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| macromolecules model activity: Optical Activity of Proteins and Other Macromolecules Bruno Jirgensons, 2012-12-06 The application of circular dichroism (CD) to various problems involving con formation of proteins and other biopolymers is emphasized in this revised and enlarged second edition. The usefulness of CD and ORD in helping to solve structural prob lems is demonstrated by many examples, and the most essential data are tabulated. The author is sincerely grateful to the editors of the series Molecular Biology, Bio chemistry and Biophysics, especially to Professor GEORG F. SPRINGER, M.D., for their interest in this edition, as well as to the many reviewers for their constructive criticism of the first edition of this book. Our previously unpublished work reported in this second edition was supported in part by grants from the R. A. Welch Foundation (grant G-051) and U.S. Public Health Service (grant CA-01785). Houston, September 1973 B. JIRGENSONS Preface to the First Edition Great advances have been made in the application of physical methods in the study of the structure of proteins and other biological macromolecules. Optical rotatory dispersion has been successful in solving structural problems, and a vast amount of literature has accumulated on this subject. Several review articles appeared between 1961 and 1965, but significant progress has been made since 1965. Important new studies, especially on the Cotton effects in the far ultraviolet spectrum, have rendered many previous publications obsolete so that a concise monograph should be useful at this time. |
| macromolecules model activity: Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens Romualdo Benigni, 2003-02-26 Applied with success in a number of areas, QSAR studies have become particularly popular in the rational design of drugs and pesticides. Much has been published on the principles of QSAR in this area, but not on their application s to toxic chemicals. This book provides the first comprehensive, interdisciplinary presentation of QSAR studies on |
| macromolecules model activity: Computer Assisted Modeling National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Committee on Computer-Assisted Modeling, 1987-02-01 In much of biology, the search for understanding the relation between structure and function is now taking place at the macromolecular level. Proteins, nucleic acids, and polysaccharides are macromolecule--polymers formed from families of simpler subunits. Because of their size and complexity, the polymers are capable of both inter- and intramolecular interactions. These interactions confer upon the polymers distinctive three-dimensional shapes. These tertiary configurations, in turn, determine the function of the macromolecule. Computers have become so inextricably involved in empirical studies of three-dimensional macromolecular structure that mathematical modeling, or theory, and experimental approaches are interrelated aspects of a single enterprise. |
| macromolecules model activity: Applying Molecular and Materials Modeling Phillip R. Westmoreland, Peter A. Kollman, Anne M. Chaka, Peter T. Cummings, Keiji Morokuma, Matthew Neurock, Ellen B. Stechel, Priya Vashishta, 2013-04-17 Computational molecular and materials modeling has emerged to deliver solid technological impacts in the chemical, pharmaceutical, and materials industries. It is not the all-predictive science fiction that discouraged early adopters in the 1980s. Rather, it is proving a valuable aid to designing and developing new products and processes. People create, not computers, and these tools give them qualitative relations and quantitative properties that they need to make creative decisions. With detailed analysis and examples from around the world, Applying Molecular and Materials Modeling describes the science, applications, and infrastructures that have proven successful. Computational quantum chemistry, molecular simulations, informatics, desktop graphics, and high-performance computing all play important roles. At the same time, the best technology requires the right practitioners, the right organizational structures, and - most of all - a clearly understood blend of imagination and realism that propels technological advances. This book is itself a powerful tool to help scientists, engineers, and managers understand and take advantage of these advances. |
| macromolecules model activity: Advances in Chromatography Eli Grushka, Nelu Grinberg, 2009-12-23 For more than four decades, scientists and researchers have relied on the Advances in Chromatography Series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. With contributions from an array of international experts, the latest volume captures new developments in this important field th |
| macromolecules model activity: New Models of the Cell Nucleus: Crowding, Entropic Forces, Phase Separation, and Fractals Ronald Hancock, Kwang W. Jeon, 2013-12-27 International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Impact factor for 2012: 4.973. Ideas from the fields of biophysics, physical chemistry, of polymer and colloid, and soft matter science have helped clarify the structure and functions of the cell nucleus. The development of powerful methods for modeling conformations and interactions of macromolecules has also contributed. The book aims to encourage cell and molecular biologists to become more familiar with and understand these new concepts and methods, and the crucial contributions they are making to our perception of the nucleus. This is the first volume to present a comprehensive review of New Models of the Cell Nucleus |
| macromolecules model activity: Molecular Optical Activity and the Chiral Discriminations Stephen F. Mason, 1982-10-14 Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine. |
| macromolecules model activity: Handbook of Food Preservation Mohammad Shafiur Rahman, 2020-06-10 The processing of food is no longer simple or straightforward, but is now a highly inter-disciplinary science. A number of new techniques have developed to extend shelf-life, minimize risk, protect the environment, and improve functional, sensory, and nutritional properties. Since 1999 when the first edition of this book was published, it has facilitated readers’ understanding of the methods, technology, and science involved in the manipulation of conventional and newer sophisticated food preservation methods. The Third Edition of the Handbook of Food Preservation provides a basic background in postharvest technology for foods of plant and animal origin, presenting preservation technology of minimally processed foods and hurdle technology or combined methods of preservation. Each chapter compiles the mode of food preservation, basic terminologies, and sequential steps of treatments, including types of equipment required. In addition, chapters present how preservation method affects the products, reaction kinetics and selected prediction models related to food stability, what conditions need be applied for best quality and safety, and applications of these preservation methods in different food products. This book emphasizes practical, cost-effective, and safe strategies for implementing preservation techniques for wide varieties of food products. Features: Includes extensive overview on the postharvest handling and treatments for foods of plants and animal origin Describes comprehensive preservation methods using chemicals and microbes, such as fermentation, antimicrobials, antioxidants, pH-lowering, and nitrite Explains comprehensive preservation by controlling of water, structure and atmosphere, such as water activity, glass transition, state diagram, drying, smoking, edible coating, encapsulation and controlled release Describes preservation methods using conventional heat and other forms of energy, such as microwave, ultrasound, ohmic heating, light, irradiation, pulsed electric field, high pressure, and magnetic field Revised, updated, and expanded with 18 new chapters, the Handbook of Food Preservation, Third Edition, remains the definitive resource on food preservation and is useful for practicing industrial and academic food scientists, technologists, and engineers. |
| macromolecules model activity: From Molecules to Networks John H. Byrne, Ruth Heidelberger, M. Neal Waxham, 2014-05-23 An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. - The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches - 80% updated and new content - New Chapter on Biophysics of Voltage-Gated Ion Channels - New Chapter on Synaptic Plasticity - Includes a chapter on the Neurobiology of Disease - Highly referenced, comprehensive and quantitative - Full color, professional graphics throughout - All graphics are available in electronic version for teaching purposes |
| macromolecules model activity: Nonlinear Computer Modeling of Chemical and Biochemical Data James F. Rusling, Thomas F. Kumosinski, 1996-02-05 Assuming only background knowledge of algebra and elementary calculus, and access to a modern personal computer, Nonlinear Computer Modeling of Chemical and Biochemical Data presents the fundamental basis and procedures of data modeling by computer using nonlinear regression analysis. Bypassing the need for intermediary analytical stages, this method allows for rapid analysis of highly complex processes, thereby enabling reliable information to be extracted from raw experimental data.By far the greater part of the book is devoted to selected applications of computer modeling to various experiments used in chemical and biochemical research. The discussions include a short review of principles and models for each technique, examples of computer modeling for real and theoretical data sets, and examples from the literature specific to each instrumental technique.The book also offers detailed tutorial on how to construct suitable models and a score list of appropriate mathematics software packages. |
| macromolecules model activity: Concepts of Biology Samantha Fowler, Rebecca Roush, James Wise, 2023-05-12 Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy. |
| macromolecules model activity: Exploring Bacterial Colonies in Solid Foods or Model Foods Using Non-Destructive Techniques Sophie Jeanson, Sylvie Lortal, Anne Thierry, 2016-02-18 Bacteria are always present in foods, either as initial contamination or as technological agents. In solid foods, they are immobilized and develop as colonies. So far, there is a lack of knowledge about the bacteria in colonies, growth and physiology. Non-destructive and resolute techniques, such as fluorescent microscopy, now allow investigating the world of bacteria in colonies and their surroundings in food, at the microscopic scale. |
| macromolecules model activity: From Molecules to Networks Ruth Heidelberger, M. Neal Waxham, John H. Byrne, James L. Roberts, 2009-01-27 An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. - Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook - Discusses emerging new understanding of non-classical molecules that affect neuronal signaling - Full colour, professional graphics throughout - Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer's disease |
| macromolecules model activity: Research Grants Index National Institutes of Health (U.S.). Division of Research Grants, 1965 |
| macromolecules model activity: Handbook of Surface and Colloid Chemistry K. S. Birdi, 2002-08-27 The science of surface and colloid chemistry has been expanding at a rapid pace, resulting in new areas of development, additional applications, and more theoretical and experimental information on related systems. Completely revised and expanded to reflect the very active worldwide research on this subject, this is the definitive handbook for the |
| macromolecules model activity: Conn's Handbook of Models for Human Aging Jeffrey L. Ram, P. Michael Conn, 2018-04-05 Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. - Combines both the methods of study for human aging and animal models - Provides a historical overview and discussion of model availability, key methods and ethical issues - Contains over 200 full color illustrations |
| macromolecules model activity: Protein Structure — Function Relationship D.L. Smith, Z.H. Zaidi, 2012-12-06 Although many pursue understanding of the relationship between protein structure and function for the thrill of pure science, the pay-off in a much broader sense is the ability to manipulate the Earth's chemistry and biology to improve the quality of life for mankind. Immediately goals of this area of research include identification of the life-supporting functions of proteins, and the fundamental forces that facilitate these functions. Upon reaching these goals, we shall have the understanding to direct and the tools required to implement changes that will dramatically improve the quality of life. For example, under standing the chemical mechanism of diseases will facilitate development of new therapeutic drugs. Likewise, understanding of chemical mechanisms of plant growth will be used with biotechnology to improve food production under adverse climatic conditions. The challenge to understand details of protein structure/function relationships is enormous and requires an international effort for success. To direct the chemistry and biology of our environment in a positive sense will require efforts from bright, imaginative scientists located throughout the world. Although the emergence of FAX, e-mail, and the World Wide Web has revolutionized international communication, there remains a need for scientists located in distant parts of the world to occasionally meet face to face. |
| macromolecules model activity: Models and Modeling Myint Swe Khine, Issa M. Saleh, 2011-03-01 The process of developing models, known as modeling, allows scientists to visualize difficult concepts, explain complex phenomena and clarify intricate theories. In recent years, science educators have greatly increased their use of modeling in teaching, especially real-time dynamic modeling, which is central to a scientific investigation. Modeling in science teaching is being used in an array of fields, everything from primary sciences to tertiary chemistry to college physics, and it is sure to play an increasing role in the future of education. Models and Modeling: Cognitive Tools for Scientific Enquiry is a comprehensive introduction to the use of models and modeling in science education. It identifies and describes many different modeling tools and presents recent applications of modeling as a cognitive tool for scientific enquiry. |
| macromolecules model activity: Modeling Inhibitors of Matrix Metalloproteinases Tarun Jha, 2023-12-29 Matrix metalloproteinases (MMPs) have been established as promising biomolecular targets for novel drug design and discovery against numerous major disease conditions including various cancers, cardiovascular, neurodegenerative, inflammatory diseases, and more. This book covers various modern molecular modeling methodologies particularly related to MMP inhibitors. Included in the text are descriptions of ligand-based drug designing and structure-based drug designing modeling strategies for designing potential and target specific or selective MMPIs. This book will benefit those who are looking for an in-depth text on the design and discovery processes of novel and selective MMPIs. Features Describes modeling strategies applied to MMPs Elaborates on the designing strategies of MMPs specifically Includes in-depth analyses of related case studies Acts as a guide for medicinal chemists, not only from pharmaceutical industries, but also from academia Covers various modern molecular modeling methodologies, particularly related to MMPIs |
| macromolecules model activity: Water Activity Rockland, 1987-05-22 8: Media and Methods for Detection and Enumeration of Microorganisms with Consideration of Water Activity Requirements -- Introduction -- Use of Salt-based Media in Food Bacteriology -- Isolation of Bacteria from Dehydrated Foods -- Isolating and Enumerating Fungi from Foods -- Conclusion -- References -- 9: Influences of Hysteresis and Temperature on Moisture Sorption Isotherms -- Introduction -- Hysteresis -- Temperature -- Future Work -- References -- 10: Critical Evaluation of Methods to Determine Moisture Sorption Isotherms -- Introduction -- Problems of Water Vapor Sorption Isotherm Measurement -- Reference System -- Conclusion -- References -- 11: Applications of Nuclear Magnetic Resonance -- Introduction -- NMR Techniques for Water -- Applications of NMR -- References -- 12: FDA Views on the Importance of aw in Good Manufacturing Practice -- Introduction -- Good Manufacturing Practice Regulations (GMPR) Governing the Processing Requirements -- Laboratory Analytical Methods for aw Determinations -- Conclusions -- References -- 13: Shelf-Stable Products and Intermediate Moisture Foods Based on Meat -- Introduction -- Hurdle Technology -- Shelf-Stable Products -- Intermediate Moisture Foods -- Conclusion -- References -- 14: Microbial Stabilization of Intermediate Moisture Food Surfaces -- Introduction -- Microbial Stabilization of IMF Surfaces -- Reduced Preservative Diffusion -- Reduced Surface pH -- Conclusions -- References -- 15: Practical Applications of Water Activity and Moisture Relations in Foods -- Introduction -- Review of Selected U.S. Patents -- Application of the Salwin Equation -- Predicting Packaging Specs Related to Shelf Life -- Effect of aw on Enzyme Activity -- Practical Applications of aw in Foods -- Conclusions -- References -- Index |
| macromolecules model activity: Equilibria and Kinetics of Biological Macromolecules Prof. Jan Hermans, Barry Lentz, 2013-10-22 Progressively builds a deep understanding of macromolecular behavior Based on each of the authors' roughly forty years of biophysics research and teaching experience, this text instills readers with a deep understanding of the biophysics of macromolecules. It sets a solid foundation in the basics by beginning with core physical concepts such as thermodynamics, quantum chemical models, molecular structure and interactions, and water and the hydrophobic effect. Next, the book examines statistical mechanics, protein-ligand binding, and conformational stability. Finally, the authors address kinetics and equilibria, exploring underlying theory, protein folding, and stochastic models. With its strong emphasis on molecular interactions, Equilibria and Kinetics of Biological Macromolecules offers new insights and perspectives on proteins and other macromolecules. The text features coverage of: Basic theory, applications, and new research findings Related topics in thermodynamics, quantum mechanics, statistical mechanics, and molecular simulations Principles and applications of molecular simulations in a dedicated chapter and interspersed throughout the text Macromolecular binding equilibria from the perspective of statistical mechanics Stochastic processes related to macromolecules Suggested readings at the end of each chapter include original research papers, reviews and monographs, enabling readers to explore individual topics in greater depth. At the end of the text, ten appendices offer refreshers on mathematical treatments, including probability, computational methods, Poisson equations, and defining molecular boundaries. With its classroom-tested pedagogical approach, Equilibria and Kinetics of Biological Macromolecules is recommended as a graduate-level textbook for biophysics courses and as a reference for researchers who want to strengthen their understanding of macromolecular behavior. |
| macromolecules model activity: Nuclear Science Abstracts , 1965 |
| macromolecules model activity: Levels of Organization in the Biological Sciences Daniel S. Brooks, James DiFrisco, William C. Wimsatt, 2021-08-24 Scientific philosophers examine the nature and significance of levels of organization, a core structural principle in the biological sciences. This volume examines the idea of levels of organization as a distinct object of investigation, considering its merits as a core organizational principle for the scientific image of the natural world. It approaches levels of organization--roughly, the idea that the natural world is segregated into part-whole relationships of increasing spatiotemporal scale and complexity--in terms of its roles in scientific reasoning as a dynamic, open-ended idea capable of performing multiple overlapping functions in distinct empirical settings. The contributors--scientific philosophers with longstanding ties to the biological sciences--discuss topics including the philosophical and scientific contexts for an inquiry into levels; whether the concept can actually deliver on its organizational promises; the role of levels in the development and evolution of complex systems; conditional independence and downward causation; and the extension of the concept into the sociocultural realm. Taken together, the contributions embrace the diverse usages of the term as aspects of the big picture of levels of organization. Contributors Jan Baedke, Robert W. Batterman, Daniel S. Brooks, James DiFrisco, Markus I. Eronen, Carl Gillett, Sara Green, James Griesemer, Alan C. Love, Angela Potochnik, Thomas Reydon, Ilya Tëmkin, Jon Umerez, William C. Wimsatt, James Woodward |
| macromolecules model activity: Microbial and Natural Macromolecules Surajit Das, Hirak Ranjan Dash, 2020-09-15 Microbial and Natural Macromolecules: Synthesis and Applications brings together active scientists and academicians in the field who share updated information and research outcomes from global experts. Microbial macromolecular diversity, molecular composure, genetics, usability of advanced molecular tools and techniques for their study as well as their applicability are discussed with detailed research perspectives. - Illustrates fundamental discoveries and methodological advancements - Discusses novel functional attributes of macromolecules - Updates progress on microbial macromolecular research |
| macromolecules model activity: Biomedical Applications of Computer Modeling Arthur Christopoulos, 2000-09-19 Up to the last decade or so, most general modeling approaches to the study of molecular components of biological responses have required significant amount of computer time, expertise, and resources, as well as highly specialized and often custom-written programs. With Biomedical Applications of Computer Modeling you don't have to be a computer sci |
| macromolecules model activity: Polarity Index in Proteins - A Bioinformatics Tool Carlos Polanco, 2016-06-29 Polarity is a physico-chemical property that characterizes the electromagnetic stability of a protein and can be used to predict its plausible pathogenic action. For this reason, polarity is regarded as a major factor in most mathematical-computational algorithms that seek to characterize peptides and proteins. The Polarity Index Method makes it possible to reproduce the main classification of peptide proteins found in different databases, with a high degree of discriminative efficiency. Polarity Index In Proteins is a brief monograph that explains the foundations of the polarity index method and presents examples of the application of this method for identifying the structural and functional relationships of different types of proteins (including cell penetrating peptides and natively unfolded proteins). The monograph is divided into sections that cover basic protein biochemistry, the computational mathematical foundations of the polarity index method, the application of the method on different protein structures, and the evaluation of the results of famous experiments on biogenesis (Miller & Urey, Fox & Harada, Rode) by the same method. Polarity Index In Proteins serves as an essential handbook for students and researchers in the field of bioinformatics, proteomics as well as for studies on the role of proteins in the origin of life. |
| macromolecules model activity: Design and Structure-activity Relationships of Ligands Binding to a Site of Known Structure Jeffrey Mark Blaney, 1982 |
| macromolecules model activity: Cell Physiology Source Book Nick Sperelakis, 2012-01-11 Cell Physiology Source Book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The 4e contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. Authored by leading researchers in the field Clear, concise, and comprehensive coverage of all aspects of cellular physiology, from fundamental concepts to more advanced topics Full color illustrations |
| macromolecules model activity: Cell Physiology Source Book Nicholas Sperelakis, 2011-11-29 Cell Physiology Source Book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The 4e contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, and synaptic transmission. - Authored by leading researchers in the field - Clear, concise, and comprehensive coverage of all aspects of cellular physiology, from fundamental concepts to more advanced topics - Full color illustrations |
| macromolecules model activity: Computational Methods for Polymers Masoud Soroush, 2020-12-10 This book presents recent advances in computational methods for polymers. It covers multiscale modeling of polymers, polymerization reactions, and polymerization processes as well as control, monitoring, and estimation methods applied to polymerization processes. It presents theoretical insights gained from multiscale modeling validated with exprimental measurements. The book consolidates new computational tools and methods developed by academic researchers in this area and presents them systematically. The book is useful for graduate students, researchers, and process engineers and managers. |
| macromolecules model activity: Modeling the 3D Conformation of Genomes Guido Tiana, Luca Giorgetti, 2019-01-15 This book provides a timely summary of physical modeling approaches applied to biological datasets that describe conformational properties of chromosomes in the cell nucleus. Chapters explain how to convert raw experimental data into 3D conformations, and how to use models to better understand biophysical mechanisms that control chromosome conformation. The coverage ranges from introductory chapters to modeling aspects related to polymer physics, and data-driven models for genomic domains, the entire human genome, epigenome folding, chromosome structure and dynamics, and predicting 3D genome structure. |
| macromolecules model activity: Atkinson's Principles of Clinical Pharmacology Shiew-Mei Huang, Juan J.L. Lertora, Paolo Vicini, Arthur J. Atkinson Jr., 2021-10-16 **Selected for Doody's Core Titles® 2024 in Pharmacology**Atkinson's Principles of Clinical Pharmacology, Fourth Edition is the essential reference on the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development. This well-regarded survey continues to focus on the basics of clinical pharmacology for the development, evaluation and clinical use of pharmaceutical products while also addressing the most recent advances in the field. Written by leading experts in academia, industry, clinical and regulatory settings, the fourth edition has been thoroughly updated to provide readers with an ideal reference on the wide range of important topics impacting clinical pharmacology. - Presents the essential knowledge for effective practice of clinical pharmacology - Includes a new chapter and extended discussion on the role of personalized and precision medicine in clinical pharmacology - Offers an extensive regulatory section that addresses US and international issues and guidelines - Provides extended coverage of earlier chapters on transporters, pharmacogenetics and biomarkers, along with further discussion on Phase 0 studies (microdosing) and PBPK |
| macromolecules model activity: Model Awareness Christine May Compton, 2005 |
| macromolecules model activity: Viral Nanotechnology Yury Khudyakov, Paul Pumpens, 2015-06-23 Viral Nanotechnology presents an up-to-date overview of the rapidly developing field of viral nanotechnology in the areas of immunology, virology, microbiology, chemistry, physics, and mathematical modeling. Its chapters are by leading researchers and practitioners, making it both a comprehensive and indispensable resource for study and research.Th |
| macromolecules model activity: Modeling and Simulation in Polymer Reaction Engineering Klaus-Dieter Hungenberg, Michael Wulkow, 2018-05-29 Introducing a unique, modular approach to modeling polymerization reactions, this useful book will enable practitioners - chemists and engineers alike - to set up and structure their own models for simulation software like Predici®, C++, MatLab® or others. The generic modules are exemplified for concrete situations for various reactor types and reaction mechanisms and allow readers to quickly find their own point of interest - a highly useful information source for polymer engineers and researchers in industry and academia. |
| macromolecules model activity: Animal Models in Toxicology Shayne C. Gad, 2006-10-30 Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of me |
| macromolecules model activity: Physics Briefs , 1989-07 |
| macromolecules model activity: The Mask Methodology and Knowledge Books Jean-Louis Ermine, Denise Bedford, Alexeis Garcia-Perez, 2025-02-17 The Mask Methodology and Knowledge Books enables an organization to develop knowledge books, which have proven to be easy to use, easy to store, find and manage, and easy to update as organizational knowledge changes. They have also proven to be highly effective self-study and training resources. |
| macromolecules model activity: Enhancement of Nutritional Profile/Biological Activity of Plant-Based Foods by Fermentation Yu Xiao, Xiaolong Ji, Xiudong Xia, 2023-01-31 With ever-increasing health consciousness among consumers in the worldwide in the last decades, great attention has been paid on the application of biotechnology methods in the agricultural and food industry. Especially for plant-based foods production, which exhibit co-benefits to human the health and climate. Traditional fermented foods play a crucial role in human diets around the world because of their unique flavors, great nutritional value, and health-beneficial effects. Fermentation is one of the most traditional but still prevalent bio-processing approaches in the food industry, with the great potential to improve the flavor, sensory, nutritional value and biological activity (including antioxidant capacity, anti-cancer, anti-diabetic anti-inflammatory, regulating intestinal flora properties) of food products. The application of microbial food processing method has attracted the interest of researchers and industries due to its simple, environmentally friendly, and cost-efficiently advantages. The use of fermentation and selected generally recognized as safe (GRAS) starters, such as lactic acid bacteria, yeasts and filamentous fungi has been considered as an excellent method to improve the nutritional value or biological activity of foods by the biosynthesis/biotransformation/generation of bioactive compounds (e.g., phenolic compounds, oligosaccharide), or by the degradation of anti-nutritional factors. In the last years, the exploitation of microbes isolated from traditional fermented foods or as the result of the inoculation of selected starters was conducted to produce novel fermented plant-based foods with beneficial viable microorganisms and/or their metabolites that positively impact on human health. This Research Topic aims to focus on the application of microorganisms in processing of fermented plant-based foods to improve nutritional profile and/or biological activity. In particular, it is welcome focusing on matrices fermentation by beneficial microorganisms, processing for food substrate/by-product valorization, augmentation of food matrix bioactive compounds via fermentation. We invite authors to submit different types of manuscripts (e.g., Original Research Articles, short communications, and Review Articles) that focus on but are not limited to the following topics: Microbial metabolic pathways associated with the accumulation of bioactive compounds of fermented foods. Innovative fermentation approaches to improve the nutritional and functional properties in the final products. Valorization of plant-based food matrices/by-products via fermentation. Plant-based anti-nutritional factors degradation by microorganisms. Development of high added-value and novel fermented products. Production of bioactive compounds with health beneficial effects. Human intestinal flora simulated effect on plant-based food. |
| macromolecules model activity: Tumor Models in Cancer Research Beverly A. Teicher, 2001-11-07 Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results. |
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