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| modeling life the mathematics of biological systems solutions: Modeling Life Alan Garfinkel, Jane Shevtsov, Yina Guo, 2017-09-06 This book develops the mathematical tools essential for students in the life sciences to describe interacting systems and predict their behavior. From predator-prey populations in an ecosystem, to hormone regulation within the body, the natural world abounds in dynamical systems that affect us profoundly. Complex feedback relations and counter-intuitive responses are common in nature; this book develops the quantitative skills needed to explore these interactions. Differential equations are the natural mathematical tool for quantifying change, and are the driving force throughout this book. The use of Euler’s method makes nonlinear examples tractable and accessible to a broad spectrum of early-stage undergraduates, thus providing a practical alternative to the procedural approach of a traditional Calculus curriculum. Tools are developed within numerous, relevant examples, with an emphasis on the construction, evaluation, and interpretation of mathematical models throughout. Encountering these concepts in context, students learn not only quantitative techniques, but how to bridge between biological and mathematical ways of thinking. Examples range broadly, exploring the dynamics of neurons and the immune system, through to population dynamics and the Google PageRank algorithm. Each scenario relies only on an interest in the natural world; no biological expertise is assumed of student or instructor. Building on a single prerequisite of Precalculus, the book suits a two-quarter sequence for first or second year undergraduates, and meets the mathematical requirements of medical school entry. The later material provides opportunities for more advanced students in both mathematics and life sciences to revisit theoretical knowledge in a rich, real-world framework. In all cases, the focus is clear: how does the math help us understand the science? |
| modeling life the mathematics of biological systems solutions: A Biologist's Guide to Mathematical Modeling in Ecology and Evolution Sarah P. Otto, Troy Day, 2011-09-19 Thirty years ago, biologists could get by with a rudimentary grasp of mathematics and modeling. Not so today. In seeking to answer fundamental questions about how biological systems function and change over time, the modern biologist is as likely to rely on sophisticated mathematical and computer-based models as traditional fieldwork. In this book, Sarah Otto and Troy Day provide biology students with the tools necessary to both interpret models and to build their own. The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction. Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists. A how-to guide for developing new mathematical models in biology Provides step-by-step recipes for constructing and analyzing models Interesting biological applications Explores classical models in ecology and evolution Questions at the end of every chapter Primers cover important mathematical topics Exercises with answers Appendixes summarize useful rules Labs and advanced material available |
| modeling life the mathematics of biological systems solutions: Modeling and Simulation in Medicine and the Life Sciences Frank C. Hoppensteadt, Charles S. Peskin, 2012-12-06 Mathematics in Medicine and the Life Sciences grew from lectures given by the authors at New York University, the University of Utah, and Michigan State University. The material is written for students who have had but one term of calculus, but it contains material that can be used in modeling courses in applied mathematics at all levels through early graduate courses. Numerous exercises are given as well, and solutions to selected exercises are included. Numerous illustrations depict physiological processes, population biology phenomena, models of them, and the results of computer simulations. Mathematical models and methods are becoming increasingly important in medicine and the life sciences. This book provides an introduction to a wide diversity of problems ranging from population phenomena to demographics, genetics, epidemics and dispersal; in physiological processes, including the circulation, gas exchange in the lungs, control of cell volume, the renal counter-current multiplier mechanism, and muscle mechanics; to mechanisms of neural control. Each chapter is graded in difficulty, so a reading of the first parts of each provides an elementary introduction to the processes and their models. Materials that deal with the same topics but in greater depth are included later. Finally, exercises and some solutions are given to test the reader on important parts of the material in the text, or to lead the reader to the discovery of interesting extensions of that material. |
| modeling life the mathematics of biological systems solutions: Calculus for the Life Sciences James L. Cornette, Ralph A. Ackerman, 2015-12-30 Freshman and sophomore life sciences students respond well to the modeling approach to calculus, difference equations, and differential equations presented in this book. Examples of population dynamics, pharmacokinetics, and biologically relevant physical processes are introduced in Chapter 1, and these and other life sciences topics are developed throughout the text. The students should have studied algebra, geometry, and trigonometry, but may be life sciences students because they have not enjoyed their previous mathematics courses. |
| modeling life the mathematics of biological systems solutions: Mathematical Modeling of Complex Biological Systems Abdelghani Bellouquid, Marcello Delitala, 2007-10-10 This book describes the evolution of several socio-biological systems using mathematical kinetic theory. Specifically, it deals with modeling and simulations of biological systems whose dynamics follow the rules of mechanics as well as rules governed by their own ability to organize movement and biological functions. It proposes a new biological model focused on the analysis of competition between cells of an aggressive host and cells of a corresponding immune system. Proposed models are related to the generalized Boltzmann equation. The book may be used for advanced graduate courses and seminars in biological systems modeling. |
| modeling life the mathematics of biological systems solutions: Collective Behavior In Systems Biology Assaf Steinschneider, 2019-09-04 Collective Behavior In Systems Biology: A Primer on Modeling Infrastructure offers a survey of established and emerging methods for quantifying process behavior in cellular systems. It introduces and applies mathematics and related abstract methods to processes in biological systems - why they are used, how they work, and what they mean. Emphasizing differential equations in an interdisciplinary approach, this book discusses infrastructure for kinetic modeling, technological system and control theories, optimization, and process behavior in cellular networks. The knowledge that the reader gains will be valuable for entering and keeping up with a rapidly developing discipline. - Introduces basics of mathematical and abstract methods for understanding, predicting, and modifying collective behavior in cellular systems - Targets biomedical professionals as well as computational specialists who are willing to take advantage of novel high-throughput data acquisition technologies |
| modeling life the mathematics of biological systems solutions: A Primer in Mathematical Models in Biology Lee A. Segel, Leah Edelstein-Keshet, 2013-05-09 A textbook on mathematical modelling techniques with powerful applications to biology, combining theoretical exposition with exercises and examples. |
| modeling life the mathematics of biological systems solutions: Mathematical Models for Society and Biology Edward Beltrami, 2013-06-19 Mathematical Models for Society and Biology, 2e, is a useful resource for researchers, graduate students, and post-docs in the applied mathematics and life science fields. Mathematical modeling is one of the major subfields of mathematical biology. A mathematical model may be used to help explain a system, to study the effects of different components, and to make predictions about behavior. Mathematical Models for Society and Biology, 2e, draws on current issues to engagingly relate how to use mathematics to gain insight into problems in biology and contemporary society. For this new edition, author Edward Beltrami uses mathematical models that are simple, transparent, and verifiable. Also new to this edition is an introduction to mathematical notions that every quantitative scientist in the biological and social sciences should know. Additionally, each chapter now includes a detailed discussion on how to formulate a reasonable model to gain insight into the specific question that has been introduced. - Offers 40% more content – 5 new chapters in addition to revisions to existing chapters - Accessible for quick self study as well as a resource for courses in molecular biology, biochemistry, embryology and cell biology, medicine, ecology and evolution, bio-mathematics, and applied math in general - Features expanded appendices with an extensive list of references, solutions to selected exercises in the book, and further discussion of various mathematical methods introduced in the book |
| modeling life the mathematics of biological systems solutions: Methods and Models in Mathematical Biology Johannes Müller, Christina Kuttler, 2015-08-13 This book developed from classes in mathematical biology taught by the authors over several years at the Technische Universität München. The main themes are modeling principles, mathematical principles for the analysis of these models and model-based analysis of data. The key topics of modern biomathematics are covered: ecology, epidemiology, biochemistry, regulatory networks, neuronal networks and population genetics. A variety of mathematical methods are introduced, ranging from ordinary and partial differential equations to stochastic graph theory and branching processes. A special emphasis is placed on the interplay between stochastic and deterministic models. |
| modeling life the mathematics of biological systems solutions: Mathematics in Medicine and the Life Sciences Frank C. Hoppensteadt, Charles S. Peskin, 2013-03-09 The aim of this book is to introduce the subject of mathematical modeling in the life sciences. It is intended for students of mathematics, the physical sciences, and engineering who are curious about biology. Additionally, it will be useful to students of the life sciences and medicine who are unsatisfied with mere description and who seek an understanding of biological mechanism and dynamics through the use of mathematics. The book will be particularly useful to premedical students, because it will introduce them not only to a collection of mathematical methods but also to an assortment of phenomena involving genetics, epidemics, and the physiology of the heart, lung, and kidney. Because of its introductory character, mathematical prerequisites are kept to a minimum; they involve only what is usually covered in the first semester of a calculus sequence. The authors have drawn on their extensive experience as modelers to select examples which are simple enough to be understood at this elementary level and yet realistic enough to capture the essence of significant biological phenomena drawn from the areas of population dynamics and physiology. Because the models presented are realistic, the book can serve not only as an introduction to mathematical methods but also as a mathematical introduction to the biological material itself. For the student, who enjoys mathematics, such an introduction will be far more stimulating and satisfying than the purely descriptive approach that is traditional in the biological sciences. |
| modeling life the mathematics of biological systems solutions: Mathematical Models in Biology Leah Edelstein-Keshet, 1987-12-01 This book is an introduction for readers interested in biological applications of mathematics and modeling in biology, showing how relatively simple mathematics can be applied to a variety of models. Despite the great advances that have taken place, the simple lessons described in the text are still important and informative. |
| modeling life the mathematics of biological systems solutions: Mathematical Modeling for the Life Sciences Jacques Istas, 2005-06-09 Provides a wide range of mathematical models currently used in the life sciences Each model is thoroughly explained and illustrated by example Includes three appendices to allow for independent reading |
| modeling life the mathematics of biological systems solutions: Mathematical Models in Biology Elizabeth Spencer Allman, John A. Rhodes, 2004 This introductory textbook on mathematical biology focuses on discrete models across a variety of biological subdisciplines. Biological topics treated include linear and non-linear models of populations, Markov models of molecular evolution, phylogenetic tree construction, genetics, and infectious disease models. The coverage of models of molecular evolution and phylogenetic tree construction from DNA sequence data is unique among books at this level. Computer investigations with MATLAB are incorporated throughout, in both exercises and more extensive projects, to give readers hands-on experience with the mathematical models developed. MATLAB programs accompany the text. Mathematical tools, such as matrix algebra, eigenvector analysis, and basic probability, are motivated by biological models and given self-contained developments, so that mathematical prerequisites are minimal. |
| modeling life the mathematics of biological systems solutions: Mathematics for the Life Sciences Erin N. Bodine, Suzanne Lenhart, Louis J. Gross, 2014-08-17 An accessible undergraduate textbook on the essential math concepts used in the life sciences The life sciences deal with a vast array of problems at different spatial, temporal, and organizational scales. The mathematics necessary to describe, model, and analyze these problems is similarly diverse, incorporating quantitative techniques that are rarely taught in standard undergraduate courses. This textbook provides an accessible introduction to these critical mathematical concepts, linking them to biological observation and theory while also presenting the computational tools needed to address problems not readily investigated using mathematics alone. Proven in the classroom and requiring only a background in high school math, Mathematics for the Life Sciences doesn't just focus on calculus as do most other textbooks on the subject. It covers deterministic methods and those that incorporate uncertainty, problems in discrete and continuous time, probability, graphing and data analysis, matrix modeling, difference equations, differential equations, and much more. The book uses MATLAB throughout, explaining how to use it, write code, and connect models to data in examples chosen from across the life sciences. Provides undergraduate life science students with a succinct overview of major mathematical concepts that are essential for modern biology Covers all the major quantitative concepts that national reports have identified as the ideal components of an entry-level course for life science students Provides good background for the MCAT, which now includes data-based and statistical reasoning Explicitly links data and math modeling Includes end-of-chapter homework problems, end-of-unit student projects, and select answers to homework problems Uses MATLAB throughout, and MATLAB m-files with an R supplement are available online Prepares students to read with comprehension the growing quantitative literature across the life sciences A solutions manual for professors and an illustration package is available |
| modeling life the mathematics of biological systems solutions: Physical Models of Living Systems Philip Nelson, 2014-12-20 This textbook helps students develop many of the competencies that form the basis of the MCAT2015. The only prerequisite for this is first-year physics. With the more advanced Track-2 sections at the end of each chapter, the book can be used in graduate-level courses as well. Written for intermediate-level undergraduates pursuing any science or engineering major, Physical Models of Living Systems, gives students the research skills they require but are often left unaddressed in traditional courses. Skills such as basic modeling, probabilistic modeling and data analysis methods. All of these basic skills, which are relevant to nearly any field of science or engineering, are presented in the context of case studies from living systems. This living systems include virus dynamics, bacterial genetics, statistical inference and synthetic biology. |
| modeling life the mathematics of biological systems solutions: Modeling and Differential Equations in Biology T. A. Burton, 1980-09-01 Persistence in lotka-volterra models of food chains and competition; Mathematical models of humoral immune response; Mathematical models of dose and cell cycle effects in multifraction radiotherapy; Theorical and experimental investigations of microbial competition in continuous culture; A liapunov functional for a class of reaction-diffusion systems; Stochastic prey-predator relationships; Coexistence in predator-prey systems; Stability of some multispecies population models; Population dynamics in patchy environments; Limit cycles in a model of b-cell simulation; Optimal age-specific harvesting policy for a cintinuous time-population model; Models involving differential and integral equations appropriate for describing a temperature dependent predator-prey mite ecosystem on apples. |
| modeling life the mathematics of biological systems solutions: Mathematical Models in Biology Valeria Zazzu, Maria Brigida Ferraro, Mario R. Guarracino, 2015 This book presents an exciting collection of contributions based on the workshop Bringing Maths to Life held October 27-29, 2014 in Naples, Italy. The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this Work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. In depth discussions of the mathematical analysis required to extract insights from complex bodies of biological datasets, to aid development in the field novel algorithms, methods and software tools for genetic variability, molecular dynamics, and complex biological systems are presented in this book. Researchers and graduate students in biology, life science, and mathematics/statistics will find the content useful as it addresses existing challenges in identifying the gaps between mathematical modeling and biological research. The shared solutions will aid and promote further collaboration between life sciences and mathematics. |
| modeling life the mathematics of biological systems solutions: Mathematical Modeling in Systems Biology Brian P. Ingalls, 2022-06-07 An introduction to the mathematical concepts and techniques needed for the construction and analysis of models in molecular systems biology. Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels. The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3–8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis. |
| modeling life the mathematics of biological systems solutions: Parabolic Equations in Biology Benoît Perthame, 2015-09-09 This book presents several fundamental questions in mathematical biology such as Turing instability, pattern formation, reaction-diffusion systems, invasion waves and Fokker-Planck equations. These are classical modeling tools for mathematical biology with applications to ecology and population dynamics, the neurosciences, enzymatic reactions, chemotaxis, invasion waves etc. The book presents these aspects from a mathematical perspective, with the aim of identifying those qualitative properties of the models that are relevant for biological applications. To do so, it uncovers the mechanisms at work behind Turing instability, pattern formation and invasion waves. This involves several mathematical tools, such as stability and instability analysis, blow-up in finite time, asymptotic methods and relative entropy properties. Given the content presented, the book is well suited as a textbook for master-level coursework. |
| modeling life the mathematics of biological systems solutions: Systems Biology Edda Klipp, Wolfram Liebermeister, Christoph Wierling, Axel Kowald, 2016-03-28 This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems biology has been included. |
| modeling life the mathematics of biological systems solutions: The Mathematics of Life Ian Stewart, 2011-06-07 Biologists have long dismissed mathematics as being unable to meaningfully contribute to our understanding of living beings. Within the past ten years, however, mathematicians have proven that they hold the key to unlocking the mysteries of our world -- and ourselves. In The Mathematics of Life, Ian Stewart provides a fascinating overview of the vital but little-recognized role mathematics has played in pulling back the curtain on the hidden complexities of the natural world -- and how its contribution will be even more vital in the years ahead. In his characteristically clear and entertaining fashion, Stewart explains how mathematicians and biologists have come to work together on some of the most difficult scientific problems that the human race has ever tackled, including the nature and origin of life itself. |
| modeling life the mathematics of biological systems solutions: Modeling Biological Systems: James W. Haefner, 2005-12-05 I Principles 1 1 Models of Systems 3 1. 1 Systems. Models. and Modeling . . . . . . . . . . . . . . . . . . . . 3 1. 2 Uses of Scientific Models . . . . . . . . . . . . . . . . . . . . . . . . 4 1. 3 Example: Island Biogeography . . . . . . . . . . . . . . . . . . . . . 6 1. 4 Classifications of Models . . . . . . . . . . . . . . . . . . . . . . . . 10 1. 5 Constraints on Model Structure . . . . . . . . . . . . . . . . . . . . . 12 1. 6 Some Terminology . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 1. 7 Misuses of Models: The Dark Side . . . . . . . . . . . . . . . . . . . 13 1. 8 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 2 The Modeling Process 17 2. 1 Models Are Problems . . . . . . . . . . . . . . . . . . . . . . . . . . 17 2. 2 Two Alternative Approaches . . . . . . . . . . . . . . . . . . . . . . 18 2. 3 An Example: Population Doubling Time . . . . . . . . . . . . . . . . 24 2. 4 Model Objectives . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 2. 5 Exercises . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 3 Qualitative Model Formulation 32 3. 1 How to Eat an Elephant . . . . . . . . . . . . . . . . . . . . . . . . . 32 3. 2 Forrester Diagrams . . . . . . . . . . . . . . . . . . . . . . . . . . . 33 3. 3 Examples . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 3. 4 Errors in Forrester Diagrams . . . . . . . . . . . . . . . . . . . . . . 44 3. 5 Advantages and Disadvantages of Forrester Diagrams . . . . . . . . . 44 3. 6 Principles of Qualitative Formulation . . . . . . . . . . . . . . . . . . 45 3. 7 Model Simplification . . . . . . . . . . . . . . . . . . . . . . . . . . 47 3. 8 Other Modeling Problems . . . . . . . . . . . . . . . . . . . . . . . . 49 viii Contents . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3. 9 Exercises 53 4 Quantitative Model Formulation: I 4. 1 From Qualitative to Quantitative . . . . . . . . . . . . . . . . . Finite Difference Equations and Differential Equations 4. 2 . . . . . . . . . . . . . . . . 4. 3 Biological Feedback in Quantitative Models . . . . . . . . . . . . . . . . . . . . . . . . . . 4. 4 Example Model . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4. 5 Exercises 5 Quantitative Model Formulation: I1 81 . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 1 Physical Processes 81 . . . . . . . . . . . . . . . 5. 2 Using the Toolbox of Biological Processes 89 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 3 Useful Functions 96 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 4 Examples 102 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5. 5 Exercises 104 6 Numerical Techniques 107 . . . . . . . . . . . . . . . . . . . . . . . 6. 1 Mistakes Computers Make 107 . . . . . . . . . . . . . . . . . . . . . . . . . . 6. 2 Numerical Integration 110 . . . . . . . . . . . . . . . . 6. 3 Numerical Instability and Stiff Equations 115 . . . . . . . . . . . . . . |
| modeling life the mathematics of biological systems solutions: Essential Mathematical Biology Nicholas Britton, 2005-12-16 This self-contained introduction to the fast-growing field of Mathematical Biology is written for students with a mathematical background. It sets the subject in a historical context and guides the reader towards questions of current research interest. A broad range of topics is covered including: Population dynamics, Infectious diseases, Population genetics and evolution, Dispersal, Molecular and cellular biology, Pattern formation, and Cancer modelling. Particular attention is paid to situations where the simple assumptions of homogenity made in early models break down and the process of mathematical modelling is seen in action. |
| modeling life the mathematics of biological systems solutions: Gibbs Measures In Biology And Physics: The Potts Model Utkir A Rozikov, 2022-07-28 This book presents recently obtained mathematical results on Gibbs measures of the q-state Potts model on the integer lattice and on Cayley trees. It also illustrates many applications of the Potts model to real-world situations in biology, physics, financial engineering, medicine, and sociology, as well as in some examples of alloy behavior, cell sorting, flocking birds, flowing foams, and image segmentation.Gibbs measure is one of the important measures in various problems of probability theory and statistical mechanics. It is a measure associated with the Hamiltonian of a biological or physical system. Each Gibbs measure gives a state of the system.The main problem for a given Hamiltonian on a countable lattice is to describe all of its possible Gibbs measures. The existence of some values of parameters at which the uniqueness of Gibbs measure switches to non-uniqueness is interpreted as a phase transition.This book informs the reader about what has been (mathematically) done in the theory of Gibbs measures of the Potts model and the numerous applications of the Potts model. The main aim is to facilitate the readers (in mathematical biology, statistical physics, applied mathematics, probability and measure theory) to progress into an in-depth understanding by giving a systematic review of the theory of Gibbs measures of the Potts model and its applications. |
| modeling life the mathematics of biological systems solutions: The Mathematical Nature of the Living World Gilbert Chauvet, 2005 The topic of the book a theory of functional biology thatincorporates the fundamental principles underlying the functioning ofliving organisms is clearly appropriate as we celebrate the 50thanniversary of the discovery by Watson and Crick of the structure ofthe DNA molecule. |
| modeling life the mathematics of biological systems solutions: Mathematical Modelling in Health, Social and Applied Sciences Hemen Dutta, 2020-02-29 This book discusses significant research findings in the field of mathematical modelling, with particular emphasis on important applied-sciences, health, and social issues. It includes topics such as model on viral immunology, stochastic models for the dynamics of influenza, model describing the transmission of dengue, model for human papillomavirus (HPV) infection, prostate cancer model, realization of economic growth by goal programming, modelling of grazing periodic solutions in discontinuous systems, modelling of predation system, fractional epidemiological model for computer viruses, and nonlinear ecological models. A unique addition in the proposed areas of research and education, this book is a valuable resource for graduate students, researchers and educators associated with the study of mathematical modelling of health, social and applied-sciences issues. Readers interested in applied mathematics should also find this book valuable. |
| modeling life the mathematics of biological systems solutions: Mathematical Modeling and Simulation Kai Velten, 2009-06-01 This concise and clear introduction to the topic requires only basic knowledge of calculus and linear algebra - all other concepts and ideas are developed in the course of the book. Lucidly written so as to appeal to undergraduates and practitioners alike, it enables readers to set up simple mathematical models on their own and to interpret their results and those of others critically. To achieve this, many examples have been chosen from various fields, such as biology, ecology, economics, medicine, agricultural, chemical, electrical, mechanical and process engineering, which are subsequently discussed in detail. Based on the author`s modeling and simulation experience in science and engineering and as a consultant, the book answers such basic questions as: What is a mathematical model? What types of models do exist? Which model is appropriate for a particular problem? What are simulation, parameter estimation, and validation? The book relies exclusively upon open-source software which is available to everybody free of charge. The entire book software - including 3D CFD and structural mechanics simulation software - can be used based on a free CAELinux-Live-DVD that is available in the Internet (works on most machines and operating systems). |
| modeling life the mathematics of biological systems solutions: Ocular Fluid Dynamics Giovanna Guidoboni, Alon Harris, Riccardo Sacco, 2019-11-25 The chapters in this contributed volume showcase current theoretical approaches in the modeling of ocular fluid dynamics in health and disease. By including chapters written by experts from a variety of fields, this volume will help foster a genuinely collaborative spirit between clinical and research scientists. It vividly illustrates the advantages of clinical and experimental methods, data-driven modeling, and physically-based modeling, while also detailing the limitations of each approach. Blood, aqueous humor, vitreous humor, tear film, and cerebrospinal fluid each have a section dedicated to their anatomy and physiology, pathological conditions, imaging techniques, and mathematical modeling. Because each fluid receives a thorough analysis from experts in their respective fields, this volume stands out among the existing ophthalmology literature. Ocular Fluid Dynamics is ideal for current and future graduate students in applied mathematics and ophthalmology who wish to explore the field by investigating open questions, experimental technologies, and mathematical models. It will also be a valuable resource for researchers in mathematics, engineering, physics, computer science, chemistry, ophthalmology, and more. |
| modeling life the mathematics of biological systems solutions: Delay Differential Equations and Applications to Biology Fathalla A. Rihan, 2021-08-19 This book discusses the numerical treatment of delay differential equations and their applications in bioscience. A wide range of delay differential equations are discussed with integer and fractional-order derivatives to demonstrate their richer mathematical framework compared to differential equations without memory for the analysis of dynamical systems. The book also provides interesting applications of delay differential equations in infectious diseases, including COVID-19. It will be valuable to mathematicians and specialists associated with mathematical biology, mathematical modelling, life sciences, immunology and infectious diseases. |
| modeling life the mathematics of biological systems solutions: Introduction to Mathematical Biology Ching Shan Chou, Avner Friedman, 2018-05-27 This book is based on a one semester course that the authors have been teaching for several years, and includes two sets of case studies. The first includes chemostat models, predator-prey interaction, competition among species, the spread of infectious diseases, and oscillations arising from bifurcations. In developing these topics, readers will also be introduced to the basic theory of ordinary differential equations, and how to work with MATLAB without having any prior programming experience. The second set of case studies were adapted from recent and current research papers to the level of the students. Topics have been selected based on public health interest. This includes the risk of atherosclerosis associated with high cholesterol levels, cancer and immune interactions, cancer therapy, and tuberculosis. Readers will experience how mathematical models and their numerical simulations can provide explanations that guide biological and biomedical research. Considered to be the undergraduate companion to the more advanced book Mathematical Modeling of Biological Processes (A. Friedman, C.-Y. Kao, Springer – 2014), this book is geared towards undergraduate students with little background in mathematics and no biological background. |
| modeling life the mathematics of biological systems solutions: Fitting Models to Biological Data Using Linear and Nonlinear Regression Harvey Motulsky, Arthur Christopoulos, 2004-05-27 Most biologists use nonlinear regression more than any other statistical technique, but there are very few places to learn about curve-fitting. This book, by the author of the very successful Intuitive Biostatistics, addresses this relatively focused need of an extraordinarily broad range of scientists. |
| modeling life the mathematics of biological systems solutions: Understanding Complex Biological Systems with Mathematics Ami Radunskaya, Rebecca Segal, Blerta Shtylla, 2018-10-24 This volume examines a variety of biological and medical problems using mathematical models to understand complex system dynamics. Featured topics include autism spectrum disorder, ectoparasites and allogrooming, argasid ticks dynamics, super-fast nematocyst firing, cancer-immune population dynamics, and the spread of disease through populations. Applications are investigated with mathematical models using a variety of techniques in ordinary and partial differential equations, difference equations, Markov-chain models, Monte-Carlo simulations, network theory, image analysis, and immersed boundary method. Each article offers a thorough explanation of the methodologies used and numerous tables and color illustrations to explain key results. This volume is suitable for graduate students and researchers interested in current applications of mathematical models in the biosciences. The research featured in this volume began among newly-formed collaborative groups at the 2017 Women Advancing Mathematical Biology Workshop that took place at the Mathematical Biosciences Institute in Columbus, Ohio. The groups spent one intensive week working at MBI and continued their collaborations after the workshop, resulting in the work presented in this volume. |
| modeling life the mathematics of biological systems solutions: Feedback Systems Karl Johan Åström, Richard Murray, 2021-02-02 The essential introduction to the principles and applications of feedback systems—now fully revised and expanded This textbook covers the mathematics needed to model, analyze, and design feedback systems. Now more user-friendly than ever, this revised and expanded edition of Feedback Systems is a one-volume resource for students and researchers in mathematics and engineering. It has applications across a range of disciplines that utilize feedback in physical, biological, information, and economic systems. Karl Åström and Richard Murray use techniques from physics, computer science, and operations research to introduce control-oriented modeling. They begin with state space tools for analysis and design, including stability of solutions, Lyapunov functions, reachability, state feedback observability, and estimators. The matrix exponential plays a central role in the analysis of linear control systems, allowing a concise development of many of the key concepts for this class of models. Åström and Murray then develop and explain tools in the frequency domain, including transfer functions, Nyquist analysis, PID control, frequency domain design, and robustness. Features a new chapter on design principles and tools, illustrating the types of problems that can be solved using feedback Includes a new chapter on fundamental limits and new material on the Routh-Hurwitz criterion and root locus plots Provides exercises at the end of every chapter Comes with an electronic solutions manual An ideal textbook for undergraduate and graduate students Indispensable for researchers seeking a self-contained resource on control theory |
| modeling life the mathematics of biological systems solutions: Mathematics in Nature John Adam, 2011-10-02 From rainbows, river meanders, and shadows to spider webs, honeycombs, and the markings on animal coats, the visible world is full of patterns that can be described mathematically. Examining such readily observable phenomena, this book introduces readers to the beauty of nature as revealed by mathematics and the beauty of mathematics as revealed in nature. Generously illustrated, written in an informal style, and replete with examples from everyday life, Mathematics in Nature is an excellent and undaunting introduction to the ideas and methods of mathematical modeling. It illustrates how mathematics can be used to formulate and solve puzzles observed in nature and to interpret the solutions. In the process, it teaches such topics as the art of estimation and the effects of scale, particularly what happens as things get bigger. Readers will develop an understanding of the symbiosis that exists between basic scientific principles and their mathematical expressions as well as a deeper appreciation for such natural phenomena as cloud formations, halos and glories, tree heights and leaf patterns, butterfly and moth wings, and even puddles and mud cracks. Developed out of a university course, this book makes an ideal supplemental text for courses in applied mathematics and mathematical modeling. It will also appeal to mathematics educators and enthusiasts at all levels, and is designed so that it can be dipped into at leisure. |
| modeling life the mathematics of biological systems solutions: Mathematical Modeling of Biological Systems, Volume II Andreas Deutsch, Rafael Bravo de la Parra, Rob J. de Boer, Odo Diekmann, Peter Jagers, Eva Kisdi, Mirjam Kretzschmar, Petr Lansky, Hans Metz, 2007-10-12 Volume II of this two-volume, interdisciplinary work is a unified presentation of a broad range of state-of-the-art topics in the rapidly growing field of mathematical modeling in the biological sciences. Highlighted throughout are mathematical and computational apporaches to examine central problems in the life sciences, ranging from the organization principles of individual cells to the dynamics of large populations. The chapters are thematically organized into the following main areas: epidemiology, evolution and ecology, immunology, neural systems and the brain, and innovative mathematical methods and education. The work will be an excellent reference text for a broad audience of researchers, practitioners, and advanced students in this rapidly growing field at the intersection of applied mathematics, experimental biology and medicine, computational biology, biochemistry, computer science, and physics. |
| modeling life the mathematics of biological systems solutions: Nonlinear Dynamics and Chaos Steven H. Strogatz, 2018-05-04 This textbook is aimed at newcomers to nonlinear dynamics and chaos, especially students taking a first course in the subject. The presentation stresses analytical methods, concrete examples, and geometric intuition. The theory is developed systematically, starting with first-order differential equations and their bifurcations, followed by phase plane analysis, limit cycles and their bifurcations, and culminating with the Lorenz equations, chaos, iterated maps, period doubling, renormalization, fractals, and strange attractors. |
| modeling life the mathematics of biological systems solutions: Mathematical Methods in Biology J. David Logan, William Wolesensky, 2009-08-17 A one-of-a-kind guide to using deterministic and probabilistic methods for solving problems in the biological sciences Highlighting the growing relevance of quantitative techniques in scientific research, Mathematical Methods in Biology provides an accessible presentation of the broad range of important mathematical methods for solving problems in the biological sciences. The book reveals the growing connections between mathematics and biology through clear explanations and specific, interesting problems from areas such as population dynamics, foraging theory, and life history theory. The authors begin with an introduction and review of mathematical tools that are employed in subsequent chapters, including biological modeling, calculus, differential equations, dimensionless variables, and descriptive statistics. The following chapters examine standard discrete and continuous models using matrix algebra as well as difference and differential equations. Finally, the book outlines probability, statistics, and stochastic methods as well as material on bootstrapping and stochastic differential equations, which is a unique approach that is not offered in other literature on the topic. In order to demonstrate the application of mathematical methods to the biological sciences, the authors provide focused examples from the field of theoretical ecology, which serve as an accessible context for study while also demonstrating mathematical skills that are applicable to many other areas in the life sciences. The book's algorithms are illustrated using MATLAB®, but can also be replicated using other software packages, including R, Mathematica®, and Maple; however, the text does not require any single computer algebra package. Each chapter contains numerous exercises and problems that range in difficulty, from the basic to more challenging, to assist readers with building their problem-solving skills. Selected solutions are included at the back of the book, and a related Web site features supplemental material for further study. Extensively class-tested to ensure an easy-to-follow format, Mathematical Methods in Biology is an excellent book for mathematics and biology courses at the upper-undergraduate and graduate levels. It also serves as a valuable reference for researchers and professionals working in the fields of biology, ecology, and biomathematics. |
| modeling life the mathematics of biological systems solutions: Mathematical Modelling in Science and Technology Xavier J.R. Avula, Rudolf E. Kalman, Anthanasios I. Liapis, 2014-05-09 Mathematical Modelling in Science and Technology: The Fourth International Conference covers the proceedings of the Fourth International Conference by the same title, held at the Swiss Federal Institute of Technology, Zurich, Switzerland on August 15-17, 1983. Mathematical modeling is a powerful tool to solve many complex problems presented by scientific and technological developments. This book is organized into 20 parts encompassing 180 chapters. The first parts present the basic principles, methodology, systems theory, parameter estimation, system identification, and optimization of mathematical modeling. The succeeding parts discuss the features of stochastic and numerical modeling and simulation languages. Considerable parts deal with the application areas of mathematical modeling, such as in chemical engineering, solid and fluid mechanics, water resources, medicine, economics, transportation, and industry. The last parts tackle the application of mathematical modeling in student management and other academic cases. This book will prove useful to researchers in various science and technology fields. |
| modeling life the mathematics of biological systems solutions: Probabilistic Boolean Networks Ilya Shmulevich, Edward R. Dougherty, 2010-01-01 This is the first comprehensive treatment of probabilistic Boolean networks (PBNs), an important model class for studying genetic regulatory networks. This book covers basic model properties, including the relationships between network structure and dynamics, steady-state analysis, and relationships to other model classes. Researchers in mathematics, computer science, and engineering are exposed to important applications in systems biology and presented with ample opportunities for developing new approaches and methods. The book is also appropriate for advanced undergraduates, graduate students, and scientists working in the fields of computational biology, genomic signal processing, control and systems theory, and computer science. |
Modelling or modeling? - WordReference Forums
Feb 28, 2007 · In the case of modeling/modelling, this amounts to a wash, since there are two possible pronunciation of modeling by a (very) naive speller. But in most other three-syllable …
modeling (psychotherapy) - WordReference Forums
May 1, 2009 · In psychotherapy, "Modeling" is the process through which, by observing the coherence between the therapist’s words and deeds, the client vicariously learns different …
3D Modelling - WordReference Forums
Nov 11, 2008 · Hey guys I was just wondering if anyone could translate 3D Modelling into Japanese for me, I wanted to say to a friend of mine "I am going to study 3D Modelling at …
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Oct 6, 2008 · I am working with a textbook author who is modeling the use of the subjunctive with cualquier, quienquiera, dondequiera, etc. She is concerned that the following two sentences …
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Aug 5, 2011 · The following is from an English exercise given by my son's teacher. 40% of lizard species worldwide could be extinct by 2080. Barry Sinerro reached the conclusion by taking …
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Jan 18, 2025 · A typo? It’s creosote bush. 中文名：三齿拉瑞阿 英（外）文名：Creosote Bush 拉丁学名：Larrea tridentata
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Apr 10, 2020 · 1 is by far the most natural way to say it. 2 is wrong. 3 is okay, but there’s no obvious reason to spell it out like that.
Year followed by E (e.g. 2019e, 2019E) (financial reporting)
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encamamiento de pacientes - WordReference Forums
Oct 25, 2006 · Hola a todos: Estoy traduciendo un documento sobre equipo médico, el texto en el que tengo duda es: El equipo es para pacientes en encamamiento, UCI y sala de …
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Jan 30, 2009 · Hola a todos!! Tengo que traducir esta frase pero estoy en duda: " publicar los productos que se van incorporando a la página web" Mi intento: "publish the products which …
Modelling or modeling? - WordReference Forums
Feb 28, 2007 · In the case of modeling/modelling, this amounts to a wash, since there are two possible pronunciation of modeling by a (very) naive speller. But in most other three-syllable …
modeling (psychotherapy) - WordReference Forums
May 1, 2009 · In psychotherapy, "Modeling" is the process through which, by observing the coherence between the therapist’s words and deeds, the client vicariously learns different …
3D Modelling - WordReference Forums
Nov 11, 2008 · Hey guys I was just wondering if anyone could translate 3D Modelling into Japanese for me, I wanted to say to a friend of mine "I am going to study 3D Modelling at …
cuandoquiera - WordReference Forums
Oct 6, 2008 · I am working with a textbook author who is modeling the use of the subjunctive with cualquier, quienquiera, dondequiera, etc. She is concerned that the following two sentences …
comparing it against/with | WordReference Forums
Aug 5, 2011 · The following is from an English exercise given by my son's teacher. 40% of lizard species worldwide could be extinct by 2080. Barry Sinerro reached the conclusion by taking …
creosote bush | WordReference Forums
Jan 18, 2025 · A typo? It’s creosote bush. 中文名：三齿拉瑞阿 英（外）文名：Creosote Bush 拉丁学名：Larrea tridentata
today's meeting or today meeting | WordReference Forums
Apr 10, 2020 · 1 is by far the most natural way to say it. 2 is wrong. 3 is okay, but there’s no obvious reason to spell it out like that.
Year followed by E (e.g. 2019e, 2019E) (financial reporting)
Oct 20, 2020 · Hello, Could someone tell me what the letter E tacked onto the numeral representation of a year means in a stock market report, e.g. in the following quote: "Oddo …
encamamiento de pacientes - WordReference Forums
Oct 25, 2006 · Hola a todos: Estoy traduciendo un documento sobre equipo médico, el texto en el que tengo duda es: El equipo es para pacientes en encamamiento, UCI y sala de …
se van incorporando a | WordReference Forums
Jan 30, 2009 · Hola a todos!! Tengo que traducir esta frase pero estoy en duda: " publicar los productos que se van incorporando a la página web" Mi intento: "publish the products which …
