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| mage biologics: Engineering the Microbial Platform for the Production of Biologics and Small-Molecule Medicines Dipesh Dhakal, Eung-Soo Kim, Mattheos Koffas, 2019-12-23 |
| mage biologics: Nonclinical Development of Biologics, Vaccines and Specialty Biologics Lisa M. Plitnick, Claudette L. Fuller, 2024-11-16 Nonclinical Development of Biologics, Biosimilars, Vaccines and Specialty Biologics, Second Edition is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. Updated and revised, the new edition compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory guidelines. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. A multi-edited book with chapters authored by leading qualified experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late-stage biologics. - Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical - Discusses the most pertinent international regulatory guidelines - Covers early derisking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines |
| mage biologics: Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies Manmohan Singh, Maya Salnikova, 2014-12-30 Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. - Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy - Highlights novel cases from current clinical trials as well as marketed products - Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies |
| mage biologics: Biologics in Otolaryngology, An Issue of Otolaryngologic Clinics of North America, E-Book Sarah K. Wise, Ashkan Monfared, Nicole Schmitt, 2021-07-09 This issue of Otolaryngologic Clinics, guest edited by Drs. Sarah K. Wise, Ashkan Monfared, and Nicole C. Schmitt is devoted to Biologics in Otolaryngology. This issue is one of six selected each year by our series consulting editor, Dr. Sujana S. Chandrasekhar. Articles in this issue include: Biologics in otolaryngology overview, Current evidence for biologic therapy in chronic rhinosinusitis with nasal polyposis, Choosing the right patient for biologic therapy in CRSwNP, Knowledge gaps and research needs for biologic therapy in rhinology practice, Mechanisms and practical use of biologic therapies for allergy and asthma indications, Immunotherapeutic strategies in head and neck cancer, Cetuximab in head and neck cancer, Anti-PD-1 immune checkpoint blockade for head and neck cancer, Advances in adoptive cell therapy for head and neck cancer, Biologics for the treatment of recurrent respiratory papillomatosis, Past and future biologics for otologic disorders, Biological treatments for Neurofibromatosis Type II and other skullbase disorders, and Biologics in treatment of autoimmune ear disorders. |
| mage biologics: Mucosal Delivery of Drugs and Biologics in Nanoparticles Pavan Muttil, Nitesh K. Kunda, 2020-03-18 Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes. |
| mage biologics: Continuous Biomanufacturing Ganapathy Subramanian, 2017-12-26 This is the most comprehensive treatise of this topic available, providing invaluable information on the technological and economic benefits to be gained from implementing continuous processes in the biopharmaceutical industry. Top experts from industry and academia cover the latest technical developments in the field, describing the use of single-use technologies alongside perfusion production platforms and downstream operations. Special emphasis is given to process control and monitoring, including such topics as 'quality by design' and automation. The book is supplemented by case studies that highlight the enormous potential of continuous manufacturing for biopharmaceutical production facilities. |
| mage biologics: Cancer Vaccines Adrian Bot, Mihail Obrocea, Francesco M. Marincola, 2015-05-06 Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments |
| mage biologics: The Inhibitor Index Daniel Purich, 2017-07-20 Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and antagonists.The Inhibitor Index is a comprehensive, curated compendium of over 7,800 enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers. |
| mage biologics: A Special Report on Gene Therapy K. K. Jain, Kewal K. Jain, 2000-04-14 This special report on Gene Therapy Companies by K.K. Jain provides an up-to-date overview of the gene therapy industry. It contains a wealth of very practical information on 105 companies. For each company, information is available on the people to contact, their contact details, a corporate history, the company's technologies and products, financial data, patents held, products in clinical trials, collaborations with other companies and selected publications from the company's scientists. Almost 200 companies were initially considered for inclusion but just over 100 companies were finally selected as they fulfilled the necessary criteria to be classified as a 'Gene Therapy Company,', defined broadly to include cell therapy companies. Not all of the companies devote their activity exclusively to gene therapy but they have sufficient relevance to be included. As part of this project, new companies were discovered that have not been reported in other publications or on the internet. Dr. Jain has spared no effort to ensure that the information is up-to-date and accurate at the time of publishing. In most instances, the information was reviewed by the companies to correct any outdated information or to add any complementary or recent information. In addition to the detailed descriptions of each company, the data is also presented in summary tabular form so that at a glance the reader can identify collaborations within the gene therapy industry, or determine which companies are pursuing strategies involving viral, non-viral or other approaches to gene therapy, and which diseases are being targetted. Given that much of the gene therapy research and development is currently being carried out within the industrial sector, it is important for scientists, managers and investors to have the relevant information at their fingertips. This special report provides that information in one accurate, easy to consult and up-to-date source. |
| mage biologics: Cutaneous Melanoma Giuseppe Argenziano, Aimilios Lallas, Caterina Longo, Elvira Moscarella, Athanassios Kyrgidis, Gerardo Ferrara, 2017-08-15 Cutaneous Melanoma: A Pocket Guide for Diagnosis and Management serves as an easy-to-consult, short, and schematic reference providing guidelines for diagnosing and managing melanoma in the context of various clinical scenarios. In the daily routine of a busy clinician, there is a need for schematic reference tools that allow quick consultation for immediate decisions. Melanoma is a deadly disease that should be promptly managed following precise and evidence-based guidelines. The guide contains many schematics and figures, vastly outnumbering the pages dedicated to text. This guide follows the sequence of a real clinical setting, going from the first screening visit to the final stages of terminal patients. - Provides a quick-access resource for diagnosis and treatment of melanoma patients at all stages - Includes succinct guidelines, schematics, and figures for busy clinicians - Concludes with a section addressing special clinical situations, including melanoma in pregnancy, pediatric melanoma, familial melanoma and MPM, atypical Spitz tumor, occult primary melanoma, and the histopathologic gray zone |
| mage biologics: Immunomodulators in Aquaculture and Fish Health Preetham Elumalai, Mehdi Soltani, Sreeja Lakshmi, 2023-10-31 This reference book provides updated information about different immunomodulators for managing fish health and sustainable aquaculture. Immunomodulators are dietary additives that enhance innate defense mechanisms and increase resistance against specific pathogens and diseases. The book covers the different types of immunostimulants, their modes of action, and their efficacies. It also reviews safety concerns, ethical regulations, limitations, and outreach to farmers. It discusses the application of herbal immunomodulators, antioxidants, pre- and pro-biotics, in disease management. Features: Reviews the pressing topic of reduction of antibiotic use in aquaculture Discusses herbal immunomodulators, nutrients, antioxidants and pre- and pro-biotics Covers the topic of progressive immunomodulation using nanotechnology Discusses fish health management in the ever-growing aquaculture industry Includes natural and synthetic immunomodulators The book is meant for researchers and industry experts in aquaculture, fisheries science, and veterinary medicine. |
| mage biologics: Engineered immune cells in cancer immunotherapy (EICCI) Cristina Maccalli, Axel Schambach, Francisco Martin, Cameron Turtle, 2023-02-28 |
| mage biologics: Cancer Immunotherapy Meets Oncology Cedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, 2014-04-23 This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients. |
| mage biologics: The Producer , 1929 |
| mage biologics: Applied Plant Biotechnology V. L. Chopra, Vedpal S. Malik, S. R. Bhat, 1999 Reviews several recent developments that relate to improving crop productivity and product diversification. Considers the genetic manipulation of major products such as carbohydrates, fatty acids, sesquiterpenes, and floriculture crops and discusses aspects of the biosafety, environmental release, and commercial exploitation of transgenics. Other topics include developing pest-resistant transgenic plants, producing human therapeutics in plants, using molecular biology techniques in plant breeding to protect intellectual property rights, and biosystematics. Annotation copyrighted by Book News, Inc., Portland, OR |
| mage biologics: Cancer Immunotherapy Principles and Practice Lisa H. Butterfield, PhD, Howard L. Kaufman, MD, FACS, Francesco M. Marincola, MD, FACS, 2017-06-28 “Drs. Butterfield, Kaufman and Marincola on behalf of the SITC have created a comprehensive must-have resource covering the basic and translational science behind approved and investigational immune therapies, and disease-by-disease clinical application of the therapies, written by leaders in the field. The textbook will be highly valuable reading for those just entering the field and for experienced scientists and clinicians looking to expand their knowledge base.” —Mario Sznol, MD, Professor of Medicine (Medical Oncology), Yale School of Medicine, New Haven, Connecticut “Given the important and exciting advances in cancer immunotherapy, it is not surprising that there is no dearth of books on the subject. Despite the competition, however, this book is a unique masterpiece and a must-have comprehensive resource for anyone interested in this area and for every medical library.” Score: 100, 5 Stars, Doody’s Medical Reviews Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), is the authoritative reference on cancer immunobiology and the immunotherapy treatments that harness the immune system to combat malignant disease. Featuring five sections and over 50 chapters covering the Basic Principles of Tumor Immunology, Cancer Immunotherapy Targets and Classes, Immune Function in Cancer Patients, Disease-Specific Treatments and Outcomes, and Regulatory Aspects of Cancer Immunotherapy, this book covers all major topics that have shaped the development of immunotherapy and propelled it to its current place at the forefront of cancer treatment innovation. This volume is a comprehensive resource for oncologists and fellows, immunologists, cancer researchers, and related practitioners seeking understanding of the basic science and clinical applications of cancer immunotherapy. As well as presenting the evidence for immune-based cancer treatment, it positions immunotherapy in the context of other available cancer treatments and provides data on response rates, risks, and toxicities across a variety of diseases. Filled with detailed tables, and instructive illustrations, as well as key points for quick reference, Cancer Immunotherapy Principles and Practice simplifies a challenging and dynamic subject. KEY FEATURES Clearly summarizes the basic principles and research supporting cancer immunotherapy clinical translation Contains expert guidance and treatment strategies for all immunotherapy classes and agents, including cell-based therapies, monoclonal antibodies, cytokine therapies, checkpoint inhibitors, oncolytic viruses, adjuvant approaches, and treatment combinations Includes expert perspectives from leading authorities in the field Provides information on all FDA-approved immunotherapies, including clinical management and outcome data Discusses clinical aspects of immunotherapy for individual cancer types, including melanoma and other skin cancers, lung cancers, gynecologic cancers, gastrointestinal cancers, hematologic cancers, genitourinary cancers, head and neck cancers, sarcomas, brain and other CNS cancers, breast cancer, and pediatric malignancies. Explains regulatory aspects behind the development and approval of immunotherapy drugs |
| mage biologics: Vaccines Stanley A. Plotkin, Walter A. Orenstein, Paul A. Offit, 2012-10-01 A guide to the enhancement of the well-being of our world. It offers a coverage of every aspect of vaccination, from the development of each vaccine to its use in reducing disease. |
| mage biologics: Journal of the National Cancer Institute , 2010 |
| mage biologics: The SAGE Handbook of Healthcare Decision Resources Inc, 2008-05-22 With escalating healthcare costs, changes to the regulatory control on pharmaceutical industries and the inevitable adjustments made in policies and investment in healthcare there is enormous interest in the commercial as well as the scientific aspects of today′s healthcare industry. The SAGE Handbook of Healthcare provides an authoritative analysis of the current (and anticipated) developments in the global healthcare industries. Providing a unique perspective that interfaces between the science and business aspects, it combines information on the latest scientific developments with applied, commercial business data from the global marketplace. The Handbook focuses on the aspects of paramount importance in the healthcare sector: - Pharmacoeconomics - Pharmacogenomics - Therapeutics - Diagnostics Areas covered include: - The role of nanotechnology, genomics and cell therapy in medicine - Diagnostics; Biomarkers and technological advances - Case studies in oncology and cardiovascular and CNS therapeutics |
| mage biologics: Influenza: New Insights for the Healthcare Professional: 2011 Edition , 2012-01-09 Influenza: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Influenza. The editors have built Influenza: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Influenza in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Influenza: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| mage biologics: Immunologic Signatures of Rejection Francesco M. Marincola, Ena Wang, 2010-11-03 This book discusses the mechanisms leading to immune-mediated tissue rejection following the hypothesis that independent of the disease process the final effector mechanism is shared by most (but not all) pathologies and it is relatively simple. The book covers evidence gathered to support the thesis by studies performed in humans during rejection or in experimental models and will focus particularly (but not exclusively) on the analysis of the rejected tissue rather than the systemic circulation. Several disease processes are discussed including example of chronic inflammatory process without resolution of the pathologic process and acute one with resolution of the pathologic process (clearance of pathogen, rejection of tumor) or unwanted tissue destruction (allograft rejection, autoimmunity). |
| mage biologics: Cancer Vaccines Ralph M. Steinman, Kenichiro Hasumi, Olivera J. Finn, Jacques Banchereau, 2009-10-12 With ten million persons afflicted each year, no one is entirely immune to cancer and its devastating effects on individuals and families. But recent advances in the development of cancer vaccines—either as therapeutic agents or as preventative measures—are hopeful indicators of progress in this field. This volume comprises invited chapters from world-renowned researchers and clinicians that shed light on recent steps forward in immunotherapeutic and preventive approaches for future cancer vaccines. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member. |
| mage biologics: Innovate or Perish Edward Kahn, 2007-02-26 Essential reading for IP managers and corporate executives, Innovate or Perish is a new road map equipping readers with the principles and tools needed for their companies to compete in the emerging creativity economy. Edited by Edward Kahn, this seminal book includes contributions from seasoned intellectual property (IP) professionals—including Ed Walsh, Karl Jorda, Wayne Jaeschke, Abha Divine, and Damon Matteo. |
| mage biologics: Progress in Cancer Immunotherapy Shuren Zhang, 2016-05-30 This book provides readers an extensive overview of recent progress in basic and clinical research on cancer immunotherapy. Thanks to rapid advances in molecular biology and immunology, it has become increasingly evident that cancer growth is influenced by host immune responses. With the success of a number of clinical trials, immunotherapy has become a promising treatment modality of cancer. This book covers five major topics, including monoclonal antibodies, biological response modifiers, cancer vaccines, adoptive cellular therapy and oncolytic viruses. It also examines the combination of different immune strategies as well as the combination of immunotherapy with other treatments to increase anti-tumor effects. Through the comprehensive discussion of the topic, the book sheds valuable new light on the treatment of tumors. |
| mage biologics: Therapeutic Delivery Solutions Chung Chow Chan, Kwok Chow, Bill McKay, Michelle Fung, 2014-06-27 Provides a comprehensive review of all types of medical therapeutic delivery solutions from traditional pharmaceutical therapy development to innovative medical device therapy treatment to the recent advances in cellular and stem cell therapy development • Provides information to potentially allow future development of treatments with greater therapeutic potential and creativity • Includes associated regulatory requirements for the development of these therapies • Provides a comprehensive developmental overview on therapeutic delivery solutions • Provides overview information for both the general reader as well as more detailed references for professionals and specialists in the field |
| mage biologics: Health and the environment, miscellaneous United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Health and the Environment, 1983 |
| mage biologics: Pulmonary Metastasectomy, An Issue of Thoracic Surgery Clinics of North America Mark W. Onaitis, Thomas A. D'Amico, 2016-01-19 This issue of Thoracic Surgery Clinics of North America focuses on Pulmonary Metastasectomy. Articles will include: Biology of Pulmonary Metastases; Preoperative Evaluations and Indications for Metastasectomy; Open Approaches to Pulmonary Metastases: Thoracotomy and Sternotomy; Ablative Approaches for Pulmonary Metastases: RFA, microwave, SBRT; Role of Lymphadenectomy with Pulmonary Metastasectomy; Results of Pulmonary Resection: Colorectal Carcinoma; Results of Pulmonary Resection: Sarcoma and Germ Cell Tumors; Isolated Lung Perfusion; Immunotherapy; Medical Management of Pulmonary Metastases: Is There a Role for Surgery?; Thoracoscopic Management of Pulmonary Metastases; Results of Pulmonary Resection: Other Epithelial Malignancies; Thoracoscopic Lung Suffusion; and more! |
| mage biologics: Public Health Reports , 1931 |
| mage biologics: Strategies for Increasing Involvement of Research Scientists in Implementation of Innovative Science Education Programs Kenneth D. Fisher, 1983 |
| mage biologics: MGMA Connexion , 2001 |
| mage biologics: Immunoglobulins , 1980 |
| mage biologics: Immunoglobulins: Advances in Research and Application: 2011 Edition , 2012-01-09 Immunoglobulins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Immunoglobulins. The editors have built Immunoglobulins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Immunoglobulins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Immunoglobulins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/. |
| mage biologics: Translational Medicine Joy A. Cavagnaro, Mary Ellen Cosenza, 2021-11-25 Translational Medicine: Optimizing Preclinical Safety Evaluation of Biopharmaceuticals provides scientists responsible for the translation of novel biopharmaceuticals into clinical trials with a better understanding of how to navigate the obstacles that keep innovative medical research discoveries from becoming new therapies or even making it to clinical trials. The book includes sections on protein-based therapeutics, modified proteins, oligonucleotide-based therapies, monoclonal antibodies, antibody–drug conjugates, gene and cell-based therapies, gene-modified cell-based therapies, combination products, and therapeutic vaccines. Best practices are defined for efficient discovery research to facilitate a science-based, efficient, and predictive preclinical development program to ensure clinical efficacy and safety. Key Features: Defines best practices for leveraging of discovery research to facilitate a development program Includes general principles, animal models, biomarkers, preclinical toxicology testing paradigms, and practical applications Discusses rare diseases Discusses What-Why-When-How highlighting different considerations based upon product attributes. Includes special considerations for rare diseases About the Editors Joy A. Cavagnaro is an internationally recognized expert in preclinical development and regulatory strategy with an emphasis on genetic medicines.. Her 40-year career spans academia, government (FDA), and the CRO and biotech industries. She was awarded the 2019 Arnold J Lehman Award from the Society of Toxicology for introducing the concept of science-based, case-by-case approach to preclinical safety evaluation, which became the foundation of ICH S6. She currently serves on scientific advisory boards for advocacy groups and companies and consults and lectures in the area of preclinical development of novel therapies. Mary Ellen Cosenza is a regulatory toxicology consultant with over 30 years of senior leadership experience in the biopharmaceutical industry in the U.S., Europe, and emerging markets. She has held leadership position in both the American College of Toxicology (ACT) and the International Union of Toxicology (IUTOX) and is also an adjunct assistant professor at the University of Southern California where she teaches graduate-level courses in toxicology and regulation of biologics. |
| mage biologics: Cancer Immunotherapy Principles and Practice, Second Edition Lisa H. Butterfield, PhD, Howard L. Kaufman, MD, FACS, Francesco M. Marincola, MD, FACS, 2021-08-25 Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs |
| mage biologics: National Library of Medicine Current Catalog National Library of Medicine (U.S.), 1971 |
| mage biologics: Current Protocols in Immunology John E. Coligan, 1991 Current Protocols in Immunology is a three-volume looseleaf manual that provides comprehensive coverage of immunological methods from classic to the most cutting edge, including antibody detection and preparation, assays for functional activities of mouse and human cells involved in immune responses, assays for cytokines and their receptors, isolation and analysis of proteins and peptides, biochemistry of cell activation, molecular immunology, and animal models of autoimmune and inflammatory diseases. Carefully edited, step-by-step protocols replete with material lists, expert commentaries, and safety and troubleshooting tips ensure that you can duplicate the experimental results in your own laboratory. Bimonthly updates, which are filed into the looseleaf, keep the set current with the latest developments in immunology methods. The initial purchase includes one year of updates and then subscribers may renew their annual subscriptions. Current Protocols publishes a family of laboratory manuals for bioscientists, including Molecular Biology, Human Genetics, Protein Science, Cytometry, Cell Biology, Neuroscience, Pharmacology, and Toxicology. |
| mage biologics: Comprehensive Toxicology , 2017-12-01 Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts |
| mage biologics: Index Medicus , 2003 Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings. |
| mage biologics: Symposium on Gamma Globulin, 26 and 27 October, 1962 Mart Mannik, 1962 |
| mage biologics: Texas State Journal of Medicine , 1937 |
如何评价英雄联盟解说mage谈恋爱后表示「生活和工作要分开 …
Dec 25, 2023 · mage作为B站二路解说，因为解说杯出色的AD表现而被大家所熟知，尤其是「晚安小马」和「带微神打辅助」两件事儿最为出圈。 「晚安小马」的故事就是解说杯最为内卷的 …
奇幻小说中有关魔法师职业 mage, magician, sorcerer ... - 知乎
Aug 18, 2014 · Mage有时也被写作Magi，原意是波斯拜火教的僧侣，在圣经故事里，当耶稣诞生在马厩里的时候，有三位来自于东方的贤人前来朝拜，献上祝福，他们就是Mage。从这点上来 …
如何评价英雄联盟解说mage谈恋爱后表示「生活和工作要分开 …
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
有问题，就会有答案 - 知乎
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
如何评价英雄联盟解说mage谈恋爱后表示「生活和工作要分开 …
Dec 25, 2023 · mage作为B站二路解说，因为解说杯出色的AD表现而被大家所熟知，尤其是「晚安小马」和「带微神打辅助」两件事儿最为出圈。 「晚安小马」的故事就是解说杯最为内卷的 …
奇幻小说中有关魔法师职业 mage, magician, sorcerer ... - 知乎
Aug 18, 2014 · Mage有时也被写作Magi，原意是波斯拜火教的僧侣，在圣经故事里，当耶稣诞生在马厩里的时候，有三位来自于东方的贤人前来朝拜，献上祝福，他们就是Mage。从这点上 …
如何评价英雄联盟解说mage谈恋爱后表示「生活和工作要分开 …
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
有问题，就会有答案 - 知乎
知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业 …
