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| enantioselective chemical synthesis methods logic and practice: Enantioselective Chemical Synthesis Elias J. Corey, Laszlo Kurti, 2013-10-23 Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. - In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. - Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. - Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules - Clearly explains stereochemical synthesis in theory and practice - Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis - Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages |
| enantioselective chemical synthesis methods logic and practice: Enantioselective Chemical Synthesis Elias J. Corey, Laszlo Kurti, 2013 Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field s progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules Clearly explains stereochemical synthesis in theory and practiceProvides a handy tool box for scientists wishing to understand and apply chiral chemical synthesisDescribes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages |
| enantioselective chemical synthesis methods logic and practice: Heterogeneous Catalysis in Sustainable Synthesis Bela Torok, Christian Schaefer, Anne Kokel, 2021-09-17 Heterogeneous Catalysis in Sustainable Synthesis is a practical guide to the use of solid catalysts in synthetic chemistry that focuses on environmentally benign applications. Collating essential information on solid catalysts into a single volume, it reveals how the efficient use of heterogeneous catalysts in synthetic chemistry can support sustainable applications. Beginning with a review of the fundamentals of heterogeneous catalytic synthesis, the book then explores the basic concepts of heterogeneous catalytic reactions from adsorption to catalyst poisons, the use of non-traditional activation methods, recommended solvents, the major types of both metal and non-metal solid catalysts, and applications of these catalysts in sustainable synthesis. Based on the extensive experience of its expert author, this book aims to encourage and support synthetic chemists in using solid catalysts in their own work, while also highlighting the important link between heterogeneous catalysis and sustainability to all those interested. - Combines foundational knowledge with a focus on practical applications - Organizes information by reaction type, allowing readers to easily find examples of how to carry out specific reaction types with solid catalysts - Highlights emerging areas such as nanoparticle catalysis and metal-organic framework (MOF) based catalysts |
| enantioselective chemical synthesis methods logic and practice: Biocatalysis in Organic Synthesis Nicholas J. Turner, Luke Humphreys, 2018-02-08 The application of biocatalysis in organic synthesis is rapidly gaining popularity amongst chemists. Compared to traditional synthetic methodologies biocatalysis offers a number of advantages in terms of enhanced selectivity (chemo-, regio-, stereo-), reduced environmental impact and lower cost of starting materials. Together these advantages can contribute to more sustainable manufacturing processes across a wide range of industries ranging from pharmaceuticals to biofuels. The biocatalytic toolbox has expanded significantly in the past five years and given the current rate of development of new engineered biocatalysts it is likely that the number of available biocatalysts will double in the next few years. This textbook gives a comprehensive overview of the current biocatalytic toolbox and also establishes new guidelines or rules for “biocatalytic retrosynthesis”. Retrosynthesis is a well known and commonly used technique whereby organic chemists start with the structure of their target molecule and generate potential starting materials and intermediates through a series of retrosynthetic disconnections. These disconnections are then used to devise a forward synthesis, in this case using biocatalytic transformations in some of the key steps. Target molecules are disconnected with consideration for applying biocatalysts, as well as chemical reagents and chemocatalysts, in the forward synthesis direction. Using this textbook, students will be able to place biocatalysis within the context of other synthetic transformations that they have learned earlier in their studies. This additional awareness of biocatalysis will equip students for the modern world of organic synthesis where biocatalysts play an increasingly important role. In addition to guidelines for identifying where biocatalysts can be applied in organic synthesis, this textbook also provides examples of current applications of biocatalysis using worked examples and case studies. Tutorials enable the reader to practice disconnecting target molecules to find the ‘hidden’ biocatalytic reactions which can be applied in the synthetic direction. The book contains a complete description of the current biocatalyst classes that are available for use and also suggests areas where new enzymes are likely to be developed in the next few years. This textbook is an essential resource for lecturers and students studying synthetic organic chemistry. It also serves as a handy reference for practicing chemists who wish to embed biocatalysis into their synthetic toolbox. |
| enantioselective chemical synthesis methods logic and practice: Liquid Phase Aerobic Oxidation Catalysis Shannon S. Stahl, Paul L. Alsters, 2016-07-13 The first book to place recent academic developments within the context of real life industrial applications, this is a timely overview of the field of aerobic oxidation reactions in the liquid phase that also illuminates the key challenges that lie ahead. As such, it covers both homogeneous as well as heterogeneous chemocatalysis and biocatalysis, along with examples taken from various industries: bulk chemicals and monomers, specialty chemicals, flavors and fragrances, vitamins, and pharmaceuticals. One chapter is devoted to reactor concepts and engineering aspects of these methods, while another deals with the relevance of aerobic oxidation catalysis for the conversion of renewable feedstock. With chapters written by a team of academic and industrial researchers, this is a valuable reference for synthetic and catalytic chemists at universities as well as those working in the pharmaceutical and fine chemical industries seeking a better understanding of these reactions and how to design large scale processes based on this technology. |
| enantioselective chemical synthesis methods logic and practice: Comprehensive Organic Chemistry Experiments for the Laboratory Classroom Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén, 2020-08-28 This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students. |
| enantioselective chemical synthesis methods logic and practice: Enzyme Cascade Design and Modelling Selin Kara, Florian Rudroff, 2021-02-24 This book provides a comprehensive overview of the recent developments achieved in the field of chemo/enzymatic cascades with topics spanning from design (in vitro and in vivo) to kinetic- and process modelling as well as process control. Opportunities and challenges of building multi-step chemo/enzymatic reactions are discussed, whereby the latter are critically assessed in each chapter and methods to ease the implementation are explored. Both, multi-enzymatic cascades and chemo-enzymatic cascades are presented with the motivation of combining the strengths of these two worlds (e.g. selectivity, activity and robustness) not neglecting the obstacles and challenges of such endeavour. Furthermore, the use of non-conventional media for catalytic cascade reactions, recent achievements and potential for future developments in a technical environment are addressed. |
| enantioselective chemical synthesis methods logic and practice: March's Advanced Organic Chemistry Michael B. Smith, 2020-02-19 The completely revised and updated, definitive resource for students and professionals in organic chemistry The revised and updated 8th edition of March's Advanced Organic Chemistry: Reactions, Mechanisms, and Structure explains the theories of organic chemistry with examples and reactions. This book is the most comprehensive resource about organic chemistry available. Readers are guided on the planning and execution of multi-step synthetic reactions, with detailed descriptions of all the reactions The opening chapters of March's Advanced Organic Chemistry, 8th Edition deal with the structure of organic compounds and discuss important organic chemistry bonds, fundamental principles of conformation, and stereochemistry of organic molecules, and reactive intermediates in organic chemistry. Further coverage concerns general principles of mechanism in organic chemistry, including acids and bases, photochemistry, sonochemistry and microwave irradiation. The relationship between structure and reactivity is also covered. The final chapters cover the nature and scope of organic reactions and their mechanisms. This edition: Provides revised examples and citations that reflect advances in areas of organic chemistry published between 2011 and 2017 Includes appendices on the literature of organic chemistry and the classification of reactions according to the compounds prepared Instructs the reader on preparing and conducting multi-step synthetic reactions, and provides complete descriptions of each reaction The 8th edition of March's Advanced Organic Chemistry proves once again that it is a must-have desktop reference and textbook for every student and professional working in organic chemistry or related fields. Winner of the Textbook & Acadmic Authors Association 2021 McGuffey Longevity Award. |
| enantioselective chemical synthesis methods logic and practice: Organic Reactions, Volume 100 , 2019-10-17 Written by a who is who of leading organic chemists, this anniversary volume represent the Organic Reactions editors' choice of the most important, ground-breaking and versatile reactions in current organic synthesis. The 15 reaction types selected for this volume include reactions for carbon-carbon bond formation, cross-coupling reactions, hydro- and halofunctionalizations, among many others. In line with the successful recipe of the series, each chapter is focused on a single reaction, discussing its mechanism and stereochemistry, scope and limitations, applications to synthesis, comparison with other methods, and experimental procedures. Each chapter concludes with a tabular survey of selected key application examples, complete with reported reaction conditions and yields, to serve as a quick reference guide for synthesis planning. |
| enantioselective chemical synthesis methods logic and practice: Biocatalysis Gonzalo de Gonzalo, Pablo Domínguez de María, 2017-11-02 Implementing biocatalytic strategies in an industrial setting at a commercial scale is a challenging task, necessitating a balance between industrial need against economic viability. With invited contributions from small and large-scale chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and key aspects to economically succeed. With its focus on industry related issues, this book will be a useful tool for future research by both practitioners and academics. |
| enantioselective chemical synthesis methods logic and practice: Intermediate Organic Chemistry Ann M. Fabirkiewicz, John C. Stowell, 2015-07-13 This book presents key aspects of organic synthesis – stereochemistry, functional group transformations, bond formation, synthesis planning, mechanisms, and spectroscopy – and a guide to literature searching in a reader-friendly manner. • Helps students understand the skills and basics they need to move from introductory to graduate organic chemistry classes • Balances synthetic and physical organic chemistry in a way accessible to students • Features extensive end-of-chapter problems • Updates include new examples and discussion of online resources now common for literature searches • Adds sections on protecting groups and green chemistry along with a rewritten chapter surveying organic spectroscopy |
| enantioselective chemical synthesis methods logic and practice: Designed Molecular Space in Material Science and Catalysis Seiji Shirakawa, 2018-09-26 This book focuses on molecular space chemistry, which is recognized as an important concept for the design of novel functional materials and catalysts. A wide variety of topics and ideas included in this book are based on that concept. The book showcases recent representative examples of molecular space design to create functional materials and catalysts possessing unique properties. This unique volume will be of great interest to chemists in a wide variety of research fields, including organic, inorganic, biological, polymer, and supramolecular chemistry. Readers will obtain new ideas and directions to create novel functional molecules, and those ideas will lead to innovative views of science. |
| enantioselective chemical synthesis methods logic and practice: The logic of chemical synthesis E.J. Corey, 1991 |
| enantioselective chemical synthesis methods logic and practice: Síntesi orgànica de molècules complexes James Corey, Elias, 2021-06-17 La publicació del professor Elias J. Corey sobre metodologia general per a la construcció de molècules complexes (Pure and Applied Chemistry, 1967) va significar un canvi de paradigma en l’àmbit de la síntesi orgànica que ha tingut impacte fins als nostres dies. També cal reconèixer Corey com l’impulsor de l’anàlisi de problemes sintètics assistida per ordinador amb la creació d’un programa capaç de generar efectivament una possible síntesi per anàlisi retrosintètica (Quarterly Reviews, 1971). La sistematització de la síntesi de molècules orgàniques complexes ha acabat essent un cas extraordinari de creativitat científica plasmat essencialment en dos aspectes. Primer, les metodologies de la retrosíntesi i de la programació computacional per a elaborar rutes sintètiques. Segon, la invenció d’una nova ontologia per a la química orgànica representada per conceptes com el sintó i la desconnexió d’enllaços. D’altra banda, aquestes innovacions s’han de valorar, sobretot, en el seu context de producció: l’ensenyament de la química. El 1960, quan Corey va accedir com a professor a la Universitat de Harvard, va desenvolupar una aproximació general al disseny de la síntesi orgànica, per tal que els seus alumnes i els seus investigadors la poguessin aprendre, dissenyar i programar. Es pot dir, doncs, que l’anàlisi retrosintètica de Corey va transformar la pedagogia i la pràctica de la planificació de la síntesi orgànica en tots els àmbits d’aplicació. |
| enantioselective chemical synthesis methods logic and practice: Comprehensive Organic Synthesis , 2014-02-14 The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively |
| enantioselective chemical synthesis methods logic and practice: Molecules and Medicine E. J. Corey, Barbara Czakó, László Kürti, 2007-08-31 Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas. |
| enantioselective chemical synthesis methods logic and practice: Classics in Total Synthesis K. C. Nicolaou, E. J. Sorensen, 1996-04-11 K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk. |
| enantioselective chemical synthesis methods logic and practice: Green Solvents for Chemistry William M. Nelson, 2003-03-27 The aim of this book is to introduce the use of green solvents throughout chemistry and to provide a comprehensive reference for solvents currently applicable in green chemistry. The first section covers solvents in chemical perspective, and the second section is a guide to green solvents. Overall, this volume defines characteristics of green solvents and their current usage, and explores their importance ecologically and economically. It includes a full range of commercial, industrial, and academic green solvents, and discusses solvents in specific commercial and non-commercial practices. Green Solvents for Chemistry differs from other works on solvents in that only solvents for green chemistry are included along with their chemical properties and toxicological issues. |
| enantioselective chemical synthesis methods logic and practice: Chemical Synthesis C. Chatgilialoglu, V. Snieckus, 1996-06-30 Chemical Synthesis: Gnosis to Prognosis (XTUllKtl ~uv8eoTr ana TT) rVWOT) OTT) npaYVWOT)) . . . . other things being equal, that field has the most merit which contributes most heavily to, and illuminates most brightly, its neighbouring scientific disciplines[l] One hundred scientists, a blend of students, industrialists, and academics from twenty countries gathered to circumscribe, understand, and elaborate this topic in the magical setting of Ravello, Italy. The mandate of this workshop? To survey existing knowledge, assess current work, and discuss the future directions of chemical synthesis as it impinges on three exciting interdisciplinary themes of science in the 1990's: bioactive molecules, man-made chemical materials, and molecular recognition. This tempting but inexact menu summoned diverse students and scientists who wished to seriously reflect upon, dissect, and eject ideas and own experiences into open debate on this topic, which is at a crossroad in internal evolution and impact on the life and material sciences. The group arrived from many directions and in various forms of transportation, matters soon forgotten, when it found itself in the village which nurtured Wagner's inspiration and set to work immediately to ponder the question which has received extensive thought, prediction, and caveat from illustrious chemists over a period of time [2], two of which, to the delight of all, in presence among the Lectures. |
| enantioselective chemical synthesis methods logic and practice: Side Reactions in Organic Synthesis Florencio Zaragoza Dörwald, 2006-03-06 Most syntheses in the chemical research laboratory fail and usually require several attempts before proceeding satisfactorily. Failed syntheses are not only discouraging and frustrating, but also cost a lot of time and money. Many failures may, however, be avoided by understanding the structure-reactivity relationship of organic compounds. This textbook highlights the competing processes and limitations of the most important reactions used in organic synthesis. By allowing chemists to quickly recognize potential problems this book will help to improve their efficiency and success-rate. A must for every graduate student but also for every chemist in industry and academia. Contents: 1 Organic Synthesis: General Remarks 2 Stereoelectronic Effects and Reactivity 3 The Stability of Organic Compounds 4 Aliphatic Nucleophilic Substitutions: Problematic Electrophiles 5 The Alkylation of Carbanions 6 The Alkylation of Heteroatoms 7 The Acylation of Heteroatoms 8 Palladium-Catalyzed C-C Bond Formation 9 Cyclizations 10 Monofunctionalization of Symmetric Difunctional Substrates |
| enantioselective chemical synthesis methods logic and practice: Process Intensification David Reay, Colin Ramshaw, Adam Harvey, 2013-06-05 Process Intensification: Engineering for Efficiency, Sustainability and Flexibility is the first book to provide a practical working guide to understanding process intensification (PI) and developing successful PI solutions and applications in chemical process, civil, environmental, energy, pharmaceutical, biological, and biochemical systems. Process intensification is a chemical and process design approach that leads to substantially smaller, cleaner, safer, and more energy efficient process technology. It improves process flexibility, product quality, speed to market and inherent safety, with a reduced environmental footprint. This book represents a valuable resource for engineers working with leading-edge process technologies, and those involved research and development of chemical, process, environmental, pharmaceutical, and bioscience systems. - No other reference covers both the technology and application of PI, addressing fundamentals, industry applications, and including a development and implementation guide - Covers hot and high growth topics, including emission prevention, sustainable design, and pinch analysis - World-class authors: Colin Ramshaw pioneered PI at ICI and is widely credited as the father of the technology |
| enantioselective chemical synthesis methods logic and practice: Classics in Total Synthesis III K. C. Nicolaou, Jason S. Chen, 2011-03-14 K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Adopting his didactically skillful approach, K.C. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. A wonderful tool for learning and teaching and a must-have for all future and present organic and biochemists. |
| enantioselective chemical synthesis methods logic and practice: Solid-Phase Organic Syntheses, Volume 1 Anthony W. Czarnik, 2004-04-07 The rapid expansion of combinatorial chemistry has renewed interest in solid-phase organic synthesis, a method that lends itself well to creating and screening large numbers of lead compounds. Solid-Phase Organic Syntheses, Volume 1 is the first volume in a series that will be updated annually, filling a gap in the existing chemical literature. Providing information previously unavailable from a single resource, this series is dedicated to providing researchers in the field with validated and tested methods for the solid-phase synthesis of interesting and biologically relevant molecules. Solid-phase methods will virtually always be invented for application in combinatorial organic synthesis. To meet these specific needs, Solid-Phase Organic Syntheses, Volume 1 focuses on a single type of synthetic transformation accomplished on solid support, and indicates how procedures are optimized to work with a structurally-wide variety of reagents. Written by recognized leaders in the field who review and test all chemical protocols before publication, organic transformations are organized by type of compound synthesized and reaction type. For the first time, experimental details for proven solid-phase synthetic molecules are collected in a single, invaluable resource. Solid-Phase Organic Syntheses, Volume 1 provides combinatorial chemists and researchers in organic chemistry and medicinal chemistry with the tools and descriptive protocols to achieve syntheses of desired compounds using a variety of solid supports and reagents. |
| enantioselective chemical synthesis methods logic and practice: Advanced Organic Chemistry Francis A. Carey, Richard J. Sundberg, 2007-06-27 Since its original appearance in 1977, Advanced Organic Chemistry has maintained its place as the premier textbook in the field, offering broad coverage of the structure, reactivity and synthesis of organic compounds. As in the earlier editions, the text contains extensive references to both the primary and review literature and provides examples of data and reactions that illustrate and document the generalizations. While the text assumes completion of an introductory course in organic chemistry, it reviews the fundamental concepts for each topic that is discussed. The two-part fifth edition has been substantially revised and reorganized for greater clarity. Among the changes: Updated material reflecting advances in the field since 2001’s Fourth Edition, especially in computational chemistry; A companion Web site provides digital models for study of structure, reaction and selectivity; Solutions to the exercises provided to instructors online. The material in Part Ais organized on the basis of fundamental structural topics such as structure, stereochemistry, conformation and aromaticity and basic mechanistic types, including nucleophilic substitution, addition reactions, carbonyl chemistry, aromatic substitution and free radical reactions. Together with Part B: Reaction and Synthesis, the two volumes are intended to provide the advanced undergraduate or beginning graduate student in chemistry with a sufficient foundation to comprehend and use the research literature in organic chemistry. |
| enantioselective chemical synthesis methods logic and practice: Chemical Process Technology Jacob A. Moulijn, Michiel Makkee, Annelies E. van Diepen, 2013-03-21 With a focus on actual industrial processes, e.g. the production of light alkenes, synthesis gas, fine chemicals, polyethene, it encourages the reader to think “out of the box” and invent and develop novel unit operations and processes. Reflecting today’s emphasis on sustainability, this edition contains new coverage of biomass as an alternative to fossil fuels, and process intensification. The second edition includes: New chapters on Process Intensification and Processes for the Conversion of Biomass Updated and expanded chapters throughout with 35% new material overall Text boxes containing case studies and examples from various different industries, e.g. synthesis loop designs, Sasol I Plant, Kaminsky catalysts, production of Ibuprofen, click chemistry, ammonia synthesis, fluid catalytic cracking Questions throughout to stimulate debate and keep students awake! Richly illustrated chapters with improved figures and flow diagrams Chemical Process Technology, Second Edition is a comprehensive introduction, linking the fundamental theory and concepts to the applied nature of the subject. It will be invaluable to students of chemical engineering, biotechnology and industrial chemistry, as well as practising chemical engineers. From reviews of the first edition: “The authors have blended process technology, chemistry and thermodynamics in an elegant manner... Overall this is a welcome addition to books on chemical technology.” – The Chemist “Impressively wide-ranging and comprehensive... an excellent textbook for students, with a combination of fundamental knowledge and technology.” – Chemistry in Britain (now Chemistry World) |
| enantioselective chemical synthesis methods logic and practice: Handbook of Essential Oils K. Husnu Can Baser, Gerhard Buchbauer, 2009-12-28 Egyptian hieroglyphs, Chinese scrolls, and Ayurvedic literature record physicians administering aromatic oils to their patients. Today society looks to science to document health choices and the oils do not disappoint. The growing body of evidence of their efficacy for more than just scenting a room underscores the need for production standards, quality control parameters for raw materials and finished products, and well-defined Good Manufacturing Practices. Edited by two renowned experts, the Handbook of Essential Oils covers all aspects of essential oils from chemistry, pharmacology, and biological activity, to production and trade, to uses and regulation. Bringing together significant research and market profiles, this comprehensive handbook provides a much-needed compilation of information related to the development, use, and marketing of essential oils, including their chemistry and biochemistry. A select group of authoritative experts explores the historical, biological, regulatory, and microbial aspects. This reference also covers sources, production, analysis, storage, and transport of oils as well as aromatherapy, pharmacology, toxicology, and metabolism. It includes discussions of biological activity testing, results of antimicrobial and antioxidant tests, and penetration-enhancing activities useful in drug delivery. New information on essential oils may lead to an increased understanding of their multidimensional uses and better, more ecologically friendly production methods. Reflecting the immense developments in scientific knowledge available on essential oils, this book brings multidisciplinary coverage of essential oils into one all-inclusive resource. |
| enantioselective chemical synthesis methods logic and practice: Fragrant Introduction to Terpenoid Chemistry Charles S Sell, 2019-05-16 Terpenoids play an important part in all our lives, from Vitamin A and hormones to perfumes and pharmaceuticals. This book provides an introduction to terpenoid chemistry, concentrating on the lower terpenoids, but the basic principles taught are also the foundation for the chemistry of the higher terpenoids. Coverage includes: the biogenesis of terpenoids; some of the history of the field; the principles of structural determination; and the importance of stereochemistry and stereoselective synthesis. Carbocation chemistry is introduced, as are the principles of total and partial synthesis. Finally, industrial chemistry (both discovery chemistry and chemical process development) is discussed, using the volatile terpenoids of perfumery to illustrate basic concepts. Ideal as both an introduction to terpenoid chemistry and as a refresher course, A Fragrant Introduction to Terpenoid Chemistry, with its real-life problems and appreciation of the relevance of chemistry to everyday life, will prove invaluable to students, lecturers and industrialists alike. |
| enantioselective chemical synthesis methods logic and practice: Elements of Synthesis Planning R. W. Hoffmann, 2009-01-07 Synthesis is at the core of organic chemistry. In order for compounds to be studied—be it as drugs, materials, or because of their physical properties— they have to be prepared, often in multistep synthetic sequences. Thus, the target compound is at the outset of synthesis planning. Synthesis involves creating the target compound from smaller, readily available building blocks. Immediately, questions arise: From which bui- ing blocks? In which sequence? By which reactions? Nature creates many highly complex “natural products” via reaction cascades, in which an asso- ment of starting compounds present within the cell is transformed by speci c (for each target structure) combinations of modular enzymes in speci c - quences into the target compounds [1, 2]. To mimic this ef ciency is the dream of an ideal synthesis [2]. However, we are at present so far from - alising such a “one-pot” operation that actual synthesis has to be achieved via a sequence of individual discrete steps. Thus, we are left with the task of planning each synthesis individually in an optimal fashion. Synthesis planning must be conducted with regard for certain speci - tions, some of which are due to the structure of the target molecule, and some of which relate to external parameters such as costs, environmental compatibility, or novelty. We will not consider these external aspects in this context. Planning of a synthesis is based on a pool of information regarding chemical reactions that can be executed reliably and in high chemical yield. |
| enantioselective chemical synthesis methods logic and practice: Introduction to Strategies for Organic Synthesis Laurie S. Starkey, 2018-03-28 Bridging the Gap Between Organic Chemistry Fundamentals and Advanced Synthesis Problems Introduction to Strategies of Organic Synthesis bridges the knowledge gap between sophomore-level organic chemistry and senior-level or graduate-level synthesis to help students more easily adjust to a synthetic chemistry mindset. Beginning with a thorough review of reagents, functional groups, and their reactions, this book prepares students to progress into advanced synthetic strategies. Major reactions are presented from a mechanistic perspective and then again from a synthetic chemist’s point of view to help students shift their thought patterns and teach them how to imagine the series of reactions needed to reach a desired target molecule. Success in organic synthesis requires not only familiarity with common reagents and functional group interconversions, but also a deep understanding of functional group behavior and reactivity. This book provides clear explanations of such reactivities and explicitly teaches students how to make logical disconnections of a target molecule. This new Second Edition of Introduction to Strategies for Organic Synthesis: Reviews fundamental organic chemistry concepts including functional group transformations, reagents, stereochemistry, and mechanisms Explores advanced topics including protective groups, synthetic equivalents, and transition-metal mediated coupling reactions Helps students envision forward reactions and backwards disconnections as a matter of routine Gives students confidence in performing retrosynthetic analyses of target molecules Includes fully-worked examples, literature-based problems, and over 450 chapter problems with detailed solutions Provides clear explanations in easy-to-follow, student-friendly language Focuses on the strategies of organic synthesis rather than a catalogue of reactions and modern reagents The prospect of organic synthesis can be daunting at the outset, but this book serves as a useful stepping stone to refresh existing knowledge of organic chemistry while introducing the general strategies of synthesis. Useful as both a textbook and a bench reference, this text provides value to graduate and advanced undergraduate students alike. |
| enantioselective chemical synthesis methods logic and practice: Total Synthesis of Bioactive Natural Products Goutam Brahmachari, 2019-04-27 Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. - Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules - Outlines each step of the process in detail, with full experimental information supported by extensive schemes - Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule |
| enantioselective chemical synthesis methods logic and practice: Process Intensification Jan Harmsen, Maarten Verkerk, 2020-07-20 Process Intensification is a comprehensive textbook and treats the theory of process intensification design, and all innovation steps from idea generation to commercial implementation, and all focused on contributing to the UN Sustainable Development Goals. This book covers the ‘hard’ elements of design, modelling, and experimental validations and the ‘soft’ elements, values of engineers, interests of stakeholders and beliefs of society. |
| enantioselective chemical synthesis methods logic and practice: Organic Synthesis Belakatte Parameshwarappa Nandeshwarappa, 2020-05-27 The book ‘Organic Synthesis - A Nascent Relook’ is a compendium of the recent progress in all aspects of organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic, green chemistry and medicinal chemistry, polymer chemistry, as well as analytical methods in organic chemistry. The book presents the latest developments in these fields. The chapters are written by chosen experts who are internationally known for their eminent research contributions. Organic synthesis is the complete chemical synthesis of a target molecule. In this book, special emphasis is given to the synthesis of various bioactive heterocycles. Careful selection of various topics in this book will serve the rightful purpose for the chemistry community and the industrial houses at all levels. |
| enantioselective chemical synthesis methods logic and practice: Organic Synthesis Douglass F. Taber, Tristan Lambert, 2017 A collection of Douglass Taber's columns originally published between 2013 - 2015 at www.organicchemistry.org |
| enantioselective chemical synthesis methods logic and practice: Sustainable Flow Chemistry Luigi Vaccaro, 2017-04-10 This ready reference not only presents the hot and emerging topic of modern flow chemistry, it is also unique in illustrating the important connection to sustainable chemistry. Focusing on more sustainable methods and applications, the text extensively covers every important field from reaction time optimization to waste minimization, and from safety improvements to microwave applications. In addition, green metrics are presented as a key aspect of the book, helping readers to evaluate the efficiency of flow technologies and their impact on the overall efficiency of a chemical process. An invaluable handbook for every chemist working in the laboratory, whether in academia or industry. |
| enantioselective chemical synthesis methods logic and practice: Modern Arylation Methods Lutz Ackermann, 2009-04-22 Today, arylation methods are belonging to the most important reaction types in organic synthesis. Lutz Ackermann, a young and ambitious professor has gathered a number of top international authors to present the first comprehensive book on the topic. Starting from a historical review, the book covers hot topics like Palladium-catalyzed arylation of N-H and alpha-C-H-acidic Bonds, Copper-catalyzed arylation of N-H and O-H Bonds, direct arylation reactions, carbanion aromatic synthesis, arylation reactions of alkenes, alkynes and much more. This compact source of high quality information is indispensable to synthetic chemists and those working in the pharmaceutical and chemical industry. |
| enantioselective chemical synthesis methods logic and practice: Molecules That Changed the World K. C. Nicolaou, Tamsyn Montagnon, 2008-03-17 K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Here, the best-selling author and renowned researcher, K. C. Nicolaou, presents around 40 natural products that all have an enormous impact on our everyday life. Printed in full color throughout with a host of pictures, this book is written in the author's very enjoyable and distinct style, such that each chapter is full of interesting and entertaining information on the facts, stories and people behind the scenes. Molecules covered span the healthy and useful, as well as the much-needed and extremely toxic, including Aspirin, urea, camphor, morphine, strychnine, penicillin, vitamin B12, Taxol, Brevetoxin and quinine. A veritable pleasure to read. |
| enantioselective chemical synthesis methods logic and practice: Asymmetric Dearomatization Reactions Shu-Li You, 2016-09-13 The first comprehensive account of the rapidly growing field of asymmetric dearomatization reactions with a focus on catalytic methods. It introduces the concept of dearomatization and describes recent progress in asymmetric reaction procedures with different catalyst systems, such as organocatalysts, transition metal catalysts, and enzymes. Chapters on dearomatizations of electron-deficient aromatic rings, dearomatization reactions via transition metal-catalyzed cross-couplings as well as dearomatization strategies in the synthesis of complex natural products are also included. Written by pioneers in the field, this is a highly valuable source of information not only for professional synthetic chemists in academia and industry but also for all those are interested in asymmetric methodologies and organic synthesis in general. |
| enantioselective chemical synthesis methods logic and practice: Name Reactions of Functional Group Transformations Jie Jack Li, E. J. Corey, 2007-07-09 This practical, well-organized reference delves deeply into functional group transformations, to provide all the detailed information that researchers need. Topics are organized into the following sections: oxidation, reduction, asymmetric synthesis, and functional group manipulations Each section includes a description of the functional group transformation, the historical perspective, mechanisms, variations and improvements on the reaction, synthetic utilities and applications for the reaction, experimental details, and references to the primary literature Contributors are well-known and respected for their work on the specific name reactions. |
| enantioselective chemical synthesis methods logic and practice: Index Medicus , 2003-07 Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings. |
| enantioselective chemical synthesis methods logic and practice: Chemija , 1999 |
Enantioselective synthesis - Wikipedia
Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often have different biological activity.
Enantioselectivity in Drug Pharmacokinetics and Toxicity ...
Enantioselective analytical methods by LC using CSPs is the primary choice to quantify enantiomers in biological matrices. Despite the use of LC-DAD, LC-UV and LC-FD, the use of LC-MS/MS allows to obtain a better selectivity, sensitivity, and …
19.15: Chemistry Matters—Enantioselective Synthesis
Sep 23, 2024 · Several approaches to enantioselective synthesis have been developed, but the most efficient are those that use chiral catalysts to temporarily hold a substrate molecule in an unsymmetrical environment—the same strategy that nature …
Enantioselective Radical Reactions Using Chiral Catalysts
Jan 24, 2022 · This review provides a comprehensive inventory of progress in enantioselective radical reactions with a goal of detailing the reaction mechanisms involved in these transformations such that any nonspecialist could find their …
Enantioselective Synthesis - SpringerLink
Jan 1, 2016 · Enantioselective synthesis is a chemical/biochemical reaction where only one enantiomer of a chiral product is preferentially formed. The synthesis can be divided into two different types, namely, catalytic synthesis …
Enantioselective synthesis - Wikipedia
Enantioselective synthesis is a key process in modern chemistry and is particularly important in the field of pharmaceuticals, as the different enantiomers or diastereomers of a molecule often …
Enantioselectivity in Drug Pharmacokinetics and Toxicity ...
Enantioselective analytical methods by LC using CSPs is the primary choice to quantify enantiomers in biological matrices. Despite the use of LC-DAD, LC-UV and LC-FD, the use of …
19.15: Chemistry Matters—Enantioselective Synthesis
Sep 23, 2024 · Several approaches to enantioselective synthesis have been developed, but the most efficient are those that use chiral catalysts to temporarily hold a substrate molecule in an …
Enantioselective Radical Reactions Using Chiral Catalysts
Jan 24, 2022 · This review provides a comprehensive inventory of progress in enantioselective radical reactions with a goal of detailing the reaction mechanisms involved in these …
Enantioselective Synthesis - SpringerLink
Jan 1, 2016 · Enantioselective synthesis is a chemical/biochemical reaction where only one enantiomer of a chiral product is preferentially formed. The synthesis can be divided into two …
Enantioselectivity - an overview | ScienceDirect Topics
Enantioselectivity is a property that allows certain enzymes to be utilised to produce enantiomerically pure chemicals for industrial applications including for agrochemicals and …
Enantioselective Synthesis in Organic Chemistry: Definition
Learn about enantioselective synthesis, its importance, and different methods of achieving it. The lesson includes a discussion of chiral pool, chiral auxiliary, and asymmetric catalysis...
Chemistry Matters—Enantioselective Synthesis - OpenStax
Several approaches to enantioselective synthesis have been developed, but the most efficient are those that use chiral catalysts to temporarily hold a substrate molecule in an unsymmetrical …
Enantioselective Synthesis: Methods & Applications - StudySmarter
Oct 21, 2023 · Enantioselective Synthesis: A chemical reaction producing a surplus of one enantiomer over the other. There are two main enantioselective synthesis methods: the use of …
Enantioselective and Enantiospecific Transition-Metal-Catalyzed …
Aug 13, 2015 · Early efforts to develop enantioselective transition-metal-catalyzed alkyl cross-coupling reactions focused primarily on the use of configurationally labile sec-alkylmetallic …
