engineering and computer science students attending advanced undergraduate and graduate courses in bioinformatics and computational biology. The book develops bioinformatics concepts from the ground up, starting with an introductory chapter on molecular biology and genetics. This chapter will enable physical science students to fully understand and appreciate the ultimate goals of applying the principles of information technology to challenges in biological data management, sequence analysis, and systems biology. The first part of the book also includes a survey of existing biological databases, tools that have become essential in today’s biotechnology research. The second part of the book covers methodologies for retrieving biological information, including fundamental algorithms for sequence comparison, scoring, and determining evolutionary distance. The main focus of the third part is on modeling biological sequences and patterns as Markov chains. It presents key principles for analyzing and searching for sequences of significant motifs and biomarkers. The last part of the book, dedicated to systems biology, covers phylogenetic analysis and evolutionary tree computations, as well as gene expression analysis with microarrays. In brief, the book offers the ideal hands-on reference guide to the field of bioinformatics and computational biology. |
| plos one computational biology: BIO2010 National Research Council, Division on Earth and Life Studies, Board on Life Sciences, Committee on Undergraduate Biology Education to Prepare Research Scientists for the 21st Century, 2003-02-13 Biological sciences have been revolutionized, not only in the way research is conductedâ€with the introduction of techniques such as recombinant DNA and digital technologyâ€but also in how research findings are communicated among professionals and to the public. Yet, the undergraduate programs that train biology researchers remain much the same as they were before these fundamental changes came on the scene. This new volume provides a blueprint for bringing undergraduate biology education up to the speed of today's research fast track. It includes recommendations for teaching the next generation of life science investigators, through: Building a strong interdisciplinary curriculum that includes physical science, information technology, and mathematics. Eliminating the administrative and financial barriers to cross-departmental collaboration. Evaluating the impact of medical college admissions testing on undergraduate biology education. Creating early opportunities for independent research. Designing meaningful laboratory experiences into the curriculum. The committee presents a dozen brief case studies of exemplary programs at leading institutions and lists many resources for biology educators. This volume will be important to biology faculty, administrators, practitioners, professional societies, research and education funders, and the biotechnology industry. |
| plos one computational biology: Pleased to Meet Me Bill Sullivan, 2019-08-06 Why are you attracted to a certain type? Why are you a morning person? Why do you vote the way you do? From a witty new voice in popular science comes a clever, life-changing look at what makes you you. I can't believe I just said that. What possessed me to do that? What's wrong with me? We're constantly seeking answers to these fundamental human questions, and now, science has the answers. The foods we enjoy, the people we love, the emotions we feel, and the beliefs we hold can all be traced back to our DNA, germs, and environment. This witty, colloquial book is popular science at its best, describing in everyday language how genetics, epigenetics, microbiology, and psychology work together to influence our personality and actions. Mixing cutting-edge research and relatable humor, Pleased to Meet Me is filled with fascinating insights that shine a light on who we really are--and how we might become our best selves. |
| plos one computational biology: AIDS and the Historian Victoria Angela Harden, Guenter B. Risse, 1991 |
| plos one computational biology: Brilliant Blunders Mario Livio, 2014-05-27 Drawing on the lives of five great scientists -- Charles Darwin, William Thomson (Lord Kelvin), Linus Pauling, Fred Hoyle and Albert Einstein -- scientist/author Mario Livio shows how even the greatest scientists made major mistakes and how science built on these errors to achieve breakthroughs, especially into the evolution of life and the universe-- |
| plos one computational biology: Advances in Bioinformatics and Computational Biology João C. Setubal, Waldeyr Mendes Silva, 2020-12-19 This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2020, held in São Paulo, Brazil, in November 2020. Due to COVID-19 pandemic the conference was held virtually The 20 revised full papers and 5 short papers were carefully reviewed and selected from 45 submissions. The papers address a broad range of current topics in computational biology and bioinformatics. |
| plos one computational biology: High Performance Computing Ponnuswamy Sadayappan, Bradford L. Chamberlain, Guido Juckeland, Hatem Ltaief, 2020-06-15 This book constitutes the refereed proceedings of the 35th International Conference on High Performance Computing, ISC High Performance 2020, held in Frankfurt/Main, Germany, in June 2020.* The 27 revised full papers presented were carefully reviewed and selected from 87 submissions. The papers cover a broad range of topics such as architectures, networks & infrastructure; artificial intelligence and machine learning; data, storage & visualization; emerging technologies; HPC algorithms; HPC applications; performance modeling & measurement; programming models & systems software. *The conference was held virtually due to the COVID-19 pandemic. Chapters Scalable Hierarchical Aggregation and Reduction Protocol (SHARP) Streaming-Aggregation Hardware Design and Evaluation, Solving Acoustic Boundary Integral Equations Using High Performance Tile Low-Rank LU Factorization, Scaling Genomics Data Processing with Memory-Driven Computing to Accelerate Computational Biology, Footprint-Aware Power Capping for Hybrid Memory Based Systems, and Pattern-Aware Staging for Hybrid Memory Systems are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. |
| plos one computational biology: A Crack in Creation Jennifer Doudna, Samuel H. Sternberg, 2017-06-15 Two Berkeley scientists explore the potential of a revolutionary genetics technology capable of easily and affordably manipulating DNA in human embryos to prevent specific diseases, addressing key concerns about related ethical and societal repercussions |
| plos one computational biology: Aging and Health Anatoli I. Yashin, S. Michal Jazwinski, 2015 Aging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society. |
| plos one computational biology: Biological Sequence Analysis Richard Durbin, 1998-04-23 Presents up-to-date computer methods for analysing DNA, RNA and protein sequences. |
| plos one computational biology: 39 Ways to Save the Planet Tom Heap, 2021-10-14 We got ourselves into this. Here's how we can get ourselves out. We know the problem: the amount of biodiversity loss, the scale of waste and pollution, the amount of greenhouse gas we pump into the air... it's unsustainable. We have to do something. And we are resourceful, adaptable and smart. We have already devised many ways to reduce climate change - some now proven, others encouraging and craving uptake. Each one is a solution to get behind. In 39 Ways to Save the Planet, Tom Heap reveals some of the real-world solutions to climate change that are happening around the world, right now. From tiny rice seeds and fossil fuel free steel to grazing elk and carbon-capturing seagrass meadows, each chapter reveals the energy and optimism in those tackling the fundamental problem of our age. Accompanying a major BBC Radio 4 series in collaboration with the Royal Geographical Society, 39 Ways to Save the Planet is a fascinating exploration of our attempt to build a better future, one solution at a time. A roadmap to global action on climate change, it will encourage you to add your own solutions to the list. |
| plos one computational biology: Regulatory Genomics Eleazar Eskin, Chris Workman, 2005-01-28 This book constitutes the thoroughly refereed post-proceedings of the RECOMB 2004 Satellite Workshop on Regulatory Genomics, RRG 2004, held in San Diego, CA, USA in March 2004. The 10 revised full papers presented were carefully reviewed and improved for inclusion in the book. The papers address a broad variety of aspects of regulatory genomics including classification, functional module detection, proteonomics, sampling, kernel methods, TF binding motifs, gene expression data analysis, regulatory network model learning, RNA regulatory sequence motifs, DNA regulatory sequence motifs, parameter landscape analysis, and biological network regulation. |
| plos one computational biology: Deadly Medicines and Organised Crime Peter C. Gøtzsche, Drummond Rennie, 2013 This title exposes the pharmaceutical industries and their charade of fraudulent behaviour, both in research and marketing where the morally repugnant disregard for human lives is the norm. |
| plos one computational biology: Enhanced Publications Marjan Vernooy-Gerritsen, 2009 The traditional publication will be overhauled by the ‘Enhanced Publication’. This is a publication that is enhanced with research data, extra materials, post publication data, and database records. It has an object-based structure with explicit links between the objects. In this book a state-of-the-art overview is given of the structural elements of an Enhanced Publication, as well as publication models, interrelationship and repository issues. The use of Enhanced Publications evokes questions on object models and functionalities. In-depth study is made of these subjects. More practically, a sample is given of datasets together with a demonstrator-project. In the final section, this book deals with long-term preservation issues, linking to the developments of digital repositories that are studied in other books in this series. |
| plos one computational biology: The Art and Politics of Science Harold Varmus, 2009 The nobel prize winning scientist and former director of the National Institue of Health recalls the events of his life and career in science, in an autobiography that also incorporates scientific information about cancer biology and issues in public health. |
| plos one computational biology: Evolution of Translational Omics Institute of Medicine, Board on Health Sciences Policy, Board on Health Care Services, Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, 2012-09-13 Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials. |
| plos one computational biology: The Perfect Predator Steffanie Strathdee, Thomas Patterson, 2019-02-26 An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. A memoir that reads like a thriller. -New York Times Book Review A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short. -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka the perfect predator, can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis. |
| plos one computational biology: Synthetic Sophia Roosth, 2017-03-01 In the final years of the twentieth century, émigrés from engineering and computer science devoted themselves to biology and resolved that if the aim of biology is to understand life, then making life would yield better theories than experimentation. Armed with the latest biotechnology techniques, these scientists treated biological media as elements for design and manufacture: viruses named for computers, bacterial genomes encoding passages from James Joyce, chimeric yeast buckling under the metabolic strain of genes harvested from wormwood, petunias, and microbes from Icelandic thermal pools. In Synthetic: How Life Got Made, cultural anthropologist Sophia Roosth reveals how synthetic biologists make new living things in order to understand better how life works. The first book-length ethnographic study of this discipline, Synthetic documents the social, cultural, rhetorical, economic, and imaginative transformations biology has undergone in the post-genomic age. Roosth traces this new science from its origins at MIT to start-ups, laboratories, conferences, and hackers’ garages across the United States—even to contemporary efforts to resurrect extinct species. Her careful research reveals that rather than opening up a limitless new field, these biologists’ own experimental tactics circularly determine the biological features, theories, and limits they fasten upon. Exploring the life sciences emblematic of our time, Synthetic tells the origin story of the astonishing claim that biological making fosters biological knowing. |
| plos one computational biology: Visualization Analysis and Design Tamara Munzner, 2014-12-01 Learn How to Design Effective Visualization SystemsVisualization Analysis and Design provides a systematic, comprehensive framework for thinking about visualization in terms of principles and design choices. The book features a unified approach encompassing information visualization techniques for abstract data, scientific visualization techniques |
| plos one computational biology: Modern Statistics for Modern Biology SUSAN. HUBER HOLMES (WOLFGANG.), Wolfgang Huber, 2018 |
| plos one computational biology: The Writers' and Artists' Yearbook Guide to Getting Published Harry Bingham, 2010-09-23 Invaluable to writers of all kinds Mark Le Fanu, The Society of Authors Written emphatically from the author's point of view, this is an expert guide to the process of getting published, from submitting your work and finding an agent, to working with a publishing house and understanding the book trade. Together with interviews from authors, agents and publishers (including the CEO of Harper Studio, and the Editorial Director of Pan Macmillan) as well as buyers from Waterstones and Asda - this is an expert guide to: * finding an agent or publisher * successful approaches for covering letters and synopses * understanding contractual terms * working with publishers and the editorial process * your role in helping to publicise your work Getting Published will enable you to market your work more professionally, understand the relationship you will have with both agent and publisher and offers a contemporary inside view of the publishing industry. Along with the essential contacts in the Writers and Artists Yearbook, this is a professional tool you will not want to be without. |
| plos one computational biology: Science Denial Gale M. Sinatra, Barbara K. Hofer, 2021 How do individuals decide whether to accept human causes of climate change, vaccinate their children, or wear a mask during a pandemic? In Science Denial: Why It Happens and What to Do About It, psychologists Gale Sinatra and Barbara Hofer identify the problem of science denial and offer tools for addressing it. |
| plos one computational biology: Rough Sets and Current Trends in Computing Shusaku Tsumoto, Roman Slowiński, Jan Komorowski, Jerzy W. Grzymala-Busse, 2004-05-21 In recent years rough set theory has attracted the attention of many researchers and practitioners all over the world, who have contributed essentially to its development and applications. Weareobservingagrowingresearchinterestinthefoundationsofroughsets, including the various logical, mathematical and philosophical aspects of rough sets. Some relationships have already been established between rough sets and other approaches, and also with a wide range of hybrid systems. As a result, rough sets are linked with decision system modeling and analysis of complex systems, fuzzy sets, neural networks, evolutionary computing, data mining and knowledge discovery, pattern recognition, machine learning, and approximate reasoning. In particular, rough sets are used in probabilistic reasoning, granular computing (including information granule calculi based on rough mereology), intelligent control, intelligent agent modeling, identi?cation of autonomous s- tems, and process speci?cation. Methods based on rough set theory alone or in combination with other - proacheshavebeendiscoveredwith awide rangeofapplicationsinsuchareasas: acoustics, bioinformatics, business and ?nance, chemistry, computer engineering (e.g., data compression, digital image processing, digital signal processing, p- allel and distributed computer systems, sensor fusion, fractal engineering), de- sion analysis and systems, economics, electrical engineering (e.g., control, signal analysis, power systems), environmental studies, informatics, medicine, mole- lar biology, musicology, neurology, robotics, social science, software engineering, spatial visualization, Web engineering, and Web mining. |
| plos one computational biology: Regulatory Genomics Hon Wai Leong, 2008 Research in the field of gene regulation is evolving rapidly in the ever-changing scientific environment. Advances in microarray techniques and comparative genomics have enabled more comprehensive studies of regulatory genomics. The study of genomic binding locations of transcription factors has enabled a more comprehensive modeling of regulatory networks. In addition, complete genomic sequences and comparison of numerous related species have demonstrated the conservation of non-coding DNA sequences, which often provide evidence for cis-regulatory binding sites. Systematic methods to decipher the regulatory mechanism are also crucial for corroborating these regulatory networks; key to these methods are motif discovery algorithms that can help predict cis-regulatory elements. These DNA-motif discovery programs are becoming more sophisticated and are beginning to leverage evidence from comparative genomics. These topics and more were discussed at the 3rd Annual RECOMB Workshop on Regulatory Genomics, which brought together more than 90 attendees and included about 22 excellent talks from leading researchers in the field. This proceedings volume contains ten selected, original manuscripts that were presented during the workshop. |
| plos one computational biology: Sick Societies David Stuckler, Karen Siegel, 2011-10-20 Chronic diseases-heart disease, diabetes, lung disease, and common cancers-claim more than one out of every two lives worldwide. Within the next few decades their toll will rise, most greatly in developing countries. Yet this rapid growth of chronic diseases is not being met with a proportionate global response. Left unaddressed, they pose a major threat to social and economic development. This book is the first to synthesize the growing evidence-base surrounding chronic disease, comprehensively addressing the prevention and control of chronic diseases from epidemiologic, economic, prevention/management, and political economy perspectives. Sick Societies is written in five main parts. The first three chapters explore the causes and consequences of chronic diseases on a global level. Chapter four identifi es different approaches to preventing and managing chronic diseases, while chapters five and six consider the power and politics in global health that have stymied an effective response to chronic disease. In chapter seven, the themes from the first three parts come into focus through a series of invited contributions from leading public health experts. The final chapter sets out a model of pragmatic and imaginative solidarity, wherein the struggles of the rich and poor to survive are united by a common cause and shared goals. |
| plos one computational biology: Reading Peer Review Martin Paul Eve, Cameron Neylon, Daniel Paul O'Donnell, Samuel Moore, Robert Gadie, Victoria Odeniyi, Shahina Parvin, 2020-12-31 This Element describes for the first time the database of peer review reports at PLOS ONE, the largest scientific journal in the world, to which the authors had unique access. Specifically, this Element presents the background contexts and histories of peer review, the data-handling sensitivities of this type of research, the typical properties of reports in the journal to which the authors had access, a taxonomy of the reports, and their sentiment arcs. This unique work thereby yields a compelling and unprecedented set of insights into the evolving state of peer review in the twenty-first century, at a crucial political moment for the transformation of science. It also, though, presents a study in radicalism and the ways in which PLOS's vision for science can be said to have effected change in the ultra-conservative contemporary university. This title is also available as Open Access on Cambridge Core. |
| plos one computational biology: Statistical Analysis of Network Data with R Eric D. Kolaczyk, Gábor Csárdi, 2014-05-22 Networks have permeated everyday life through everyday realities like the Internet, social networks, and viral marketing. As such, network analysis is an important growth area in the quantitative sciences, with roots in social network analysis going back to the 1930s and graph theory going back centuries. Measurement and analysis are integral components of network research. As a result, statistical methods play a critical role in network analysis. This book is the first of its kind in network research. It can be used as a stand-alone resource in which multiple R packages are used to illustrate how to conduct a wide range of network analyses, from basic manipulation and visualization, to summary and characterization, to modeling of network data. The central package is igraph, which provides extensive capabilities for studying network graphs in R. This text builds on Eric D. Kolaczyk’s book Statistical Analysis of Network Data (Springer, 2009). |
| plos one computational biology: The Bitterest Pills J. Moncrieff, 2013-09-15 A challenging reappraisal of the history of antipsychotics, revealing how they were transformed from neurological poisons into magical cures, their benefits exaggerated and their toxic effects minimized or ignored. |
| plos one computational biology: Computational Cancer Biology Mathukumalli Vidyasagar, 2012-11-23 This brief introduces people with a basic background in probability theory to various problems in cancer biology that are amenable to analysis using methods of probability theory and statistics. The title mentions “cancer biology” and the specific illustrative applications reference cancer data but the methods themselves are more broadly applicable to all aspects of computational biology. Aside from providing a self-contained introduction to basic biology and to cancer, the brief describes four specific problems in cancer biology that are amenable to the application of probability-based methods. The application of these methods is illustrated by applying each of them to actual data from the biology literature. After reading the brief, engineers and mathematicians should be able to collaborate fruitfully with their biologist colleagues on a wide variety of problems. |
| plos one computational biology: Ant Encounters Deborah M. Gordon, 2010-03-22 How do ant colonies get anything done, when no one is in charge? An ant colony operates without a central control or hierarchy, and no ant directs another. Instead, ants decide what to do based on the rate, rhythm, and pattern of individual encounters and interactions--resulting in a dynamic network that coordinates the functions of the colony. Ant Encounters provides a revealing and accessible look into ant behavior from this complex systems perspective. Focusing on the moment-to-moment behavior of ant colonies, Deborah Gordon investigates the role of interaction networks in regulating colony behavior and relations among ant colonies. She shows how ant behavior within and between colonies arises from local interactions of individuals, and how interaction networks develop as a colony grows older and larger. The more rapidly ants react to their encounters, the more sensitively the entire colony responds to changing conditions. Gordon explores whether such reactive networks help a colony to survive and reproduce, how natural selection shapes colony networks, and how these structures compare to other analogous complex systems. Ant Encounters sheds light on the organizational behavior, ecology, and evolution of these diverse and ubiquitous social insects. |
| plos one computational biology: How People Learn II National Academies of Sciences, Engineering, and Medicine, Division of Behavioral and Social Sciences and Education, Board on Science Education, Board on Behavioral, Cognitive, and Sensory Sciences, Committee on How People Learn II: The Science and Practice of Learning, 2018-10-27 There are many reasons to be curious about the way people learn, and the past several decades have seen an explosion of research that has important implications for individual learning, schooling, workforce training, and policy. In 2000, How People Learn: Brain, Mind, Experience, and School: Expanded Edition was published and its influence has been wide and deep. The report summarized insights on the nature of learning in school-aged children; described principles for the design of effective learning environments; and provided examples of how that could be implemented in the classroom. Since then, researchers have continued to investigate the nature of learning and have generated new findings related to the neurological processes involved in learning, individual and cultural variability related to learning, and educational technologies. In addition to expanding scientific understanding of the mechanisms of learning and how the brain adapts throughout the lifespan, there have been important discoveries about influences on learning, particularly sociocultural factors and the structure of learning environments. How People Learn II: Learners, Contexts, and Cultures provides a much-needed update incorporating insights gained from this research over the past decade. The book expands on the foundation laid out in the 2000 report and takes an in-depth look at the constellation of influences that affect individual learning. How People Learn II will become an indispensable resource to understand learning throughout the lifespan for educators of students and adults. |
| plos one computational biology: Kernel Methods in Computational Biology Bernhard Schölkopf, Koji Tsuda, Jean-Philippe Vert, 2004 A detailed overview of current research in kernel methods and their application to computational biology. |
| plos one computational biology: The Book Of Strange New Things Michel Faber, 2014-11-18 I am with you always, even unto the end of the world . . . Peter Leigh is a missionary called to go on the journey of a lifetime. Leaving behind his beloved wife, Bea, he boards a flight for a remote and unfamiliar land, a place where the locals are hungry for the teachings of the Bible—his book of strange new things. It is a quest that will challenge Peter's beliefs, his understanding of the limits of the human body and, most of all, his love for Bea. The Book of Strange New Things is a wildly original tale of adventure, faith and the ties that might hold two people together when they are worlds apart. This momentous novel from the author of The Crimson Petal and the White sees Faber at his expectation-defying best. |
| plos one computational biology: Introduction to Computational Molecular Biology João Carlos Setubal, João Meidanis, 1997 Basic concepts of molecular biology. Strings, graphs, and algorithms. Sequence comparasion and database search. Fragment assembly of DNA. Physical mapping of DNA. Phylogenetic trees. Genome rearrangements. Molecular structure prediction. epilogue: computing with DNA. Answers to selected exercises. References. index. |
| plos one computational biology: Public Access to Federally-funded Research United States. Congress. House. Committee on Oversight and Government Reform. Subcommittee on Information Policy, Census, and National Archives, 2011 |
| plos one computational biology: BIOINFORMATICS, FIFTH EDITION RASTOGI, S.C., RASTOGI, PARAG, MENDIRATTA, NAMITA, 2022-04-05 Designed as a comprehensive text for students and professionals pursuing careers in the fields of bioinformatics, molecular biology, pharmacy and drug research, the Fifth Edition continues to offer a fascinating and authoritative treatment of the entire spectrum of bioinformatics, covering a wide range of high-throughput technologies. The content can be used for four core courses: bioinformatics fundamentals, genomics, proteomics and drug discovery and design. The Fifth Edition takes a completely new pedagogical approach and the book is divided into eight distinct Units for the ease of learning: Bioinformatics Fundamentals, Sequence Alignment, Phylogenetic Analysis, Genomics, Protein Structure and Function, Drug Discovery Methods, Drug Design and Development and Integrative Topics. Accordingly, all the chapters are revised and updated in the new edition, besides introduction of seven new chapters and another seven completely re-written chapters. As a student-friendly text, it embodies several pedagogical features such as detailed examples, numerous tables, a large number of diagrams, flow charts and web resources. The book in its present edition should prove an invaluable asset to the students and researchers in the fields of bioinformatics, biotechnology, computer-aided drug design, information technology, medical diagnostics, molecular biology and pharmaceutical sciences. NEW TO THE FIFTH EDITION • Re-written chapters — Biological database search and data retrieval, Pair-wise alignment of sequences, PSSMs and Hidden Markov Models, Gene Mapping, Gene Prediction, Protein Structure Overview and Protein Structure Prediction. • Inclusion of new chapters—Scoring Matrices, Gene Sequencing, Regulatory Elements Prediction, Comparative Genomics, Protein Structure Databases, Protein Function Prediction and Potential Drug Targets. KEY FEATURES • Covers the field of bioinformatics in a complete and integrated approach – moving from the fundamentals to theory and practical applications. • State-of-the-art technologies for gene identification, molecular modeling and monitoring of cellular processes. • Data mining, data curation and analysis, classification, interpretation and efficient structure determination of genomes and proteomes. • Companion website provides useful resources for the teachers as well as for the students. So, visit Learning Centre https:// www.phindia.com/bioinformatics_mendiratta_rastogi to have access of Lecture notes, solutions manual, MCQs, problems set for practice, glossary of important terms, etc. TARGET AUDIENCE • UG and PG Students of Bioinformatics, Biotechnology, Molecular Biology and Pharmacy. |
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Leading the future of open science publishing - PLOS
PLOS is a non-profit organization on a mission to drive open science forward with measurable, meaningful change in research publishing, policy, and practice.
PLOS One
Feb 11, 2025 · Discover a faster, simpler path to publishing in a high-quality journal. PLOS ONE promises fair, rigorous peer review, broad scope, and wide readership – a perfect fit for your …
PLOS Medicine
Mar 26, 2025 · Antimicrobial Resistance: Addressing a Global Threat to Humanity. In this Editorial, Guest Editors Timothy R. Walsh, Ana C. Gales, Ramanan Laxminarayan, and our …
PLOS - Wikipedia
PLOS (for Public Library of Science; PLoS until 2012 [1]) is a nonprofit publisher of open-access journals in science, technology, and medicine and other scientific literature, under an open …
Our journal portfolio - PLOS
Our leading life science journal, PLOS Biology is a leading life science journal that champions inclusive, high-impact research across all disciplines—from molecules to ecosystems. We …
PLOS Biology
May 30, 2025 · Malaria parasites survive in red blood cells by breaking down hemoglobin in their digestive vacuole (DV). Gagandeep Saggu, Sanjay Desai and coworkers identify BVAC as a …
About PLOS
Building on a strong legacy of pioneering innovation, PLOS continues to be a catalyst, reimagining models to meet open science principles, removing barriers and promoting inclusion in …
About Collections - PLOS Collections
Feb 3, 2025 · PLOS Collections help you discover topics that fascinate you and keep you up-to-date with the latest research in your community. Covering a connected body of work and …
Analyses of electronic health records utilization in a large ... - PLOS
Jul 1, 2020 · Introduction The Electronic Health Record (EHR) has become an integral component of healthcare delivery. Survey based studies have estimated that physicians spend 4–6 hours …
PLOS journal policies
PLOS is a member of the Committee on Publication Ethics (COPE) and abides by the COPE Code of Conduct and best practices. We investigate all concerns raised about PLOS …
