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| downstream processing in industrial microbiology: UPSTREAM AND DOWNSTREAM PROCESSING OF BIOPRODUCTS R. Puvanakrishnan, S. Sivasubramanian, T. Hemalatha, 2019-06-20 Microorganisms have been exploited for many centuries for the production of fermented foods and beverages and for bread-making. The production of alcoholic beverages using microbes was the first major industrialized process. The technology developed for large-scale brewing was adapted for other anaerobic processes such as acetone and butanol in the early 1900s. With the discovery of penicillins, rapid developments were made in the technology of submerged culture fermentation of aerobic microorganisms under controlled conditions. The advancements in microbiology and process biochemistry improved our ability to harness the potential of microorganisms through improved bioprocessing methods to manufacture new products with economic viability. Microbial derived bioproducts have been gaining importance in the food, pharmaceutical, textile, leather, cosmetic and chemical industries, and most important among them are therapeutic proteins and peptides, enzymes, antigens, vaccines, antibiotics, drugs, etc.Not all microbial production processes involve culture of the organism in liquid medium. Instead, the organism can be grown on the surface of a solid substrate. Solid substrate (or solid state) fermentation (SSF) is an established traditional technology in many countries, producing edible mushrooms, fungal- fermented foods and soy sauce. Before the development of processes in liquid culture, citric acid and some microbial enzymes were produced by SSF. Carbon composting is also a form of SSF. |
| downstream processing in industrial microbiology: Downstream Industrial Biotechnology Michael C. Flickinger, 2013-07-17 DOWNSTREAM INDUSTRIAL BIOTECHNOLOGY An affordable, easily accessible desk reference on biomanufacturing, focused on downstream recovery and purification Advances in the fundamental knowledge surrounding biotechnology, novel materials, and advanced engineering approaches continue to be translated into bioprocesses that bring new products to market at a significantly faster pace than most other industries. Industrial scale biotechnology and new manufacturing methods are revolutionizing medicine, environmental monitoring and remediation, consumer products, food production, agriculture, and forestry, and continue to be a major area of research. The downstream stage in industrial biotechnology refers to recovery, isolation, and purification of the microbial products from cell debris, processing medium and contaminating biomolecules from the upstream process into a finished product such as biopharmaceuticals and vaccines. Downstream process design has the greatest impact on overall biomanufacturing cost because not only does the biochemistry of different products ( e.g., peptides, proteins, hormones, antibiotics, and complex antigens) dictate different methods for the isolation and purification of these products, but contaminating byproducts can also reduce overall process yield, and may have serious consequences on clinical safety and efficacy. Therefore downstream separation scientists and engineers are continually seeking to eliminate, or combine, unit operations to minimize the number of process steps in order to maximize product recovery at a specified concentration and purity. Based on Wiley’s Encyclopedia of Industrial Biotechnology: Bioprocess, Bioseparation, and Cell Technology, this volume features fifty articles that provide information on down- stream recovery of cells and protein capture; process development and facility design; equipment; PAT in downstream processes; downstream cGMP operations; and regulatory compliance. It covers: Cell wall disruption and lysis Cell recovery by centrifugation and filtration Large-scale protein chromatography Scale down of biopharmaceutical purification operations Lipopolysaccharide removal Porous media in biotechnology Equipment used in industrial protein purification Affinity chromatography Antibody purification, monoclonal and polyclonal Protein aggregation, precipitation and crystallization Freeze-drying of biopharmaceuticals Biopharmaceutical facility design and validation Pharmaceutical bioburden testing Regulatory requirements Ideal for graduate and advanced undergraduate courses on biomanufacturing, biochemical engineering, biopharmaceutical facility design, biochemistry, industrial microbiology, gene expression technology, and cell culture technology, Downstream Industrial Biotechnology is also a highly recommended resource for industry professionals and libraries. |
| downstream processing in industrial microbiology: Industrial Microbiology Michael J. Waites, Neil L. Morgan, John S. Rockey, Gary Higton, 2013-05-22 Of major economic, environmental and social importance, industrialmicrobiology involves the utilization of microorganisms in theproduction of a wide range of products, including enzymes, foods,beverages, chemical feedstocks, fuels and pharmaceuticals, andclean technologies employed for waste treatment and pollutioncontrol. Aimed at undergraduates studying the applied aspects of biology,particularly those on biotechnology and microbiology courses andstudents of food science and biochemical engineering, this textprovides a wide-ranging introduction to the field of industrialmicrobiology. The content is divided into three sections: key aspects of microbial physiology, exploring the versatilityof microorganisms, their diverse metabolic activities andproducts industrial microorganisms and the technology required forlarge-scale cultivation and isolation of fermentationproducts investigation of a wide range of established and novelindustrial fermentation processes and products Written by experienced lecturers with industrial backgrounds,Industrial Microbiology provides the reader with groundwork in boththe fundamental principles of microbial biology and the varioustraditional and novel applications of microorganisms to industrialprocesses, many of which have been made possible or enhanced byrecent developments in genetic engineering technology. A wide-ranging introduction to the field of industrialmicrobiology Based on years of teaching experience by experienced lecturerswith industrial backgrounds Explains the underlying microbiology as well as the industrialapplication. Content is divided into three sections: 1. key aspects of microbial physiology, exploring theversatility of microorganisms, their diverse metabolic activitiesand products 2. industrial microorganisms and the technology required forlarge-scale cultivation and isolation of fermentation products 3. investigation of a wide range of established and novelindustrial fermentation processes and products |
| downstream processing in industrial microbiology: Industrial Microbiology David B. Wilson, Hermann Sahm, Klaus-Peter Stahmann, Mattheos Koffas, 2020-03-09 Focusing on current and future uses of microbes as production organisms, this practice-oriented textbook complements traditional texts on microbiology and biotechnology. The editors have brought together leading researchers and professionals from the entire field of industrial microbiology and together they adopt a modern approach to a well-known subject. Following a brief introduction to the technology of microbial processes, the twelve most important application areas for microbial technology are described, from crude bulk chemicals to such highly refined biomolecules as enzymes and antibodies, to the use of microbes in the leaching of minerals and for the treatment of municipal and industrial waste. In line with their application-oriented topic, the authors focus on the translation of basic research into industrial processes and cite numerous successful examples. The result is a first-hand account of the state of the industry and the future potential for microbes in industrial processes. Interested students of biotechnology, bioengineering, microbiology and related disciplines will find this a highly useful and much consulted companion, while instructors can use the case studies and examples to add value to their teaching. |
| downstream processing in industrial microbiology: Modern Industrial Microbiology and Biotechnology Nduka Okafor, 2016-03-09 This book is directed towards undergraduates and beginning graduate students in microbiology, food science and chemical engineering. Those studying pharmacy, biochemistry and general biology will find it of interest. The section on waste disposal will be of interest to civil engineering and public health students and practitioners. For the benefit of those students who may be unfamiliar with the basic biological assumptions underlying industrial microbiology, such as students of chemical and civil engineering, elements of biology and microbiology are introduced. The new elements which have necessitated the shift in paradigm in industrial microbiology such as bioinformatics, genomics, proteomics, site-directed mutation, metabolic engineering, the human genome project and others are also introduced and their relevance to industrial microbiology and biotechnology indicated. As many references as space will permit are included. The various applications of industrial microbiology are covered broadly, and the chapt |
| downstream processing in industrial microbiology: Manual of Industrial Microbiology and Biotechnology Richard H. Baltz, Arnold L. Demain, Julian E. Davies, 2010-03-25 A rich array of methods and discussions of productive microbial processes. • Reviews of the newest techniques, approaches, and options in the use of microorganisms and other cell culture systems for the manufacture of pharmaceuticals, industrial enzymes and proteins, foods and beverages, fuels and fine chemicals, and other products. • Focuses on the latest advances and findings on the current state of the art and science and features a new section on the microbial production of biofuels and fine chemicals, as well as a stronger emphasis on mammalian cell culture methods. • Covers new methods that enhance the capacity of microbes used for a wide range of purposes, from winemaking to pharmaceuticals to bioremediation, at volumes from micro- to industrial scale. |
| downstream processing in industrial microbiology: Industrial Microbiology and Biotechnology Pradeep Verma, 2023-07-08 The second volume of the Book-Industrial Microbiology and Biotechnology covers various emerging concepts in microbial technology which have been developed to harness the potential of the microbes. The book examines the microbes-based products that have widespread applications in various domains i.e., agriculture, biorefinery, bioremediation, pharmaceutical, and medical sectors. It focusses on recent advances and emerging topics such as CRISPR technology, advanced topics of genomics, including functional genomics, metagenomics, metabolomics, and structural and system biology approaches for enhanced production of industrially relevant products. It further gives an insight into the advancement of genetic engineering with special emphasis on value-added products via microalgal systems and their techno-economics analysis and life cycle assessment. The book towards the end presents recent advancements in the use of microbes for the production of industrial relevant enzymes, amino acids, vitamins, and nutraceuticals, on vaccine development and their biomedical applications. The book is an essential source for researchers working in allied fields of microbiology, biotechnology, and bioengineering. |
| downstream processing in industrial microbiology: Biochemical Engineering and Biotechnology Ghasem Najafpour, 2015-02-23 Biochemical Engineering and Biotechnology, Second Edition outlines the principles of biochemical processes and explains their use in the manufacturing of everyday products. The text covers the major concepts of biochemical engineering and biotechnology, and is an ideal reference for chemical engineering students who need to learn and apply biological knowledge in engineering principles. The author takes a direct, useful approach in presenting the concepts and practical applications, including many solved problems, case studies, examples, and demonstrations of detailed experiments, with simple design equations and required calculations also included. It is ideal for both those interested in more advanced research in the field of biotechnology, also acting as a guide for beginners seeking direction on establishing research in this field. Covers major concepts of biochemical engineering and biotechnology, including applications in bioprocesses, fermentation technologies, enzymatic processes, and membrane separations, amongst others Accessible to chemical engineering students who need to both learn, and apply, biological knowledge in engineering principals Includes solved problems, examples, and demonstrations of detailed experiments with simple design equations and all required calculations Offers many graphs that present actual experimental data, figures, and tables, along with explanations |
| downstream processing in industrial microbiology: Introduction to Biomanufacturing Northeast Biomanufacturing Center & Collaborative, 2012-11-03 Today is a time of unparalleled excitement in the world of biopharmaceuticals. This book is a compendium of a tremendous body of knowledge, distilled into its most essential parts. Not only are there theoretical and conceptual ideas about biopharmaceutical manufacturing, but also content specific to skills and abilities. It serves as a well-paced guide for beginning learners as well as a cogent reference for seasoned biotechnology professionals alike. This book will help a new generation of students to become inspired and familiarize themselves with the theories, principles, and vernacular of biopharmaceutical production and all that it entails. A quick overview of contents include; Operational Excellence, Facilities, Metrology, Validation, Environmental Health & Safety (EHS), Quality Assurance, Microbiological Control, Quality Control Biochemistry, Upstream Processing, Downstream Processing, Process Development, and a Master Glossary. |
| downstream processing in industrial microbiology: Principles of Fermentation Technology Peter F. Stanbury, Allan Whitaker, Stephen J Hall, 2013-10-22 This second edition has been thoroughly updated to include recent advances and developments in the field of fermentation technology, focusing on industrial applications. The book now covers new aspects such as recombinant DNA techniques in the improvement of industrial micro-organisms, as well as including comprehensive information on fermentation media, sterilization procedures, inocula, and fermenter design. Chapters on effluent treatment and fermentation economics are also incorporated. The text is supported by plenty of clear, informative diagrams.This book is of great interest to final year and post-graduate students of applied biology, biotechnology, microbiology, biochemical and chemical engineering. |
| downstream processing in industrial microbiology: Bioprocess Engineering Pau Loke Show, Chien Wei Ooi, Tau Chuan Ling, 2019-05-24 Bioprocess Engineering: Downstream Processing is the first book to present the principles of bioprocess engineering, focusing on downstream bioprocessing. It aims to provide the latest bioprocess technology and explain process analysis from an engineering point of view, using worked examples related to biological systems. This book introduces the commonly used technologies for downstream processing of biobased products. The covered topics include centrifugation, filtration, membrane separation, reverse osmosis, chromatography, biosorption, liquid-liquid separation, and drying. The basic principles and mechanism of separation are covered in each of the topics, wherein the engineering concept and design are emphasized. This book is aimed at bioprocess engineers and professionals who wish to perform downstream processing for their feedstock, as well as students. |
| downstream processing in industrial microbiology: Textbook of Industrial Microbiology Renu Agrawal, 2024-11-23 Textbook of Industrial Microbiology is a groundbreaking book encompassing the entire spectrum of industrial microbiology, filling a significant void in the field. From tracing its historical roots to exploring primary and secondary metabolites, down to downstream processing and product recovery, this book offers a cohesive narrative previously unavailable in a single resource. The meticulously structured chapters discuss the systematic journey of metabolites, covering the screening of microorganisms, preservation techniques, fermentation media, fermenters, and the significance of industrially vital secondary metabolites. It provides insights for industrialists, elucidating crucial process parameters essential for comprehending and optimizing microbial processes. This textbook serves as a great resource for undergraduate, and postgraduate students, researchers, industrialists, and technologists |
| downstream processing in industrial microbiology: Downstream Process Technology: A New Horizon In Biotechnology Krishna Kant Prasad, Nooralabettu Krishna Prasad, 2010-01-30 Today, biochemical process industry demands fast and economic processes for the partitioning and purification of biomolecules that give high yield and high purity of the product. An integral and cost intensive part of these processes is associated with downstream processing for product isolation and purification. The aim of this comprehensive text is to provide an insightful overview of the whole aspects of downstream processing for biochemical product recovery. Intended for undergraduate and postgraduate students of biotechnology and chemical engineering, this self-contained text includes the chapters based on the recent developments in the industry and academics. It covers the importance of the downstream processing in terms of its relevancy to modern days ever-changing consumer needs, process design criteria relevance to set objectives, and physicochemical factors that help to formulate the strategy to develop a configuration among the raw material, methodology and instruments. This overview is followed by different downstream processing steps. The text concludes with the discussion on stabilization of the product to improve the shelf life of the product. Key Features Includes detailed biological, mathematical, chemical and physical aspects of downstream processing. Distinguishes downstream processing from analytical bioseparation. Contains numerous illustrations and solved problems. |
| downstream processing in industrial microbiology: Industrial Microbiology and Fermentation Technology Mr. Rohit Manglik, 2024-03-04 EduGorilla Publication is a trusted name in the education sector, committed to empowering learners with high-quality study materials and resources. Specializing in competitive exams and academic support, EduGorilla provides comprehensive and well-structured content tailored to meet the needs of students across various streams and levels. |
| downstream processing in industrial microbiology: Biomass and Biofuels from Microalgae Navid R. Moheimani, Mark P. McHenry, Karne de Boer, Parisa A. Bahri, 2015-04-11 This comprehensive book details the most recent advances in the microalgae biological sciences and engineering technologies for biomass and biofuel production in order to meet the ongoing need for new and affordable sources of food, chemicals and energy for future generations. The chapters explore new microalgae cultivation techniques, including solid (biofilm) systems, and heterotrophic production methods, while also critically investigating topics such as combining wastewater as a source of nutrients, the effect of CO2 on growth, and converting biomass to methane through anaerobic digestion. The book highlights innovative bioproduct optimization and molecular genetic techniques, applications of genomics and metabolomics, and the genetic engineering of microalgae strains targeting biocrude production. The latest developments in microalgae harvesting and dewatering technologies, which combine biomass production with electricity generation, are presented, along with detailed techno-economic modeling. This extensive volume was written by respected experts in their fields and is intended for a wide audience of researchers and engineers. |
| downstream processing in industrial microbiology: Microbial Process Development Horst W Doelle, 1994-02-24 This book outlines the vast potential of the microbial catalyst for present and future microbial process development without waste formation, leading to a clean environment. It is intended to inspire scientists and biochemical engineers to isolate new microorganisms from nature and to explore the optimal potential of the genotype before altering its code through genetical engineering. This book is structured to encourage the reader to use basic scientific and biochemical engineering concepts for the development of new and improved fermentation technology industries. It leads the reader from aspects of isolation, identification and preservation of microbial strains to the use of thermodynamics and their biochemistry to the final endproducts and their purification. Special emphasis is given to the restoration of our present and the preservation of our future environment using socioecological and biotechnological concepts. Drawing on many years of experience teaching and working in the Asia-Pacific and Africa, the author presents an interesting, informative and enlightening account of his knowledge in this field. |
| downstream processing in industrial microbiology: Advances in Agricultural and Industrial Microbiology Suraja Kumar Nayak, Bighneswar Baliyarsingh, Ilaria Mannazzu, Ashutosh Singh, Bibhuti Bhusan Mishra, 2022-05-03 Diversity of microbial communities in soil and their multifaceted functionalities has paved the way for utilization of microbes in industries. This book comprises of soil microbial diversity and role of microbes in agro-industry. This volume is the compilation of the updated research from resource persons on impact of soil microbial diversity like increasing soil fertility, CO2 sequestration, and understanding soil microbial communities through cutting edge technology. Besides, the book embodies microbes renewed role in production of bioplastics, nutraceuticals, dairy products, drugs from macro-fungi, potential economic development from agrowaste or fish waste, and advance approaches in bioprospecting of biocatalyst and biosensing of secondary metabolites. This will not only improve knowledge but also enhance research on exploiting soil microbes in industry or agro-industry. The proposed book, Advances in Agricultural and Industrial Microbiology, Vol I can be very effective to bridge the gap between vastness of literatures available pertaining to agricultural and industrial microbiology and their applications with authoritative chapters containing latest updates available in this area of science. The content of the book is an exhaustive reference resource for soil microbiologist, agricultural scientists, academia, policymakers, industrial microbiologists pursuing teaching and research in these domains. |
| downstream processing in industrial microbiology: Industrial Biotechnology Wim Soetaert, Erick J. Vandamme, 2010-03-30 Describing all topics of white biotechnology admitted to the 7th EU Frame Programme and new industrial production processes aiming towards the Kyoto objectives, this comprehensive overview covers the technology, applications, economic potential and implications for society. Directed at readers with a general interest in a specific technology, this is equally suitable as an introductory handbook to a wide range of industries, including chemicals, biotechnology and pharmaceuticals, food and feed, paper and pulp, personal care, energy and agriculture. |
| downstream processing in industrial microbiology: Handbook of Downstream Processing E. Goldberg, 1997 The last two decades have witnessed a phenomenal growth in the field of genetic or biochemical engineering, and a variety of products has been developed and marketed through the manipulation and growth of different types of microorganisms and the recovery and purification of the associated products. |
| downstream processing in industrial microbiology: Bioprocess Engineering Kim Gail Clarke, 2013-10-31 Biotechnology is an expansive field incorporating expertise in both the life science and engineering disciplines. In biotechnology, the scientist is concerned with developing the most favourable biocatalysts, while the engineer is directed towards process performance, defining conditions and strategies that will maximize the production potential of the biocatalyst. Increasingly, the synergistic effect of the contributions of engineering and life sciences is recognised as key to the translation of new bioproducts from the laboratory bench to commercial bioprocess. Fundamental to the successful realization of the bioprocess is a need for process engineers and life scientists competent in evaluating biological systems from a cross-disciplinary viewpoint. Bioprocess engineering aims to generate core competencies through an understanding of the complementary biotechnology disciplines and their interdependence, and an appreciation of the challenges associated with the application of engineering principles in a life science context. Initial chapters focus on the microbiology, biochemistry and molecular biology that underpin biocatalyst potential for product accumulation. The following chapters develop kinetic and mass transfer principles that quantify optimum process performance and scale up. The text is wide in scope, relating to bioprocesses using bacterial, fungal and enzymic biocatalysts, batch, fed-batch and continuous strategies and free and immobilised configurations. - Details the application of chemical engineering principles for the development, design, operation and scale up of bioprocesses - Details the knowledge in microbiology, biochemistry and molecular biology relevant to bioprocess design, operation and scale up - Discusses the significance of these life sciences in defining optimum bioprocess performance |
| downstream processing in industrial microbiology: Industrial Biotechnology: An Introduction Jiby John Mathew, Sajeshkumar N. K., Prem Jose Vazhacharickal, 2018-05-29 A bioprocess is any process that uses complete living cells or their components to obtain desired products. Production of a commercially useful chemical or fuel by a biological process, such as microbial fermentation or degradation. This book is divided into four modules. Module 1 deals with Bioprocess and Chemical process, Introduction to Industrial Biotechnology (IBT) or Bioprocess technology (BPT), Microbial growth, nutrition and kinetics, Microbial metabolism and industrially important microbial metabolites, Fermentation: definition, types and applications, Isolation and screening of industrially important microorganisms and strain improvement. In module 2, Media classification and bacterial nutritional requirements, Defined vs undefined media, Fermentation broth, Designing fermentation media, Effect of pH, temperature and salt concentration in fermentation, Media optimization, Fermentation starter / starter culture and Media for identifying microorganisms. Module 3 explains about Fermentor / Bioreactor, Types of Fermenters / Bioreactors, Bioreactor control, Bioreactor instrumentation and sterilization, Mode of culturing microorganisms and Downstream processing (DSP). Module 4 deals with the scope of industrial microbiology, Immobilization of cells and Industrial use of enzymes. |
| downstream processing in industrial microbiology: Modern Industrial Microbiology and Biotechnology Nduka Okafor, Benedict C. Okeke, 2017-11-22 The field of industrial microbiology involves a thorough knowledge of the microbial physiology behind the processes in the large-scale, profit-oriented production of microbe-related goods which are the subject of the field. In recent times a paradigm shift has occurred, and a molecular understanding of the various processes by which plants, animals and microorganisms are manipulated is now central to industrial microbiology. Thus the various applications of industrial microbiology are covered broadly, with emphasis on the physiological and genomic principles behind these applications. Relevance of the new elements such as bioinformatics, genomics, proteomics, site-directed mutation and metabolic engineering, which have necessitated the paradigm shift in industrial microbiology are discussed. |
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| downstream processing in industrial microbiology: Manual of Industrial Microbiology and Biotechnology Arnold L. Demain, Julian E. Davies, Ronald M. Atlas, 1999 The editors have enlisted a broad range of experts, including microbial ecologists, physiologists, geneticists, biochemists, molecular biologists, and biochemical engineers, who offer practical experience not found in texts and journals. This comprehensive perspective makes MIMB a valuable how to resource, the structure of which resembles the sequence of operation involved in the development of a commercial biological process and product. |
| downstream processing in industrial microbiology: Food Biosynthesis Alexandru Mihai Grumezescu, Alina Maria Holban, 2017-06-19 Food Biosynthesis, Volume One in the Handbook of Food Bioengineering series, describes the main aspects related to the biological production of synthetic ingredients and natural foods, highlighting the impact of bacteria and plants in the biosynthesis of key food components. Biosynthesis methods could help solve issues like food shortages, providing consumers with preferred 'natural' food options. This book represents how biologically synthesized ingredients, such as vanilla flavoring, soy, milk and egg substitutes can be utilized as a desired option future foods. It is ideal for scientists and researchers who want to improve their knowledge on the field of food biosynthesis. - Presents practical approaches of biosynthesis and the impact of biological origin on the field of food engineering - Offers alternative applications to produce natural foods - Includes processes and techniques to produce health promoting foods - Discusses the positive effects of biosynthesis on microbial production to enhance food safety - Offers a variety of perspectives on biosynthesis and its benefits for food ingredient production |
| downstream processing in industrial microbiology: Industrial Biotechnology Mr. Rohit Manglik, 2024-07-07 EduGorilla Publication is a trusted name in the education sector, committed to empowering learners with high-quality study materials and resources. Specializing in competitive exams and academic support, EduGorilla provides comprehensive and well-structured content tailored to meet the needs of students across various streams and levels. |
| downstream processing in industrial microbiology: Encyclopedia of Microbiology , 2009-01-14 Available as an exclusive product with a limited print run, Encyclopedia of Microbiology, 3e, is a comprehensive survey of microbiology, edited by world-class researchers. Each article is written by an expert in that specific domain and includes a glossary, list of abbreviations, defining statement, introduction, further reading and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields. 16 separate areas of microbiology covered for breadth and depth of content Extensive use of figures, tables, and color illustrations and photographs Language is accessible for undergraduates, depth appropriate for scientists Links to original journal articles via Crossref 30% NEW articles and 4-color throughout – NEW! |
| downstream processing in industrial microbiology: The Basics of Agricultural Microbiology Nanda Kaniyar, 2025-01-03 The Basics of Agricultural Microbiology delves into one of the most crucial topics in agriculture and science. Understanding soil fertility and microbial interactions is essential for anyone connected to farming. This book provides detailed insights into agricultural microbiology, helping protect crops from harmful pests and diseases to boost productivity. We cover the development of microbiology, from foundational concepts to advanced topics, ensuring comprehensive knowledge. The book explores microbial activities, their role in agriculture, and detailed information about bacteria and pathogens. Written in simple and reader-friendly language, this book is a complete package of knowledge in microbiology and biotechnology. It serves as an invaluable guide for anyone looking to deepen their understanding of agriculture and its microbial aspects. |
| downstream processing in industrial microbiology: Textbook of Microbiology Naveen Kango, 2013-12-30 Textbook of Microbiology provides a structured approach to learning by covering all the important topics in a simple, uniform and systematic format. The book is written in a manner suited to the undergraduate and postgraduate of Microbiology / Industrial Microbiology courses. The language and diagrams are particularly easy to understand and reproduce while answering essay type questions. Sections I of the book covers essentials of Microbiology including history, scope and milestones in the development of microbiology. This is followed by detailed accounts of characteristics and classification of microorganisms including bacteria, virus, fungi and actinomycetes. Individual chapters on microscopy, isolation and maintenance of microorganisms, microbial growth provide a detailed account of these techniques and their use in microbiology. Section II of the book covers biochemistry, microbial genetics and some instrumentation including chapters on carbohydrates, proteins, lipids, nucleic acids, gene regulation, translation and transcription along with detailed accounts of spectrophotometry, pH meter and fermenters. It broadly covers: Fundamentals of Microbiology Tools and Techniques used in Microbiology Basic Biochemistry Microbial genetics |
| downstream processing in industrial microbiology: Biosafety in Industrial Biotechnology P. Hambleton, T. Salusbury, 1994-09-30 As an industry, biotechnology may be likened to the Hymn Book, being both ancient and modern. Whereas activities such as baking, brewing, the fermenting of foods date from our earliest attempts to control and utilise the environment, the application of recombinant DNA technology is recognised as being at the forefront of novel industrial development. Perhaps because of its association with processing foodstuffs together with the benefits derived from applications in the early organic chemistry and pharmaceutical industries, biotechnology has been regarded as being inherently safe. Yet unlike other modern industries, such as chemical and nuclear, where regulation has followed from incidents or accidents, modern biotechnology has been subject to close scrutiny and regulation almost from its inception. The process of regulation itself is somewhat unusual in that it was initially self-imposed by the very scientists who developed the fundamental techniques of recombinant DNA technology. They recognised the signific ance of their development but were concerned of the effects on humans and the environment of uncontrolled application of the new, powerful technology. Concern about the possible consequences of genetic manipula tion has undoubtedly been the driving force behind the regulations that are now in place in many parts of the world and which are the subject of this book. Safety issues in the biotechnology industry can be categorised under three headings: worker, environmental and consumer (product) safety. |
| downstream processing in industrial microbiology: Industrial Biotechnology Christoph Wittmann, James C. Liao, 2017-03-06 The latest volume in the Advanced Biotechnology series provides an overview of the main product classes and platform chemicals produced by biotechnological processes today, with applications in the food, healthcare and fine chemical industries. Alongside the production of drugs and flavors as well as amino acids, bio-based monomers and polymers and biofuels, basic insights are also given as to the biotechnological processes yielding such products and how large-scale production may be enabled and improved. Of interest to biotechnologists, bio and chemical engineers, as well as those working in the biotechnological, chemical, and food industries. |
| downstream processing in industrial microbiology: Microbial Biopolyester Production, Performance and Processing Microbiology, Feedstocks, and Metabolism Martin Koller, 2016-09-30 Global plastic production is estimated to be over 300Mt annually. Most conventional plastics are predominantly produced from fossil fuels and are highly resistant to biodegradation, and only a small share of about 20% of spent plastics is believed to be recycled, which is a cause for environmental concern. Biodegradable plastics would solve this concern as they are a sustainable alternative, yet these do not even cover 5% of the global plastic market. Microbial polyhydroxyalkanoates (PHAs) are a versatile group of polyesters produced by nature as prokaryotic storage materials. PHAs can be produced through sustainable bioprocess engineering and have displayed remarkable flexibility in their physical and chemical properties. PHAs are the subject of several scientific papers and numerous PHA patents have also been filed, generating significant interest in the plastic production industry. To develop overall sustainable and efficient production processes, all bioprocess steps need to be thoroughly understood and accounted for. These processes start with the selection of suitable inexpensive raw materials (microbes and enzymes), optimizing the process engineering and process regime, and conclude with the enhancement of product recovery in terms of time, energy, and material input. Microbial Biopolyester Production, Performance and Processing: Microbiology, Feedstocks, and Metabolism encompasses eight chapters that cover aspects of the microbiology and biotechnology of producing biodegradable plastics. The contents focus on the selection of powerful archaeal and eubacterial production strains, genetic engineering as a tool for optimized PHA production and inexpensive carbon sources for microbial cultures. The volume is a useful resource for bioprocess engineers, microbiologists, biotechnologists and chemical engineers interested in the basics of biodegradable plastic production. Recent Advances in Biotechnology is a book series comprising of peer-reviewed reference works and monographs that compile the latest developments in the field of biotechnology. Each volume has a thematic focus and features topical reviews written by experts. The series will highlight multidisciplinary perspectives to interested readers (biotechnologists, microbiologists, bioprocess engineers, agronomists, medical professionals, sustainability researchers etc.) |
| downstream processing in industrial microbiology: Formula Mastery in Microbiology: A Handbook for Speedy Analysis N.B. Singh, Formula Mastery in Microbiology: A Handbook for Speedy Analysis is an essential guide designed to streamline the understanding of key formulas in microbiology. Geared towards students, researchers, and professionals in the field, this handbook provides a quick and efficient reference for essential equations, facilitating swift analysis and interpretation of microbiological data. Covering a spectrum of microbial processes, the book enhances mastery of formulas related to microbial growth, genetics, and other crucial aspects. With clarity and conciseness, it serves as an invaluable resource for those seeking proficiency in applying formulas to expedite analysis in the dynamic realm of microbiology. |
| downstream processing in industrial microbiology: Fundamental Of Microbiology Jharna Gautam, 2023-11-09 The book “Fundamentals of Microbiology” explains germs’ fundamental principles in the vast web of life. Through intellectual study, the book shows the ubiquitous existence and basic functioning of bacteria, viruses, fungi, and other small creatures. Ecological equilibrium and biogeochemical cycles depend on microorganisms. They also form symbiotic relationships with larger creatures, helping us understand nature. The study explores microorganism composition and function. The cellular structures of bacteria, archaea, fungi, and protozoa have been discovered, revealing their molecular mechanisms. Microbial metabolism, development, and reproduction are essential to understanding their dynamic nature. The book takes one on a fascinating journey through the world of bacteria genetics and variety while turn the pages. From how genetic information is passed on to how evolutionary forces shape microbial diversity, readers learn about the processes that allow microbes to evolve and adapt. The beautiful simplicity of bacterial genetics is very different from the complex exchange of genes in human microorganisms. This makes the genetic roots of microbes even more interesting. “Fundamentals of Microbiology” is a fascinating look into the study of microbes that is perfect for students, teachers, and microbiology fans. With its mix of interesting stories, pictures, and tasks that make you think, the book is a great way to go on a trip of discovery in this fast-paced and always-changing field of science. |
| downstream processing in industrial microbiology: Protein Hydrolysates in Biotechnology Vijai K. Pasupuleti, Arnold L. Demain, 2010-08-28 Protein hydrolysates, otherwise commonly known as peptones or peptides, are used in a wide variety of products in fermentation and biotechnology industries. The term “peptone” was first introduced in 1880 by Nagelli for growing bacterial cultures. However, later it was discovered that peptones derived from the partial digestion of proteins would furnish organic nitrogen in readily available form. Ever since, p- tones, which are commonly known as protein hydrolysates, have been used not only for growth of microbial cultures, but also as nitrogen source in commercial fermen- tions using animal cells and recombinant microorganisms for the production of value added products such as therapeutic proteins, hormones, vaccines, etc. Today, the characterization, screening and manufacturing of protein hyd- lysates has become more sophisticated, with the introduction of reliable analytical instrumentation, high throughput screening techniques coupled with statistical design approaches, novel enzymes and efficient downstream processing equipment. This has enabled the introduction of custom-built products for specialized appli- tions in diverse fields of fermentation and biotechnology, such as the following. 1. Protein hydrolysates are used as much more than a simple nitrogen source. For example, the productivities of several therapeutic drugs made by animal cells and recombinant microorganisms have been markedly increased by use of p- tein hydrolysates. This is extremely important when capacities are limited. 2. Protein hydrolysates are employed in the manufacturing of vaccines by ferm- tation processes and also used as vaccine stabilizers. |
| downstream processing in industrial microbiology: Process Industries 1 Jean-Pierre Dal Pont, Marie Debacq, 2020-11-03 Of crucial economic and societal importance, process industries transform matter by chemical, physical or biological means. They cover broad fields such as chemistry, oil, pharmacy, metallurgy and agri-food, to name a few. As a result of knowledge exchange between the academic and industrial worlds, Process Industries 1 decrypts the operations and technical management of these industries in order to formulate and manufacture products with use-value, in a sustainable way. Using concrete examples, this book presents the fundamentals for defining the reaction and purification conditions that form the basis of chemical engineering. The unit operations – the technological building blocks of the production units – are the subject of scientific and technical descriptions supplemented by numerous videos. Frameworks, written by well-known specialists, provide a deep understanding of topics related to these themes. Process Industries 1 is intended for students, teachers, professionals and decision-makers interested in learning more about these industries. |
| downstream processing in industrial microbiology: Encyclopedia of Microbiology, Four-Volume Set Martin Alexander, Barry R. Bloom, David A. Hopwood, Roger Hull, Barbara H. Iglewski, Allen I. Laskin, Stephen G. Oliver, Moselio Schaechter, William C. Summers, 2000-02-10 The First Edition of the Encyclopedia of Microbiology was hailed by leading scientists and researchers around the world as excellent, outstanding, and impressive. This Second Edition will serve as an up-to-date version of this reference which has been useful to academic, industrial, and personal libraries for years. The Encyclopedia of Microbiology, Second Edition both challenges and stimulates the reader, and illustrates the importance of microbiology, a field that cannot be over emphasized in this booming biotechnology age. Key Features* Completely redesigned and revised approach with 65% new material* Contains approximately 300 articles, 1000 illustrations, and 400 tables* New design includes thematic table of contents, combined glossary of terms, and appendix* Provides color plate sections in each volume* 17 subject areas, including exciting coverage of microbes in extreme environments and microbes in emerging infections |
| downstream processing in industrial microbiology: Industrial Biotechnology of Vitamins, Biopigments, and Antioxidants Erick J. Vandamme, José Luis Revuelta, 2016-07-26 Vitamins are a group of physiologically very important, chemically quite complex organic compounds, that are essential for humans and animals. Some vitamins and other growth factors behave as antioxidants, while some can be considered as biopigments. As their chemical synthesis is laborious, their biotechnology-based synthesis and production via microbial fermentation has gained substantial interest within the last decades. Recent progress in microbial genetics and in metabolic engineering and implementation of innovative bioprocess technology has led to a biotechnology-based industrial production of many vitamins and related compounds. Divided into three sections, this volume covers: 1. water-soluble vitamins 2. fat-soluble vitamin compounds and 3. other growth factors, biopigments, and antioxidants. They are all reviewed systematically: from natural occurrence and assays, via biosynthesis, strain development, to industrially-employed biotechnological syntheses and applications. |
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Downstream - definition of downstream by The Free Dictionary
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