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| david p clark molecular biology: Molecular Biology David P. Clark, 2005-06-24 Molecular Biology: Academic Cell Update provides an introduction to the fundamental concepts of molecular biology and its applications. It deliberately covers a broad range of topics to show that molecular biology is applicable to human medicine and health, as well as veterinary medicine, evolution, agriculture, and other areas. The present Update includes the study guide with online content, journal specific images, and test bank. It also offers vocabulary flashcards and online self-quizzing called Test Prep. The book begins by defining some basic concepts in genetics such as biochemical pathways, phenotypes and genotypes, chromosomes, and alleles. It explains the characteristics of cells and organisms, DNA, RNA, and proteins. It also describes genetic processes such as transcription, recombination and repair, regulation, and mutations. The chapters on viruses and bacteria discuss their life cycle, diversity, reproduction, and gene transfer. Later chapters cover topics such as molecular evolution; the isolation, purification, detection, and hybridization of DNA; basic molecular cloning techniques; proteomics; and processes such as the polymerase chain reaction, DNA sequencing, and gene expression screening. *Now with an online study guide with the most current, relevant research from Cell Press *Full supplements including test bank, powerpoint and online self quizzing *Up to date description of genetic engineering, genomics, and related areas * Basic concepts followed by more detailed, specific applications * Hundreds of color illustrations enhance key topics and concepts * Covers medical, agricultural, and social aspects of molecular biology * Organized pedagogy includes running glossaries and keynotes (mini-summaries) to hasten comprehension |
| david p clark molecular biology: Molecular Biology David P. Clark, Nanette J. Pazdernik, 2012-02-13 Viruses 18. |
| david p clark molecular biology: Molecular Biology David P. Clark, 2009-10-21 Molecular Biology: Academic Cell Update provides an introduction to the fundamental concepts of molecular biology and its applications. It deliberately covers a broad range of topics to show that molecular biology is applicable to human medicine and health, as well as veterinary medicine, evolution, agriculture, and other areas. The present Update includes journal specific images and test bank. It also offers vocabulary flashcards. The book begins by defining some basic concepts in genetics such as biochemical pathways, phenotypes and genotypes, chromosomes, and alleles. It explains the characteristics of cells and organisms, DNA, RNA, and proteins. It also describes genetic processes such as transcription, recombination and repair, regulation, and mutations. The chapters on viruses and bacteria discuss their life cycle, diversity, reproduction, and gene transfer. Later chapters cover topics such as molecular evolution; the isolation, purification, detection, and hybridization of DNA; basic molecular cloning techniques; proteomics; and processes such as the polymerase chain reaction, DNA sequencing, and gene expression screening. - Up to date description of genetic engineering, genomics, and related areas - Basic concepts followed by more detailed, specific applications - Hundreds of color illustrations enhance key topics and concepts - Covers medical, agricultural, and social aspects of molecular biology - Organized pedagogy includes running glossaries and keynotes (mini-summaries) to hasten comprehension |
| david p clark molecular biology: Biotechnology David P. Clark, Nanette J. Pazdernik, 2009 Unlike most textbooks on this subject, Biotechnology approaches modern biotechnology from a molecular basis. Using straightforward, less technical jargon, Clark and Pazdernik introduce students to the topics and walk them through the process as it evolves into a more specific detailed principle. This up-to-date text covers a wide realm of topics that are encountered in current media and movies. One of the chapters covers the burgeoning field of nanobiotechnology, stimulating the student to think about biotechnology from a new and much smaller point of view. Another chapter explains the real biotechnology behind crime scene investigations portrayed so dramatically on the hit show CSI. In addition, students will learn about the biotechnology behind making vaccines, genetically-modified plants, stem-cell research, gene therapy, and aging, among many other topics that are part of mainstream media coverage. Students will also learn the molecular basis for many viral diseases, cancer, and bacterial diseases that are bound to affect them or other family members. Finally, the text includes a very thought-provoking chapter on the bioethics of these new advances and applications of today's world of biotechnology, which stimulates the student to think rather than memorize.--BOOK JACKET. |
| david p clark molecular biology: Germs, Genes, & Civilization David Clark, 2010-01-08 In Germs, Genes and Civilization, Dr. David Clark tells the story of the microbe-driven epidemics that have repeatedly molded our human destinies. You'll discover how your genes have been shaped through millennia spent battling against infectious diseases. You'll learn how epidemics have transformed human history, over and over again, from ancient Egypt to Mexico, the Romans to Attila the Hun. You'll learn how the Black Death epidemic ended the Middle Ages, making possible the Renaissance, western democracy, and the scientific revolution. Clark demonstrates how epidemics have repeatedly shaped not just our health and genetics, but also our history, culture, and politics. You'll even learn how they may influence religion and ethics, including the ways they may help trigger cultural cycles of puritanism and promiscuity. Perhaps most fascinating of all, Clark reveals the latest scientific and philosophical insights into the interplay between microbes, humans, and society - and previews what just might come next. |
| david p clark molecular biology: Biotechnology B.N. Pandey, 2008 |
| david p clark molecular biology: Medical Cell Biology Steven R. Goodman, 2007-11-26 Medical Cell Biology, Third Edition, focuses on the scientific aspects of cell biology important to medical students, dental students, veterinary students, and prehealth undergraduates. With its National Board-type questions, this book is specifically designed to prepare students for this exam. The book maintains a concise focus on eukaryotic cell biology as it relates to human and animal disease, all within a manageable 300-page format. This is accomplished by explaining general cell biology principles in the context of organ systems and disease. This updated version contains 60% new material and all new clinical cases. New topics include apoptosis and cell death from a neural perspective; signal transduction as it relates to normal and abnormal heart function; and cell cycle and cell division related to cancer biology. - 60% New Material! - New Topics include: - Apoptosis and cell dealth from a neural perspective - Signal transduction as it relates to normal and abnormal heart function - Cell cycle and cell division related to cancer biology - All new clinical cases - Serves as a prep guide to the National Medical Board Exam with sample board-style questions (using Exam Master(R) technology): www.exammaster.com - Focuses on eukaryotic cell biology as it related to human disease, thus making the subject more accessible to pre-med and pre-health students |
| david p clark molecular biology: Molecular Biology Techniques Heather B. Miller, D. Scott Witherow, Sue Carson, 2011-10-18 This manual is an indispensable tool for introducing advanced undergraduates and beginning graduate students to the techniques of recombinant DNA technology, or gene cloning and expression. The techniques used in basic research and biotechnology laboratories are covered in detail. Students gain hands-on experience from start to finish in subcloning a gene into an expression vector, through purification of the recombinant protein. The third edition has been completely re-written, with new laboratory exercises and all new illustrations and text, designed for a typical 15-week semester, rather than a 4-week intensive course. The project approach to experiments was maintained: students still follow a cloning project through to completion, culminating in the purification of recombinant protein. It takes advantage of the enhanced green fluorescent protein - students can actually visualize positive clones following IPTG induction. - Cover basic concepts and techniques used in molecular biology research labs - Student-tested labs proven successful in a real classroom laboratories - Exercises simulate a cloning project that would be performed in a real research lab - Project approach to experiments gives students an overview of the entire process - Prep-list appendix contains necessary recipes and catalog numbers, providing staff with detailed instructions |
| david p clark molecular biology: Molecular Biology David P. Clark, 2009-12-11 Now available with the most current and relevant research from Cell Press, Clark's Molecular Biology, Academic Cell Update Edition, gives readers both the concepts and the applications students need to know to fully grasp Molecular Biology. Clark introduces basic concepts and then follows with specific applications in research today. This book is further enhanced by its inclusion in the Academic Cell collaboration, providing it with links to current and recently published research. Molecular Biology draws in the applications from a number of fields including human cellular research, human medicine, agriculture research and veterinary medicine. *Now with an online study guide with the most current, relevant research from Cell Press *Full supplements including test bank, powerpoint and online self quizzing *Up to date description of genetic engineering, genomics, and related areas * Basic concepts followed by more detailed, specific applications * Hundreds of color illustrations enhance key topics and concepts * Covers medical, agricultural, and social aspects of molecular biology * Organized pedagogy includes running glossaries and keynotes (mini-summaries) to hasten comprehension |
| david p clark molecular biology: The Molecular and Cellular Biology of Wound Repair R.A.F. Clark, 2013-11-11 'Provides comprehensive detail on the various aspects of particular molecules involved in the phases of injury and repair and the cellular movements and processes....This is an excellent reference book for libraries serving biology and health science clientele and for workers in this field of research.' -American Scientist, from a review of the First Edition All chapters of this second edition have been completely revised and expanded-especially the chapters on growth factors and extracellular matrix molecules. New chapters discuss provisional matrix proteins, extracellular matrix receptors, and scarring versus nonscarring wound healing. |
| david p clark molecular biology: Molecular Biology Nancy Craig, Rachel Green, Orna Cohen-Fix, Carol Greider, Gisela Storz, Cynthia Wolberger, 2014-05 The biological world operates on a multitude of scales - from molecules to tissues to organisms to ecosystems. Throughout these myriad levels runs a common thread: the communication and onward passage of information, from cell to cell, from organism to organism and ultimately, from generation to generation. But how does this information come alive to govern the processes that constitute life? The answer lies in the molecular components that cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function, Second Edition, offers a fresh approach to the teaching of molecular biology by focusing on the commonalities that exist between the three kingdoms of life, and discussing the differences between the three kingdoms to offer instructive insights into molecular processes and components. This gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity. Additionally, an integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics As an experimental science, molecular biology requires an appreciation for the approaches taken to yield the information from which concepts and principles are deduced. Experimental Approach panels throughout the text describe research that has been particularly valuable in elucidating difference aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Molecular Biology further enriches the learning experience with full-color artwork, end-of-chapter questions and summaries, suggested further readings grouped by topic, and an extensive glossary of key terms. Features: A focus on the underlying principles of molecular biology equips students with a robust conceptual framework on which to build their knowledge An emphasis on their commonalities reflects the processes and components that exist between bacteria, archae, and eukaryotes Experimental Approach panels demonstrate the importance of experimental evidence by describing research that has been particularly valuable in the field |
| david p clark molecular biology: Long Non Coding RNA Biology M.R.S. Rao, 2017-08-16 This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms. |
| david p clark molecular biology: Thrive in Biochemistry and Molecular Biology Lynne Cox, David Harris, Catherine Pears, 2012-05-31 The Thrive in Bioscience revision guides are written to help undergraduate students achieve exam success in all core areas of bioscience. They communicate all the key concepts in a succinct, easy-to-digest way, using features and tools - both in the book and in digital form - to make learning even more effective. |
| david p clark molecular biology: Pattern Recognition in Computational Molecular Biology Mourad Elloumi, Costas Iliopoulos, Jason T. L. Wang, Albert Y. Zomaya, 2015-11-30 A comprehensive overview of high-performance pattern recognition techniques and approaches to Computational Molecular Biology This book surveys the developments of techniques and approaches on pattern recognition related to Computational Molecular Biology. Providing a broad coverage of the field, the authors cover fundamental and technical information on these techniques and approaches, as well as discussing their related problems. The text consists of twenty nine chapters, organized into seven parts: Pattern Recognition in Sequences, Pattern Recognition in Secondary Structures, Pattern Recognition in Tertiary Structures, Pattern Recognition in Quaternary Structures, Pattern Recognition in Microarrays, Pattern Recognition in Phylogenetic Trees, and Pattern Recognition in Biological Networks. Surveys the development of techniques and approaches on pattern recognition in biomolecular data Discusses pattern recognition in primary, secondary, tertiary and quaternary structures, as well as microarrays, phylogenetic trees and biological networks Includes case studies and examples to further illustrate the concepts discussed in the book Pattern Recognition in Computational Molecular Biology: Techniques and Approaches is a reference for practitioners and professional researches in Computer Science, Life Science, and Mathematics. This book also serves as a supplementary reading for graduate students and young researches interested in Computational Molecular Biology. |
| david p clark molecular biology: Molecular Modeling Hans-Dieter Höltje, Gerd Folkers, 2008-07-11 Written by experienced experts in molecular modeling, this books describes the basics to the extent that is necessary if one wants to be able to reliably judge the results from molecular modeling calculations. Its main objective is the description of the various pitfalls to be avoided. Without unnecessary overhead it leads the reader from simple calculations on small molecules to the modeling of proteins and other relevant biomolecules. A textbook for beginners as well as an invaluable reference for all those dealing with molecular modeling in their daily work! |
| david p clark molecular biology: Brock Biology of Microorganisms Michael T. Madigan, 2009 A text for introductory microbiology. It balances the most current coverage with the major classical and contemporary concepts essential for understanding microbiology. |
| david p clark molecular biology: Molecular Evolution Roderick D.M. Page, Edward C. Holmes, 2009-07-14 The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility. |
| david p clark molecular biology: Molecular Biology and Pathogenicity of Mycoplasmas Shmuel Razin, Richard Herrmann, 2007-05-08 was the result of the efforts of Robert Cleverdon. The rapidly developing discipline of molecular biology and the rapidly expanding knowledge of the PPLO were brought together at this meeting. In addition to the PPLO specialists, the conference invited Julius Marmur to compare PPLO DNA to DNA of other organisms; David Garfinkel, who was one of the first to develop computer models of metabolism; Cyrus Levinthal to talk about coding; and Henry Quastler to discuss information theory constraints on very small cells. The conference was an announcement of the role of PPLO in the fundamental understanding of molecular biology. Looking back 40-some years to the Connecticut meeting, it was a rather bold enterprise. The meeting was international and inter-disciplinary and began a series of important collaborations with influences resonating down to the present. If I may be allowed a personal remark, it was where I first met Shmuel Razin, who has been a leading figure in the emerging mycoplasma research and a good friend. This present volume is in some ways the fulfillment of the promise of that early meeting. It is an example of the collaborative work of scientists in building an understanding of fundamental aspects of biology. |
| david p clark molecular biology: Matrix Metalloproteinase Protocols Ian M. Clark, 2010-03-04 Since the discovery of a collagen-degrading protease in the tadpole tail in 1962, matrix metalloproteinase research has led to the discovery of more than twenty distinct vertebrate MMPs, along with a variety of homologues from diverse organisms such as the sea urchin, plants, insects, and nematode worms. Fully updating and adding to the popular first edition, Matrix Metalloproteinase Protocols, Second Edition includes a series of state-of-the-art techniques provided by eminent experts in the field. Beginning with a brief overview of the MMP arena, from how these enzymes fit into the larger degradome to what occurs when their expression and function in the mouse is modulated, the volume continues with sections on the expression and purification of MMPs and TIMPs, the detection of MMPs and TIMPs at both the protein and mRNA level, and our ability to assay MMP and TIMP activities in a wide variety of circumstances. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Matrix Metalloproteinase Protocols, Second Edition is an ideal source for many of the essential laboratory techniques for both novice and seasoned researchers alike collected in one convenient volume. |
| david p clark molecular biology: Basic Neurochemistry R. Wayne Albers, Donald L. Price, 2011-11-02 Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. - Completely updated text with new authors and material, and many entirely new chapters - Over 400 fully revised figures in splendid color - 61 chapters covering the range of cellular, molecular and medical neuroscience - Translational science boxes emphasizing the connections between basic and clinical neuroscience - Companion website at http://elsevierdirect.com/companions/9780123749475 |
| david p clark molecular biology: The Right Tools for the Job Adele E. Clarke, Joan H. Fujimura, 2014-07-14 This volume examines scientific practice through studies of research tools in an array of twentieth-century life sciences. The contributors draw upon and extend the multidisciplinary perspectives in current science studies to understand the processes through which scientific researchers constructed the right--and, in some cases, the wrong--tools for the job. The articles portray the crafting or accessing of specific materials, techniques, instruments, models, funds, and work arrangements involved in doing scientific work. They demonstrate the historical and local contingencies of scientific problem construction and solving by highlighting the articulation between the tools and jobs. Indeed, the very rightness of the tools is contingently constructed, maintained, lost, and refashioned. The cases examined include evolutionary biology laboratory systems (James R. Griesemer), the plasmid prep procedure in molecular biology (Kathleen Jordan and Michael Lynch), models in the human ecology of African pastoralists (Peter Taylor), the micromanometer in metabolic studies (Frederic L. Holmes), genetics research and the role played by Planaria (Gregg Mitman and Anne Fausto-Sterling) and by corn (Barbara A. Kimmelman), quantitative data in field biology (Yrj Haila), taxidermy in natural history (Susan Leigh Star), technical standardization in bacteriology (Patricia Peck Gossell), and the discipline of immunology as the tool for stabilizing conceptual definitions in the field (Peter Keating, Alberto Cambrosio, and Michael Mackenzie). Originally published in 1992. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. |
| david p clark molecular biology: The Processes of Life Lawrence E. Hunter, 2012-01-13 A brief and accessible introduction to molecular biology for students and professionals who want to understand this rapidly expanding field. Recent research in molecular biology has produced a remarkably detailed understanding of how living things operate. Becoming conversant with the intricacies of molecular biology and its extensive technical vocabulary can be a challenge, though, as introductory materials often seem more like a barrier than an invitation to the study of life. This text offers a concise and accessible introduction to molecular biology, requiring no previous background in science, aimed at students and professionals in fields ranging from engineering to journalism—anyone who wants to get a foothold in this rapidly expanding field. It will be particularly useful for computer scientists exploring computational biology. A reader who has mastered the information in The Processes of Life is ready to move on to more complex material in almost any area of contemporary biology. |
| david p clark molecular biology: Introduction to the Cellular and Molecular Biology of Cancer Margaret Knowles, Peter Selby, 2005-07-28 This title includes the following features: Great breadth of coverage inone volume: covers all aspects of cancer, in a concise and affordable format;Provides a comprehensive introduction to the initiation, development, andtreatment of cancer; Chapter are written by experts in each field, giving astate-of-the-art summary of each topic; Extensive references provide links toall the relevant literature, facilitating further study |
| david p clark molecular biology: Molecular Biology and Biotechnology of Plant Organelles Henry Daniell, Christine D. Chase, 2004 Plant organelles have intrigued biologists since the discovery of their endosymbiontic origin and maternal inheritance. The first application of organelle biotechnology was the role of cytoplasmic male sterility in hybrid seed production and Green Revolution. In modern times, plant organelles are again leading the way for the creation of genetically modified crops. On a global scale, 75% of GM crops are engineered for herbicide resistance and most of these herbicides target pathways that reside within plastids. Several thousand proteins are imported into chloroplasts that participate in biosynthesis of fatty acids, amino acids, pigments, nucleotides and numerous metabolic pathways including photosynthesis. Thus, from green revolution to golden rice, plant organelles have played a critical role in revolutionizing agriculture. This book details not only basic concepts and current understanding of plant organelle genetics and molecular biology but also focuses on the synergy between basic biology and biotechnology. Forty four authors from nine countries have contributed twenty four chapters containing many figures and tables. Section 1 on organelle genomes and proteomes discusses molecular features of plastid and mitochondrial genomes, evolutinary origins, somatic and sexual inheritance, proteomics, bioinformatics and functional genomics. Section 2 on organelle gene expression and signalling discusses transcription, translation, RNA processing/editing, introns and splicing, protein synthesis, proteolysis, import of proteins into chloroplast and mitochondria and their regulation. Section 3 on organelle biotechnology discusses chloroplast and nuclear genetic engineering for biotic/abiotic stress tolerance, improved fatty acid/amino acid biosynthesis, biopharmaceuticals, biopolymers and biomaterials, cytoplasmic male sterility for hybrid seed production, plant improvement and restoration of fertility. This book is designed to serve as a comprehensive volume and reference guide for teachers, advanced undergraduates and graduate students and researchers in plant molecular biology and biotechnology. |
| david p clark molecular biology: Molecular Biology in Cellular Pathology John Crocker, Paul G. Murray, 2003-09-12 The latest edition of this highly successful text, covers the major advances in the methods used in cellular and molecular pathology. In recent years, knowledge of the molecular organization of the cell has led to the development of powerful new techniques that bring greater accuracy and objectives to the diagnosis, prognosis and management of many diseases and to the study of pathological states. This book describes the latest molecular techniques available for the analysis of diseases. In particular it includes new techniques using fluorescent dyes, DNA microarrays, protein chemistry, and mass spectrometry. It also incorporates information from the Human Genome Project, and the new disciplines of genomics and proteomics, where relevant to pathology. Color plates are a new feature of this edition, illustrating the advances in fluorescence labeling of cells. |
| david p clark molecular biology: ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology Nicole Gallo-Payet, Antoine Martinez, André Lacroix, 2017-07-27 By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies. |
| david p clark molecular biology: Guide to Yeast Genetics and Molecular Biology Christine Guthrie, Gerald R. Fink, 1991-01-28 Guide to Yeast Genetics and Molecular Biology presents, for the first time, a comprehensive compilation of the protocols and procedures that have made Saccharomyces cerevisiae such a facile system for all researchers in molecular and cell biology. Whether you are an established yeast biologist or a newcomer to the field, this volume contains all the up-to-date methods you will need to study Your Favorite Gene in yeast. Basic Methods in Yeast Genetics**Physical and genetic mapping**Making and recovering mutants**Cloning and Recombinant DNA Methods**High-efficiency transformation**Preparation of yeast artificial chromosome vectors**Basic Methods of Cell Biology**Immunomicroscopy**Protein targeting assays**Biochemistry of Gene Expression**Vectors for regulated expression**Isolation of labeled and unlabeled DNA, RNA, and protein |
| david p clark molecular biology: Essential Cell Biology Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter, 2015-01-01 Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. The Fourth Edition has been thoroughly revised, and covers the latest developments in this fast-moving field, yet retains the academic level and length of the previous edition. The book is accompanied by a rich package of online student and instructor resources, including over 130 narrated movies, an expanded and updated Question Bank. Essential Cell Biology, Fourth Edition is additionally supported by the Garland Science Learning System. This homework platform is designed to evaluate and improve student performance and allows instructors to select assignments on specific topics and review the performance of the entire class, as well as individual students, via the instructor dashboard. Students receive immediate feedback on their mastery of the topics, and will be better prepared for lectures and classroom discussions. The user-friendly system provides a convenient way to engage students while assessing progress. Performance data can be used to tailor classroom discussion, activities, and lectures to address students’ needs precisely and efficiently. For more information and sample material, visit http://garlandscience.rocketmix.com/. |
| david p clark molecular biology: Biomedical Politics Institute of Medicine, Division of Health Sciences Policy, Committee to Study Decision Making, 1991-02-01 The abortifacient RU-486 was born in the laboratory, but its history has been shaped by legislators, corporate marketing executives, and protesters on both sides of the abortion debate. This volume explores how society decides what to do when discoveries such as RU-486 raise complex and emotional policy issues. Six case studies with insightful commentary offer a revealing look at the interplay of scientists, interest groups, the U.S. Congress, federal agencies, and the public in determining biomedical public policyâ€and suggest how decision making might become more reasoned and productive in the future. The studies are fascinating and highly readable accounts of the personal interactions behind the headlines. They cover dideoxyinosine (ddI), RU-486, Medicare coverage for victims of chronic kidney failure, the human genome project, fetal tissue transplantation, and the 1975 Asilomar conference on recombinant DNA. |
| david p clark molecular biology: Introduction to Biotechnology William J. Thieman, Michael Angelo Palladino, 2009 With its balanced coverage of basic molecular biology, historical developments and contemporary applications, this text provides students with the tools and basic knowledge for success in the biotech industry. This second edition features a rewritten chapter on ethics. |
| david p clark molecular biology: Molecular Biology And Biotechnology J M Walker, E B Gingold, 1999 |
| david p clark molecular biology: Molecular Biology 2nd Edition Craig/Green/Greider/Storz/Wolberger/Cohen Fix, 2016-05-12 |
| david p clark molecular biology: Biochemistry Trudy McKee, James Robert McKee, 2014 This book is for readers who do not specialize in biochemistry but who require a strong grasp of biochemical principles. The goal of this book is to enrich the coverage of chemistry while better highlighting the biological context. Once concepts and problem-solving skills have been mastered, readers are prepared to tackle the complexities of science, modern life, and their chosen professions. |
| david p clark molecular biology: Modern Phylogenetic Comparative Methods and Their Application in Evolutionary Biology László Zsolt Garamszegi, 2016-09-22 Phylogenetic comparative approaches are powerful analytical tools for making evolutionary inferences from interspecific data and phylogenies. The phylogenetic toolkit available to evolutionary biologists is currently growing at an incredible speed, but most methodological papers are published in the specialized statistical literature and many are incomprehensible for the user community. This textbook provides an overview of several newly developed phylogenetic comparative methods that allow to investigate a broad array of questions on how phenotypic characters evolve along the branches of phylogeny and how such mechanisms shape complex animal communities and interspecific interactions. The individual chapters were written by the leading experts in the field and using a language that is accessible for practicing evolutionary biologists. The authors carefully explain the philosophy behind different methodologies and provide pointers – mostly using a dynamically developing online interface – on how these methods can be implemented in practice. These “conceptual” and “practical” materials are essential for expanding the qualification of both students and scientists, but also offer a valuable resource for educators. Another value of the book are the accompanying online resources (available at: http://www.mpcm-evolution.com), where the authors post and permanently update practical materials to help embed methods into practice. |
| david p clark molecular biology: Molecular Biology Robert Franklin Weaver, 2008 |
| david p clark molecular biology: Biotechnology David P. Clark, Nanette J. Pazdernik, 2010-07-21 Unlike most biotechnology textbooks, Dr. David P. Clark's Biotechnology approaches modern biotechnology from a molecular basis, which grew out of the increasing biochemical understanding of physiology. Using straightforward, less-technical jargon, Clark manages to introduce each chapter with a basic concept that ultimately evolves into a more specific detailed principle. This up-to-date text covers a wide realm of topics, including forensics and bioethics, using colorful illustrations and concise applications.This book will help readers understand molecular biotechnology as a scientific discipline, how the research in this area is conducted, and how this technology may impact the future.· Up-to-date text focuses on modern biotechnology with a molecular foundation· Basic concepts followed by more detailed, specific applications · Clear, color illustrations of key topics and concepts · Clearly written without overly technical jargon or complicated examples |
| david p clark molecular biology: Human Molecular Genetics Jamie Benton &, 2019-01-23 Molecular Genetics is one of the fast moving fields of science that has undergone a variable revolution over the last two decades leading to major advances in the understanding of gene structure and function at molecular level. Human Molecular Genetics is the study of the molecular basis of human genetic disease, developmental genetics, neurogenetics, chromosome structure and function, molecular aspects of cancer genetics, gene therapy, biochemical genetics, major advances in gene mapping and understanding of genome organization. Genetics is the study of how genes bring about characteristics, or traits, in living things and how those characteristics are inherited. Genes are portions of DNA molecules that determine characteristics of living things. Through the processes of meiosis and reproduction, genes are transmitted from one generation to the next. Heredity is a biological process where a parent passes certain genes onto their children or offspring. Genetics uses information from one or two genes to explain a disease or condition, whereas genomics examines all of the genetic information to determine biological markers predisposing an individual to disease. Genes are the best understood subsequence of DNA code. Most genes clearly encode the data sequence representing a particular protein. However, all of the genes together are only a small part of DNA code. The 30,000 odd genes in human DNA might only make up 4% of human DNA. This book presents a view in depth of the principal aspects of life science. Each chapter treats a discrete topic within the scope of biology and each is designed for students who are exposed to the topics for the first time. Since considerable ferment exists in the biological sciences today, it is increasingly important to keep pace with current developments. |
| david p clark molecular biology: Biotechnology David P. Clark, Nanette J. Pazdernik, 2011-01-06 Now available with the most current and relevant journal articles from Cell Press, Biotechnology Academic Cell Update Edition approaches modern biotechnology from a molecular basis, which grew out of the increasing biochemical understanding of physiology. Using straightforward, less-technical jargon, Clark and Pazdernik manage to introduce each chapter with a basic concept that ultimately evolves into a more specific detailed principle. This up-to-date text covers a wide realm of topics, including the forensics used in crime scene investigations, the burgeoning field of nanobiotechnology, bioethics and other cutting edge topics in today's world of biotechnology. - Basic concepts followed by more detailed, specific applications with clear, color illustrations of key topics and concepts |
| david p clark molecular biology: Molecular Biology Online Study Guide Access Card David P. Clark, Nanette J. Pazdernik, 2012-05-30 |
| david p clark molecular biology: Molecular Biology Made Simple and Fun , 2000 |
DAVID Functional Annotation Bioinformatics Microarray Analysis
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DAVID Functional Annotation Bioinformatics Microarray Analysis
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