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| neurobiology shepherd: Fundamental Neuroscience Larry Squire, James L. Roberts, Nicholas C. Spitzer, Michael J. Zigmond, Darwin Berg, Floyd E. Bloom, Sascha du Lac, Anirvan Ghosh, Larry R. Squire, Susan K. McConnell, 2002-11-19 With over 300 training programs in neuroscience currently in existence, demand is great for a comprehensive textbook that both introduces graduate students to the full range of neuroscience, from molecular biology to clinical science, but also assists instructors in offering an in-depth course in neuroscience to advanced undergraduates.The second edition of Fundamental Neuroscience accomplishes all this and more. The thoroughly revised text features over 25% new material including completely new chapters, illustrations, and a CD-ROM containing all the figures from the text. More concise and manageable than the previous edition, this book has been retooled to better serve its audience in the neuroscience and medical communities.Key Features* Logically organized into 7 sections, with uniform editing of the content for a one-voice feel throughout all 54 chapters* Includes numerous text boxes with concise, detailed descriptions of specific experiments, disorders, methodological approaches, and concepts* Well-illustrated with over 850 full color figures, also included on the accompanying CD-ROM |
| neurobiology shepherd: Neurogastronomy Gordon Shepherd, 2013-07-16 Leading neuroscientist Gordon M. Shepherd embarks on a paradigm-shifting trip through the human brain flavor system, laying the foundations for a new scientific field: neurogastronomy. Challenging the belief that the sense of smell diminished during human evolution, Shepherd argues that this sense, which constitutes the main component of flavor, is far more powerful and essential than previously believed. Shepherd begins Neurogastronomy with the mechanics of smell, particularly the way it stimulates the nose from the back of the mouth. As we eat, the brain conceptualizes smells as spatial patterns, and from these and the other senses it constructs the perception of flavor. Shepherd then considers the impact of the flavor system on contemporary social, behavioral, and medical issues. He analyzes flavor's engagement with the brain regions that control emotion, food preferences, and cravings, and he even devotes a section to food's role in drug addiction and, building on Marcel Proust's iconic tale of the madeleine, its ability to evoke deep memories. Shepherd connects his research to trends in nutrition, dieting, and obesity, especially the challenges that many face in eating healthily. He concludes with human perceptions of smell and flavor and their relationship to the neural basis of consciousness. Everyone from casual diners and ardent foodies to wine critics, chefs, scholars, and researchers will delight in Shepherd's fascinating, scientific-gastronomic adventures. |
| neurobiology shepherd: Neurobiology Gordon M. Shepherd, 1988 The second edition of this highly acclaimed textbook was thoroughly revised to incorporate a multitude of recent research findings in neuroscience. A new chapter on molecular neurobiology was added and the basic concepts of the synapse, impulse, neurotransmitters, and neuromodulators were put on a molecular basis. The author greatly extended the treatment of developmental and memory mechanisms and also introduced the field of neuroimmunology. |
| neurobiology shepherd: The Synaptic Organization of the Brain Gordon M. Shepherd, 2004 This is a thorough revision of the standard text on local circuits in the different regions of the brain. In this fifth edition, the results of the mouse and human genome projects are incorporated for the first time. Also for the first time, the reader is oriented to supporting neuroscience databases. Among the new advances covered are 2-photon confocal laser microscopy of dendrites and dendritic spines, biochemical analyses, and dual patch and multielectrode recordings, applied together with an increasing range of behavioral and gene-targeting methods. |
| neurobiology shepherd: The Neurobiology of Olfaction Anna Menini, 2009-11-24 Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely |
| neurobiology shepherd: Neurogastronomy Gordon M. Shepherd, 2011-12-02 “A personal yet magisterial account of the new brain-based approach to flavor perception . . . [a] panoramic view of science, culture, and behavior.”—Avery Gilbert, author of What the Nose Knows Leading neuroscientist Gordon M. Shepherd embarks on a paradigm-shifting trip through the “human brain flavor system,” laying the foundations for a new scientific field: neurogastronomy. Challenging the belief that the sense of smell diminished during human evolution, Shepherd argues that this sense, which constitutes the main component of flavor, is far more powerful and essential than previously believed. Shepherd begins Neurogastronomy with the mechanics of smell, particularly the way it stimulates the nose from the back of the mouth. As we eat, the brain conceptualizes smells as spatial patterns, and from these and the other senses it constructs the perception of flavor. Shepherd then considers the impact of the flavor system on contemporary social, behavioral, and medical issues. He analyzes flavor’s engagement with the brain regions that control emotion, food preferences, and cravings, and he even devotes a section to food’s role in drug addiction and, building on Marcel Proust’s iconic tale of the madeleine, its ability to evoke deep memories. Shepherd connects his research to trends in nutrition, dieting, and obesity, especially the challenges that many face in eating healthily. He concludes with human perceptions of smell and flavor and their relationship to the neural basis of consciousness. Everyone from casual diners and ardent foodies to wine critics, chefs, scholars, and researchers will delight in Shepherd’s fascinating, scientific-gastronomic adventures. “Those who make the effort will be rewarded: they’ll never look at eating the same way again.”—Library Journal |
| neurobiology shepherd: Creating Modern Neuroscience: The Revolutionary 1950s Gordon M. Shepherd MD, DPhil, 2009-10-28 For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more. The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances. |
| neurobiology shepherd: Neurobiology Georg F. Striedter, 2016 Focusing on the problems that brains help organisms solve, Neurobiology: A Functional Approach asks not only how the nervous system works but also why it works as it does. This text introduces readers to neurobiology through an evolutionary, organismal, and experimental perspective. With a strong emphasis on neural circuits and systems, it bridges the gap between the cellular and molecular end and the cognitive end of the neuroscience spectrum, allowing students to grasp the full breadth of the subject. Neurobiology covers not only what neuroscientists have learned about the brain in terms of facts and ideas, but also how they have learned it through key experiments. |
| neurobiology shepherd: Biological Neural Networks: Hierarchical Concept of Brain Function Konstantin V. Baev, 2012-12-06 This book is devoted to a novel conceptual theoretical framework of neuro science and is an attempt to show that we can postulate a very small number of assumptions and utilize their heuristics to explain a very large spectrum of brain phenomena. The major assumption made in this book is that inborn and acquired neural automatisms are generated according to the same func tional principles. Accordingly, the principles that have been revealed experi mentally to govern inborn motor automatisms, such as locomotion and scratching, are used to elucidate the nature of acquired or learned automat isms. This approach allowed me to apply the language of control theory to describe functions of biological neural networks. You, the reader, can judge the logic of the conclusions regarding brain phenomena that the book derives from these assumptions. If you find the argument flawless, one can call it common sense and consider that to be the best praise for a chain of logical conclusions. For the sake of clarity, I have attempted to make this monograph as readable as possible. Special attention has been given to describing some of the concepts of optimal control theory in such a way that it will be under standable to a biologist or physician. I have also included plenty of illustra tive examples and references designed to demonstrate the appropriateness and applicability of these conceptual theoretical notions for the neurosciences. |
| neurobiology shepherd: Fundamental Neuroscience Larry R. Squire, 2008 The fourth edition of Fundamental Neuroscience reinvents itself as an engrossing and comprehensive presentation of the discipline of neuroscience, from molecules to cognition. Thorough but succinct, and lavishly illustrated, the book builds from an introductory section that includes fundamental neuroanatomy and goes on to cover cellular and molecular neuroscience, development, sensory systems, motor systems, regulatory systems, and behavioral and cognitive neuroscience. The book has been retooled to better serve its audience in the neuroscience and medical communities. The chapters include more than 100 boxes describing clinical conditions, techniques, and other special topics. Each chapter went through a thorough review process, giving the book an evenness of tone. The chapters are authored by outstanding working scientists who are experts on the topics they cover. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries 30% new material including new chapters on dendritic development and spine morphogenesis, chemical senses, cerebellum, eye movements, circadian timing, sleep and dreaming, and consciousness Accompanying website for students and instructors Additional text boxes describing key experiments, disorders, methods, and concepts More than 650 four-color illustrations, micrographs, and neuroimages Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing |
| neurobiology shepherd: Instinct and Revelation Alondra Oubre, 2013-10-11 Instinct and Revelation revolves around the hypothesis that ritual behavior and imaginative awareness in early hominids may have helped to spawn the evolution of the human brain and human consciousness. Using an integral perspective comparable with systems theory, the book carefully interweaves fact and theory from physical and cultural anthropology, psychobiology and the brain sciences, psychology, and to a lesser degree, eastern philosophy. This book breaks from tradition by discussing from a primarily anthropological perspective the origin of human consciousness within a philosophical framework that embraces precepts from human evolution, evolutionary psychology, the neurosciences, biocultural anthropology, and cultural symbolic anthropology. |
| neurobiology shepherd: The Neurobiological Basis of Memory and Behavior Hinrich Rahmann, Mathilde Rahmann, 2012-12-06 Of all the areas of biological science, there is, perhaps, none that has experienced in recent decades so great an increase in findings as neurobiology, the discipline that concerns memory in all of its myriad aspects. The notion of exploring memory, that capacity to store and recall individual experience, has received attention increasingly in our society. Of course, animals can exhibit astounding powers of memory, but memory is of paramount importance to human beings due to the significant role it plays in the transmission of our cultural traditions. It is tradition, after all, that ensures the passing on of qualities established by lineage, a continuous link from generation to generation, between past and present. And it is tradition that inspires bodies of thought (knowledge and customs, for example) to be handed down by a multiplicity of information bearing devices (i. e. , word, writing, picture, electronic data carriers). The objective of this book is to inform the reader in one clear volume of the groundwork which has been established in memory research from the diverse disciplines of neurobiology. It is intended, primarily, for students of medicine, zoology, biology, psychology and psychiatry, but will certainly prove to be a valuable resource to others with a healthy interest in the area. |
| neurobiology shepherd: Principles of Neurobiology Liqun Luo, 2015-07-14 Principles of Neurobiology presents the major concepts of neuroscience with an emphasis on how we know what we know. The text is organized around a series of key experiments to illustrate how scientific progress is made and helps upper-level undergraduate and graduate students discover the relevant primary literature. Written by a single author in |
| neurobiology shepherd: The Central Nervous System of Vertebrates Rudolf Nieuwenhuys, Hendrik Jan Donkelaar, Charles Nicholson, 1998 This comprehensive reference is clearly destined to become the definitive anatomical basis for all molecular neuroscience research. The three volumes provide a complete overview and comparison of the structural organisation of all vertebrate groups, ranging from amphioxus and lamprey through fishes, amphibians and birds to mammals. This thus allows a systematic treatment of the concepts and methodology found in modern comparative neuroscience. Neuroscientists, comparative morphologists and anatomists will all benefit from: * 1,200 detailed and standardised neuroanatomical drawings * the illustrations were painstakingly hand-drawn by a team of graphic designers, specially commissioned by the authors, over a period of 25 years * functional correlations of vertebrate brains * concepts and methodology of modern comparative neuroscience * five full-colour posters giving an overview of the central nervous system of the vertebrates, ideal for mounting and display This monumental work is, and will remain, unique; the only source of such brilliant illustrations at both the macroscopic and microscopic levels. |
| neurobiology shepherd: Cognitive and Behavioral Rehabilitation Jennie Ponsford, 2004-01-23 Written by leading experts in the field, this invaluable text situates the practice of cognitive and behavioral rehabilitation in the latest research from neurobiology and cognitive neuroscience. Initial chapters review current findings on neuronal injury, plasticity, and recovery. The volume next examines the neurobiology of core cognitive domains--attention, memory, language, visuospatial awareness, and executive functioning--focusing on the processes underpinning both healthy and impaired functioning. Highlighting the practical applications of the research, authors describe available interventions in each domain and set forth clear recommendations for clinical practice. Also addressed are ways to understand and manage challenging behaviors, such as aggression, that may emerge in brain-injured persons. The concluding chapter provides overall strategies for helping people recover from the two most common forms of acquired neurological disability: traumatic brain injury and stroke. |
| neurobiology shepherd: The Neurobehavioral and Social-emotional Development of Infants and Children Edward Tronick, 2007 Organized into five parts, this book represents his major ideas and studies regarding infant-adult interactions, developmental processes, and mutual regulation.--BOOK JACKET. |
| neurobiology shepherd: Theoretical Mechanics of Biological Neural Networks Ronald J. MacGregor, 2012-12-02 Theoretical Mechanics of Biological Neural Networks presents an extensive and coherent discusson and formulation of the generation and integration of neuroelectric signals in single neurons. The approach relates computer simulation programs for neurons of arbitrary complexity to fundamental gating processes of transmembrance ionic fluxes of synapses of excitable membranes. Listings of representative computer programs simulating arbitrary neurons, and local and composite neural networks are included. - Develops a theory of dynamic similarity for characterising the firing rate sensitivites of neurons in terms of their characteristic anatomical and physiological parameters - Presents the sequential configuration theory - a theoretical presentation of coordinated firing patterns in entire neural population - Presents the outlines of mechanics for multiple interacting networks in composite systems |
| neurobiology shepherd: The Theoretical Foundation of Dendritic Function Wilfrid Rall, 1995 This collection of fifteen previously published papers, some of them not widely available, have been carefully chosen and annotated by Rall's colleagues and other leading neuroscientists. |
| neurobiology shepherd: Microcircuits Sten Grillner, Ann M. Graybiel, 2006 Leading neuroscientists discuss the function of microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior. Microcircuits, functional modules that act as elementary processing units bridging single cells to systems and behavior, could provide the link between neurons and global brain function. Microcircuits are designed to serve particular functions; examples of these functional modules include the cortical columns in sensory cortici, glomeruli in the olfactory systems of insects and vertebrates, and networks generating different aspects of motor behavior. In this Dahlem Workshop volume, leading neuroscientists discuss how microcircuits work to bridge the single cell and systems levels and compare the intrinsic function of microcircuits with their ion channel subtypes, connectivity, and receptors, in order to understand the design principles and function of the microcircuits. The chapters cover the four major areas of microcircuit research: motor systems, including locomotion, respiration, and the saccadic eye movements; the striatum, the largest input station of the basal ganglia; olfactory systems and the neural organization of the glomeruli; and the neocortex. Each chapter is followed by a group report, a collaborative discussion among senior scientists. Contributors Lidia Alonso-Nanclares, Hagai Bergman, Maria Blatow, J. Paul Bolam, Ansgar Büschges, Antonio Caputi, Jean-Pierre Changeux, Javier DeFelipe, Carsten Duch, Paul Feinstein, Stuart Firestein, Yves Frégnac, Rainer W. Friedrich, C. Giovanni Galizia, Ann M. Graybiel, Charles A. Greer, Sten Grillner, Tadashi Isa, Ole Kiehn, Minoru Kimura, Anders Lanser, Gilles Laurent, Pierre-Marie Lledo, Wolfgang Maass, Henry Markram, David A. McCormick, Christoph M. Michel, Peter Mombaerts, Hannah Monyer, Hans-Joachim Pflüger, Dietmar Plenz, Diethelm W. Richter, Silke Sachse, H. Sebastian Seung, Keith T. Sillar, Jeffrey C. Smith, David L. Sparks, D. James Surmeier, Eörs Szathmáry, James M. Tepper, Jeff R. Wickens, Rafael Yuste |
| neurobiology shepherd: Brain Theory C. Wolfe, 2014-05-13 Philosophy has long puzzled over the relation between mind and brain. This volume presents some of the state-of-the-art reflections on philosophical efforts to 'make sense' of neuroscience, as regards issue including neuroaesthetics, brain science and the law, neurofeminism, embodiment, race, memory and pain. |
| neurobiology shepherd: From Molecules to Networks Ruth Heidelberger, M. Neal Waxham, John H. Byrne, James L. Roberts, 2009-01-27 An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. - Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook - Discusses emerging new understanding of non-classical molecules that affect neuronal signaling - Full colour, professional graphics throughout - Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer's disease |
| neurobiology shepherd: Handbook of Brain Microcircuits Gordon M. Shepherd, Sten Grillner, 2018 In order to focus on principles, each chapter in this work is brief, organized around 1-3 wiring diagrams of the key circuits, with several pages of text that distil the functional significance of each microcircuit |
| neurobiology shepherd: Neuroinformatics Stephen H. Koslow, Michael F. Huerta, 2013-03-07 Modern neuroscience is providing profound insights into nature's most mysterious puzzle -- the human brain -- while applications of information and computer science are transforming the way people interact with each other and with the world around them. The new science of neuroinformatics, which sits at the junction, integrates knowledge and promises to catalyze progress in these dynamic and seemingly disparate areas of study. Neuroinformatics research will allow brain and behavioral scientists to make better sense and use of their data through advanced information tools and approaches. These include new ways to acquire, store, visualize, analyze, integrate, synthesize, and share data, as well as the means for electronic scientific collaboration. In this country, the principal source of support for neuroinformatics research is the Human Brain Project. The project, which is led by the National Institute of Mental Health, now supports neuroinformatics research performed by over 60 scientists. This volume presents the findings of the first group of researchers. Their efforts will begin to arm the next generation of brain and behavioral scientists with tools to attack the serious problem of information overload, and ultimately relate their findings to those obtained from different species, levels of biological organization, methods, and laboratories. And the challenges presented by the amount, diversity, and complexity of brain and behavioral data will give informatics researchers the impetus to test and expand the limits of their own science. The work described in this volume signals a change in the way scientists interact with data, instruments and each other, and points the way to a very different and richer future understanding of the human brain and mind. |
| neurobiology shepherd: Neural Circuit Development and Function in the Healthy and Diseased Brain , 2013-05-06 The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development |
| neurobiology shepherd: Angelo Mosso's Circulation of Blood in the Human Brain Marcus E. Raichle, Gordon M. Shepherd, 2014-09-17 Modern brain imaging is revolutionizing the study of brain function in health and disease. However, few realize that its origins began in the nineteenth century with Dr. Angelo Mosso's pioneering experiments. A foremost Italian physiologist and scientist, Angelo Mosso studied several patients brought to him with head injuries that exposed their live brains to direct, long-term observation. He took advantage of these rare opportunities to document, for the first time, changes in cerebral blood flow in response to different stimuli, behaviors, and emotions, the very same changes that are now the basis for the measurements underlying modern functional brain imaging. Mosso was widely recognized by his contemporaries for his highly original studies, published both in Italian in 1878 and in German in 1881. Yet there has never been a translation through which this groundbreaking work could be appreciated by the English-speaking world. Indeed, Angelo Mosso's sophisticated experiments were to neuroscience what surgeon William Beaumont's in vivo observations were to gastric physiology fifty years earlier. This unique monograph establishes Mosso's rightful role as the pioneer of brain imaging. Through it, the modern reader, whether expert neuroscientist or interested student, can gain a new perspective on the author's remarkable insights: how behaviors as subtle as thinking about a subject or feeling an emotion produce the changes in pulsations of the brain that he observed and recorded for posterity. Special features of this volume include first a brief summary of Mosso's life. Two pioneers of modern brain imaging, Marcus E. Raichle (winner of the Kavli Prize for Neuroscience) and Gordon M. Shepherd (Yale University Professor of Neurobiology) then review Mosso's work and provide extensive commentary to explain its relevance to modern brain science. The authors not only emphasize Mosso's pioneering role in brain imaging, but also his fundamental contribution to the rise of cognitive neuroscience. The English translation (by historian of medicine Christiane Nockels Fabbri) follows, together with all of the plates and illustrations of the original volume. The result is a classic of neuroscience, now available for wide appreciation by neuroscientists, neurologists, psychologists, psychiatrists, historians of science and medicine, and the general public. |
| neurobiology shepherd: Behavioral Neurobiology of Bipolar Disorder and its Treatment Husseini K. Manji, Carlos A. Zarate Jr., 2010-11-10 This book offers the most up-to-date information about research surrounding the neurobiology of bipolar disorder as well as currently available and novel therapeutic options. The volume has assembled a widely respected group of preclinical and clinical researchers who bring their expertise to bear upon this illness by reviewing cutting-edge research and clinical evidence regarding the pathophysiology and treatment of bipolar disorder. Early chapters review the course and outcome and genetics of this highly heritable condition, including chapters on epigenetics and clinical endophenotypes. Several chapters offer a remarkably thorough and unique overview of the neurobiology of the disorder, including what is known from neuroimaging work and the development of animal models. Finally, the book covers treatment strategies for bipolar disorder, including both traditional and novel therapeutics, as well as non-pharmacological treatments. It offers both researchers and clinicians key insights into this devastating disorder. |
| neurobiology shepherd: Child and Adolescent Behavioral Health Edilma L. Yearwood, Geraldine S. Pearson, Jamesetta A. Newland, 2021-03-09 Research has shown that a range of adult psychiatric disorders and mental health problems originate at an early age, yet the psychiatric symptoms of an increasing number of children and adolescents are going unrecognized and untreated—there are simply not enough child psychiatric providers to meet this steadily rising demand. It is vital that advanced practice registered nurses (APRNs) and primary care practitioners take active roles in assessing behavioral health presentations and work collaboratively with families and other healthcare professionals to ensure that all children and adolescents receive appropriate treatment. Child and Adolescent Behavioral Health helps APRNs address the mental health needs of this vulnerable population, providing practical guidance on assessment guidelines, intervention and treatment strategies, indications for consultation, collaboration, referral, and more. Now in its second edition, this comprehensive and timely resource has been fully updated to include DSM-5 criteria and the latest guidance on assessing, diagnosing, and treating the most common behavioral health issues facing young people. New and expanded chapters cover topics including eating disorders, bullying and victimization, LGBTQ identity issues, and conducting research with high-risk children and adolescents. Edited and written by a team of accomplished child psychiatric and primary care practitioners, this authoritative volume: Provides state-of-the-art knowledge about specific psychiatric and behavioral health issues in multiple care settings Reviews the clinical manifestation and etiology of behavioral disorders, risk and management issues, and implications for practice, research, and education Offers approaches for interviewing children and adolescents, and strategies for integrating physical and psychiatric screening Discusses special topics such as legal and ethical issues, cultural influences, the needs of immigrant children, and child and adolescent mental health policy Features a new companion website containing clinical case studies to apply concepts from the chapters Designed to specifically address the issues faced by APRNs, Child and Adolescent Behavioral Health is essential reading for nurse practitioners and clinical nurse specialists, particularly those working in family, pediatric, community health, psychiatric, and mental health settings. *Second Place in the Child Health Category, 2021 American Journal of Nursing Book of the Year Awards* |
| neurobiology shepherd: Elements of Molecular Neurobiology C. U. M. Smith, 2003-06-13 This edition of the popular text incorporates recent advances in neurobiology enabled by modern molecular biology techniques. Understanding how the brain works from a molecular level allows research to better understand behaviours, cognition, and neuropathologies. Since the appearance six years ago of the second edition, much more has been learned about the molecular biology of development and its relations with early evolution. This evodevo (as it has come to be known) framework also has a great deal of bearing on our understanding of neuropathologies as dysfunction of early onset genes can cause neurodegeneration in later life. Advances in our understanding of the genomes and proteomes of a number of organisms also greatly influence our understanding of neurobiology. * Well known and widely used as a text throughout the UK, good reviews from students and lecturers. * Good complement to Fundementals of Psychopharmacology by Brian Leonard. This book will be of particular interest to biomedical undergraduates undertaking a neuroscience unit, neuroscience postgraduates, physiologists, pharmacologists. It is also a useful basic reference for university libraries. Maurice Elphick, Queen Mary, University of London I do like this book and it is the recommended textbook for my course in Molecular Neuroscience. The major strength of the book is the overall simplicity of the format both in terms of layout and diagrams. |
| neurobiology shepherd: The Book of GENESIS James M. Bower, David Beeman, 2012-12-06 This is the second edition of a step-by -step tutorial for professionals, researchers and students working in the area of neuroscience in general, and computational neuroscience in particular. It can also be used as an interactive self-study guide to understanding biological neuronal and network structure for those working in the area of artificial neural networks and the cognitive sciences. The tutorials are based upon the GENESIS neural simulation system, which is now being used for teaching and research in at least 26 countries. The following chapters consist of a combination of edited contributions from researchers in computational neuroscience and current users of the system, as well as several chapters that we have written ourselves. This book, and the tutorial simulations on which it is based, grew out of a simulation laboratory accompanying the annual Methods in Computational Neuroscience course taught at the Marine Biological Laboratory in Woods Hole, MA from 1988 to 1992. Since that time, the tutorials have been further developed and refined while being used in courses taught at Caltech and several other institutions, including the Crete course in Computational Neuroscience. For this second edition, we have made many revisions and additions based on comments, suggestions and corrections from members of the GENESIS Users Group, BABEL, and from students and teachers who have used this book. |
| neurobiology shepherd: Patterning and Cell Type Specification in the Developing CNS and PNS , 2013-05-06 The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells |
| neurobiology shepherd: The Computational Brain, 25th Anniversary Edition Patricia S. Churchland, Terrence J. Sejnowski, 2016-10-28 An anniversary edition of the classic work that influenced a generation of neuroscientists and cognitive neuroscientists. Before The Computational Brain was published in 1992, conceptual frameworks for brain function were based on the behavior of single neurons, applied globally. In The Computational Brain, Patricia Churchland and Terrence Sejnowski developed a different conceptual framework, based on large populations of neurons. They did this by showing that patterns of activities among the units in trained artificial neural network models had properties that resembled those recorded from populations of neurons recorded one at a time. It is one of the first books to bring together computational concepts and behavioral data within a neurobiological framework. Aimed at a broad audience of neuroscientists, computer scientists, cognitive scientists, and philosophers, The Computational Brain is written for both expert and novice. This anniversary edition offers a new preface by the authors that puts the book in the context of current research. This approach influenced a generation of researchers. Even today, when neuroscientists can routinely record from hundreds of neurons using optics rather than electricity, and the 2013 White House BRAIN initiative heralded a new era in innovative neurotechnologies, the main message of The Computational Brain is still relevant. |
| neurobiology shepherd: The Computational Brain Patricia Smith Churchland, Terrence Joseph Sejnowski, 1992 The Computational Brain addresses a broad audience: neuroscientists, computer scientists, cognitive scientists, and philosophers. It is written for both the expert and novice. A basic overview of neuroscience and computational theory is provided, followed by a study of some of the most recent and sophisticated modeling work in the context of relevant neurobiological research. Technical terms are clearly explained in the text, and definitions are provided in an extensive glossary. The appendix contains a précis of neurobiological techniques.--Jacket. |
| neurobiology shepherd: Rethinking Neural Networks Karl H. Pribram, 2014-04-08 The result of the first Appalachian Conference on neurodynamics, this volume focuses on processing in biological neural networks. How do brain processes become organized during decision making? That is, what are the neural antecedents that determine which course of action is to be pursued? Half of the contributions deal with modelling synapto-dendritic and neural ultrastructural processes; the remainder, with laboratory research findings, often cast in terms of the models. The interchanges at the conference and the ensuing publication also provide a foundation for further meetings. These will address how processes in different brain systems, coactive with the neural residues of experience and with sensory input, determine decisions. |
| neurobiology shepherd: Creating Modern Neuroscience: The Revolutionary 1950s Gordon M. Shepherd MD, DPhil, 2009-10-28 For modern scientists, history often starts with last week's journals and is regarded as largely a quaint interest compared with the advances of today. However, this book makes the case that, measured by major advances, the greatest decade in the history of brain studies was mid-twentieth century, especially the 1950s. The first to focus on worldwide contributions in this period, the book ranges through dozens of astonishing discoveries at all levels of the brain, from DNA (Watson and Crick), through growth factors (Hamburger and Levi-Montalcini), excitability (Hodgkin and Huxley), synapses (Katz and Eccles), dopamine and Parkinson's (Carlsson), visual processing (Hartline and Kuffler), the cortical column (Mountcastle), reticular activating system (Morruzzi and Magoun) and REM sleep (Aserinsky), to stress (Selye), learning (Hebb) and memory (HM and Milner). The clinical fields are also covered, from Cushing and Penfield, psychosurgery and brain energy metabolism (Kety), to most of the major psychoactive drugs in use today (beginning with Delay and Deniker), and much more. The material has been the basis for a highly successful advanced undergraduate and graduate course at Yale, with the classic papers organized and accessible on the web. There is interest for a wide range of readers, academic, and lay because there is a focus on the creative process itself, on understanding how the combination of unique personalities, innovative hypotheses, and new methods led to the advances. Insight is given into this process through describing the struggles between male and female, student and mentor, academic and private sector, and the roles of chance and persistence. The book thus provides a new multidisciplinary understanding of the revolution that created the modern field of neuroscience and set the bar for judging current and future advances. |
| neurobiology shepherd: Olfaction Joel L. Davis, Howard Eichenbaum, 1991 Computational neuroscientists have recently turned to modeling olfactory structures because these are likely to have the same functional properties as currently popular network designs for perception and memory. This book provides a useful survey of current work on olfactory system circuitry, including connections of this system to brain structures involved in cognition and memory, and describes the computational models of olfactory processing that have been developed to date. Contributions cover empirical investigations of the neurobiology of the olfactory systems (anatomy, physiology, synaptic plasticity, behavioral physiology) as well as the application of computer models to understanding these systems. Fundamental issues in olfactory processing by the nervous systems such as experimental strategies in the study of olfaction, stages of odor processing, and critical questions in sensory coding are considered across empirical/applied boundaries and throughout the contributions. ContributorsI. Fundamental Anatomy, Physiology, and Plasticity of the Olfactory System, Gordon M. Shepherd. John S. Kauer, S. R. Neff, Kathryn A. Hamilton, and Angel R. Cinelli. Kevin L. Ketchum, Lewis B. Haberly. Joseph L. Price, S. Thomas Carmichael, Ken M. Carnes, Marie Christine Clugnet, Masaru Kuroda, and James P. Ray. Michael Leon, Donald A. Wilson, and Kathleen M. Guthrie. Gary Lynch and Richard Granger. Howard Eichenbaum, Tim Otto, Cynthia Wible, and Jean Piper. - II. Developments in Computational Models of the Olfactory System, DeLiang Wang, Joachim Buhmann, and Christoph von der Marlsburg. Walter Freeman. Richard Granger, Ursula Staubi, José Ambrose-Ingersoll, and Gary Lynch. James M. Bower. Dan Hammerstrom and Eric Means. |
| neurobiology shepherd: Plant Electrophysiology Alexander G. Volkov, 2012-05-03 This book compiles new findings from the work of internationally renowned experts in plant electrophysiology, biophysics, bioelectrochemistry, ion channels, membrane transport, imaging of water transport, photosynthesis, mechanosensors, osmotic motors, sensing and actuation in plants. First volume covers modern methods in plant electrophysiology and cell electrophysiology. Second volume deals with signal transduction and responses in plants. |
| neurobiology shepherd: Behavioral Measures of Neurotoxicity National Research Council, Division of Behavioral and Social Sciences and Education, Commission on Behavioral and Social Sciences and Education, U.S. National Committee for the International Union of Psychological Science, 1990-02-01 Exposure to toxic chemicalsâ€in the workplace and at homeâ€is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed. |
| neurobiology shepherd: Foundations of the Neuron Doctrine Gordon M Shepherd, 2015-10-06 The neuron doctrine, first formulated in 1891, states that the brain is constructed of individual neurons, organized into functioning circuits that mediate behavior. It is the fundamental principal that underlies all of neuroscience and clinical neurology. Foundations of the Neuron Doctrine gives an authoritative account of how this theory was the product of an explosion of histological studies and vigorous debates near the end of the nineteenth century by an extraordinary group of scientists, led by Santiago Ramon y Cajal of Spain, using a selective stain discovered by Camillo Golgi of Italy. They were the first to describe the distinctive branching patterns of nerve cells, providing evidence that the cells interact as individual units to form circuits, opposed however by Golgi, who held out for a view that the nerve cells form syncytial networks. Studies in the 1950s appeared to confirm the nerve cell as an individual unit, as embodied in the neuron doctrine, which became the basis for the rise of concepts of normal and disordered neural function since then. This 25th Anniversary Edition is timely. Recent studies are showing a much greater degree of complexity in neuronal organization, so that the debate of neuron versus network is again coming to the fore in neuroscience research. Unique to this Anniversary Edition is the inclusion of commentaries by distinguished international leaders - Marina Bentivoglio, Xavier De Felipe, Sten Grillner, Paolo Mazzarello, Larry Swanson, and Rafael Yuste - on the continuing relevance of the neuron doctrine for modern studies of the brain at all levels, from genes and molecules to microcircuits, neural networks, and behavior. As this new wave of modern studies expands our concepts of nervous function as the basis of behavior, Foundations of the Neuron Doctrine will be a unique source providing conceptual continuity from classical times to the present and into the future. With commentaries from Marina Bentivoglio Paolo Mazzarello Javier DeFelipe Larry Swanson Sten Grillner Rafael Yuste |
| neurobiology shepherd: Topographic Psychology Charles Raymond Snow, 2023-01-22 Contemporary psychology believes that there exists an entity, called the mind, whose task is to deliberately control the body. This entity is said to inhabit a dimension that's separate from the physical reality that's occupied by the brain. Were this to be true, then it might be possible for the mind to survive the death of its owner and be imported into another biological or mechanical body, or be elevated into some metaphysical plane. Topographic psychology dispenses with the concept of the mind. Instead, it asserts that the brain is a biological machine that uses an internal world model to transform sensation into movement. This idea renders superfluous the concept of mindedness, and enables human and animal behavior to be calibrated against evolution. A world model largely consists of topographic maps. Among these are a map of the proprietary territory of the brain’s owner and a map of the owner’s bones and muscles. Although the territory exists in the outside world, while the organs exist in the internal world of the body, to the brain, both maps represent pieces of the same reality. Inhabiting the model’s central axis is a neural artifact called the self object, which serves within the owner’s thinking as a proxy for the owner. A transition from sensing to moving is called a decision. Decisions that are made in the brain are facilitated by neural artifacts, which are derived from sensory input, that reside within the world model. There are two fundamental kinds of artifacts, objects and connections, from which larger neural structures are assembled. These include effectors, which represent unitary actions by one party; transactions, which represent reciprocal actions between two parties; polygon stacks, which represent analogies, inferences, and stories; a special polygon stack that represents the owner’s autobiography; pyramids, which represent referents in the outside world; and a special pyramid that represents the self object. In order to promote its owner’s survival, a world model reacts to events in the external world by cycling the body between three physiological states. There are three such states, violence, sex, and work, each of which reconfigures the body so that it can optimally respond to a threat or opportunity. |
| neurobiology shepherd: Single Neuron Computation Thomas M. McKenna, Joel L. Davis, Steven F. Zornetzer, 2014-05-19 This book contains twenty-two original contributions that provide a comprehensive overview of computational approaches to understanding a single neuron structure. The focus on cellular-level processes is twofold. From a computational neuroscience perspective, a thorough understanding of the information processing performed by single neurons leads to an understanding of circuit- and systems-level activity. From the standpoint of artificial neural networks (ANNs), a single real neuron is as complex an operational unit as an entire ANN, and formalizing the complex computations performed by real neurons is essential to the design of enhanced processor elements for use in the next generation of ANNs.The book covers computation in dendrites and spines, computational aspects of ion channels, synapses, patterned discharge and multistate neurons, and stochastic models of neuron dynamics. It is the most up-to-date presentation of biophysical and computational methods. |
What is Neurobiology? – Introduction to Neurobiology
Neurobiology is the study of the structure and function of the nervous system, the collection of nerve cells that interpret all sorts of information which allows the body to coordinate activity in …
What Is Neurobiology? | UCLA Med School
Jun 16, 2018 · What Is Neurobiology? Dr. Micevych says neurobiology is a broad field. "It's the biology of nerve cells and glial cells that make up the brain — how they fit together and make …
Neuroscience - Wikipedia
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. [1][2][3] It is a multidisciplinary science that …
Understanding the Brain: The Neurobiology of Everyday Life
Learn how the nervous system produces behavior, how we use our brain every day, and how neuroscience can explain the common problems afflicting people today.
Neurobiology
We are proud that HMS Neurobiology stands for excellence and inclusion in neuroscience research and training. We welcome you to explore these pages to learn more about our …
Neurobiology vs Neuroscience: Understanding the Differences …
Apr 2, 2023 · Neurobiology is a sub-discipline of biology that focuses on the cellular and molecular aspects of the nervous system. It investigates how neural cells function and …
Fundamentals of Neuroscience | Harvard Online
Based on the introductory neurobiology courses taught at Harvard College, Fundamentals of Neuroscience is a three-part series that explores the structure and function of the entire …
Neurobiology – EMOTIV
Neurobiology is the study of the nervous system and how the brain works. The field studies nervous system functions, brain function and the related structures such as the spinal cord. …
Neurobiology - ScienceDaily
Aug 24, 2022 · Neurobiology is the study of cells of the nervous system and the organization of these cells into functional circuits that process information and mediate behavior. It is...
Neurobiology - MIT Department of Biology
Elly Nedivi studies the mechanisms underlying brain circuit plasticity — characterizing the genes and proteins involved, as well as visualizing synaptic and neuronal remodeling in the living …
What is Neurobiology? – Introduction to Neurobiology
Neurobiology is the study of the structure and function of the nervous system, the collection of nerve cells that interpret all sorts of information which allows the body to coordinate activity in …
What Is Neurobiology? | UCLA Med School
Jun 16, 2018 · What Is Neurobiology? Dr. Micevych says neurobiology is a broad field. "It's the biology of nerve cells and glial cells that make up the brain — how they fit together and make …
Neuroscience - Wikipedia
Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. [1][2][3] It is a multidisciplinary science that …
Understanding the Brain: The Neurobiology of Everyday Life
Learn how the nervous system produces behavior, how we use our brain every day, and how neuroscience can explain the common problems afflicting people today.
Neurobiology
We are proud that HMS Neurobiology stands for excellence and inclusion in neuroscience research and training. We welcome you to explore these pages to learn more about our …
Neurobiology vs Neuroscience: Understanding the Differences …
Apr 2, 2023 · Neurobiology is a sub-discipline of biology that focuses on the cellular and molecular aspects of the nervous system. It investigates how neural cells function and …
Fundamentals of Neuroscience | Harvard Online
Based on the introductory neurobiology courses taught at Harvard College, Fundamentals of Neuroscience is a three-part series that explores the structure and function of the entire …
Neurobiology – EMOTIV
Neurobiology is the study of the nervous system and how the brain works. The field studies nervous system functions, brain function and the related structures such as the spinal cord. …
Neurobiology - ScienceDaily
Aug 24, 2022 · Neurobiology is the study of cells of the nervous system and the organization of these cells into functional circuits that process information and mediate behavior. It is...
Neurobiology - MIT Department of Biology
Elly Nedivi studies the mechanisms underlying brain circuit plasticity — characterizing the genes and proteins involved, as well as visualizing synaptic and neuronal remodeling in the living …
