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| frontiers cellular neuroscience impact factor: The Metric Tide James Wilsdon, 2016-01-20 ‘Represents the culmination of an 18-month-long project that aims to be the definitive review of this important topic. Accompanied by a scholarly literature review, some new analysis, and a wealth of evidence and insight... the report is a tour de force; a once-in-a-generation opportunity to take stock.’ – Dr Steven Hill, Head of Policy, HEFCE, LSE Impact of Social Sciences Blog ‘A must-read if you are interested in having a deeper understanding of research culture, management issues and the range of information we have on this field. It should be disseminated and discussed within institutions, disciplines and other sites of research collaboration.’ – Dr Meera Sabaratnam, Lecturer in International Relations at the School of Oriental and African Studies, University of London, LSE Impact of Social Sciences Blog Metrics evoke a mixed reaction from the research community. A commitment to using data and evidence to inform decisions makes many of us sympathetic, even enthusiastic, about the prospect of granular, real-time analysis of our own activities. Yet we only have to look around us at the blunt use of metrics to be reminded of the pitfalls. Metrics hold real power: they are constitutive of values, identities and livelihoods. How to exercise that power to positive ends is the focus of this book. Using extensive evidence-gathering, analysis and consultation, the authors take a thorough look at potential uses and limitations of research metrics and indicators. They explore the use of metrics across different disciplines, assess their potential contribution to the development of research excellence and impact and consider the changing ways in which universities are using quantitative indicators in their management systems. Finally, they consider the negative or unintended effects of metrics on various aspects of research culture. Including an updated introduction from James Wilsdon, the book proposes a framework for responsible metrics and makes a series of targeted recommendations to show how responsible metrics can be applied in research management, by funders, and in the next cycle of the Research Excellence Framework. The metric tide is certainly rising. Unlike King Canute, we have the agency and opportunity – and in this book, a serious body of evidence – to influence how it washes through higher education and research. |
| frontiers cellular neuroscience impact factor: Common Knowledge Moira Cockell, 2011-01-01 Structure is a central theme of construction, of interest to both engineers and architects; this book on architectural structures aims to facilitate the dialogue between these two professions. The chapters are organized into a progressive, step-by-step analysis of increasing complexity - a structural path - stressing an intuitive approach and conveying with diagrams and simple equations the requirements behind the dimensioning of all types of structures employed in construction. This approach is particularly useful for students, providing them with an intuitive understanding of form and function, as well as the insight to make their designs more sensible, coherent and elegant. The art of structures has been written for architects, civil engineers and construction professionals, and for all those need to acquire an intuitive and practical approach to the design and appropriate dimensioning of load bearing structures. |
| frontiers cellular neuroscience impact factor: Translational Research in Traumatic Brain Injury Daniel Laskowitz, Gerald Grant, 2016-04-21 Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme |
| frontiers cellular neuroscience impact factor: Brain Neurotrauma Firas H. Kobeissy, 2015-02-25 With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries. |
| frontiers cellular neuroscience impact factor: Neurotrophins , 2017-02-15 Neurotrophins, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on crystal structures and basic structural studies on neurotrophins and their receptors, neurotrophin functions, and the biological actions of neurotrophins related to clinical conditions and disease. Each volume is thoroughly reviewed and focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others. - Provides cutting-edge reviews concerning the molecular and cellular biology of vitamins and hormones - Contains expertise from world-renowned contributors - Focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances such as transmitters, cytokines, growth factors, and others - Presents in-depth, current information from the molecular to clinical level |
| frontiers cellular neuroscience impact factor: The Neurobiology of Olfaction Anna Menini, 2009-11-24 Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely |
| frontiers cellular neuroscience impact factor: Presidential Age Steven C. Hertler, Aurelio José Figueredo, Mateo Peñaherrera-Aguirre, 2025-02-08 This book on presidential age is not about Alzheimer's Disease and associated pathologies of the aging brain. It is instead about the normally aging brain. Brains don’t simply develop and maintain their functionality into older adulthood unless otherwise impaired by neurocognitive disease. Were this the case, this book might be about leveraging prodromal biomarkers of neurodegenerative diseases to screen prospective presidential candidates. Instead, the normal decline age brings to all human brains begs a different type of book—and a broader and more blanketed warning about electing increasingly older presidents. |
| frontiers cellular neuroscience impact factor: Global Excellence in Cellular Neuropathology: Ukraine Oleg Krishtal, Elena A. Lukyanetz, Dirk M. Hermann, Andrii O. Cherninskyi, 2024-01-22 Global collaboration is the cornerstone of scientific advancement. Frontiers in Cellular Neuroscience has organized a series of special edition Research Topics, with the goal of highlighting the latest advancements in Neuropathology across the globe, showcasing the academic excellence and high-quality work of internationally recognized researchers. These collections aim to shed light on the recent progress made across the entire breadth of the Cellular Neuropathology field and reflect on the future challenges faced by researchers across borders. |
| frontiers cellular neuroscience impact factor: Neuronal Self-Defense: Compensatory Mechanisms in Neurodegenerative Disorders Rosanna Parlato, Pier Giorgio Mastroberardino, 2016-02-26 Neurodegenerative disorders are characterized by the progressive loss of specific populations of neurons with consequent deterioration of brain's function and dramatic impact on human behavior. At present, there are no effective cures for neurodegenerative diseases. Because unambiguous diagnosis is possible only after manifestation of symptoms, when a large proportion of neurons has been already lost, therapies are necessarily confined to alleviation of symptoms. Development of cures halting the disease course is hampered by our rudimentary understanding of the etiopathology. Most neurodegenerative disorders are sporadic and age-related and - even for those of known genetic origin - the mechanisms influencing disease onset and progression have not been fully characterized. The different diseases, however, share important similarities in the mechanisms responsible for neuronal loss, which is caused by a combination of endogenous and exogenous challenges. Trophic deprivation, oxidative stress, accumulation of abnormal protein aggregates, and bioenergetics defects have been described in most, if not all, neurodegenerative disease. To counterbalance these noxious stimuli cells deploy, at least during the initial pathogenic states, intrinsic neuroprotective responses. These are general compensatory mechanisms, common to several neurodegenerative conditions, which reprogram cellular physiology to overcome stress. Adaptation includes strategies to optimize energetic resources, for instance reduction of rRNA synthesis to repress translation, suppression of transcription, and bioenergetics and metabolic redesign. Additional mechanisms include potentiation of antioxidant capacity, induction of endoplasmic reticulum (ER) stress, and activation of protein quality control systems and autophagy. Ineffective execution of these compensatory strategies severely threatens cellular homeostasis and favors onset of pathology. Therefore, a better understanding of these buffering mechanisms and of their interconnections may help to devise more effective therapeutic tools to prolong neuronal survival and activity, independently of the original genetic mutations and stress insults. This Research Topic focuses on the initial compensatory responses protecting against failure of those mechanisms that sustain neuronal survival and activity. The collection intends to summarize the state-of-the-art in this field and to propose novel research contributes, with the ultimate goal of inspiring innovative studies aimed to contrast progression of neurodegenerative diseases. |
| frontiers cellular neuroscience impact factor: Developing stem cell-based therapies for neural repair Clare Parish, Lachlan Thompson, 2015-01-28 Current pharmacotherapies and surgical intervention provide limited benefit in the treatment of neural injuries or halting disease progression and has resulted in significant hope for the successes of stem cell research. The properties of stem cells render them appropriate for cell replacement therapy, endogenous repair, disease modeling as well as high-throughput drug screening and development. Such applications will aide in increasing our knowledge and developing treatments for neurodegenerative disorders such as Parkinson’s disease and Huntington’s diseases as well as neural traumas including ischemic brain damage and traumatic brain injury. This Frontiers Research topic encouraged contributions from the general field of stem cell biology, with a particular emphasis on utilizing these cells to develop new therapies for neural repair. Related articles deal with issues such as: breakthroughs in stem cell proliferation/differentiation methodologies, using pluripotent and neural stem cells for transplantation and endogenous repair, the use of patient derived stem cells for disease modeling, using stem cells for drug discovery as well as the ethical issues related to the use of stem cells. |
| frontiers cellular neuroscience impact factor: Cytokines as Players of Neuronal Plasticity and Sensitivity to Environment in Healthy and Pathological Brain Silvia Alboni, Laura Maggi, 2016-03-18 It is now accepted that immune molecules are not only present within the brain during pathology but they exert physiological functions in the “healthy” brain as well. Increasing evidence points to a neuro-modulatory role of cytokines and chemokines (CHEMOtactic cytoKINES) in basal transmission and plasticity processes where signaling between peri-synaptic astrocytes, microglia and neurons plays an important role. Nevertheless, the exact mechanisms as to how cytokines, and in particular chemokines, participate in the molecular and cellular processes thought to subserve memory formation, plasticity processes and responsiveness to environmental stimuli remain to be clarified. Interestingly, in in vitro preparations, molecules like TNF-α, interleukin (IL)-1β, IL-6, CX3CL1, CXCL12, CCL2 and CCL3 are implicated in synaptic formation and scaling, in modulation of glutamatergic transmission, in plasticity and neurogenesis, in particular in the hippocampus. The hippocampus is an extremely plastic structure, one of the main neurogenic niches in the adult brain, that exhibits a marked sensibility to environmental stimuli. Indeed exposure of mice to environmental enrichment (EE) modifies learning and memory abilities increasing neurogenesis and neuronal plasticity whether exposure to severe stressful experiences diminishes neurotrophic support, impairs neurogenesis, plasticity and cognition. In the hippocampus cytokines play a key role in mediating both positive as well as negative effects of the environment affecting neuronal plasticity also in stress related pathologies, such as depression. It has been reported that mice lacking type 1 receptor for IL-1 display impaired hippocampal memory and LTP that are restored by EE; moreover negative effects on neuronal plasticity (and thus behavior) induced by stress exposure can be prevented by blocking IL-1 activity. In addition, mice lacking IL-6 have improved cognitive functions whereas the absence of microglia-driven CX3CR1 signaling increases hippocampal plasticity and spatial memory occluding the potentiating effects of EE. However, the factors mediating the effect of environmental stimuli on behavior and plasticity has been only partially identified. Interestingly, it has been suggested that chemokines can play a key role in the flexibility of hippocampal structure and may modulate neuronal signaling during behavior. The question is how cytokines may translate environmental stimuli in plasticity and behavioral changes. This research topic is proposed to explore the role of cytokines, and more in particular chemokines, in the modulation of neuronal activity as a fundamental step for the correct brain wiring, function and susceptibility to environment. We encourage the submission of original research reports, review articles, commentaries, perspectives or short communications, in the following (but not limited to) topics: - Role of cytokines and chemokines in neuronal plasticity - Immune molecules and responsiveness to environment - Role of chemokine in the flexibility of hippocampal structure |
| frontiers cellular neuroscience impact factor: Glial Cells: Managers of Neuro-immunity Carlos Barcia, Gilles J. Guillemin, James F. Curtin, Jeffrey M. Zirger, 2016-05-30 Immune responses within the brain are still scarcely explored. Nerve tissue damage is accompanied by the activation of glial cells, primarily microglia and astroglia, and such activation is responsible for the release of cytokines and chemokines that maintain the local inflammatory response and actively recruit lymphocytes and monocytes to the damaged areas. Theoretically, these responses are designed to repair the brain damage. However, alterations, or a chronic perpetuation of these responses may underlie a number of neuro-pathologies. It is thought that each inflammatory scenario within the brain have a specific biochemical footprint characterized by the release of determined cytokines, chemokines and growing factors able to define particular immunological responses. Alongside, glial cells transform their cell body, become larger and develop higher number of branches adopting an active morphological phenotype. These changes are related with the search of interactions with other cells, such as bystander resident cells of the brain parenchyma, but also cells homing from the blood stream. In this process, microglia and astrocytes communicates with other cells by the formation of specific intercellular connections that are still poorly understood. These interactions are complex and entail the arrangement of cytoskeletal compounds, secretory and phagocytic domains. In this particular crosstalk there is a two-way communication in which glial cells and target cells come together establishing interfaces with specific information exchange. This way, glial cells orchestrate the particular response recruiting cellular subsets within the central nervous system and organizing the resolution of the brain damage. In this Frontiers Research Topic, we compile a selection of articles unfolding diverse aspects of glial-derived inflammation, focused on neurodegenerative diseases and other nervous system disorders, with special emphasis on microglia/macrophages as leading actors managing neuro-immunity. |
| frontiers cellular neuroscience impact factor: The Metabolic Syndrome Raj K. Keservani, Durgavati Yadav, Rajesh K. Kesharwani, Sippy Singh, Kumar Sandeep, 2023-08-04 This new book discusses the physiological factors that contribute to metabolic syndrome within the human body and spotlights the beneficial effects on the body of nutraceuticals and functional ingredients, botanicals and natural dietary supplements, structurally numerous antioxidants, B-vitamins, and diverse amino acids and vital nutrients. The book considers the need to preserve a balance between energy delivery and strength expenditure that is essential for maintaining an appropriate body mass index (BMI), which can contribute to less obesity and fewer metabolic disorders, such as diabetes type II, cardiovascular illnesses, etc. The authors present recent research that proves that proper vitamins—including antioxidants, nutrients, micronutrients, and selected amino acids—can enhance the body’s metabolism and defend it from inflammatory onslaughts. |
| frontiers cellular neuroscience impact factor: Essential Psychiatry for the Aesthetic Practitioner Evan A. Rieder, Richard G. Fried, 2021-04-08 ESSENTIAL PSYCHIATRY FOR THE AESTHETIC PRACTITIONER Aesthetic practice requires an understanding of human psychology, yet professionals across cosmetic medicine and related fields receive no formal training in identifying and managing psychological conditions. Essential Psychiatry for the Aesthetic Practitioner provides concise yet comprehensive guidance on approaching patient assessment, identifying common psychiatric diseases, and managing challenging situations in cosmetic practice. This much-needed guide brings together contributions by dermatologists, plastic surgeons, psychiatrists, psychologists, and other experts to help practitioners understand the role of psychology in cosmetic practice and improve interpersonal relations with their patients. Assuming no previous background knowledge in psychiatry, the text provides cosmetic practitioners of all training and experience levels with clear guidance, real-world advice, and effective psychological tools to assist their practice. Through common clinical scenarios, readers learn to determine if a patient is a good candidate for a cosmetic procedure, enhance the patient experience, deal with difficult personalities in the cosmetic clinic, recognize obsessive compulsive and body dysmorphic disorders, and more. Describes how to use psychologically informed approaches and treatments for aesthetic patients Features easy-to-use psychological tools such as motivational interviewing, progressive muscle relaxation, guided imagery, and acceptance and commitment therapy Includes extensive references and practical tips for understanding the psychological implications of cosmetic treatments Covers cosmetic consultations for female, male, and transgender patients Discusses the history and psychology of beauty as well as the role of cosmetics and cosmeceuticals Emphasizes the importance of screening for common psychological comorbidities Addresses the impact of social media on self-image and its role in a growing crisis in beauty and appearance Highlights the need to develop new guidelines to treat rapidly evolving patient populations Explores how gender fluidity and variations in ethnicity are changing the approaches to aesthetic patients Essential Psychiatry for the Aesthetic Practitioner is required reading for dermatologists, plastic surgeons, cosmetic doctors, dentists, nurses, and physician assistants and all other professionals working in aesthetic medicine. |
| frontiers cellular neuroscience impact factor: Cellular and Molecular Mechanisms of Neurotrophin Function in the Nervous System Pedro Bekinschtein, Oliver von Bohlen und Halbach, 2020-06-15 |
| frontiers cellular neuroscience impact factor: The Immune System and Mental Health Hymie Anisman, Shawn Hayley, Alexander W. Kusnecov, 2018-07-19 The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry. Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson's and Alzheimer's-like dementia are explored. - Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan - Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences - Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health |
| frontiers cellular neuroscience impact factor: Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury Arthur Liesz, Christoph Kleinschnitz, 2015-11-13 Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms. |
| frontiers cellular neuroscience impact factor: Neuronal mechanisms of epileptogenesis Roberto Di Maio, 2015-01-13 Several types of brain injuries are causes of acquired temporal lobe epilepsy (TLE). The seizure-free latent period that often follows the brain injury is of unknown mechanistic significance but is commonly considered as the epileptogenic period characterized by gradual pathogenic processes leading to the onset of clinically detectable epilepsy. Acute convulsive status epilepticus (SE) is often associated with an adverse developmental outcome characterized by learning disabilities related to the cumulative effects of seizures and development of TLE. The symptomatic manifestations of TLE appear only after a widespread irreversible damage of entorhinal cortex, and hippocampus, the brain area most affected by this disease. These pathological features of TLE reduce the possibility of successful therapeutic approaches, often rendering the disease refractory. The difficult clinical management of chronic TLE and the limited success rate of surgical approaches, increase the incapacitating nature of this specific epileptic disorder. Prevention of TLE with an appropriate intervention after a known inciting event (in the case of acquired epilepsy) might represent the most ambitious goal in the clinical treatment of this epileptic disorder, but has been largely unsuccessful to this point. Clinical trials aimed at prevention of chronic epilepsy have often produced negative, disappointing results. However, in most cases, these studies ultimately evaluated the downstream clinical manifestations, failing to monitor early, specific molecular epileptogenic events. Therefore, elucidation of the underlying mechanisms of epileptogenesis, and their time course(s) are essential. The primary purpose of this topic is to collect scientific contributions providing novel insights in the cellular and molecular mechanisms of epileptogenesis as potential targets for innovative therapeutic approaches aimed at preventing the chronic epileptic disorder. |
| frontiers cellular neuroscience impact factor: Regulatory RNAs in the Nervous System, 2nd Edition Tommaso Pizzorusso, Alessandro Cellerino, Laure Bally-Cuif, 2018-11-13 Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory role of nc-RNAs exert in many biological processes. Overall, these studies are making increasingly clear that, both in model organisms and in humans, complexity is not a function of the number of protein-coding genes, but results from the possibility of using combinations of genetic programs and controlling their spatial and temporal regulation during development, senescence and in disease by regulatory RNAs. This has generated a novel picture of gene regulatory networks where regulatory nc-RNAs represent novel layers of regulation. Particularly well-characterized is the role of microRNAs (miRNAs), small nc-RNAs, that bind to mRNAs and regulate gene expression after transcritpion. This message is particularly clear in the nervous system, where miRNAs have been involved in regulating cellular pathways controlling fundamental functions during development, synaptic plasticity and in neurodegenerative disease. It has also been shown that neuronal miRNAs are tightly regulated by electrical activity at the level of transcription, biogenesis, stability and specifically targeted to dendrites and synapses. Deregulation of expression of miRNAs is proposed not only as potential disease biomarker, but it has been implicated directly in the pathogenesis of complex neurodegenerative disease. This so-called RNA revolution also lead to the exploitation of RNA interference and the development of related tools as potential treatment of a vast array of CNS disease that could benefit from regulation of disease-associated genes. In spite of these advancements, the relatively young age of this field together with the inherent high molecular complexity of RNA regulation of biological processes have somewhat hindered its communication to the whole of the neuroscience community. This Research Topic aims at improving this aspect by putting around the same virtual table scientists covering aspects ranging from basic molecular mechanisms of regulatory RNAs in the nervous system to the analysis of the role of specific regulatory RNAs in neurobiological processes of development, plasticity and aging. Furthermore, we included papers analyzing the role of regulatory RNAs in disease models from neuromuscular to higher cognitive functions, and more technically oriented papers dealing with new methodologies to study regulatory RNA biology and its translational potential. |
| frontiers cellular neuroscience impact factor: Homeostatic Synaptic Plasticity: From Synaptic Circuit Assembly to Neurological Disorders Lorenzo A. Cingolani, Mathieu Letellier, 2021-07-08 |
| frontiers cellular neuroscience impact factor: The Nervous System Reset Jessica Maguire, 2024-08-13 From Vagus nerve expert and the voice behind @repairing_the_nervous_system, a cutting-edge program to heal your nervous system —essential reading for anyone struggling with anxiety, chronic pain, burnout, depression, IBS, PTSD, rheumatoid arthritis, and more. Most of us have heard of the mind-body connection, but did you know that there is a physical structure that connects the mind and body? That connection is the Vagus nerve, and it’s singularly responsible for maintaining balance in our mental and physical health. In The Nervous System Reset, Jessica Maguire shares the wisdom of her popular Nervous System School masterclasses and shows readers how to unlock the power of their Vagus nerve. Drawing on the science of polyvagal theory and drawing on decades of her own study and coaching experience, Jessica teaches readers neural exercises, breathwork, and somatic practices to widen their window of tolerance in order to… Regulate their emotions Resolve trauma and PTSD symptoms Overcome mental health challenges like anxiety, depression, or burnout Improve symptoms of chronic pain, fatigue, and autoimmune conditions Heal digestive disorders like IBS and SIBO Smart, accessible, and revolutionary The Nervous System Reset is a practical, science-backed program to heal your nervous system for good. |
| frontiers cellular neuroscience impact factor: Advances in Immunology Frederick W. Alt, Kenneth Murphy, 2023-04-14 Advances in Immunology, Volume 157, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Chapters in this new release include Antigen receptor structure and signaling, T cells in the brain inflammation, The molecular mechanism of RIG-I/MDA5 activation and signaling, GSDMD biology, cGAS-STING pathway, The CARD8 inflammasome in HIV infection, and much more. - Presents current developments and comprehensive reviews in immunology - Provides the latest in a longstanding and respected serial on the subject matter - Focuses on recent advances in t cells and HIV infection |
| frontiers cellular neuroscience impact factor: Hormones, Regulators and Hippocampus Gerald Litwack, 2022-02-16 Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Vitamins and Hormones serials - Updated release includes the latest information on Hormones, Regulators and Hippocampus |
| frontiers cellular neuroscience impact factor: Cellular and molecular mechanisms of motor neuron death in amyotrophic lateral sclerosis Ricardo Tapia, 2015-02-11 Amyotrophic lateral sclerosis (ALS), which was described since 1869 by Jean Martin Charcot, is a devastating neurodegenerative disease characterized by the selective and progressive loss of upper and lower motor neurons of the cerebral cortex, brainstem and the spinal cord. The cognitive process is not affected and is not merely the result of aging because may occur at young ages. The only known cause of the disease is associated with genetic mutations, mainly in the gene encoding superoxide dismutase 1 (familial ALS), whereas there is no known cause of the sporadic form of ALS (SALS), which comprises >90% of cases. Both ALS types develop similar histopathological and clinical characteristics, and there is no treatment or prevention of the disease. Because effective treatments for ALS, as for other neurodegenerative diseases, can only result from the knowledge of their cellular and molecular pathophysiological mechanisms, research on such mechanisms is essential. Although progress in neurochemical, physiological and clinical investigations in the last decades has identified several mechanisms that seem to be involved in the cell death process, such as glutamate-mediated excitotoxicity, alterations of inhibitory circuits, inflammatory events, axonal transport deficits, oxidative stress, mitochondrial dysfunction and energy failure, the understanding of the origin and temporal progress of the disease is still incomplete and insufficient. Clearly, there is a need of further experimental models and approaches to discern the importance of such mechanisms and to discover the factors that determine the selective death of motor neurons characteristic of ALS, in contrast to other neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Whereas studies in vitro in cell cultures, tissue slices or organotypic preparations can give useful information regarding cellular and molecular mechanisms, the experiments in living animal models obviously reflect more closely the situation in the human disease, provided that the symptoms and their development during time mimics as close as possible those of the human disease. It is necessary to correlate the experimental findings in vitro with those in vivo, as well as those obtained in genetic models with those in non-genetic models, aiming at designing and testing therapeutic strategies based on the results obtained. |
| frontiers cellular neuroscience impact factor: Glycolysis Rita Ferreira, Pedro Fontes Oliveira, Rita Nogueira-Ferreira, 2023-10-13 Glycolysis: Tissue-Specific Metabolic Regulation in Physio-Pathological Conditions provides an integrated overview of glycolysis, spanning basic biochemistry, patho-physiology and therapeutic applications. The book also instructs in methods available to study the involvement of the glycolytic events in healthy biology and disease pathology. It begins with an overview of fundamental glycobiology followed by chapters dedicated to glycolysis physiology in organs and systems, pathologic conditions related to glycolytic alterations, glycolysis as a therapeutic target and in drug discovery efforts, and methodological approaches to advance new glycolysis research. Disease areas considered range from cancer to heart failure, diabetes, inborn glycolytic pathway defects, hematologic malignancies, osteoporosis, neurodegenerative diseases and viral Infections. Omics and computational modeling, interactive study methods, and glycolysis flux measurement are described in detail, with step-by-step descriptions of experimental protocols, set-up and analysis. - Features chapter contributions from international leaders in the field - Spans fundamental aspects of glycolysis, patho-physiology and drug discovery - Includes step-by-step instruction in a range of research protocols, ranging from Omics to interactive analysis and measuring glycolysis flux |
| frontiers cellular neuroscience impact factor: Cellular CNS repair strategies, technologies and therapeutic developments Jorg Dietrich, Tim-Henrik Bruun, Ulrich - Bogdahn, Anna Klingseisen, 2023-06-29 |
| frontiers cellular neuroscience impact factor: Common Pathways Linking Neurodegenerative Diseases – The Role of Inflammation Grzegorz Kreiner, Andrii Domanskyi, Małgorzata Kujawska, 2021-11-01 |
| frontiers cellular neuroscience impact factor: From Cell Physiology to Emerging Brain Functions Philippe Isope, Lisa Mapelli, Marylka Yoe Uusisaari, Alexander Tang, 2020-09-11 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| frontiers cellular neuroscience impact factor: Nanotechnologies in Neuroscience and Neuroengineering Ioan Opris, Mikhail Lebedev, Ruxandra Vidu, Victor Manuel Pulgar, Marius Enachescu, Manuel Fernando Casanova, 2020-05-05 |
| frontiers cellular neuroscience impact factor: Connecting Form and Function: Recent Advances in Understanding Dendrite Morphogenesis and Plasticity Quan Yuan, Chun Han, Peter Soba, 2022-03-03 |
| frontiers cellular neuroscience impact factor: Emerging Mechanisms in Neuronal Signaling: From Cell Biology to Pathogenesis Mario Eduardo Guido, Gabriela Alejandra Salvador, Alejandra Alonso, 2020-11-12 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| frontiers cellular neuroscience impact factor: Handbook of Sleep Research , 2019-06-21 Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders. - Emphasizes a comparative and multidisciplinary approach to the topic of sleep - Covers the neurobiology and physiology of sleep stages, mechanisms of waking, and dreaming - Discusses in detail the proposed functions of sleep, from health and rest, to memory consolidation and synaptic plasticity - Examines the current state of research in mammalian and non-mammalian species, ranging from primates to invertebrates |
| frontiers cellular neuroscience impact factor: The Genetics of Political Behavior Michael Ryan, 2020-11-29 In this unique amalgam of neuroscience, genetics, and evolutionary psychology, Ryan argues that leftists and rightists are biologically distinct versions of the human species that came into being at different moments in human evolution. The book argues that the varying requirements of survival at different points in history explain why leftists and rightists have anatomically different brains as well as radically distinct behavioral traits. Rightist traits such as callousness and fearfulness emerged early in evolution when violence was pervasive in human life and survival depended on the fearful anticipation of danger. Leftist traits such as pro-sociality and empathy emerged later as environmental adversity made it necessary for humans to live in larger social groups that required new adaptive behavior. The book also explores new evolutionary theories that emphasize the role of the environment in shaping not only human political behavior but also humans' genetic architecture. With implications for the future of politics, the book explores how the niche worlds we build for ourselves through political action can have consequences for the evolution of the species. Proposing a new way of understanding human politics, this is fascinating reading for students and academics in psychology, the social sciences, and humanities, as well as general readers interested in political behavior. |
| frontiers cellular neuroscience impact factor: Empowering Innovations in Advanced Autism Research and Management Alexiou, Athanasios, Ashraf, Ghulam Md, Sgantzos, Markos, 2025-01-31 Autism Spectrum Disorder (ASD) affects hundreds of thousands worldwide. ASD research has been used to inform medical and surgical practices to better the care provided to those with ASD. Additionally, innovations in the management of autism have led to the use of predictive language processing for the development of communication skills. Autism management has advanced in areas such as parent training, development of soft skills, and education. To continue to better the lives of those with ASD, it is important to advance the research and global use of innovations to empower those with ASD. Empowering Innovations in Advanced Autism Research and Management explores innovative advancements in autism research, focusing on innovative strategies for diagnosis, intervention, and support that enhances the quality of life for individuals on the spectrum. It highlights the role of emerging technologies, personalized approaches, and collaborative frameworks in driving meaningful progress in autism care and research. Covering topics such as autism pathogenesis, healthcare practices, and special education, this book is an excellent resource for researchers, clinicians, healthcare professionals, educators, policymakers, and more. |
| frontiers cellular neuroscience impact factor: The Personalized Autism Nutrition Plan Julie S. Matthews, 2025-03-18 Create the right diet to support your child with autism or other neurodevelopmental delays through this step-by-step guide to optimal nutrition for their unique needs. If your child with autism spectrum disorder struggles with common symptoms such as irritability, anxiety, stimming, or gastrointestinal upset, you are not alone—and you are not powerless to help. This groundbreaking book offers the first personalized approach to help improve these disruptive symptoms through your child’s diet, supplying you with the information and resources you need to holistically help them thrive. Certified nutrition consultant Julie Matthews pairs more than 20 years of clinical experience with practical advice and an attainable and adaptable 12-step plan for effectively addressing the symptoms of autism spectrum disorder, ADHD, ADD, Tourette’s syndrome, Down syndrome, learning delays, anxiety, aggression, and defiant disorders. Matthews illustrates the underlying biochemical factors that cause these symptoms, and explains how therapeutic diets and nutritional supplements can have profound benefits for your child’s body and brain. This scientifically proven program includes: Common and impactful diets to implement Adjustable daily meal plan ideas for each diet Detailed lists of key foods and nutritional supplements 50 nourishing and picky eater–approved recipes Symptom questionnaires for determining the right diet Just as every child with autism spectrum disorder is unique, there is no one-size-fits-all diet recommendation. The Personalized Autism Nutrition Plan is tailored yet flexible, empowering you with tools to drastically improve your child’s well-being and help them thrive—with food as medicine. |
| frontiers cellular neuroscience impact factor: Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS Part I , 2021-10-23 Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing CNS, Volume 161 in the International Review on Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics including Cannabis Exposure During Adolescence: A Uniquely Sensitive Period for Neurobiological Effects, The Stoned-Age: A Systematic Review of the Neurobiological Effects of Adolescent Cannabinoid Exposure on Preclinical Animal Models, Genetic Influences Impacting Nicotine Use and Abuse During Adolescence: Insights from Human and Animal Studies, the Impact of Adolescent Nicotine Exposure on Adulthood Alcohol Consumption: The Role of Neuropeptides, and much more. Additional chapters cover The Role of Sex in the Persistent Effects of Adolescent Alcohol Exposure on Behavior and Neurobiology in Rodents, The Effects of Peri-Adolescent Alcohol Use on the Developing Hippocampus, Regulation of Glutamate Signaling in the Extended Amygdala by Adolescent Alcohol Exposure, Peri-Adolescent Binge Drinking Effects on Hippocampal Neurogenesis, Neuroepigenetic Consequences of Adolescent Ethanol Exposure, Adolescent Neuroimmunity and Its Interaction with Alcohol, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the International Review on Neurobiology series - Updated release includes the latest information on the Effects of Peri-Adolescent Licit and Illicit Drug Use on the Developing Central Nervous System |
| frontiers cellular neuroscience impact factor: Peripheral Nerve Regeneration Giovanna Gambarotta, Kirsten Haastert-Talini, Esther Udina, Stefania Raimondo, James Phillips, 2019-12-24 |
| frontiers cellular neuroscience impact factor: Dendrites Greg Stuart, Nelson Spruston, Michael Häusser, 2017-04-13 Dendrites are complex neuronal structures that receive and integrate synaptic input from other nerve cells. They therefore play a critical role in brain function. Although dendrites were discovered over a century ago, due to the development of powerful new techniques there has been a dramatic resurgence of interest in the properties and function of these beautiful structures. This is the third edition of the first book devoted exclusively to dendrites. It contains a comprehensive survey of the current state of dendritic research across a wide range of topics, from dendritic morphology, evolution, development, and plasticity through to the electrical, biochemical and computational properties of dendrites, and finally to the key role of dendrites in brain disease. The third edition has been thoroughly revised, with the addition of a number of new chapters and comprehensive updates or rewrites of existing chapters by leading experts. Dendrites will be of interest to researchers and students in neuroscience and related fields, as well as to anyone interested in how the brain works. |
| frontiers cellular neuroscience impact factor: Delivering Therapeutics to the Inner Ear Peter S. Steyger, Larry Hoffman, Benjamin Shapiro, Sylvain Celanire, Stefan K. Plontke, 2021-08-17 Topic Editor Benjamin Shapiro is President and co-founder of Otomagnetics. Topic Editor Sylvain Celanire is a co-Founder and Chief Executive Officer of PRAGMA Therapeutics. All other Topic Editors declare no competing commercial interests with regards to the Research Topic subject. |
| frontiers cellular neuroscience impact factor: Emerging Cellular Stress Sensors in Neurological Disorders: Closing in on the Nucleolus and the Primary Cilium Rosanna Parlato, Kerry Lee Tucker, 2020-05-21 |
Frontiers in Cellular Neuroscience
Part of the world's most cited neuroscience journal series that advances our understanding of the cellular mechanisms underlying cell function in the nervous system across all species.
Frontiers in Cellular Neuroscience | Journal Report
Impact Factor. Citations (Scopus total) Articles published (total) ... Frontiers in Cellular Neuroscience. IF . Most cited journals in Neurosciences. Journals. ... For more information: …
Frontiers in Cellular Neuroscience | About
Frontiers in Cellular Neuroscience is a multidisciplinary journal publishing research that advances our understanding of the cellular mechanisms underlying the function of neural and glial cells …
Journal impact: Frontiers in Neuroscience journal series
Jul 6, 2018 · Frontiers in Neuroscience journal series: 2017 Impact Factor and CiteScore science journal rankings. Figure 2: Analysis of Impact Factor and CiteScore rankings in the JCR …
Frontiers | Frontiers' impact
To benchmark the reach, influence and quality of our journals, we measure and communicate a range of indicators of our journals’ impact, including Journal Impact Factors, CiteScores, …
Frontiers in Cellular Neuroscience | Cellular Neurophysiology
The Cellular Neurophysiology section is dedicated to publishing research focused on advancing the understanding of cellular and molecular mechanisms of neuronal excitability, …
Frontiers in Cellular Neuroscience
Part of the world's most cited neuroscience journal series, this section aims to advance our understanding of the pathological mechanisms of cellular damage in different models of disease.
Frontiers | Report
The Frontiers in Neuroscience journal series is the 1st most cited in Neurosciences. With an Impact Factor of 4.555, Frontiers in Cellular Neuroscience is the 2nd most cited open-access …
Frontiers journal ranking analysis: Neurosciences
Jun 28, 2017 · With an Impact Factor of 3.267, Frontiers in Neuroanatomy is the 2nd most cited Anatomy & Morphology journal in the world with an Impact Factor ranking as high as the 96th …
Frontiers in Cellular Neuroscience | Non-Neuronal Cells
Led by Dr. Marie-Ève Tremblay from the University of Victoria, the Non-Neuronal Cells section welcomes submissions in the various domains of cellular neuroscience, which connect the …
Frontiers in Cellular Neuroscience
Part of the world's most cited neuroscience journal series that advances our understanding of the cellular mechanisms underlying cell …
Frontiers in Cellular Neuroscience | Journal Report
Impact Factor. Citations (Scopus total) Articles published (total) ... Frontiers in Cellular Neuroscience. IF . Most cited journals in Neurosciences. Journals. …
Frontiers in Cellular Neuroscience | About
Frontiers in Cellular Neuroscience is a multidisciplinary journal publishing research that advances our understanding of the cellular …
Journal impact: Frontiers in Neuroscience journal series
Jul 6, 2018 · Frontiers in Neuroscience journal series: 2017 Impact Factor and CiteScore science journal rankings. Figure 2: Analysis of Impact Factor …
Frontiers | Frontiers' impact
To benchmark the reach, influence and quality of our journals, we measure and communicate a range of indicators of our journals’ impact, including …
