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| gnotobiotic mouse technology an illustrated guide: Gnotobiotic Mouse Technology Chriss J. Vowles, 2016-01-05 The popularity of germ-free animal models, particularly mice, for investigation of human physiology and disease has recently exploded. Gnotobiotic Mouse Technology: An Illustrated Guide provides the first manual for the maintenance, husbandry, and experimental manipulation of germ-free and gnotobiotic mice. It includes information on all aspects of |
| gnotobiotic mouse technology an illustrated guide: Gnotobiotic Mouse Technology Chriss J. Vowles, Natalie E. Anderson, Kathryn A. Eaton, 2016-01-05 The popularity of germ-free animal models, particularly mice, for investigation of human physiology and disease has recently exploded. Gnotobiotic Mouse Technology: An Illustrated Guide provides the first manual for the maintenance, husbandry, and experimental manipulation of germ-free and gnotobiotic mice. It includes information on all aspects of |
| gnotobiotic mouse technology an illustrated guide: Gnotobiotics Trenton R Schoeb, Kathryn A Eaton, 2017-08-11 Gnotobiotics summarizes and analyzes the research conducted on the use of gnotobiotes, providing detailed information regarding actual facility operation and derivation of gnotobiotic animals. In response to the development of new tools for microbiota and microbiome analysis, the increasing recognition of the various roles of microbiota in health and disease, and the consequent expanding demand for gnotobiotic animals for microbiota/microbiome related research, this volume collates the research of this expanding field into one definitive resource. - Reviews and defines gnotobiotic animal species - Analyzes microbiota in numerous contexts - Presents detailed coverage of the protocols and operation of a gnotobiotic facility |
| gnotobiotic mouse technology an illustrated guide: Practical Management of Research Animal Care and Use Programs Javier Guillén, Viola Galligioni, 2024-11-06 This book provides a complete guide to all the aspects to consider during planning, establishing and managing ethically and efficiently research animal care and use programs, taking into account all stakeholders involved in the process. Practical information on how to address the general and particular needs of all animal care and use program areas is provided. Consequently, the reader is supported with getting their project ethically and legally compliant, and implemented efficiently with organizing safe and appropriate facilities and equipment as well as hiring sufficiently trained personnel. Furthermore, strategies for impactful internal and external communication are outlined. Responsible use of animals in research can be nothing but teamwork. The environment and professional experience of all involved stakeholders are the key for ensuring quality science, as well as animal and personnel welfare. Research animal care and use programs represent a complex system in which animals, legislation and good practices, facility personnel and researchers interact on a daily basis. Thoughtful planning from the first step ensures animal welfare and improves the quality of in vivo experimentation. This book addresses animal program managers, veterinarians, researchers and technicians working in research animal facilities. Chapter 18 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. |
| gnotobiotic mouse technology an illustrated guide: Animal Models for Microbiome Research National Academies of Sciences, Engineering, and Medicine, Division on Earth and Life Studies, Institute for Laboratory Animal Research, Roundtable on Science and Welfare in Laboratory Animal Use, 2018-04-23 The surface of the human body and its mucous membranes are heavily colonized by microorganisms. Our understanding of the contributions that complex microbial communities make to health and disease is advancing rapidly. Most microbiome research to date has focused on the mouse as a model organism for delineating the mechanisms that shape the assembly and dynamic operations of microbial communities. However, the mouse is not a perfect surrogate for studying different aspects of the microbiome and how it responds to various environmental and host stimuli, and as a result, researchers have been conducting microbiome studies in other animals. To examine the different animal models researchers employ in microbiome studies and to better understand the strengths and weaknesses of each of these model organisms as they relate to human and nonhuman health and disease, the Roundtable on Science and Welfare in Laboratory Animal Use of the National Academies of Sciences, Engineering, and Medicine convened a workshop in December 2016. The workshop participants explored how to improve the depth and breadth of analysis of microbial communities using various model organisms, the challenges of standardization and biological variability that are inherent in gnotobiotic animal-based research, the predictability and translatability of preclinical studies to humans, and strategies for expanding the infrastructure and tools for conducting studies in these types of models. This publication summarizes the presentations and discussions from the workshop. |
| gnotobiotic mouse technology an illustrated guide: Inflammation, Infection, and Microbiome in Cancers Jun Sun, 2021-04-20 This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists. |
| gnotobiotic mouse technology an illustrated guide: Journal of the American Veterinary Medical Association American Veterinary Medical Association, 2016 |
| gnotobiotic mouse technology an illustrated guide: The Gut Microbiome in Health and Disease Dirk Haller, 2018-07-27 The book provides an overview on how the gut microbiome contributes to human health. The readers will get profound knowledge on the connection between intestinal microbiota and immune defense systems. The tools of choice to study the ecology of these highly-specialized microorganism communities such as high-throughput sequencing and metagenomic mining will be presented. In addition the most common diseases associated to the composition of the gut flora are discussed in detail. The book will address researchers, clinicians and advanced students working in biomedicine, microbiology and immunology. |
| gnotobiotic mouse technology an illustrated guide: American Journal of Veterinary Research , 2016 Volumes for 1956- include selected papers from the proceedings of the American Veterinary Medical Association. |
| gnotobiotic mouse technology an illustrated guide: The Human Microbiome, Diet, and Health Food Forum, Food and Nutrition Board, Institute of Medicine, 2013-02-27 The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment. |
| gnotobiotic mouse technology an illustrated guide: The Laboratory Mouse Peggy J. Danneman, Mark A. Suckow, Cory Brayton, 2012-09-25 Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a |
| gnotobiotic mouse technology an illustrated guide: Guide to the Care and Use of Experimental Animals , 1980 |
| gnotobiotic mouse technology an illustrated guide: Bioavailability of Contaminants in Soils and Sediments National Research Council, Division on Earth and Life Studies, Water Science and Technology Board, Committee on Bioavailability of Contaminants in Soils and Sediments, 2003-05-03 Bioavailability refers to the extent to which humans and ecological receptors are exposed to contaminants in soil or sediment. The concept of bioavailability has recently piqued the interest of the hazardous waste industry as an important consideration in deciding how much waste to clean up. The rationale is that if contaminants in soil and sediment are not bioavailable, then more contaminant mass can be left in place without creating additional risk. A new NRC report notes that the potential for the consideration of bioavailability to influence decision-making is greatest where certain chemical, environmental, and regulatory factors align. The current use of bioavailability in risk assessment and hazardous waste cleanup regulations is demystified, and acceptable tools and models for bioavailability assessment are discussed and ranked according to seven criteria. Finally, the intimate link between bioavailability and bioremediation is explored. The report concludes with suggestions for moving bioavailability forward in the regulatory arena for both soil and sediment cleanup. |
| gnotobiotic mouse technology an illustrated guide: Microbial Products for Health, Environment and Agriculture Pankaj Kumar Arora, 2021-09-21 This edited volume discusses the role of various microbial products in healthcare, environment and agriculture. Several microbial products are directly involved in solving major health problems, agricultural and environmental issues. In healthcare sector, microbes are used as anti-tumor compounds, antibiotics, anti-parasitic agents, enzyme inhibitors and immunosuppressive agents. Microbial products are also used to degrade xenobiotic compounds and bio-surfactants, for biodegradation process. In agriculture, microbial products are used to enhance nutrient uptake, to promote plant growth, or to control plant diseases. The book presents several such applications of microbes in the ecosystems. The chapters are contributed from across the globe and contain up-to-date information. This book is of interest to teachers, researchers, microbiologists and ecologists. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. |
| gnotobiotic mouse technology an illustrated guide: Nutrition Abstracts and Reviews , 1978 |
| gnotobiotic mouse technology an illustrated guide: The Welfare of Laboratory Animals Eila Kaliste, 2007-04-18 Animal welfare is attracting increasing interest worldwide, but particularly from those in developed countries, who now have the knowledge and resources to be able to offer the b est management systems for their farm animals, as well as potentially being able to offer plentiful resources for companion, zoo and laboratory animals. The increased attention given to animal welfare in the West derives la rgely from the fact that the relentless pursuit of financial reward and efficiency has lead to the development of intensive animal production systems that offend the conscience of many consumers in those countries. In devel oping countries, human survival is still a daily uncertainty, so that provision fo r animal welfare has to be balanced against human welfare. Welfare is usua lly provided for only if it supports the output of the animal, be it food, work, clothing, sport or companionship. In reality there are resources for all if they are properly husbanded in both developing and developed countries. The inequitable division of the world’s riches creates physical and psychological poverty for humans and animals alike in all sectors of the world. Liv estock are the world’s biggest land user (FAO, 2002) and the population, particularly of monogastric animals, is increasing rapidly to meet the need of an expanding human population. Populations of animals managed by humans are therefore increasing worldwide, so there is the tendency to allocate fewer resources to each one. |
| gnotobiotic mouse technology an illustrated guide: A Rat Is a Pig Is a Dog Is a Boy Wesley Smith, 2012-07-17 Over the past thirty years, as Wesley J. Smith details in his latest book, the concept of animal rights has been seeping into the very bone marrow of Western culture. One reason for this development is that the term “animal rights” is so often used very loosely, to mean simply being nicer to animals. But although animal rights groups do sometimes focus their activism on promoting animal welfare, the larger movement they represent is actually advancing a radical belief system. For some activists, the animal rights ideology amounts to a quasi religion, one whose central doctrine declares a moral equivalency between the value of animal lives and the value of human lives. Animal rights ideologues embrace their beliefs with a fervor that is remarkably intense and sustained, to the point that many dedicate their entire lives to “speaking for those who cannot speak for themselves.” Some believe their cause to be so righteous that it entitles them to cross the line from legitimate advocacy to vandalism and harassment, or even terrorism against medical researchers, the fur and food industries, and others they accuse of abusing animals. All people who love animals and recognize their intrinsic worth can agree with Wesley J. Smith that human beings owe animals respect, kindness, and humane care. But Smith argues eloquently that our obligation to humanity matters more, and that granting “rights” to animals would inevitably diminish human dignity. In making this case with reason and passion, A Rat Is a Pig Is a Dog Is a Boy strikes a major blow against a radically antihuman dogma. |
| gnotobiotic mouse technology an illustrated guide: Improving the Safety of Fresh Meat John N. Sofos, 2005-08-12 The safety of fresh meat continues to be a major concern for consumers. As a result, there has been a wealth of research on identifying and controlling hazards at all stages in the supply chain. Improving the Safety of Fresh Meat reviews this research and its implications for the meat industry. Part I discusses identifying and managing hazards on the farm. There are chapters on the prevalence and detection of pathogens and on chemical and other contaminants. A number of chapters also discuss ways of controlling such hazards in the farm environment. Part II of the book reviews the identification and control of hazards during and after slaughter. There are chapters on both contamination risks and how they can best be managed. The book also discusses the range of decontamination techniques available to meat processors as well as such areas as packaging and storage. With its distinguished editor and international team of contributors, Improving the Safety of Fresh Meat will be a standard reference for the meat industry. |
| gnotobiotic mouse technology an illustrated guide: Burns Emily S. McLaughlin, 2012 This book presents topical research in the study of the prevention, causes and treatment of burns. Topics discussed in this compilation include emergency burn care; nanotechnology and nanomedicine advancements in burn therapy; post-burn hand deformities; the role of apoptosis in burn injury; burns during arthroscopy due to the use of electrosurgical devices; the body's local and consecutive, systemic pathophysiological reaction to thermal lesions; the burn reconstructive units on the face and neck; use of modern day technology for pain management during burn injury rehabilitation; carbon monoxide intoxication in burns; the clinical application of Versajet Hydrosurgery System in burn debridement and escharotomy techniques in burn injuries. |
| gnotobiotic mouse technology an illustrated guide: The nutrition and health potential of geographical indication foods Food and Agriculture Organization of the United Nations , 2021-03-30 Traditional foods, diets and food systems play an important role in people’s nutritional status. As the best products of traditional food systems, geographical indication (GI) foods have a great potential to contribute to healthy diets and curb non-communicable diseases. This paper presents five case studies around the world on the nutritional potential of registered GI foods and explores the link between the production processes and the nutritional composition of the final products. The nutritional characteristics of these foods can be largely attributed to their unique ingredients and production procedures, which are linked to their geographical origins.The paper also discusses the development of GI specifications to maintain and improve nutritional values, the role of GI foods in healthy diets, and the determination of food composition. Finally, suggestions on how to leverage GI foods for healthy diets are provided. |
| gnotobiotic mouse technology an illustrated guide: Principles of Laboratory Animal Science L. F. M. van Zutphen, Vera Baumans, Anton C. Beynen, 1993 It is now widely recognized that education and training in laboratory animal science are essential for the humane use of animals for scientific purposes and for the quality of results. This book contains basic facts and principles covering the main theoretical aspects of this subject, encompassing welfare as well as ethical issues. presented on the biology and husbandry of the most frequently used animal species and the relationship between behaviour, stress and well-being. The book also covers aspects of standardization, diseases of laboratory animals and their effect on welfare and experiment results, recognition of pain and distress, anaesthesia, the possibilities and limitations of the use of alternatives and the ethics of animal experimentation. indirectly in the care and use of (experimental) laboratory animals. |
| gnotobiotic mouse technology an illustrated guide: Toxicology in the Use, Misuse, and Abuse of Food, Drugs, and Chemicals P.L. Chambers, S. Gitter, C.M. Chambers, 2012-12-06 Many chemotherapeutic agents introduced for use in humans are carcinogenic in laboratory animals (Conklin et al. 1965; Shimkin et al. 1966; Griswold et al. 1968; Harris 1976). However, initially their beneficial effect in disseminated cancer was of such short duration that the inevitable death of the patient from his primary disease precluded any clinical manifestation of the carcinogenic potential. During the last decade, chemotherapy has radically changed the outlook for many patients with cancer. Combinations of drugs, administered as the primary treatment, have resulted in high rates of cure in patients with disseminated malignancies, such as stage IV Hodgkin's disease or childhood acute lymphocytic leukemia. In other disseminated forms of neoplasia, induction of a remission, a substantial palliation and a prolongation of survival have been achieved. In many instances of localised disease, where surgery with or without radiotherapy are the primary form of treatment, anticancer drugs have been used with success as adjuvant therapy for distant microscopic disease. With these spectacular achievements, secondary malignancies, in particular acute non-lymphocytic leukemia (ANLL), has become of major concern. Incidence Acute leukemia is the most frequent form of secondary neoplasia in patients treated for cancer (Penn 1981). In one large series, 5. 9% of all ANLL could be attributed to previous chemotherapy (Kapadia et al. 1980). |
| gnotobiotic mouse technology an illustrated guide: Ferret Medicine and Surgery Cathy Johnson-Delaney, 2016-10-14 The text is currently the most up-to-date book on ferret medicine and as such, would be an important addition to the library of veterinary practices seeing these lively, curious and fun-loving pets. Aidan Raftery, Veterinary Record 17 March 2018 Ferrets are becoming increasingly popular as pets, rivalling rabbits as the third most favoured domestic pet after dogs and cats. Ferret Medicine and Surgery discusses the veterinary aspects of this incredible little creature. The book covers ferret medicine and common surgeries, providing a comprehensive reference for the veterinary practitioner. Each chapter of disorders is designed to be inclusive and includes cross references to other chapters throughout as well as some highlights of anatomy and physiology as a review. The format allows easy access to information providing answers to problems that arise in practice. Thoroughly illustrated with high-quality photographs and line drawings, the book is designed to provide quick, concise information of immediate use to the practitioner. |
| gnotobiotic mouse technology an illustrated guide: The Role of Biofilms in Device-Related Infections Mark Shirtliff, Jeff G. Leid, 2008-12-19 Approximately 60% of all hospital-associated infections, over one million cases per year, are due to biofilms that have formed on indwelling medical devices. Device-related biofilm infections increase hospital stays and add over one billion dollars/year to U.S. hospitalization costs. Since the use and the types of indwelling medical devices commonly used in modern healthcare are continuously expanding, especially with an aging population, the incidence of biofilm infections will also continue to rise. The central problem with microbial biofilm infections of foreign bodies is their propensity to resist clearance by the host immune system and all antimicrobial agents tested to date. In fact, compared to their free floating, planktonic counterparts, microbes within a biofilm are 50 – 500 times more resistant to antimicrobial agents. Therefore, achieving therapeutic and non-lethal dosing regimens within the human host is impossible. The end result is a conversion from an acute infection to one that is persistent, chronic, and recurrent, most often requiring device removal in order to eliminate the infection. This text will describe the major types of device-related infections, and will explain the host, pathogen, and the unique properties of their interactions in order to gain a better understanding of these recalcitrant infections. |
| gnotobiotic mouse technology an illustrated guide: Emerging Viral Diseases Institute of Medicine, Board on Global Health, Forum on Microbial Threats, 2015-03-19 In the past half century, deadly disease outbreaks caused by novel viruses of animal origin - Nipah virus in Malaysia, Hendra virus in Australia, Hantavirus in the United States, Ebola virus in Africa, along with HIV (human immunodeficiency virus), several influenza subtypes, and the SARS (sudden acute respiratory syndrome) and MERS (Middle East respiratory syndrome) coronaviruses - have underscored the urgency of understanding factors influencing viral disease emergence and spread. Emerging Viral Diseases is the summary of a public workshop hosted in March 2014 to examine factors driving the appearance, establishment, and spread of emerging, re-emerging and novel viral diseases; the global health and economic impacts of recently emerging and novel viral diseases in humans; and the scientific and policy approaches to improving domestic and international capacity to detect and respond to global outbreaks of infectious disease. This report is a record of the presentations and discussion of the event. |
| gnotobiotic mouse technology an illustrated guide: Principles of Nutrigenetics and Nutrigenomics Raffaele De Caterina, Alfredo J. Martinez, Martin Kohlmeier, 2019-09-19 Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. |
| gnotobiotic mouse technology an illustrated guide: Handbook of Laboratory Animal Management and Welfare Sarah Wolfensohn, Maggie Lloyd, 2013-01-03 This bestseller has been an essential book for all those working with laboratory animals since it was first published in 1994. This fourth edition retains all the classic features that have made it a must-have reference including emphasis on best practice in order to improve animal welfare. The contents have been thoroughly updated and reorganised to make sure it is a really practical book for day-to-day use in the laboratory. The first section of the book covers principles applicable to all species, for example husbandry, handling and the education and training required by scientists and technical staff working with animals in the laboratory. Later chapters focus on specific species or groups of species. New to this edition: • Reflects changes in European legislation and their impact on national legislation • Covers recommendations for the education and training of those carrying out animal experiments across Europe • New chapters on ethical considerations and balancing animal welfare with science • New information on environmental enrichment for laboratory animals • Covers advancements in anaesthesia and analgesia and techniques • Spiral bound for ease-of-use as a bench-top reference This book is ideal for all personnel carrying out scientific procedures using animals, particularly during training and also for the new researcher. It will also be essential reading for study directors designing research programmes, animal technicians and veterinarians working with laboratory animal species. |
| gnotobiotic mouse technology an illustrated guide: The Lung Microbiome Michael J. Cox, Markus J. Ege, Erika von Mutius, 2019-03-01 Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment. |
| gnotobiotic mouse technology an illustrated guide: Environmental Microbiology: Fundamentals and Applications Jean-Claude Bertrand, Pierre Caumette, Philippe Lebaron, Robert Matheron, Philippe Normand, Télesphore Sime-Ngando, 2015-01-26 This book is a treatise on microbial ecology that covers traditional and cutting-edge issues in the ecology of microbes in the biosphere. It emphasizes on study tools, microbial taxonomy and the fundamentals of microbial activities and interactions within their communities and environment as well as on the related food web dynamics and biogeochemical cycling. The work exceeds the traditional domain of microbial ecology by revisiting the evolution of cellular prokaryotes and eukaryotes and stressing the general principles of ecology. The overview of the topics, authored by more than 80 specialists, is one of the broadest in the field of environmental microbiology. The overview of the topics, authored by more than 80 specialists, is one of the broadest in the field of environmental microbiology. |
| gnotobiotic mouse technology an illustrated guide: A Companion to Cognitive Anthropology David B. Kronenfeld, Giovanni Bennardo, Victor C. de Munck, Michael D. Fischer, 2011-04-25 A Companion to Cognitive Anthropology offers a comprehensive overview of the development of cognitive anthropology from its inception to the present day and presents recent findings in the areas of theory, methodology, and field research in twenty-nine key essays by leading scholars. Demonstrates the importance of cognitive anthropology as an early constituent of the cognitive sciences Examines how culturally shared and complex cognitive systems work, how they are structured, how they differ from one culture to another, how they are learned and passed on Explains how cultural (or collective) vs. individual knowledge distinguishes cognitive anthropology from cognitive psychology Examines recent theories and methods for studying cognition in real-world scenarios Contains twenty-nine key essays by leading names in the field |
| gnotobiotic mouse technology an illustrated guide: A Modern Epidemic Professor Louise A Baur, Stephen M Twigg, Roger S Magnusson, 2012-03-21 Obesity and diabetes are not just problems for the individual. They pose risks to the environmental, psychological and economic stability of the entire world. The solutions, therefore, need to be equally wide-ranging and accessible to all. The authors write about the causes and consequences of obesity and diabetes, as well as prevention and treatment. |
| gnotobiotic mouse technology an illustrated guide: Pathology of Laboratory Rodents and Rabbits Stephen W. Barthold, Stephen M. Griffey, Dean H. Percy, 2016-01-04 Now in its fourth edition, Pathology of Laboratory Rodents and Rabbits has become a standard text for veterinary pathologists, laboratory animal veterinarians, students, and others interested in these species. • The standard reference on the pathogenesis and cardinal diagnostic features of diseases of mice, rats, hamsters, gerbils, guinea pigs, and rabbits • Expanded coverage of rabbit disease, normal anatomic features, and biology • Over 450 color photographs illustrating gross and microscopic pathology • Companion website offering images from the text in PowerPoint |
| gnotobiotic mouse technology an illustrated guide: Ten years in public health 2007-2017 Margaret Chan, 2018-04-27 Ten years in public health 2007-2017 chronicles the evolution of global public health over the decade that Margaret Chan served as Director-General at the World Health Organization. This series of chapters evaluates successes setbacks and enduring challenges during the decade. They show what needs to be done when progress stalls or new threats emerge. The chapters show how WHO technical leadership can get multiple partners working together in tandem under coherent strategies. The importance of country leadership and community engagement is stressed repeatedly throughout the chapters. Together we have made tremendous progress. Health and life expectancy have improved nearly everywhere. Millions of lives have been saved. The number of people dying from malaria and HIV has been cut in half. WHO efforts to stop TB saved 49 million lives since the start of this century. In 2015 the number of child deaths dropped below 6 million for the first time a 50% decrease in annual deaths since 1990. Every day 19 000 fewer children die. We are able to count these numbers because of the culture of measurement and accountability instilled in WHO. These chapters tell a powerful story of global challenges and how they have been overcome. In a world facing considerable uncertainty international health development is a unifying – and uplifting – force for the good of humanity. |
| gnotobiotic mouse technology an illustrated guide: Prebiotics and Probiotics Science and Technology Dimitris Charalampopoulos, Robert A. Rastall, 2009-08-12 A comprehensive overview on the advances in the field, this volume presents the science underpinning the probiotic and prebiotic effects, the latest in vivo studies, the technological issues in the development and manufacture of these types of products, and the regulatory issues involved. It will be a useful reference for both scientists and technologists working in academic and governmental institutes, and the industry. |
| gnotobiotic mouse technology an illustrated guide: Genomics in Aquaculture Simon A MacKenzie, Sissel Jentoft, 2016-07-29 Genomics in Aquaculture is a concise, must-have reference that describes current advances within the field of genomics and their applications to aquaculture. Written in an accessible manner for anyone—non-specialists to experts alike—this book provides in-depth coverage of genomics spanning from genome sequencing, to transcriptomics and proteomics. It provides, for ease of learning, examples from key species most relevant to current intensive aquaculture practice. Its coverage of minority species that have a specific biological interest (e.g., Pleuronectiformes) makes this book useful for countries that are developing such species. It is a robust, practical resource that covers foundational, functional, and applied aspects of genomics in aquaculture, presenting the most current information in a field of research that is rapidly growing. - Provides the latest scientific methods and technologies to maximize efficiencies for healthy fish production, with summary tables for quick reference - Offers an extended glossary of technical and methodological terms to help readers better understand key biological concepts - Describes state-of-the-art technologies, such as transcriptomics and epigenomics, currently under development for future perspective of the field - Covers minority species that have a specific biological interest (e.g., Pleuronectiformes), making the book useful to countries developing such species |
| gnotobiotic mouse technology an illustrated guide: Laboratory Animal Medicine James G. Fox, Bennett J. Cohen, Franklin M. Loew, 2013-10-02 Laboratory Animal Medicine is a compilation of papers that deals with the diseases and biology of major species of animals used in medical research. The book discusses animal medicine, experimental methods and techniques, design and management of animal facilities, and legislation on laboratory animals. Several papers discuss the biology and diseases of mice, hamsters, guinea pigs, and rabbits. Another paper addresses the dog and cat as laboratory animals, including sourcing of these animals, housing, feeding, and their nutritional needs, as well as breeding and colony management. The book also describes ungulates as laboratory animals, including topics on sourcing, husbandry, preventive medical treatments, and housing facilities. One paper addresses primates as test animals, covering the biology and diseases of old world primates, Cebidae, and ferrets. Some papers pertain to the treatment, diseases, and needed facilities for birds, amphibians, and fish. Other papers then deal with techniques of experimentation, anesthesia, euthanasia, and some factors (spontaneous diseases) that complicate animal research. The text can prove helpful for scientists, clinical assistants, and researchers whose work involves laboratory animals. |
| gnotobiotic mouse technology an illustrated guide: Avian Influenza Virus Erica Spackman, 2008-02-28 With the growing global fear of a major pandemic, avian influenza (AI) virus research has greatly increased in importance. In Avian Influenza Virus, an expert team of researchers and diagnosticians examine the fundamental, yet essential, virological methods for AI virus research and diagnostics as well as some of the newest molecular procedures currently used for basic and applied research. They present exciting, cutting-edge new methods that focus both on studying the virus itself and on work with avian hosts, an area greatly lacking in research. |
| gnotobiotic mouse technology an illustrated guide: Immunoendocrinology: Scientific and Clinical Aspects George S. Eisenbarth, 2010-12-13 Immunoendocrinology is a rapidly developing field of research that seeks to understand the intersection of the immune and endocrine systems. Immunoendocrinology: Scientific and Clinical Aspects explores in detail the current knowledge of immunoendocrinology, namely endocrine disorders produced by disorders of immune function. Chapters cover both basic pathophysiology informed by studies of animal models as well as current understanding of multiple related clinical diseases—their pathophysiology, diagnosis, and therapy. Immunoendocrinology: Scientific and Clinical Aspects captures the central role of immunoendocrinologic processes in the pathogenesis of not only type 1 diabetes but in a range of other autoimmune and endocrine disorders. |
| gnotobiotic mouse technology an illustrated guide: Psychology and Pathophysiological Outcomes of Eating Akikazu Takada, Hubertus Himmerich, 2021 The psychology of eating is regulated by neural mechanisms. When not well controlled, eating may result in disorders and health hazards such as obesity, type 2 diabetes mellitus, and vascular diseases. Lifestyles and cultures influence eating habits, thus there are differences in the prevalence of health problems depending upon living environments. This book examines the psychology and the pathophysiological outcomes of eating. Chapters address such topics as the influence of lifestyle, circadian rhythm, sleep, and fragrant odors on appetite and weight regulation; the impact of glucose, sucrose, lactate, and ketone bodies on the brain; the consequences of glycation stress on the skeletal muscle; and much more. |
| gnotobiotic mouse technology an illustrated guide: Clostridia Hubert Bahl, Peter Dürre, 2001-10-15 Clostridia have a high biotechnological potential, although they are generally still regarded more as a group of pathogenic microorganisms. They undertake a broad variety of biocatalytic reactions some of which are unique and of use in the chemical and biotechnology industry for the production of chemicals or for biopharmaceutical purposes. Even some of the clostridial toxins are of medical relevance and can be used as therapeutic agents; The book presents the biology, pyhsiology, and genetics, including genome projects of Clostridia and highlights their potential for industrial and medical applications. It is mostly based on research during the last decade which has brought significant progress in the field and outlines future perspectives of industrial interest. |
Gnotobiosis - Wikipedia
Gnotobiosis (from Greek roots gnostos "known" and bios "life") refers to an engineered state of an organism in which all forms of life (i.e., microorganisms) in or on it, including its microbiota, …
Microorganisms, Sterile Conditions, Symbiosis - Britannica
gnotobiosis, (from the Greek meaning “known life”), condition of life in which only known kinds of organisms are present. Gnotobiotic organisms are of two major types: germfree, that is, free of …
Gnotobiotics - PMC
The largest questions in the study of the microbiome—how colonies of microorganisms are established and maintained, how they affect their host, and how the host shapes the …
Gnotobiotic | definition of gnotobiotic by Medical dictionary
gnotobiotic literally ‘known life’; typically referring to an environment or animal that is essentially germ- (microorganism-) free, or one in which the microbial flora present is known, usually …
Gnotobiotics - an overview | ScienceDirect Topics
‘Gnotoxenic’ or ‘gnotobiotic’ (Table 4.6.2) refers to animals living in the absence of detectable microorganisms (axenic or germfree) or associated with a well-defined microflora in the …
Gnotobiotics: Past, present and future - PubMed
Gnotobiotics or gnotobiology is a research field exploring organisms with a known microbiological state. In animal research, the development of gnotobiotics started in the late 19th century with …
What is gnotobiotic research in controlled microenvironments
Gnotobiotic studies facilitate the assessment of microbial community dynamics and allow researchers to monitor shifts in microbiome composition in response to dietary changes, …
Foundational Gnotobiotics Concepts | Taconic Biosciences
Gnotobiology means the study of "known life." Hence, a "gnotobiotic animal" is a host animal harboring only defined (known) microbial life, if any. Gnotobiotic animal models may be either …
Gnotobiotics and the Microbiome - PMC
Nov 19, 2022 · This chapter provides an overview of germfree (GF), gnotobiotic (GN), and defined flora (DF) laboratory rats, relating their history, traditional and modern derivation procedures, …
Gnotobiotic Mice: Key Features and Colonization Methods
Apr 29, 2025 · A defining characteristic of gnotobiotic mice is their altered physiological development due to microbial absence or controlled presence. Germ-free mice exhibit …
Gnotobiosis - Wikipedia
Gnotobiosis (from Greek roots gnostos "known" and bios "life") refers to an engineered state of an organism in which all forms of life (i.e., microorganisms) in or on it, including its microbiota, …
Microorganisms, Sterile Conditions, Symbiosis - Britannica
gnotobiosis, (from the Greek meaning “known life”), condition of life in which only known kinds of organisms are present. Gnotobiotic organisms are of two major types: germfree, that is, free of …
Gnotobiotics - PMC
The largest questions in the study of the microbiome—how colonies of microorganisms are established and maintained, how they affect their host, and how the host shapes the …
Gnotobiotic | definition of gnotobiotic by Medical dictionary
gnotobiotic literally ‘known life’; typically referring to an environment or animal that is essentially germ- (microorganism-) free, or one in which the microbial flora present is known, usually …
Gnotobiotics - an overview | ScienceDirect Topics
‘Gnotoxenic’ or ‘gnotobiotic’ (Table 4.6.2) refers to animals living in the absence of detectable microorganisms (axenic or germfree) or associated with a well-defined microflora in the …
Gnotobiotics: Past, present and future - PubMed
Gnotobiotics or gnotobiology is a research field exploring organisms with a known microbiological state. In animal research, the development of gnotobiotics started in the late 19th century with …
What is gnotobiotic research in controlled microenvironments
Gnotobiotic studies facilitate the assessment of microbial community dynamics and allow researchers to monitor shifts in microbiome composition in response to dietary changes, …
Foundational Gnotobiotics Concepts | Taconic Biosciences
Gnotobiology means the study of "known life." Hence, a "gnotobiotic animal" is a host animal harboring only defined (known) microbial life, if any. Gnotobiotic animal models may be either …
Gnotobiotics and the Microbiome - PMC
Nov 19, 2022 · This chapter provides an overview of germfree (GF), gnotobiotic (GN), and defined flora (DF) laboratory rats, relating their history, traditional and modern derivation procedures, …
Gnotobiotic Mice: Key Features and Colonization Methods
Apr 29, 2025 · A defining characteristic of gnotobiotic mice is their altered physiological development due to microbial absence or controlled presence. Germ-free mice exhibit …
