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| df swaab: We Are Our Brains D. F. Swaab, 2014-01-07 A vivid account of what makes us human. Based groundbreaking new research, We Are Our Brains is a sweeping biography of the human brain, from infancy to adulthood to old age. Renowned neuroscientist D. F. Swaab takes us on a guided tour of the intricate inner workings that determine our potential, our limitations, and our desires, with each chapter serving as an eye-opening window on a different stage of brain development: the gender differences that develop in the embryonic brain, what goes on in the heads of adolescents, how parenthood permanently changes the brain. Moving beyond pure biological understanding, Swaab presents a controversial and multilayered ethical argument surrounding the brain. Far from possessing true free will, Swaab argues, we have very little control over our everyday decisions, or who we will become, because our brains predetermine everything about us, long before we are born, from our moral character to our religious leanings to whom we fall in love with. And he challenges many of our prevailing assumptions about what makes us human, decoding the intricate “moral networks” that allow us to experience emotion, revealing maternal instinct to be the result of hormonal changes in the pregnant brain, and exploring the way that religious “imprinting” shapes the brain during childhood. Rife with memorable case studies, We Are Our Brains is already a bestselling international phenomenon. It aims to demystify the chemical and genetic workings of our most mysterious organ, in the process helping us to see who we are through an entirely new lens. Did you know? • The father’s brain is affected in pregnancy as well as the mother’s. • The withdrawal symptoms we experience at the end of a love affair mirror chemical addiction. • Growing up bilingual reduces the likelihood of Alzheimer’s. • Parental religion is imprinted on our brains during early development, much as our native language is. Praise for We Are Our Brains “Swaab’s ‘neurobiography’ is witty, opinionated, passionate, and, above all, cerebral.”—Booklist (starred review) “A fascinating survey . . . Swaab employs both personal and scientific observation in near-equal measure.”—Publishers Weekly (starred review) “A cogent, provocative account of how twenty-first-century ‘neuroculture’ has the potential to effect profound medical and social change.”—Kirkus Reviews |
| df swaab: Sex Differences in the Human Brain, their Underpinnings and Implications , 2010-12-03 This volume of Progress in Brain Research documents recent developments and research findings in relation to sex and how the brain's function and behavior differs from men to women. Specific areas include cerebral function, morphology and organization, sexual dimorphism, neural origins,and genetics and epigenetics, as well as potential causes/affects of stress, pain, sexual orientation and identity and other social issues such as distribution of disorders across the sexes and autism. - Informs and updates on all the latest developments in the field - Highlights areas for future research - Contributions from leading authorities and industry experts |
| df swaab: The Human Hypothalamus in Health and Disease , 1992-11-02 The Human Hypothalamus in Health and Disease |
| df swaab: Progress in Alzheimer’s and Parkinson’s Diseases Abraham Fisher, Israel Hanin, Mitsuo Yoshinda, 2012-12-06 This book represents the fourth ina series of international conferences related to Alzheimer's (AD) and Parkinson's (PO) diseases. The first one took place in EHat, Israel in 1985; the second in Kyoto, Japan, in 1989; and the third in Chicago, IL, USA in 1993. This book incorporates the proceedings of the Fourth International Conference on Pro gress in Alzheimer's and Parkinson's Diseases, held in EHat, Israel, on May 18-23, 1997. This Conference was the 41st in the series of annual OHOLO Conferences sponsored by the Israel Institute for Biological Research (IIBR). It was also conducted under the aus pices of the Alzheimer's Association Ronald and Nancy Reagan Research Institute, USA. The Conference was attended by 550 participants from 28 countries, representing a broad spectrum of research interests; and included a well-balanced representation from aca demia, clinical institutions and pharmaceutical industry. The four-and-one-half day meeting served as an excellent medium for surveying the current preclinical and clinical develop ments in AD, PO, and other related disorders. The scientific program was divided into 24 oral sessions and daily poster sessions. The conference culminated in a round table discus sion. There were 122 talks and 161 posters. This book incorporates a combination of both. |
| df swaab: The Postmortem Brain in Psychiatric Research Galila Agam, Ian P. Everall, Robert Haim Belmaker, 2013-03-09 Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the brain. The human postmortem brain offers the most appropriate experimental paradigm towards understanding the etiology of psychiatric disorders. The availability of post-mortem human samples from psychiatric patients and comparison groups in recent years has contributed prominently to the accumulating body of information leading to a better understanding of these disorders. This is the first book to summarize this research approach and the meaningful data which has recently been acquired. |
| df swaab: Aging and Dementia Erik Johan Anton Scherder, Erik Scherder, 2011 Drawing on the most current research, this study is the perfect companion for those who work alongside elderly people with and without dementia. The book explains why changes in cognition, motor skills, and pain are typical for the elderly while describing the most prevalent subtypes of dementia, including Alzheimer's disease, vascular dementia, and frontotemporal dementia. Focusing on the motor skills of hand motor activity and gait, the study also illustrates changes in the various aspects of pain experience, explaining them clearly through the use of neuropathology of the medial and lateral pain systems. Updates concerning compensation and rehabilitation are also included. |
| df swaab: Neuroscience: From the Molecular to the Cognitive Floyd E. Bloom, 1994-07-19 This hundredth volume is a commemorative milestone in the prestigeous Progress in Brain Research series. Accordingly, authors were invited to write on any topic, given that their choice represented the topic most near and dear to their own efforts over a significant period of the recent past, and to which they would likely continue to be devoted in the future. In that sense, this volume does not represent a scientific meeting, but rather an overview sample of problems and methodologies that epitomize brain research broadly at this special moment in the maturation of the field. The chapters comprising this volume assort themselves readily into five or six established categories of topics: developmental brain research, molecular brain research, integrative brain research, neuroplasticity, and neuro-psychiatric conditions. This volume reports through a sample of recognized leaders in the neuroscientific community at a significant instant in the history and evolution of the field. |
| df swaab: Aging of the Brain and Alzheimer's Disease , 2011-09-22 Aging of the Brain and Alzheimer's Disease |
| df swaab: Human Neuroanatomy James R. Augustine, 2008 This textbook provides a thorough and comprehensive overview of the human brain and spinal cord. |
| df swaab: Endogenous Peptides and Learning and Memory Processes Joe L. Jr. Martinez, 2012-12-02 Endogenous Peptides and Learning and Memory Processes presents the role of pituitary and central nervous system peptidergic systems in the modulation of memory and learning. This book discusses the various experimental findings concerning the role of peptides in attention, memory, conditioning, opiate tolerance, and amnesia. Organized into five parts encompassing 26 chapters, this book starts with an overview of the possible chemical relationship between melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). This text then discusses the complex behavioral activities of ACTH involving processes that serve the adaptive abilities of the organism, such as memory, learning, motivation, attention, and arousal. Other chapters consider the possibility that post-training injection of some hormones may aid retention performance following training in a one-trial inhibitory avoidance task. The final chapter deals with the various types of behavioral tests for studying the central nervous system effects of peptides. This book is a valuable resource for specialists, teachers, clinicians, and researchers in the fields of neuropharmacology, behavioral pharmacology, experimental psychology, and psychopharmacology. |
| df swaab: Connections, Cognition and Alzheimer’s Disease Bradley T. Hyman, Charles Duyckaerts, 2012-12-06 The fundamental relationship between the neuropathological lesions of Alzheimer's disease and the problem of what underlies the clinical syndrome has remained unsolved since the beginning of the century. Are neurofibrillary tangles and senile plaques directly related to clinical symptoms, or are they epiphenomena that signal synaptic and neuronal loss? In the last decade, these questions have been revisited through systematic studies of individuals with various degrees of dementia using newer immunohistochemical techniques and quantitative approaches to neuropathological study. It is now possible to have a uniform picture of Alzheimer's disease dementia as resulting from collapse of specific neural systems, as pathological changes selectively and specifically involve structures related to memory and higher cognitive functions.This book contains the proceedings of a meeting organized by the Fondation Ipsen which brought together researchers in neuropathology, molecular biology, genetics, neuropsychology, brain imagery and clinical neurology. . |
| df swaab: The Endocrinology of Aging Werner A. Scherbaum, Winfried Rossmanith, 2012-02-13 No detailed description available for The Endocrinology of Aging. |
| df swaab: Biological Risk Factors for Psychosocial Disorders European Network on Longitudinal Studies on Individual Development, 1991-11-29 It has been known for many years that physical disease or damage, especially of the brain, is associated with an increased risk for psychosocial disorders. However, the understanding of the mechanisms involved in these biological risk processes, and of the marked individual differences in response, is of much more recent origin. The role of genetic factors, perinatal brain damage, sex hormones, allergy, drugs, and language disorder, are among the topics reviewed by this book's expert contributors. Papers were selected to illustrate the wide range of mechanisms involved in the development of psychosocial disorders in childhood or later life. Authors were asked to write for a multidisciplinary audience, to adopt a lifespan approach, to focus on the principles involved, and to highlight the outstanding research and clinical issues in each field. |
| df swaab: Adaptive Capabilities of the Nervous System , 2011-09-22 Adaptive Capabilities of the Nervous System |
| df swaab: Circumventricular Organs and Brain Fluid Environment , 1992-08-04 Circumventricular Organs and Brain Fluid Environment |
| df swaab: The Primate Nervous System, Part I Floyd E. Bloom, A. Bjorklund, T. Hokfelt, 1997-05-07 This volume is a new, timely and fitting extension to the Handbook of Chemical Neuroanatomy, focussing on the neurochemical circuitry of the primate brain. The book will compliment the growing efforts to apply the analytical strategies of chemical neuroanatomy to the primate brain.The goal of this volume is to develop a broad-based coverage of human and non-human primate chemical neuroanatomic details together within a volume in which details on transmitters and systems can be appreciated.The eight comprehensive chapters that comprise this volume deal with large global concepts and datasets which not only create an initial coverage of the entire primate neuraxis, but also capture useful points of information on the chemical neuranatomy of the primate nervous system.An excellent, informative book, and a welcome addition to the sparse literature in this field. |
| df swaab: Peptides of the Pars Intermedia David Evered, Geralyn Lawrenson, 2009-09-14 The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world. |
| df swaab: The Neuroendocrine Immune Network in Ageing R.H. Straub, Eugenio Mocchegiani, 2004-07-24 The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity. |
| df swaab: The Peptidergic Neuron B. Krisch, 2012-12-06 Neuropeptides rank among the phylogenetically oldest interneuronal signal substances. In the concept of neuro-secretion they were identified as neurohormones by which - via the blood - the brain regulates peripheral functions. It is now evident that the neuropeptides act as neurotransmitters/-modulators, as (neuro-)hormones, and paracrine or autocrine signal substances in diverse parts of the body. This book reviews, in several comprehensive articles written by distinguished specialists, the state of the art in the field of neuropeptides and peptidergic neurons. Special topics concern molecular aspects of processing, release and degradation of neuropeptides, receptors and signal transduction, comparative and behavioural aspects, and immunoregulatory effects of neuropeptides and their involvement on pathology of the central nervous system. |
| df swaab: Sex Differences in Neurology and Psychiatry , 2020-09-30 Sex Differences in Neurology and Psychiatry, Volume 175, addresses this important issue by viewing major neurological and psychiatric conditions through the lens of sexual dimorphism, providing an entirely novel approach to understanding vulnerability factors, as well as potential new treatment strategies in several common neuropsychiatric disorders. The handbook comprises four major sections: (1) Introduction to sex differences in neuroanatomy and neurophysiology, (2) Description of the impact of genetic, epigenetic, sex hormonal and other environmental effects on cerebral sex dimorphism, (3) Review of sex differences in neurologic disorders, and (4) Review of sex differences in psychiatric disorders. - Explores sex differences in human neuroanatomy and neurophysiology - Offers a pathway toward a gender-specific treatment of neurologic and psychiatric disorders - Provides an overview of the genetics of sex hormones, human brain structure, and function, as well as the epigenetics, environment and social context |
| df swaab: Frontiers in Clinical Drug Research - Alzheimer Disorders Atta-ur-Rahman, 2015-11-27 Frontiers in Clinical Drug Research - Alzheimer Disorders is an e-Book series concerned with Alzheimer's disease (AD) that causes dementia, or loss of brain function. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on (Alzheimer Disorders) drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in field of Alzheimer’s Disease research. The fourth volume of this series features research on - Melatoninergic Pathways in Alzheimer's disease, - Nutritional Approaches in Alzheimer’s disease prevention, - Updates on drugs and strategies for Alzheimer’s disease prevention |
| df swaab: Neuropeptides and Brain Function E. R. de Kloet, V. M. Wiegant, David de Wied, 1987 NEUROPEPTIDES AND BRAIN FUNCTION. |
| df swaab: Pediatric Gender Assignment Stephen A. Zderic, Douglas A. Canning, Michael C. Carr, Howard McC. Snyder III, 2012-12-06 This book represents the proceedings from a conference that took place in Dallas in the spring of 1999 which was entitled Pediatric Gender Assignment - A Critical Reappraisal. Some participants rightfully argued that the conference really focused on the issue of pediatric gender assignment, and that reassignment was not applied in most cases. Their comments were reflected in the title of this monograph. This multidisciplinary meeting was sponsored by a conference grant from the National Institutes of Health, and a broad inquiry into this complex topic took place from many points of view. Basic scientists offered insight into mechanisms of sexual differentiation of the gonads, physical phenotype and imprinting of the central nervous system. Endocrinologists reviewed their experience in diagnosis and management, surgeons described traditional as well as innovative approaches, and there was strong representation from the ethical and behavioral sciences. In putting together such a panel, it was essential that we identify a cast of speakers who could address their viewpoints with strong convictions, and yet not let their passions render the meeting counter productive. We were not disappointed. While many differing points of view were firmly expressed by the panelists and audience, all viewpoints were accorded the respect they deserved. The concept behind the meeting and this book really originated in 1997 shortly after Diamond and Sigmundson published their long term follow up study of the John/Joan case. |
| df swaab: International Review of Cytology Kwang W. Jeon, 2004-12-18 International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address therapeutic strategies for duchenne and becker dystrophies, cellular distribution and functions of P2 receptor subtypes in different systems, neuropeptides in hypothalamic neuronal disorders, and multiple parallelisms in animal cytokinesis. |
| df swaab: Integrative Hypothalamic Activity , 2011-09-21 Integrative Hypothalamic Activity |
| df swaab: The Male Brain Louann Brizendine, MD, 2011-01-25 From the author of the groundbreaking New York Times bestseller The Female Brain, here is the eagerly awaited follow-up book that demystifies the puzzling male brain. Dr. Louann Brizendine, the founder of the first clinic in the country to study gender differences in brain, behavior, and hormones, turns her attention to the male brain, showing how, through every phase of life, the male reality is fundamentally different from the female one. Exploring the latest breakthroughs in male psychology and neurology with her trademark accessibility and candor, she reveals that the male brain: -is a lean, mean, problem-solving machine. Faced with a personal problem, a man will use his analytical brain structures, not his emotional ones, to find a solution. -thrives under competition, instinctively plays rough and is obsessed with rank and hierarchy. -has an area for sexual pursuit that is 2.5 times larger than the female brain, consuming him with sexual fantasies about female body parts. -experiences such a massive increase in testosterone at puberty that he perceive others' faces to be more aggressive. The Male Brain finally overturns the stereotypes. Impeccably researched and at the cutting edge of scientific knowledge, this is a book that every man, and especially every woman bedeviled by a man, will need to own. |
| df swaab: Advances in Brain Vasopressin I.J.A. Urban, J.P.H. Burbach, D. De Wied, 1999-02-16 Advances in Brain Vasopressin elucidates the functions of the regulatory peptide vasopressin in the nervous system, and reviews the current status of this field at different levels. It deals with the cell biology and anatomy of the neurons that produce vasopressin in the brain, and provides an overview on the receptors of vasopressin and the signal transduction pathways that they activate, including the cellular responses that are triggered by vasopressin. Reviews are presented on the modulation of behavior induced by vasopressin in a number of different contexts, such as sex-linked and steroid-dependent behaviors, social behaviors, and learning and memory. Furthermore, the volume deals with several controversial issues in the field by presenting overlapping chapters from different research groups in order to provide the reader with current views. Highly relevant and useful, for those working on this first neuropeptide, and for young investigators entering the field, and in addition, shows how important a multidisciplinary approach is to unravelling the function of a neuropeptide in the brain. |
| df swaab: Migraine Biology, Diagnosis, and Co-Morbidities Jerry W. Swanson, Manjit Matharu, 2023-11-30 Migraine Biology, Diagnosis, and Co-Morbidities, Volume 195 covers a wide range of issues related to migraine. The epidemiology, global and personal impacts of migraine are covered, including topics on the pathophysiology of migraine and migraine aura, the pathophysiology of the associated symptoms of photophobia and phonophobia, and the genetics of migraine. The classification and diagnostic criteria of common and uncommon subtypes of migraine are also explored in detail, including childhood variants. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness are also covered. The important comorbidities of migraine such as anxiety, depression and other forms of chronic pain will also be discussed, along with the current state and future directions of migraine research and management. - Summarizes research and clinical information on the pathophysiology of migraines - Explores the pathophysiology of aura, photophobia, and phonophobia - Discusses migraine triggers - Reviews migraine subtypes and comorbid conditions in migraine - Explores the relationship of migraine to chronic pain and cerebrovascular and psychological conditions - Concludes with future directions in migraine research and treatment |
| df swaab: Cell and Gene Therapies for Neurologic Diseases , 2024-10-02 Cell and Gene Therapies for Neurologic Diseases, Volume 205 comprehensively covers the scientific background, translational efforts, clinical developments and registered biologics that have entered into clinical practice. Coverage includes types of therapies available and in development, and best practice uses for a variety of neurological disorders including Parkinson's, Huntington's, ALS, stroke, spinal cord RP, demyelination, and epilepsy. As the emergence of gene and cellular therapeutics has changed the clinical landscape for a variety of disorders, and is now ready to do so for neurological diseases, these therapeutic modalities currently complement, and may in time, supplant small molecule drugs. - Summarizes advances in cell and gene therapy for neurological diseases - Describes the therapies available and in development - Includes surgical, ethical, and manufacturing considerations - Identifies best practices for specific neurological diseases - Covers Huntington's, Parkinson's, ALS, Stroke, Demyelination, epilepsy, and more |
| df swaab: Hematopoietic Stem Cell Transplantation for Neurologic Diseases , 2024-08-05 Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity. - Reviews immunological mechanisms of HSCT and CNS autoimmunity - Identifies neurological diseases showing treatment efficacy with HSCT - Includes MS, myasthenia gravis, neuromyelitis optica, and more - Covers early and late side effects of HSCT |
| df swaab: Paraneoplastic Neurologic Disorders , 2024-03-15 This book extensively reviews Paraneoplastic Neurological Syndromes in light of the most recent descriptions of autoantibodies against neuronal cell surface antigens (only partly associated with paraneoplastic disorders) and the introduction of new immuno-oncological drugs that can contribute to causing diseases that are pathogenetically indistinguishable from paraneoplastic syndromes. These two new developments have not been addressed in other volumes available on the market. Section 1 focuses on immunological defense mechanisms against tumors. Besides investigating the pathogenetic mechanisms of these disorders, this section will also explore what the introduction of new drugs used in immune checkpoint inhibitor cancer therapy is teaching us in terms of immunopathogenesis. The second section will present individual syndromes (phenotypical clinical manifestations) of the CNS, PNS, NMJ and muscle. These chapters will, however, be preceded by an epidemiological analysis and a chapter describing the clinical approach to patients with these disorders. Consideration will also be given in specific chapters to general therapeutic strategies and the techniques used to search for diagnostically relevant autoantibodies. Presentation of the individual diseases will be followed by a third section investigating the role of antibody markers, presented in three chapters differentiating cytoplasmic, nuclear and neuronal cell surface reactivities. The innovative component of the final two sections compared to previously published volumes lies in their presentation of the profile of paraneoplastic diseases by tumor type. Special attention will be given to thymoma (involved particularly with novel antibodies against surface antigens), and neuroendocrine tumours, which are as yet comparatively unexplored in the literature. Lastly, a clinical update will be provided on gynecological, hematological and testicular malignancies. The last section will address side effects of the new immuno-oncological drugs increasingly used in cancer therapy. The high number of neurological complications that occur when tumor checkpoints are inhibited against immune defences provides the ideal experimental model for understanding the pathogenesis of these diseases. - Profiles paraneoplastic diseases by tumor type - Identifies the pathogenetic mechanisms of PNS and provides epidemiological analysis - Presents individual syndromes of the CNS, PNS, NMJ, and muscle - Investigates the role of antibody markers - Differentiates cytoplasmic, nuclear, and neuronal cell surface reactivities - Discusses immune-oncological drugs causing diseases that are indistinguishable from PNS - Reviews therapeutic strategies and clinical approach to PNS patients |
| df swaab: Focal Neuropathies , 2024-04-30 This volume summarizes research and treatment on focal neuropathies to update clinicians on nerve biology and new diagnostic techniques to guide investigation and treatment of mononeuropathies. The book explores research broadly applicable to all types of mononeuropathies as well as individual mononeuropathy syndromes. Chapters on individual mononeuropathies include anatomy, causes, controversial diagnoses, and current or potential future treatments. - Summarizes new research on treatment for focal neuropathies - Differentiates and advises on controversial diagnoses - Includes neuropathies by location as well as syndrome or type of neuropathy - Covers biology, diagnosis, imaging, etiology, and treatment |
| df swaab: Coma, Stupor, and Related Disorders of Consciousness Peter W. Kaplan, Romergryko G. Geocadin, 2025-02-26 Coma, Stupor, and Related Disorders of Consciousness reviews recent research and best practice in the assessment and treatment of coma, stupor, and disorders of consciousness. It encompasses the neural circuits, anatomy & physiology of stupor and coma, differential diagnosis and clinical assessment, imagery, EEGs, therapy/intervention, decision making and prognosis. - Reviews recent advances in disorders of consciousness - Provides neural circuits and anatomy of DoC - Identifies basis for differential diagnosis - Summarizes best practices for therapy/intervention - Includes imagery, EEG, evoked potentials of DoC |
| df swaab: Neurologic Channelopathies , 2024-08-20 In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies.Ion channels are critical membrane bound proteins that underpin many fundamental processes in the central and peripheral nervous system including action potential generation and propagation and the control of neurotransmitter release at all CNS synapses as well as at the neuromuscular junction. Ion channels are consequently essential for all motor actions, cognitive functions and sensory perceptions. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given the fundamental processes that are dependent on ion channel function, it is perhaps unsurprising that genetic or immunologically mediated ion channel dysfunction can result in almost any neurological symptom; patients may present to virtually any subspecialty within both adult and child neurology. The advances that have been made here have not only increased knowledge about the fundamental molecular mechanisms at play, but have also improved our ability to both diagnose and treat many of these disorders in clinical practice. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the Neurological Channelopathies.The book will begin with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations but with potential for common treatment approaches. This initial chapter considers the classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter will consider•Pathophysiological underpinnings - genetic or immunological•Clinical presentations•Diagnostic approach•Treatment and management - Identifies importance of ion channels to CNS & PNS function - Considers the classification, genetics, and physiology of ion channels - Presents all major immunological and genetic channelopathies - Provides clinical presentation, diagnosis, and treatment of channelopathies |
| df swaab: Inherited White Matter Disorders and Their Mimics , 2024-09-23 Inherited White Matter Disorders and Their Mimics, Volume 204 discusses where imaging abnormalities and pathology lie predominantly in the CNS white matter. Many acquired causes, such as multiple sclerosis, are readily diagnosed and familiar to the majority of neurologists. However, less common acquired causes and genetic disorders (the leukodystrophies and genetic leukoencephalopathies) often present a diagnostic challenge. The evaluation of patients with White matter disorders (WMDs) has evolved enormously in recent decades, due to advances in genetics, radiology, and the development of treatments for specific disorders. This book brings together WMD research, spanning basic science, molecular genetics, and clinical and radiological phenotyping.This volume presents both common WMDs and rare disorders according to their presentations or pathophysiology. Chapters lay out the clinical and radiological presentation of the disorder, followed by genetics and diagnostics, and finally discussion of pathophysiology and treatment. Chapter contain imaging, clinical pearls to diagnosis, and reference tables for genotype-phenotype correlation. For diagnostic work-up, easy to read algorithms are presented as well as clear guidance on indications for treatment, where applicable. - Includes common and rare white matter disorders (WMDs) - Summarizes advances in genetics, radiology, and treatments for WMDs - Provides clinical and radiological phenotyping - Contains imaging, diagnostic algorithms, and guidance on treatment |
| df swaab: Circadian Rhythms, Sleep, and Sleep Disorders , 2025-01-24 Circadian rhythms, sleep, and sleep disorders covers the topic in two sections focusing on basic science and clinical application. In the basic section, new developments and research findings focusing on basic circadian rhythm and sleep physiology in animals and humans is highlighted. The chapters are written in short mini-review formats in order to concisely describe the fundamentals, and current hot topics.The basic part starts with a chapter on the fundamentals and new discoveries on oscillating circuitries in the sleeping rodent and human brain. This sets the stage for chap 2, focusing on circadian and homeostatic aspects of human sleep regulation. Chap 3 extends these aspects to human cognition. The next chapter reports on visual and non-visual effects of light on human behavior, particularly endocrine and electrophysiological correlates. Chap 5 covers chronic sleep restriction effects on functional connectivity states. The last two chapters (6 and 7) give a broad overview on sleep modeling across physiological levels, with a focus on a quantitative model of sleep-wake dynamics based on the physiology of the brainstem ascending arousal system.The clinical section of the book describes the circadian rhythm sleep-wake disorders, from epidemiology to clinical picture and treatment. Disorders covered include delayed and advanced sleep phase syndrome, Irregular sleep-wake rhythm disorder, shift work disorder, restless legs syndrome, nocturnal eating syndrome, narcolepsy, and sleep apnea. Pharmacological and non-pharmacological treatments of insomnia are explored, as well as the role of sleep-wake modulation in the pathogenesis and clinical profile of neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease. - Covers basic science and clinical disorders - Includes homeostatic aspects of sleep regulation - Discusses effects of sleep and sleep deprivation on cognition and behavior - Provides quantitative models of sleep-wake dynamics - Reviews epidemiology, clinical picture, and treatment of disorders - Identifies pharmacological and nonpharmacological treatments of insomnia - Explores sleep disorders accompanying Parkinson's, Alzheimer's and other disorders |
| df swaab: Migraine Management Jerry W. Swanson, Manjit Matharu, 2024-02-01 Migraine Management, Volume 196 covers the effective treatment of migraines, including different subtypes of migraines in different patient populations. The classification and diagnostic criteria of common and uncommon subtypes of migraine is explored in detail, including childhood variants. An in-depth analysis of the pharmacology of acute and prophylactic agents is presented, along with an evidence-based review of pharmacologic management. This includes recently developed CGRP monoclonal antibodies and non-peptide small molecule CGRP antagonists. Advances in neuromodulatory treatments, both noninvasive and implantable, are also critically reviewed. Finally, specific treatment-related issues in pregnancy and lactation and childhood as well as the elderly are covered. Issues related to the diagnosis and management of vestibular migraine and the co-morbid disorder of persistent postural-perceptual dizziness is also explored. - Summarizes evidence-based best treatment for migraines - Differentiates treatment based on patient population, migraine type, and clinical setting - Includes pharmacological, biobehavioral, and physical treatments - Provides specialized treatments for children, the elderly, and pregnant patients |
| df swaab: Biochemical Basis of Functional Neuroteratology , 1988-07-01 Biochemical Basis of Functional Neuroteratology |
| df swaab: Neurobiology of Psychiatric Disorders Thomas E Schlaepfer, Charles B. Nemeroff, 2012-07-09 This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, brain diseases, this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A must have reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain |
| df swaab: Functional Neurobiology of Aging Patrick R. Hof, Charles V. Mobbs, 2001-01-11 Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. - Organized by function, making it easy to find and understand the material - Addresses impairments both associated with diseases and not associated with diseases - Written by leading researchers in the field - Most comprehensive source of information on the neurobiology of aging |
How do I select rows from a DataFrame based on column values?
df[df["cost"].eq(250)] cost revenue A 250 100 Compare DataFrames for greater than inequality or equality elementwise. df[df["cost"].ge(100)] cost revenue A 250 100 B 150 250 C 100 300 …
How can I iterate over rows in a Pandas DataFrame?
Mar 19, 2019 · df_original["A_i_minus_2"] = df_original["A"].shift(2) # val at index i-2 df_original["A_i_minus_1"] = df_original["A"].shift(1) # val at index i-1 df_original["A_i_plus_1"] …
How do I get the row count of a Pandas DataFrame?
Apr 11, 2013 · Of the three methods above, len(df.index) (as mentioned in other answers) is the fastest. Note. All the methods above are constant time operations as they are simple attribute …
Selecting multiple columns in a Pandas dataframe
newdf = df[df.columns[2:4]] # Remember, Python is zero-offset! The "third" entry is at slot two. As EMS points out in his answer, df.ix slices columns a bit more concisely, but the .columns …
disk usage - Differences between df, df -h, and df -l - Ask Ubuntu
df -h tells df to display sizes in Gigabyte, Megabyte, or Kilobyte as appropriate, akin to the way a human would describe sizes. Actually, the h stands for "human-readable". df -l tells df to …
Creating an empty Pandas DataFrame, and then filling it
df = pd.DataFrame(columns=['A', 'B', 'C'], index=range(5)) df A B C 0 NaN NaN NaN 1 NaN NaN NaN 2 NaN NaN NaN 3 NaN NaN NaN 4 NaN NaN NaN It creates a DataFrame of object …
Difference between df [df ['col a']] and df ['col a']? - Stack Overflow
Jun 10, 2022 · So we use df[df['col a']== x] instead of just df['col a'] == x because to optimize the dataframe itself you are escencially telling the data frame with df['col a'] == x that you want a …
python - How do I combine two dataframes? - Stack Overflow
Mar 19, 2019 · frames = [df_A, df_B] # Or perform operations on the DFs result = pd.concat(frames) This is pointed out in the pandas docs under concatenating objects at the …
Difference between df[x], df[[x]], df['x'] , df[['x']] and df.x
May 12, 2018 · df.x — dot accessor notation, equivalent to df['x'] (there are, however, limitations on what x can be named if dot notation is to be successfully used). Returns pd.Series With …
PySpark DataFrame Column Reference: df.col vs. df ['col'] vs. F.col ...
Mar 11, 2019 · >>> df.2col File "", line 1 df.2col ^ SyntaxError: invalid syntax Under the hood, it checks to see if the column name is contained in df.columns …
How do I select rows from a DataFrame based on column values?
df[df["cost"].eq(250)] cost revenue A 250 100 Compare DataFrames for greater than inequality or equality elementwise. df[df["cost"].ge(100)] cost revenue A 250 100 B 150 250 C 100 300 …
How can I iterate over rows in a Pandas DataFrame?
Mar 19, 2019 · df_original["A_i_minus_2"] = df_original["A"].shift(2) # val at index i-2 df_original["A_i_minus_1"] = df_original["A"].shift(1) # val at index i-1 df_original["A_i_plus_1"] …
How do I get the row count of a Pandas DataFrame?
Apr 11, 2013 · Of the three methods above, len(df.index) (as mentioned in other answers) is the fastest. Note. All the methods above are constant time operations as they are simple attribute …
Selecting multiple columns in a Pandas dataframe
newdf = df[df.columns[2:4]] # Remember, Python is zero-offset! The "third" entry is at slot two. As EMS points out in his answer, df.ix slices columns a bit more concisely, but the .columns …
disk usage - Differences between df, df -h, and df -l - Ask Ubuntu
df -h tells df to display sizes in Gigabyte, Megabyte, or Kilobyte as appropriate, akin to the way a human would describe sizes. Actually, the h stands for "human-readable". df -l tells df to …
Creating an empty Pandas DataFrame, and then filling it
df = pd.DataFrame(columns=['A', 'B', 'C'], index=range(5)) df A B C 0 NaN NaN NaN 1 NaN NaN NaN 2 NaN NaN NaN 3 NaN NaN NaN 4 NaN NaN NaN It creates a DataFrame of object …
Difference between df [df ['col a']] and df ['col a']? - Stack Overflow
Jun 10, 2022 · So we use df[df['col a']== x] instead of just df['col a'] == x because to optimize the dataframe itself you are escencially telling the data frame with df['col a'] == x that you want a …
python - How do I combine two dataframes? - Stack Overflow
Mar 19, 2019 · frames = [df_A, df_B] # Or perform operations on the DFs result = pd.concat(frames) This is pointed out in the pandas docs under concatenating objects at the …
Difference between df[x], df[[x]], df['x'] , df[['x']] and df.x
May 12, 2018 · df.x — dot accessor notation, equivalent to df['x'] (there are, however, limitations on what x can be named if dot notation is to be successfully used). Returns pd.Series With …
PySpark DataFrame Column Reference: df.col vs. df ['col'] vs. F.col ...
Mar 11, 2019 · >>> df.2col File "", line 1 df.2col ^ SyntaxError: invalid syntax Under the hood, it checks to see if the column name is contained in df.columns …
