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| ebmt handbook 2019: The EBMT Handbook Nicolaus Kröger, Mohamad Mohty, Carlo Dufour, 2020-10-08 This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors. |
| ebmt handbook 2019: The European Blood and Marrow Transplantation Textbook for Nurses Michelle Kenyon, Aleksandra Babic, 2018-03-14 This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge. |
| ebmt handbook 2019: The EBMT/EHA CAR-T Cell Handbook Nicolaus Kröger, John Gribben, Christian Chabannon, Ibrahim Yakoub-Agha, Hermann Einsele, 2022 |
| ebmt handbook 2019: Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy Mahmoud Aljurf, John A. Snowden, Patrick Hayden, Kim H. Orchard, Eoin McGrath, 2021-02-19 This open access book provides a concise yet comprehensive overview on how to build a quality management program for hematopoietic stem cell transplantation (HSCT) and cellular therapy. The text reviews all the essential steps and elements necessary for establishing a quality management program and achieving accreditation in HSCT and cellular therapy. Specific areas of focus include document development and implementation, audits and validation, performance measurement, writing a quality management plan, the accreditation process, data management, and maintaining a quality management program. Written by experts in the field, Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy: A Practical Guide is a valuable resource for physicians, healthcare professionals, and laboratory staff involved in the creation and maintenance of a state-of-the-art HSCT and cellular therapy program. |
| ebmt handbook 2019: The EBMT Handbook Anna Sureda, Selim Corbacioglu, Raffaella Greco, Nicolaus Kröger, Enric Carreras, 2024-04-10 This Open Access new edition of the EBMT handbook with its new format, addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. Consisting of 94 chapters, it has been written by 210 leading experts in the field. Discussing all types of hematopoietic cell transplantation, including selection of stem cell sources, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies and new infections (COVID-19). This book provides an unparalleled description of current practices to enhance readers’ knowledge and practice skills. |
| ebmt handbook 2019: Clinical Manual of Blood and Bone Marrow Transplantation Syed A. Abutalib, Parameswaran Hari, 2017-04-19 Providing the practicing and trainee hematologist with a practical and immediately applicable compendium of answers the Clinical Manual of Blood and Bone Marrow Transplantation covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program. Supplies the practicing and trainee hematologist with a practical and immediately applicable compendium of answers to clinical questions Covers the spectrum of the hematopoietic cell transplant specialty, in particular practical issues in transplant patient care, and the set up and functioning of a transplant program Contains concise chapters written with a focus on tables, algorithms and figures to aid rapid referral Benefits from expert contributions from an international authorship |
| ebmt handbook 2019: Blood and Marrow Transplant Handbook Richard T. Maziarz, Susan Schubach Slater, 2015-04-20 This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. Concise, comprehensive, and easy-to-use, Blood and Marrow Transplant Handbook, 2nd Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees. |
| ebmt handbook 2019: The Comprehensive Cancer Center Mahmoud Aljurf, Navneet S. Majhail, Mickey B.C. Koh, Mohamed A. Kharfan-Dabaja, Nelson J. Chao, 2021-10-28 This open access book provides a valuable resource for hospitals, institutions, and health authorities worldwide in their plans to set up and develop comprehensive cancer care centers. The development and implementation of a comprehensive cancer program allows for a systematic approach to evidence-based strategies of prevention, early detection, diagnosis, treatment, and palliation. Comprehensive cancer programs also provide a nexus for the running of clinical trials and implementation of novel cancer therapies with the overall aim of optimizing comprehensive and holistic care of cancer patients and providing them with the best opportunity to improve quality of life and overall survival. This book's self-contained chapter format aims to reinforce the critical importance of comprehensive cancer care centers while providing a practical guide for the essential components needed to achieve them, such as operational considerations, guidelines for best clinical inpatient and outpatient care, and research and quality management structures. Intended to be wide-ranging and applicable at a global level for both high and low income countries, this book is also instructive for regions with limited resources. The Comprehensive Cancer Center: Development, Integration, and Implementation is an essential resource for oncology physicians including hematologists, medical oncologists, radiation oncologists, surgical oncologists, and oncology nurses as well as hospitals, health departments, university authorities, governments and legislators. |
| ebmt handbook 2019: Advances in Allogeneic Hematopoietic Stem Cell Transplantation Richard K. Burt, Mary M. Brush, 2000-02-29 The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1). |
| ebmt handbook 2019: Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases Richard K. Burt, Dominique Farge, Milton A. Ruiz, Riccardo Saccardi, John A. Snowden, 2021-11-17 This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight |
| ebmt handbook 2019: The Oxford Handbook of Adult Cognitive Disorders Robert A. Stern (Ph. D.), Michael L. Alosco, 2019 The Oxford Handbook of Adult Cognitive Disorders is an up-to-date, scholarly, and comprehensive volume that covers most diseases, conditions, and injuries resulting in impairments in cognitive function in adults. The Handbook is appropriate for both clinicians and clinical researchers, from advanced trainees to seasoned professionals. |
| ebmt handbook 2019: Contemporary Bone Marrow Transplantation Mammen Chandy, Reghu Sukumaran, 2019 Bone Marrow transplantation or Hematopoietic stem cell transplantation is a life saving procedure in a number of diseases,hematological and non hematological, which fail alternative medical management or have no other treatment options. It has transformed the lives of thousands of patients and their families around the world battling with fatal or debilitating diseases.There are many unique aspects of bone marrow transplantation which makes it very different from solid organ transplants. There is an enormous amount of research going on in this field both at clinical and basic science levels.With the rapidly changing world and field of transplantation, there is a need for an authoritative and up to date resource for transplant professionals. This book titled Contemporary Bone Marrow Transplantation aims to be a reference text comprehensively covering various facets of hematopoietic stem cell transplants with latest insights about the technique and basic science behind it . The book is the product of collective effort of transplant professionals round the world, and will reflect their experience as well as the current standard of care practices in Stem cell transplantation. The book will be divided into different sections focusing on the basic science of bone marrow transplant, the technical aspects of the procedure itself and the supportive care of transplant patients.There will also be a section each on epidemiology, upcoming trends and also case studies , which will discuss real case scenarios from the experience of the authors, to illustrate the practical challenges in managing bone marrow transplant recipients. |
| ebmt handbook 2019: Stem Cell Transplantation for Hematologic Malignancies Robert J. Soiffer, 2004-01-29 A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation. |
| ebmt handbook 2019: Haploidentical Transplantation Stefan O. Ciurea, Rupert Handgretinger, 2018-05-03 In this book, world-renowned experts in the field express well-reasoned opinions on a range of issues and controversies relating to haploidentical transplantation with the aim of providing practicing hematologists with clinically relevant and readily applicable information. Among the areas covered are graft manipulation and methods to control T-cell alloreactivity, the nature of the ideal graft and donor, haploidentical transplantation in pediatric and adult patients with malignant and nonmalignant diseases, immunologic reconstitution following transplantation, complications, and the prevention and treatment of relapse post transplantation. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. The book will provide practical support for hematologists and transplant physicians as they attempt to provide optimal care in this exciting but increasingly complex medical specialty. |
| ebmt handbook 2019: Basic Science for the MRCS Andrew T. Raftery, Michael S. Delbridge, Helen E. Douglas, 2012 A guide to the core basic sciences - anatomy, physiology and pathology - which comprise the essential knowledge required by the trainee entering the specialty of surgery. It focuses on those topics which tend to be recurring examination themes for initial surgical training. |
| ebmt handbook 2019: Handbook of Terminology Management , 1997-03-21 The Handbook of Terminology Management is a unique work designed to meet the practical needs of terminologists, translators, lexicographers, subject specialists (e.g., engineers, medical professionals, etc.), standardizers and others who have to solve terminological problems in their daily work. In more than 900 pages, the Handbook brings together contributions from approximately 50 expert authorities in the field. The Handbook covers a broad range of topics integrated from an international perspective and treats such fundamental issues as: practical methods of terminology management; creation and use of terminological tools (terminology databases, on-line dictionaries, etc.); terminological applications. The high level of expertise provided by the contributors, combined with the wide range of perspectives they represent, results in a thorough coverage of all facets of a burgeoning field. The lay-out of the Handbook is specially designed for quick and for cross reference, with hypertext and an extensive index. See also Handbook of Terminology Management set (volumes 1 and 2). |
| ebmt handbook 2019: Vessel Health and Preservation Nancy L Moureau, 2020-10-09 This Open access book offers updated and revised information on vessel health and preservation (VHP), a model concept first published in poster form in 2008 and in JVA in 2012, which has received a great deal of attention, especially in the US, UK and Australia. The book presents a model and a new way of thinking applied to vascular access and administration of intravenous treatment, and shows how establishing and maintaining a route of access to the bloodstream is essential for patients in acute care today. Until now, little thought has been given to an intentional process to guide selection, insertion and management of vascular access devices (VADs) and by default actions are based on crisis management when a quickly selected VAD fails. The book details how VHP establishes a framework or pathway model for each step of the patient experience, intentionally guiding, improving and eliminating risk when possible. The evidence points to the fact that reducing fragmentation, establishing a pathway, and teaching the process to all stakeholders reduces complications with intravenous therapy, improves efficiency and diminishes cost. As such this book appeals to bedside nurses, physicians and other health professionals. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors. |
| ebmt handbook 2019: Chianti Classico Bill Nesto, Frances Di Savino, 2016-09-20 This book tells the story of the ancient land named Chianti and the modern wine appellation known as Chianti Classico. In 1716, TuscanyÕs penultimate Medici ruler, Cosimo III, anointed the region of Chianti, along with three smaller areas in the Florentine State, as the worldÕs first legal appellations of origin for wine. In the succeeding centuries, this milestone was all but forgotten. By the late nineteenth century, the name Chianti, rather than signifying this historic region and its celebrated wine, identified a simple Italian red table wine in a straw-covered flask. Ê In the twenty-first century, Chianti Classico emerged as one of ItalyÕs most dynamic and fashionable wine zones. Chianti Classico relates the fascinating evolution of Chianti as a wine region and reveals its geographic and cultural complexity. Bill Nesto, MW, and Frances Di Savino explore the townships of Chianti Classico and introduce readers to the modern-day winegrowers who are helping to transform the region. The secrets of Sangiovese, the principal vine variety of Chianti, are also revealed as the book unlocks the myths and mysteries of one of ItalyÕs most storied wine regions. The publication of Chianti Classico coincides with the three hundredth anniversary of the Medici decree delimiting the region of Chianti on September 24, 1716. |
| ebmt handbook 2019: Radiation Chimeras O. Van Bekkum, H. De Vries, 1967-01-01 |
| ebmt handbook 2019: Encyclopedia of Biomedical Gerontology , 2019-11-20 Encyclopedia of Biomedical Gerontology, Three Volume Set presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years |
| ebmt handbook 2019: CDC Yellow Book 2020 Centers for Disease Control and Prevention (CDC), 2019-05-14 The definitive reference for travel medicine, updated for 2020! A beloved travel must-have for the intrepid wanderer. -Publishers Weekly A truly excellent and comprehensive resource. -Journal of Hospital Infection The CDC Yellow Book offers everything travelers and healthcare providers need to know for safe and healthy travel abroad. This 2020 edition includes: · Country-specific risk guidelines for yellow fever and malaria, including expert recommendations and 26 detailed, country-level maps · Detailed maps showing distribution of travel-related illnesses, including dengue, Japanese encephalitis, meningococcal meningitis, and schistosomiasis · Guidelines for self-treating common travel conditions, including altitude illness, jet lag, motion sickness, and travelers' diarrhea · Expert guidance on food and drink precautions to avoid illness, plus water-disinfection techniques for travel to remote destinations · Specialized guidelines for non-leisure travelers, study abroad, work-related travel, and travel to mass gatherings · Advice on medical tourism, complementary and integrative health approaches, and counterfeit drugs · Updated guidance for pre-travel consultations · Advice for obtaining healthcare abroad, including guidance on different types of travel insurance · Health insights around 15 popular tourist destinations and itineraries · Recommendations for traveling with infants and children · Advising travelers with specific needs, including those with chronic medical conditions or weakened immune systems, health care workers, humanitarian aid workers, long-term travelers and expatriates, and last-minute travelers · Considerations for newly arrived adoptees, immigrants, and refugees Long the most trusted book of its kind, the CDC Yellow Book is an essential resource in an ever-changing field -- and an ever-changing world. |
| ebmt handbook 2019: Chronic Graft Versus Host Disease Georgia B. Vogelsang, Steven Z. Pavletic, 2009-04-20 Chronic graft versus host disease (GVHD) is the most common complication of allogenic bone marrow transplantation. Because of the protracted clinical course of chronic GVHD, transplant centers and hematology/oncology offices are inadequately equipped to manage these immuno-incompetent patients with a multi-system disorder. Practitioners need to be able to recognize and effectively manage chronic GVHD as a late effect of more than half of allogenic transplantations. The text is oriented for the clinician, with chapters covering staging, organ site and system-specific manifestations, treatment options, and supportive care. Drs Georgia B. Vogelsang and Steven Z. Pavletic have been pioneers in the recognition of the multi-organ complexity of this disease and have gathered the input of a variety of subspecialist physicians for this book. This book fills the gap in practical literature on chronic GVHD, providing a comprehensive, up-to-date, and clinically relevant resource for anyone who deals with cancer patients post-transplant. |
| ebmt handbook 2019: Carotenoids in Health and Disease Norman I. Krinsky, Susan T. Mayne, Helmut Sies, 2004-08-30 The first source to collect the latest evidence linking carotenoids to human health and disease, this stimulating reference studies the role of carotenoids in the prevention of chronic disease and reviews breakthrough studies from more than 40 field authorities on the latest research. The book reveals the most recent findings regarding the use of c |
| ebmt handbook 2019: Clinical Neuroimmunology Jack P. Antel, 2005 Clinical Neurimmunology is the major reference text in the field, providing broad and comprehensive coverage of the interaction between the nervous and immune systems in both normal and diseased states. Understanding this interaction is fundamental to developing therapeutic approaches to disease and injury of the nervous system that are currently only marginally amenable to therapy. Neuroimmunology is a well-recognised and growing specialty world wide, both at the basic science and clinical level. It is a fast moving field and this is the most up to date text available. Chapters are dedicated to the role of the immune system in disorders affecting both the central and peripheral nervous systems, including important neurodegenerative diseases (such as multiple sclerosis and HIV-related neural degeneration) which cause life-long disability. Extensive coverage is given to a whole array of immune-directed therapies. The book has a strong international team of well respected, high profile editors and authors. The first edition published to extensive and positive reviews and has established itself as the principal reference source in the field. This second edition summarizes recent advances in clinical neuroimmunology in a comprehensive and unbiased way. |
| ebmt handbook 2019: Finding What Works in Health Care Institute of Medicine, Board on Health Care Services, Committee on Standards for Systematic Reviews of Comparative Effectiveness Research, 2011-07-20 Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research. |
| ebmt handbook 2019: Guide to the Quality and Safety of Tissues and Cells for Human Application European Directorate for the Quality of Medicines & Healthcare, 2013-10-11 This guide provides state-of-the-art information in order to maximise the quality and minimise the risks during donation, procurement, testing, processing, preservation, storage and distribution of tissues and cells. As with all transplanted material of human origin, tissues and cells carry risks of disease transmission, which must be controlled by the application of scrupulous donor selection criteria (including testing) and comprehensive quality systems. The idea behind this guide is to help professionals on a practical level by providing generic guidance that will help improve the rate of successful clinical application of tissues and cells. The guide makes reference to EU mandatory requirements where appropriate and describes generally-accepted good practice. It has been divided into two parts. Part A contains general requirements applicable to all establishments involved in the donation, procurement, testing, processing, preservation, storage and distribution of tissues and cells. Part B contains specific guidelines and requirements for the different tissue and/or cell types |
| ebmt handbook 2019: Single Cell Analysis J. Paul Robinson, Andrea Cossarizza, 2017-04-18 This book highlights the current state of the art in single cell analysis, an area that involves many fields of science – from clinical hematology, functional analysis and drug screening, to platelet and microparticle analysis, marine biology and fundamental cancer research. This book brings together an eclectic group of current applications, all of which have a significant impact on our current state of knowledge. The authors of these chapters are all pioneering researchers in the field of single cell analysis. The book will not only appeal to those readers more focused on clinical applications, but also those interested in highly technical aspects of the technologies. All of the technologies identified utilize unique applications of photon detection systems. |
| ebmt handbook 2019: Congenital and Acquired Bone Marrow Failure Mahmoud Deeb Aljurf, Eliane Gluckman, Carlo Dufour, 2017-01-09 Congenital and Acquired Bone Marrow Failure is a comprehensive guide to congenital and acquired bone marrow failure in adult and pediatric patients. Chapters are divided into two sections, acquired aplastic anemia and inherited bone marrow failure syndromes. Content ranges from the basic, to the translational, and from the epidemiology of acquired aplastic anemia and telomere biology, to the management, treatment, and supportive care of pediatric, adult, and geriatric patients. Contributors are world leading experts in the field of bone marrow failure. The book is required reading for residents, fellows, clinicians, and researchers across hematology, oncology, pathology, bone marrow transplantation, pediatrics, and internal medicine. |
| ebmt handbook 2019: Manual of Hematopoietic Cell Transplantation and Cellular Therapies - E-Book Qaiser Bashir, Elizabeth J. Shpall, Richard E. Champlin, 2022-12-23 Led by authors from MD Anderson's Stem Cell Transplantation and Cellular Therapy Department, the world's largest and highly respected program at the forefront of rapidly advancing treatments in the field, Manual of Hematopoietic Cell Transplantation and Cellular Therapies is a comprehensive, focused reference covering the latest clinical developments and applications of stem cell transplant and cellular therapies for hematologic malignancies and solid tumors. This cutting-edge title, with a majority contribution from the MD Anderson Cancer Center and leading faculty from other academic institutions, covers breakthrough cell-based therapies for various diseases including lymphoma, multiple myeloma, leukemia, and select solid tumor and autoimmune diseases. This unique, definitive resource is essential for hematologists, fellows in hematology and immunotherapy, mid-level providers, pharmacists, and oncologists who refer patients for cell-based therapies. - Addresses hematologic conditions including leukemia, lymphoma, and myeloma. - Offers guidance on hematopoietic cell transplantation for solid tumors. - Covers basic science principles, clinical aspects, pharmacology, radiation therapy, and disease-specific guidelines, including prevention and management of complications. - Discusses key topics such as hematopoietic cell collection, bone marrow harvesting, umbilical cord blood transplantation, CAR T-cell therapy, and patient/donor selection and preparation of HCT. - Features extensive summary boxes, bulleted content, and algorithms throughout for quick and easy reference. - Offers team-based, clinically-focused coverage from world-renowned leaders in the field. |
| ebmt handbook 2019: Mesenchymal Stem Cell Therapy Lucas G. Chase, Mohan C Vemuri, 2012-12-11 Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field. |
| ebmt handbook 2019: The Puzzle of Ethics Peter Vardy, Paul Grosch, 1997 First Published in 1994. Routledge is an imprint of Taylor & Francis, an Informa company. |
| ebmt handbook 2019: How to Read a Paper Trisha Greenhalgh, 2019-04-05 Required reading in many medical and healthcare institutions, How to Read a Paper is a clear and wide-ranging introduction to evidence-based medicine and healthcare, helping readers to understand its central principles, critically evaluate published data, and implement the results in practical settings. Author Trisha Greenhalgh guides readers through each fundamental step of inquiry, from searching the literature to assessing methodological quality and appraising statistics. How to Read a Paper addresses the common criticisms of evidence-based healthcare, dispelling many of its myths and misconceptions, while providing a pragmatic framework for testing the validity of healthcare literature. Now in its sixth edition, this informative text includes new and expanded discussions of study bias, political interference in published reports, medical statistics, big data and more. Offers user-friendly guidance on evidence-based healthcare that is applicable to both experienced and novice readers Authored by an internationally recognised practitioner and researcher in evidence-based healthcare and primary care Includes updated references, additional figures, improved checklists and more How to Read a Paper is an ideal resource for healthcare students, practitioners and anyone seeking an accessible introduction to evidence-based healthcare. |
| ebmt handbook 2019: Ray Tracing Gems Eric Haines, Tomas Akenine-Möller, 2019-02-25 This book is a must-have for anyone serious about rendering in real time. With the announcement of new ray tracing APIs and hardware to support them, developers can easily create real-time applications with ray tracing as a core component. As ray tracing on the GPU becomes faster, it will play a more central role in real-time rendering. Ray Tracing Gems provides key building blocks for developers of games, architectural applications, visualizations, and more. Experts in rendering share their knowledge by explaining everything from nitty-gritty techniques that will improve any ray tracer to mastery of the new capabilities of current and future hardware. What you'll learn: The latest ray tracing techniques for developing real-time applications in multiple domains Guidance, advice, and best practices for rendering applications with Microsoft DirectX Raytracing (DXR) How to implement high-performance graphics for interactive visualizations, games, simulations, and more Who this book is for: Developers who are looking to leverage the latest APIs and GPU technology for real-time rendering and ray tracing Students looking to learn about best practices in these areas Enthusiasts who want to understand and experiment with their new GPUs |
| ebmt handbook 2019: Childhood Acute Lymphoblastic Leukemia Ajay Vora, 2017-04-21 This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia. |
| ebmt handbook 2019: The European Blood and Marrow Transplantation Textbook for Nurses Michelle Kenyon, Aleksandra Babic, 2023-04-07 This Open Access Second Edition textbook, endorsed by the EBMT, provides adult and pediatric nurses with a full and informative guide covering all aspects of transplant nursing including a new chapter dedicated to cellular therapy, nursing implications and care. This book takes the reader from basic principles to advanced concepts on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This second edition specifically intended for nurses, complements the EBMT Handbook, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational reference tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the only one of its kind written by nurse experts, specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes to patient care in this area. This new volume presents updated content that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to refresh their knowledge. This Textbook is open access under a CC BY 4.0 license. |
| ebmt handbook 2019: Aesthetica Botanica Sandu Publications, 2017-12 Many have discovered the joys of living with indoor plants. They contribute not only to a healthier environment, but with proper styling, add a nice element to interior design schemes. For some living in more urban settings it is a matter of necessity as home gardens are rare. For others living in more rural or suburban surroundings it is a matter of choice. Aesthetica Botanica visits the homes of artists, florists, gardeners and other plant enthusiasts who exemplify green living and are happy to share their stories and tips on caring for and decorating with plants. With handy chapters on green plants, cacti and succulents, and flowers, this book caters to any inclination providing practical information alongside stunning photographs. |
| ebmt handbook 2019: Handbook of Stem Cell Transplantation and Cellular Therapy Management Edwin P. Alyea, III, MD, Vincent T. Ho, MD, Brett E. Glotzbecker, MD, Prashant Nageshwar, MD, PhD, 2020-09-29 Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma and allogenic transplantation for leukemia, lymphoma, and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, and more clinical issues. Concluding chapters address new CAR T-cell therapies, including their mechanisms of action, indications, and unique associated toxicities, in addition to a chapter dedicated to biostatistics and clinical trials. Throughout the book, extensive tables, flow diagrams, and other figures highlight, simplify, and illustrate key concepts. Written by experienced clinicians at the world-renowned Dana Farber Cancer Center and Harvard Medical School in Boston as well as leading experts at other institutions, this stem cell transplantation handbook combines the clinical knowledge, expertise and practical application of these potential life-saving cell therapies in one quick, point-of-care reference. With real-world clinical vignettes interwoven among the chapters, this handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies. Key Features: Provides latest insights and recommendations for managing challenging treatment complications and adverse events Consolidates key information such as diagnosis criteria, disease staging, common complications, and more using detailed tables and diagrams Shares real-world clinical vignette examples, which provide insight into clinical assessment, treatment, and management Emphasizes patient management and best practices Discusses short- and long-term risks for stem cell transplantation and cellular therapy |
| ebmt handbook 2019: Hematopoietic Stem Cell Transplantation for Neurologic Diseases , 2024-08-05 Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity. - Reviews immunological mechanisms of HSCT and CNS autoimmunity - Identifies neurological diseases showing treatment efficacy with HSCT - Includes MS, myasthenia gravis, neuromyelitis optica, and more - Covers early and late side effects of HSCT |
| ebmt handbook 2019: Cord Blood Transplantations Mitchell Horwitz, Nelson Chao, 2017-07-21 In this book, experts in the field express their well-reasoned opinions on a spectrum of important and complex issues in the area of cord blood transplantation. The aim is to provide practicing hematologists, including hematopoietic transplant physicians, with clinically relevant and immediately applicable information that will assist in the delivery of optimal care. The book opens by offering a historical perspective and examining current concepts and practices in cord blood banking. Sections are then devoted to strategies for cord blood graft selection and to areas of consensus and controversy in cord blood transplantation for neoplastic diseases - and nonmalignant - in children and adults. Attention is drawn to the implications of high-impact clinical trials whenever such trials are available. The readily intelligible text is complemented by numerous helpful tables, algorithms, and figures. This book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients and will offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee. |
| ebmt handbook 2019: Total Marrow Irradiation Jeffrey Y. C. Wong, Susanta K. Hui, 2021-03-01 This book, written by a team of international experts, concisely reviews the rationale and clinical application of image-guided total marrow irradiation, a rapidly emerging area in radiation oncology and hematopoietic cell transplantation. The aim is to provide the practicing radiation oncologist, hematologist, medical physicist, and bone marrow transplant researcher with a fundamental understanding of key aspects and an appreciation of the increasing significance of total marrow irradiation as conditioning for bone marrow transplantation. Detailed attention is paid to the impacts of recent advances in radiation therapy technology, functional PET and MRI, and understanding of the response of bone marrow to radiation. Full consideration is also given to the ways in which technological advances in image-guided radiation therapy have created new opportunities to treat bone marrow transplant patients with limited transplant options due to advanced disease, age, or co-morbidities. Further topics covered include the ways in which cancer stem cells and the marrow microenvironment influence response to radiation therapy and the implementation of new-generation predictive radiobiologic factors in the clinic. |
The EBMT
The EBMT is a non-profit medical and scientific organisation established in 1974 which hosts a unique patient registry providing a pool of data to perform studies and assess new trends.
EBMT (European Society for Blood and Marrow Transplantation)
Members of the EBMT are centres and individuals active in the field of hematopoietic stem cell transplantation and cellular therapy research, or any other organisation involved in the care of …
Bone Marrow Transplantation - Nature
Aug 29, 2024 · Publishing high quality, peer reviewed original research and reviews addressing all aspects of basic biology and clinical use of haemopoietic cell transplantation. Official journal of …
Chapter 2 The EBMT: History, Present, and Future - National …
Apr 11, 2024 · Today, EBMT (www.ebmt.org) is a nonprofit organization with a clear mission statement: “To save the lives of patients with blood cancers and other life-threatening diseases …
The EBMT Handbook: Hematopoietic Stem Cell Transplantation and ... - PubMed
2. The EBMT: History, Present, and Future 3. The Role of Unrelated Donor Registries in HSCT 4. The HSCT Unit 5. JACIE Accreditation of HSCT Programs 6. Statistical Methods in HSCT and …
EBMT Handbook
This thoroughly revised second edition of the EBMT Handbook addresses the most recent developments and innovations in HCT and cellular therapy, presented by more than 200 …
Physicians - EBMT
EBMT Exam Preparatory Course - Members Prepare for the 2025 EBMT Exam at the Annual Congress in Florence with a comprehensive online course focused on Haematopoietic Cell …
The EBMT Handbook: Hematopoietic Cell Transplantation and …
This Open Access new edition of the EBMT handbook with its new format, addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. …
The EBMT Handbook - NCBI Bookshelf - National Center for …
Apr 11, 2024 · The EBMT Handbook, 8th edition Hematopoietic Cell Transplantation and Cellular Therapies Editors: Anna Sureda , Selim Corbacioglu , Raffaella Greco , Nicolaus Kröger , and …
The EBMT-ADWP and the CIBMTR - PMC
Jan 25, 2025 · The EBMT Autoimmune Diseases Working Party (ADWP) is central to bringing together HSCT and disease-specialist communities. The AD section of the EBMT registry is …
The EBMT
The EBMT is a non-profit medical and scientific organisation established in 1974 which hosts a unique patient registry providing a pool of data to perform studies and assess new trends.
EBMT (European Society for Blood and Marrow Transplantation)
Members of the EBMT are centres and individuals active in the field of hematopoietic stem cell transplantation and cellular therapy research, or any other organisation involved in the care of …
Bone Marrow Transplantation - Nature
Aug 29, 2024 · Publishing high quality, peer reviewed original research and reviews addressing all aspects of basic biology and clinical use of haemopoietic cell transplantation. Official journal of …
Chapter 2 The EBMT: History, Present, and Future - National …
Apr 11, 2024 · Today, EBMT (www.ebmt.org) is a nonprofit organization with a clear mission statement: “To save the lives of patients with blood cancers and other life-threatening diseases …
The EBMT Handbook: Hematopoietic Stem Cell Transplantation and ... - PubMed
2. The EBMT: History, Present, and Future 3. The Role of Unrelated Donor Registries in HSCT 4. The HSCT Unit 5. JACIE Accreditation of HSCT Programs 6. Statistical Methods in HSCT and …
EBMT Handbook
This thoroughly revised second edition of the EBMT Handbook addresses the most recent developments and innovations in HCT and cellular therapy, presented by more than 200 …
Physicians - EBMT
EBMT Exam Preparatory Course - Members Prepare for the 2025 EBMT Exam at the Annual Congress in Florence with a comprehensive online course focused on Haematopoietic Cell …
The EBMT Handbook: Hematopoietic Cell Transplantation and …
This Open Access new edition of the EBMT handbook with its new format, addresses the latest developments and innovations in hematopoietic cell transplantation and cellular therapy. …
The EBMT Handbook - NCBI Bookshelf - National Center for …
Apr 11, 2024 · The EBMT Handbook, 8th edition Hematopoietic Cell Transplantation and Cellular Therapies Editors: Anna Sureda , Selim Corbacioglu , Raffaella Greco , Nicolaus Kröger , and …
The EBMT-ADWP and the CIBMTR - PMC
Jan 25, 2025 · The EBMT Autoimmune Diseases Working Party (ADWP) is central to bringing together HSCT and disease-specialist communities. The AD section of the EBMT registry is …
