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| esact conference: Environmental Policy and Public Health Barry L. Johnson, Maureen Y. Lichtveld, 2017-10-24 As with the first edition, this second edition describes how environmental health policies are developed, the statutes and other policies that have evolved to address public health concerns associated with specific environmental hazards, and the public health foundations of the policies. It lays out policies for what is considered the major environmental physical hazards to human health. Specifically, the authors describe hazards from air, water, food, hazardous substances, and wastes. To this list the authors have added the additional concerns from climate change, tobacco products, genetically-modified organisms, environment-related diseases, energy production, biodiversity and species endangerment, and the built environment. And as with the first edition, histories of policymaking for specific environmental hazards are portrayed. This edition differs from its antecedent in three significant themes. Global perspectives are added to chapters that describe specific environmental hazards, e.g., air pollution policies in China and India. Also there is the material on the consequences of environmental hazards on both human and ecosystem health. Additionally readers are provided with information about interventions that policymakers and individuals can consider in mitigating or preventing specific environmental hazards. |
| esact conference: Cell Culture Technology for Pharmaceutical and Cell-Based Therapies Sadettin Ozturk, Wei-Shou Hu, 2005-08-30 Edited by two of the most distinguished pioneers in genetic manipulation and bioprocess technology, this bestselling reference presents a comprehensive overview of current cell culture technology used in the pharmaceutical industry. Contributions from several leading researchers showcase the importance of gene discovery and genomic technology devel |
| esact conference: Modern Approaches to Animal Cell Technology R.E. Spier, J.B. Griffiths, 2013-10-02 Modern Approaches to Animal Cell Technology is a collection of papers presented at the 1987 joint European Society for Animal Cell Technology-OHOLO conference held in Tiberias, Israel. Contributors explore modern approaches to animal cell technology and discuss the construction of the animal cell substrate, the physiology of those cells in a bioreactor type of environment, and the ways in which different products can be made from animal cells in culture and tested. This book is comprised of 59 chapters divided into nine sections and begins by outlining the history of issues and decisions that were made regarding the acceptability of various cell substrates, along with the use of continuous cell lines in biotechnology. The next chapter explores the feasibility, reproducibility, and the sensitivity of the dot-blot filter hybridization test to detect minute amounts of residual cellular DNA. The reader is then introduced to cells and cell lines such as monoclonal antibodies; cell growth and development; physiology of cells; and the use of bioreactors for culturing animal cells. Downstream unit processes, vaccines, immune system products, and toxicity testing with animal cells are also considered. This monograph will be a valuable resource for animal-cell technologists, biotechnologists, and microbiologists. |
| esact conference: Large-Scale Mammalian Cell Culture Technology Lubiniecki, 2018-05-02 An interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. The volume offers a biological perspective of large-scale animal cell culture and examines diverse processing strategies, process management, regulator |
| esact conference: Current Catalog National Library of Medicine (U.S.), 1993 First multi-year cumulation covers six years: 1965-70. |
| esact conference: Biopharmaceutical Production Technology Ganapathy Subramanian, 2012-05-14 Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: - Upstream Technologies - Protein Recovery - Advances in Process Development - Analytical Technologies - Quality Control - Process Design and Management - Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner. |
| esact conference: Disposable Bioreactors Regine Eibl, Dieter Eibl, 2009-11-27 Over the past five years, the immense financial pressure on the development and manufacturing of biopharmaceuticals has resulted in the increasing use and acce- ance of disposables, which are discarded after harvest and therefore intended only for single use. In fact, such disposables are implemented in all the main bioprocess production stages today and an even higher growth than those in the biopharmac- tical market is predicted (reaching double figures). Alongside disposable filter capsules, membrane chromatography units, tubing, connectors, flexible containers processing or containing fluids, freezer systems, mixers and pumps, and fully c- trolled disposable bioreactors of up to 2,000 L culture volume are already available on the market. Numerous studies highlight the advantages of disposable bioreactors and reveal their potential for simple, safe and fast seed inoculum production, process devel- ment and small as well as middle volume production (e.g. bioactive substances, viruses for vaccines and gene therapies etc.). They suggest that such disposable bioreactors (typically characterized by the cultivation chamber or bag from plastic materials) may be advantageous for plant, animal and microbial cells. Running industrial activities such as CFD-modelling, development of single-use process monitoring and control technology, and standardized film formulations are attempting to resolve the limitations of the current disposable bioreactors. These achievements, along with substantial improvements in product yield, will reduce the use of stainless steel in the biomanufacturing facilities of the future. |
| esact conference: Water and Society Darrell W. Pepper, C. A. Brebbia, 2012 This book contains the papers presented at a conference co-organized by the University of Nevada-Las Vegas and the Wessex Institute of Technology to facilitate trans-disciplinary communication on issues related to the nature of water, and its use and exploitation by society. With adequate water supply becoming a critical issue in more and more area, \there is a great and urgent need to bridge the gap between the broad spectrum of social sciences and humanistic disciplines and the specialists in physical and natural sciences, biology, environmental sciences, and health. Many issues are also trans-national in nature and relate to rights of states and hence it is essential to discuss these at international level to arrive at equitable and binding solutions that will ensure the rights of society to quality water supplies. The book discusses The nature of water; Water as a human right; Water as the source of life; Water in a changing climate; Future water demands and adaptation strategies; Water resources contamination; Surface and sub-surface water resources; Irrigation and desertification; Water, sanitation and health; Transnational water rights; Legislation and controls; Water through the ages; Lessons to be learnt; and Water and disaster management. |
| esact conference: Animal Cell Technology R. E. Spier, J. B. Griffiths, W. Berthold, 2013-10-22 Animal Cell Technology: Products of Today, Prospects for Tomorrow is a collection of papers that discusses the advancement and future of biotechnology. The book presents a total of 164 materials that are organized into 22 sections. The coverage of the text includes the various methodologies involved in animal cell technology, such as post translational modifications; kinetics and modeling; and measurement and assay. The book also covers product safety and consistency testing; products from animal cells in culture; and apoptosis and cell biology. The text will be of great use to biologists, biotechnicians, and biological engineers. Readers who have an interest in the advancement of biotechnology will also benefit from the book. |
| esact conference: Proceedings of the 7th General Meeting on Advances in Animal Cell Technology European Society of Animal Cell Technology. General Meeting, 1987 |
| esact conference: National Library of Medicine Current Catalog National Library of Medicine (U.S.), |
| esact conference: Eukaryotic Cell Cultures Ronald T. Acton, 2013-03-09 The Second International Cell Culture Congress was structured as was the First Congress to bring together scientists from academia and industry to discuss the use of cell culture in support of bioscience. It was felt that a forum whereby state-of the-art presentations were followed by informal workshops would provide opportunity for the greatest exchange of information. Within the atmosphere of the workshop, problems common to basic as well as applied research were discussed and directions for the future were brought to light. These proceedings reflect and epitomize those discussions. Although it is difficult to cover all scientific disciplines utilizing cells in culture, we feel key areas were addressed at the Congress and are herein presented. Considerable emphasis has been given to the methods for establishing cells in culture and characterizing the cells once established as well as the improved technology for growing established cell lines. Examples of how recombinant DNA technology is being used to manipulate genes within mammalian cells, to clone mammalian genes and to insert them in prokaryotes has been included. Major emphasis has been given to the use of lymphocytes in culture for understanding immune responsiveness and the culturing of a variety of cell types as a means to understand disease states. |
| esact conference: Continuous Processing in Pharmaceutical Manufacturing Ganapathy Subramanian, 2015-02-09 With contributions from biotechnologists and bioengineers, this ready reference describes the state of the art in industrial biopharmaceutical production, with a strong focus on continuous processes. Recent advances in single-use technology as well as application guidelines for all types of biopharmaceutical products, from vaccines to antibodies, and from bacterial to insect to mammalian cells are covered. The efficiency, robustness, and quality control of continuous production processes for biopharmaceuticals are reviewed and compared to traditional batch processes for a range of different production systems. |
| esact conference: Bioprocesses and Applied Enzymology R. Blaszczyk, 1990 |
| esact conference: Animal Cell Technology: From Target to Market European Society of Animal Cell Technology. General Meeting, 2001-11-30 This book is the lasting product, a resource of up-to-date information in the scientific literature for the field of animal cell technology, as it was presented during a pleasant and stimulating meeting in Tylösand, Sweden, in June 2001. The title of the meeting, From Target to Market, indicates the usefulness of Animal Cell Technology during all steps in the pharmaceutical development process. Following the biotech products reaching the market, it shows an upward trend in the contribution of biotech products to total New Molecular Entity output in the nineties, which continued until 1996 when biotech represented 25% of the annual output. Since then the proportion has been decreasing. A perceived hurdle from a market perspective is that a protein per definition is biodegradable and thus requires intravenous, or for some drugs subcutaneous administration. New promising administration technologies such as pulmonary delivery were highlighted at this meeting. The emphasis on project selection prior to entry in the development phase has triggered a portfolio management using more extensive preclinical data before a development decision is taken. Animal cells have become a very important tool in the drug discovery process. The next generation of products will evolve from applications such as gene therapy, novel vaccines, cell therapy, and gene regulation. Animal cell technology has a major role to play in the post-sequence era. |
| esact conference: Developments in Biological Standardization , 1974 Consists of proceedings of symposia organized by the International Association of Biological Standardization. |
| esact conference: Animal Cell Biotechnology Hansjörg Hauser, Roland Wagner, 2014-11-10 This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology. |
| esact conference: Genetic Engineering & Biotechnology News , 2009 |
| esact conference: Bioreactor Systems for Tissue Engineering Cornelia Kasper, Martijn van Griensven, Ralf Pörtner, 2009-02-03 The editors of this special volume would first like to thank all authors for their excellent contributions. We would also like to thank Prof. Dr. Thomas Scheper, Dr. Marion Hertel and Ulrike Kreusel for providing the opportunity to compose this volume and Springer for organizational and technical support. Tissue engineering represents one of the major emerging fields in modern b- technology; it combines different subjects ranging from biological and material sciences to engineering and clinical disciplines. The aim of tissue engineering is the development of therapeutic approaches to substitute diseased organs or tissues or improve their function. Therefore, three dimensional biocompatible materials are seeded with cells and cultivated in suitable systems to generate functional tissues. Many different aspects play a role in the formation of 3D tissue structures. In the first place the source of the used cells is of the utmost importance. To prevent tissue rejection or immune response, preferentially autologous cells are now used. In particular, stem cells from different sources are gaining exceptional importance as they can be differentiated into different tissues by using special media and supplements. In the field of biomaterials, numerous scaffold materials already exist but new composites are also being developed based on polymeric, natural or xenogenic sources. Moreover, a very important issue in tissue en- neering is the formation of tissues under well defined, controlled and reprod- ible conditions. Therefore, a substantial number of new bioreactors have been developed. |
| esact conference: Alternatives to Laboratory Animals , 2009 |
| esact conference: Optical Sensor Systems in Biotechnology Govind Rao, 2009-11-03 Of all things natural, light is the most sublime. From the very existential belief of the origins of the universe to its role in the evolution of life on earth, light has been inextricably woven into every aspect of our lives. I am grateful to Springer-Verlag and Thomas Scheper for this invitation to organize this volume that continues to expand the use of light to create next generation sensing applications. Indeed, the very act of expanding the frontiers of learning and knowledge are referred to in many languages and cultures as enlightenment. Early optical instruments relied largely on simple combinations of mirrors, prisms and lenses. With these simple devices, substantial progress was made in our understanding of the properties of light and of its interactions with matter. Things got more complicated with the evolution of optical instruments in labo- tory use. Early systems used bulky and expensive hardware to generate light, split it into the desired wavelengths and finally collect it for analysis. The discovery of the laser pushed the technology further, but did not do much to make its adoption more widespread as the lasers themselves were large and required substantial el- trical power to operate. The true revolution is just beginning. Advances in mic- electronics have resulted in the possibility of truly low-cost (using the consumer electronics industry as a parallel) devices that exploit optical measurement technology. |
| esact conference: Animal Cell Technology: Developments towards the 21st Century E.C. Beuvery, W.P. Zeijlemaker, J.B. Griffiths, 2012-12-06 Animal cell technology is a discipline of growing importance, which aims not merely at understanding structure, function and behaviour of differentiated animal cells, but especially at the development of their abilities useful for clinical application. Topics of interest in this regard include: viral vaccines, pharmaceutical proteins and novel applications such as gene therapy and organ culture. Undoubtedly, these Proceedings of the joint Meeting of the European Society for Animal Cell Technology and the Japanese Association for Animal Cell Technology (Veldhoven, The Netherlands, September 1994) review the most recent status of the field, and will be most valuable to anyone actively involved in the culture of animal cells and its applications. The contributions to this volume were strictly selected on the basis of quality and novelty of contents. Kluwer is honoured to be able to add this work to its strongly developing publication programme in cell and tissue culture, which now has its connections to all major Societies in this field worldwide. Audience: Cell biologists, biochemists, molecular biologists, immunologists, virologists and all other disciplines related to animal cell technology, working in an academic environment, as well as in (biotechnology or pharmaceutical) industry. |
| esact conference: Disposable Bioprocessing Systems Sarfaraz K. Niazi, 2016-04-19 Written by a researcher with experience designing, establishing, and validating biological manufacturing facilities worldwide, this is the first comprehensive introduction to disposable systems for biological drug manufacturing. It reviews the current state of the industry; tackles questions about safety, costs, regulations, and waste disposal; and guides readers to choose disposable components that meet their needs. This practical manual covers disposable containers, mixing systems, bioreactors, connectors and transfers, controls and sensors, downstream processing systems, filling and finishing systems, and filters. The author also shares his predictions for the future, calling disposable bioprocessing technology a game changer. |
| esact conference: PAT Applied in Biopharmaceutical Process Development And Manufacturing Cenk Undey, Duncan Low, Jose C. Menezes, Mel Koch, 2011-12-07 As with all of pharmaceutical production, the regulatory environment for the production of therapeutics has been changing as a direct result of the US FDA-initiated Quality by Design (QbD) guidelines and corresponding activities of the International Committee for Harmonization (ICH). Given the rapid growth in the biopharmaceutical area and the comp |
| esact conference: Annual Conference Proceedings American Society for Engineering Education. Conference, 1995 |
| esact conference: Index of Conference Proceedings British Library. Document Supply Centre, 2002 |
| esact conference: Animal Cell Culture Mohamed Al-Rubeai, 2014-11-28 Animal cells are the preferred “cell factories” for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a recommended volume for all biotechnology libraries. |
| esact conference: The GMO Handbook Sarad R. Parekh, 2004-05-15 A comprehensive and accessible survey of the best current accomplishments of GMO research in all their complexity and ramifications. The authors introduce the fundamentals of biotechnology as a scientific discipline, show how GMO research is conducted today, discuss the problems that have arisen from genetic technology and the tools needed to resolve them, and describes how GMO-derived technology may impact our lives in the future. On the technical side, the authors examine a wide range of current technologies employed for constructing GMOs, and describe approaches to novel research, appropriate protocols, and the process of constructing and screening a GMO. The discussion of plant and animal cells covers new strategies employed and the large-scale expression and purification of recombinant products in cultured cells. Social political, and legal issues are also discussed. |
| esact conference: Animal Cell Biotechnology Ralf Pörtner, 2007-04-05 The second edition of this book constitutes a comprehensive manual of new techniques for setting up mammalian cell lines for production of biopharmaceuticals, and for optimizing critical parameters for cell culture considering the whole cascade from lab to final production. The chapters are written by world-renowned experts and the volume’s five parts reflect the processes required for different stages of production. This book is a compendium of techniques for scientists in both industrial and research laboratories that use mammalian cells for biotechnology purposes. |
| esact conference: Bibliographic Guide to Conference Publications New York Public Library. Research Libraries, 1984 Vols. for 1975- include publications cataloged by the Research Libraries of the New York Public Library with additional entries from the Library of Congress MARC tapes. |
| esact conference: The OIE Global Conference on Aquatic Animal Health, Bergen, Norway, 9-12 October 2006 Betty Dodet, 2007 Aquaculture is one of the fastest growing industries globally; its production volume currently represents over 40% of all fisheries and within a few years will surpass that of traditional fisheries. New species and methodologies contribute to the fact that new emerging diseases are increasingly being discovered within this field, and aquatic animal welfare issues are only just beginning to be considered. This OIE Global Conference on Aquatic Animal Health was an opportunity for the OIE and its Member Countries to help build a framework for improved involvement and cooperation between the authorities (Veterinary and Fish Health, Fisheries and Environment), the scientific community and the private sector on aquatic animal health and welfare; help clarify the roles and responsibilities of all stakeholders in the process of early disease detection, rapid response and reporting; help increase aquatic animal health emergency response capabilities; exchange information on emerging diseases and animal welfare issues; help develop a science-based approach to the management of aquatic animal health and welfare; and present the valuable experience gained in the past few years. Following the presentations and discussions, recommendations were developed to better define roles and responsibilities and to assist in the evaluation and improvement of the current standards and guidelines for better control of infectious aquatic animal health, and the preparedness of countries for aquatic animal disease emergencies. |
| esact conference: First International Conference of the OIE Reference Laboratories and Collaborating Centres, Florianopolis, Brazil, 3-5 December 2006 Michel Lombard, Betty Dodet, 2007 The 'OIE Global Network' of Reference Laboratories and Collaborating Centres is a key resource for the early and accurate diagnosis of animal disease pathogens and information pertaining to them. It provides expert support with the supply of science-based international reagents as well as the development of standards and guidelines for animal welfare and the food safety aspects of animal production, and recommendations for the prevention, detection and control of diseases such as zoonoses. The first international meeting of experts from 'OIE Reference Laboratories and Collaborating Centres' addressed the updating and setting of standards for methodologies in the fields of diagnostics, vaccine quality and biosecurity; the improvement of methods for internet networking, and the building of closer links between existing Reference Laboratories, Collaborating Centres and national and private veterinary laboratories. It demonstrated the need for OIE institutions to support developing and in-transition countries in facing current challenges and new threats linked to globalization and climate change through twinning, capacity building, and training programs. |
| esact conference: Cell Line Development Mohamed Al-Rubeai, 2009-08-11 Mammalian cell lines command an effective monopoly for the production of therapeutic proteins that require post-translational modifications. This unique advantage outweighs the costs associated with mammalian cell culture, which are far grater in terms of development time and manufacturing when compared to microbial culture. The development of cell lines has undergone several advances over the years, essentially to meet the requirement to cut the time and costs associated with using such a complex hosts as production platforms. This book provides a comprehensive guide to the methodology involved in the development of cell lines and the cell engineering approach that can be employed to enhance productivity, improve cell function, glycosylation and secretion and control apoptosis. It presents an overall picture of the current topics central to expression engineering including such topics as epigenetics and the use of technologies to overcome positional dependent inactivation, the use of promoter and enhancer sequences for expression of various transgenes, site directed engineering of defined chromosomal sites, and examination of the role of eukaryotic nucleus as the controller of expression of genes that are introduced for production of a desired product. It includes a review of selection methods for high producers and an application developed by a major biopharmaceutical industry to expedite the cell line development process. The potential of cell engineering approch to enhance cell lines through the manipulation of single genes that play important roles in key metabolic and regulatory pathways is also explored throughout. |
| esact conference: Congressional Record United States. Congress, 1976 |
| esact conference: Index of Conference Proceedings Received British Library. Lending Division, 1988-07 |
| esact conference: Genetic Engineering News , 2005 |
| esact conference: Invertebrate Cell Culture Karl Maramorosch, Jun Mitsuhashi, 1997 This text aims to provide readers with a balanced cross-section of current developments within the research on invertebrate cell culture. Attention is focused on such topics as: the biochemistry and physiology of cultured invertebrate cells; aspects of virus infection; novel cultivation methods; assays of viruses affecting shrimp and insect cells; engineering of invertebrate cells for the production of baculovirus pesticides; application of microgravity to in vitro cell cultivation; and other aspects of biotechnology. The large body of information brings into focus the significant recent achievements in the laboratories of Africa, America, Europe and Asia. |
| esact conference: The British National Bibliography Arthur James Wells, 2002 |
| esact conference: Upstream Industrial Biotechnology, 2 Volume Set Michael C. Flickinger, 2013-07-22 Biotechnology represents a major area of research focus, and many universities are developing academic programs in the field. This guide to biomanufacturing contains carefully selected articles from Wiley's Encyclopedia of Industrial Biotechnology, Bioprocess, Bioseparation, and Cell Technology as well as new articles (80 in all,) and features the same breadth and quality of coverage and clarity of presentation found in the original. For instructors, advanced students, and those involved in regulatory compliance, this two-volume desk reference offers an accessible and comprehensive resource. |
| esact conference: Bioreactors and Biotransformations G.W. Moody, P.B. Baker, 1987-11-30 |
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Levenshulme A bustling community which stretches along Stockport Road – popular with families – there are many things to do near Levenshulme, Manchester. It has undergone a period of …
