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| biomarker guide: The Biomarker Guide K. E. Peters, C. C. Walters, J. M. Moldowan, 2005 The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. |
| biomarker guide: The Biomarker Guide: Biomarkers and isotopes in petroleum systems and Earth history Kenneth E. Peters, 2005 |
| biomarker guide: The Biomarker Guide: Volume 1, Biomarkers and Isotopes in the Environment and Human History K. E. Peters, C. C. Walters, J. M. Moldowan, 2007-08-16 The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. Now in two volumes, it provides a comprehensive account of the role that biomarker technology plays both in petroleum exploration and in understanding Earth history and processes. Biomarkers and Isotopes in the Environment and Human History details the origins of biomarkers and introduces basic chemical principles relevant to their study. It discusses analytical techniques, and applications of biomarkers to environmental and archaeological problems. The Biomarker Guide is an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental scientists and archaeologists. |
| biomarker guide: The Biomarker Guide: Volume 2, Biomarkers and Isotopes in Petroleum Systems and Earth History K. E. Peters, C. C. Walters, J. M. Moldowan, 2007-08-16 The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. Now in two volumes, it provides a comprehensive account of the role that biomarker technology plays both in petroleum exploration and in understanding Earth history and processes. Biomarkers and Isotopes in Petroleum Exploration and Earth History itemizes parameters used to genetically correlate petroleum and interpret thermal maturity and extent of biodegradation. It documents most known petroleum systems by geologic age throughout Earth history. The Biomarker Guide is an invaluable resource for geologists, petroleum geochemists, biogeochemists, and environmental scientists. |
| biomarker guide: The Handbook of Biomarkers Kewal K. Jain, 2010-02-06 Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various -omics technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering ourunderstanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today. |
| biomarker guide: The Biomarker Guide Kenneth Eric Peters, 2004 The first part of an all-inclusive two volume reference on biological markers in petroleum geochemistry, environmental science and archaeology. |
| biomarker guide: The Handbook of Biomarkers Kewal K. Jain, 2017-09-16 Involved in nearly every therapeutic area, particularly cancer, biomarkers have experienced tremendous advances since the first edition of this book, both in the discovery of biomarkers and in their applications. To aid in this imperative research, Prof. Kewal K. Jain’s Handbook of Biomarkers, Second Edition features a full revision and additional chapters to thoroughly describe many different types of biomarkers and their discovery using various -omics technologies, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers, Second Edition serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important trends in healthcare today. |
| biomarker guide: The Biomarker Guide Kenneth E. Peters, 2007 |
| biomarker guide: Biomarker Analysis in Clinical Trials with R Nusrat Rabbee, 2020-03-11 The world is awash in data. This volume of data will continue to increase. In the pharmaceutical industry, much of this data explosion has happened around biomarker data. Great statisticians are needed to derive understanding from these data. This book will guide you as you begin the journey into communicating, understanding and synthesizing biomarker data. -From the Foreword, Jared Christensen, Vice President, Biostatistics Early Clinical Development, Pfizer, Inc. Biomarker Analysis in Clinical Trials with R offers practical guidance to statisticians in the pharmaceutical industry on how to incorporate biomarker data analysis in clinical trial studies. The book discusses the appropriate statistical methods for evaluating pharmacodynamic, predictive and surrogate biomarkers for delivering increased value in the drug development process. The topic of combining multiple biomarkers to predict drug response using machine learning is covered. Featuring copious reproducible code and examples in R, the book helps students, researchers and biostatisticians get started in tackling the hard problems of designing and analyzing trials with biomarkers. Features: Analysis of pharmacodynamic biomarkers for lending evidence target modulation. Design and analysis of trials with a predictive biomarker. Framework for analyzing surrogate biomarkers. Methods for combining multiple biomarkers to predict treatment response. Offers a biomarker statistical analysis plan. R code, data and models are given for each part: including regression models for survival and longitudinal data, as well as statistical learning models, such as graphical models and penalized regression models. |
| biomarker guide: The Biomarker Guide Peters, Kenneth E. Peters, 2005 |
| biomarker guide: Biomarkers in Cardiovascular Disease Vijay Nambi, 2018-11-27 Get a quick, expert overview of the ways in which biomarkers can be used to assess and guide the management of cardiovascular disease in the clinical setting. This concise, clinically-focused resource by Dr. Vijay Nambi consolidates today's available information on this rapidly changing topic into one convenient resource, making it an ideal, easy-to-digest reference for cardiology practitioners, fellows, and residents. - Covers lab standards and statistical interpretation of biomarkers with a clinical focus. - Discusses relevant conditions such as hypertension and diabetes as key markers of injury and prognosis. - Includes current information on biomarkers to assess and guide the management of heart failure, acute coronary syndrome, chest pain, shortness of breath, and more. - Concludes the book with a timely chapter on how biomarkers may guide cardiologists in the future. |
| biomarker guide: Biomarkers for Geologists Douglas Waples, Tsutomu Machihara, 1991 |
| biomarker guide: The Biomarker Guide Kenneth E. Peters, J. Michael Moldowan, 1993 This indispensable reference provides the only comprehensive discussion of biomarkers and how they are used with other geochemical methods to reduce the risk associated with exploration for petroleum. The guide brings together information on biomarkers and related technology that is now disseminated in hundreds of research papers, and creates general guidelines for the use of selected parameters. For a broad audience including company exploration geologies, geochemists, geochemical coordinators, and managers. |
| biomarker guide: The Biomarker Guide K. E. Peters, 2007 The second edition of The Biomarker Guide is a fully updated and expanded version of this essential reference. Now in two volumes, it provides a comprehensive account of the role that biomarker technology plays both in petroleum exploration and in understanding Earth history and processes. Biomarkers and Isotopes in Petroleum Exploration and Earth History itemizes parameters used to genetically correlate petroleum and interpret thermal maturity and extent of biodegradation. It documents most known petroleum systems by geologic age throughout Earth history. The Biomarker Guide is an invaluable. |
| biomarker guide: The Biomarker Guide K. E. Peters, C. C. Walters, J. M. Moldowan, 2004-12-16 Biomarkers are compounds found in crude oil with structures inherited from once-living organisms. They persist in oil spills, refinery products and archaeological artifacts, and can be used to identify the origin, geological age and environmental conditions prevalent during their formation and alteration. These two volumes will be an invaluable resource for geologists, petroleum geochemists, biogeochemists, environmental and forensic scientists, natural product chemists and archaeologists. The first of two volumes of The Biomarker Guide discusses the origins of biomarkers and introduces basic chemical principles relevant to their study. It goes on to discuss analytical techniques, and the applications of biomarkers in environmental and archaeological problems. |
| biomarker guide: Targeted Biomarker Quantitation by LC-MS Naidong Weng, Wenying Jian, 2017-07-10 The first book to offer a blueprint for overcoming the challenges to successfully quantifying biomarkers in living organisms The demand among scientists and clinicians for targeted quantitation experiments has experienced explosive growth in recent years. While there are a few books dedicated to bioanalysis and biomarkers in general, until now there were none devoted exclusively to addressing critical issues surrounding this area of intense research. Target Biomarker Quantitation by LC-MS provides a detailed blueprint for quantifying biomarkers in biological systems. It uses numerous real-world cases to exemplify key concepts, all of which were carefully selected and presented so as to allow the concepts they embody to be easily expanded to future applications, including new biomarker development. Target Biomarker Quantitation by LC-MS primarily focuses on the assay establishment for biomarker quantitation—a critical issue rarely treated in depth. It offers comprehensive coverage of three core areas of biomarker assay establishment: the relationship between the measured biomarkers and their intended usage; contemporary regulatory requirements for biomarker assays (a thorough understanding of which is essential to producing a successful and defendable submission); and the technical challenges of analyzing biomarkers produced inside a living organism or cell. Covers the theory of and applications for state-of-the-art mass spectrometry and chromatography and their applications in biomarker analysis Features real-life examples illustrating the challenges involved in target biomarker quantitation and the innovative approaches which have been used to overcome those challenges Addresses potential obstacles to obtain effective biomarker level and data interpretation, such as specificity establishment and sample collection Outlines a tiered approach and fit-for-purpose assay protocol for target biomarker quantitation Highlights the current state of the biomarker regulatory environment and protocol standards Target Biomarker Quantitation by LC-MS is a valuable resource for bioanalytical scientists, drug metabolism and pharmacokinetics scientists, clinical scientists, analytical chemists, and others for whom biomarker quantitation is an important tool of the trade. It also functions as an excellent text for graduate courses in pharmaceutical, biochemistry and chemistry. |
| biomarker guide: Handbook of Biomarkers and Precision Medicine Claudio Carini, Mark Fidock, Alain van Gool, 2019-04-16 The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work. -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL. |
| biomarker guide: Evaluation of Biomarkers and Surrogate Endpoints in Chronic Disease Institute of Medicine, Food and Nutrition Board, Board on Health Sciences Policy, Board on Health Care Services, Committee on Qualification of Biomarkers and Surrogate Endpoints in Chronic Disease, 2010-07-25 Many people naturally assume that the claims made for foods and nutritional supplements have the same degree of scientific grounding as those for medication, but that is not always the case. The IOM recommends that the FDA adopt a consistent scientific framework for biomarker evaluation in order to achieve a rigorous and transparent process. |
| biomarker guide: Biomarkers in Drug Development Michael R. Bleavins, Claudio Carini, Mallé Jurima-Romet, Ramin Rahbari, 2011-09-20 Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development. |
| biomarker guide: Comprehensive Biomarker Discovery and Validation for Clinical Application Péter Horvatovich, Rainer Bischoff, 2013-06-17 Comprehensive Biomarker Discovery and Validation for Clinical Application provides the reader with an extensive introduction into all aspects of proteomics biomarker discovery, validation and development. It discusses the current status of science and technology, its limitations, bottlenecks as well as future development trends to improve the success rate of translating biomarker discovery into useful clinical tests. The most important feature of the book is to provide an overview of current technologies and the challenges encountered during biomarker discovery and validation, such as patient selection, sample handling, data processing, statistical analysis and registration and approval of validated biomarkers through European and US regulatory authorities. The authors introduce the reader to each of these topics in significant detail and provide examples or guidelines for best practice. There are prominent chapters included on biomarkers in translational and personalised medicine; an introduction to regulatory affairs and bring biomarkers to the market; biomarker discovery and the use of mass spectrometry based profiling platforms; MALDI imaging techniques in tissue-based biomarkers discovery and a clinical application study on the use of diagnostic assays for early diagnosis of heart failure using various proteomic methods. The book concludes with a final chapter on future trends in biomarker discovery and validation. The book targets a readership of industrial and academic researchers that are involved in biomarker discovery and validation or that manage biobanks, develop sample preparation methods, analytical profiling systems and bioinformatics tools. Common pitfalls and success stories in biomarker discovery are highlighted and guidelines for best practice are provided for the different parts of the procedure. The book will be an essential information resource for scientists working in the field. |
| biomarker guide: The Biomarker Guide: Biomarkers in petroleum systems and Earth history Kenneth E. Peters, Clifford C. Walters, J. Michael Moldowan, 2004 |
| biomarker guide: Clinical Trials Tom Brody, 2011-10-25 Clinical Trials: Study Design, Endpoints and Biomarkers, Drug Safety, and FDA and ICH Guidelines is a practical guidebook for those engaged in clinical trial design. This book details the organizations and content of clinical trials, including trial design, safety, endpoints, subgroups, HRQoL, consent forms and package inserts. It provides extensive information on both US and international regulatory guidelines and features concrete examples of study design from the medical literature. This book is intended to orient those new to clinical trial design and provide them with a better understanding of how to conduct clinical trials. It will also act as a guide for the more experienced by detailing endpoint selection and illustrating how to avoid unnecessary pitfalls. This book is a straightforward and valuable reference for all those involved in clinical trial design. - Provides extensive coverage of the study schema and related features of study design - Offers a hands-on reference that contains an overview of the process, but more importantly details a step-by-step account of clinical trial design - Features examples from the medical literature to highlight how investigators choose the most suitable endpoint(s) for clinical trial and includes graphs from real clinical trials to help explain each concept in study design - Integrates clinical trial design, pharmacology, biochemistry, cell biology and legal aspects to provide readers with a comprehensive look at all aspects of clinical trials - Includes chapters on core material and important ancillary topics, such as package inserts, consent forms, and safety reporting forms used in the United States, England and Europe - For complimentary access to our sample chapter (chapter 24), please copy and paste this link into your browser: http://tinyurl.com/awwutvn |
| biomarker guide: The Biomarker Guide Kenneth E. Peters, 2007 |
| biomarker guide: The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes Michael Ritsner, 2009-04-21 Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer’s disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances. This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: “Neuropsychological Endophenotypes and Biomarkers” (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), “Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers”, “Metabolic and Peripheral Biomarkers” and “Molecular Genetic and Genomic Markers”. The contributors are internationally and nationally recognized researchers and experts from 16 countries. This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health. |
| biomarker guide: Evolution of Translational Omics Institute of Medicine, Board on Health Sciences Policy, Board on Health Care Services, Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials, 2012-09-13 Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials. |
| biomarker guide: Chemical Biomarkers in Aquatic Ecosystems Thomas S. Bianchi, Elizabeth A. Canuel, 2011-02-28 This textbook provides a unique and thorough look at the application of chemical biomarkers to aquatic ecosystems. Defining a chemical biomarker as a compound that can be linked to particular sources of organic matter identified in the sediment record, the book indicates that the application of these biomarkers for an understanding of aquatic ecosystems consists of a biogeochemical approach that has been quite successful but underused. This book offers a wide-ranging guide to the broad diversity of these chemical biomarkers, is the first to be structured around the compounds themselves, and examines them in a connected and comprehensive way. This timely book is appropriate for advanced undergraduate and graduate students seeking training in this area; researchers in biochemistry, organic geochemistry, and biogeochemistry; researchers working on aspects of organic cycling in aquatic ecosystems; and paleoceanographers, petroleum geologists, and ecologists. Provides a guide to the broad diversity of chemical biomarkers in aquatic environments The first textbook to be structured around the compounds themselves Describes the structure, biochemical synthesis, analysis, and reactivity of each class of biomarkers Offers a selection of relevant applications to aquatic systems, including lakes, rivers, estuaries, oceans, and paleoenvironments Demonstrates the utility of using organic molecules as tracers of processes occurring in aquatic ecosystems, both modern and ancient |
| biomarker guide: Handbook of Water Pollution Inamuddin, Tariq Altalhi, Arwa Alrooqi, 2024-04-09 HANDBOOK of WATER POLLUTION Handbook of Water Pollution discusses a wide range of contaminants heavily affecting our environment and water bodies. The chapters discuss heavy metals, metalloids, pesticides, explosives, toxic chemicals, dyes, plastics, e-wastes, fertilizers, detergents, nitrates/nitrites, phosphates, hydrocarbons, and fecal wastes, along with their sources of action against our environment, their methods of analysis, and finally, their treatments are all presented in detail. Our environment is heavily affected due to extreme human activities. Environmental pollution is a major concern worldwide. Within this, water pollution is one of the major challenges that puts the total ecology at risk. Water pollution is alarming everywhere; many governing authorities believe it is also an unavoidable result of human activity. However, the economic cost of water pollution far outweighs the benefits of skimping on its cause. Water pollution is not just merely related to financial cost but related to all living beings. Toxic waste is getting into the water bodies in various regions, causing many illnesses in humans and poisoning other living things. The destruction of any single component of our ecosystem can have a devastating effect on our biodiversity. Therefore, it is necessary to understand the causes of pollution, their nature and mechanism, and, at the same time, study the remedies. The major causes of water pollution are industrial waste, sewage, plastics, oil leakage, biological organisms, toxic chemicals and radioactive waste, and so on. A tremendous amount of research work is going on around the world to understand the causes, their mechanism, and solutions. Many new works are published every day, therefore it’s important to gather some of the most relevant findings in one place. This will serve as a link between collected knowledge and current advancements, while also facilitating future thinking. |
| biomarker guide: Fluid Inclusions and Biomarkers in the Upper Mississippi Valley Zinc-lead District E. Lanier Rowan, Martin B. Goldhaber, 1996 A multidisciplinary approach to research studies of sedimentary rocks and their constituents and the evolution of sedimentary basins, both ancient and modern. |
| biomarker guide: Standard Handbook Oil Spill Environmental Forensics Scott Stout, Zhendi Wang, 2016-02-03 Standard Handbook Oil Spill Environmental Forensics: Fingerprinting and Source Identification, Second Edition, provides users with the latest information on the tools and methods that have become popular over the past ten years. The book presents practitioners with the latest environmental forensics techniques and best practices for quickly identifying the sources of spills, how to form an effective response, and how to determine liability. This second edition represents a complete overhaul of the existing chapters, and includes 13 new chapters on methods and applications, such as emerging application of PAHi isomers in oil spill forensics, development and application of computerized oil spill identification (COSI), and fingerprinting of oil in biological and passive sampling devices. - Contains 13 new chapters on methods and applications, including emerging application of PAH isomers in oil drill forensics, the development and application of computerized oil spill identification (COSI), and the fingerprinting of oil in biological and passive sampling devices - Presents the latest technology and methods in biodegradation of oil hydrocarbons and its implications for source identification, surface trajectory modeling of marine oil spills, and identification of hydrocarbons in biological samples for source determination - Contains new case studies to illustrate key applications, methods, and techniques |
| biomarker guide: Analytical Geomicrobiology Janice P. L. Kenney, Harish Veeramani, Daniel S. Alessi, 2019-07-18 A comprehensive handbook outlining state-of-the-art analytical techniques used in geomicrobiology, for advanced students, researchers and professional scientists. |
| biomarker guide: ENVIRONMENTAL AND ECOLOGICAL CHEMISTRY - Volume II Aleksandar Sabljic, 2009-02-04 Environmental and Ecological Chemistry is a component of Encyclopedia of Chemical Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme on Environmental and Ecological Chemistry prsents the essential aspects such as: Fundamental Environmental Chemistry; Atmospheric Chemistry; Soil Chemistry; Aquatic Chemistry; Ecological Chemistry; Chemistry of Organic Pollutants Including Agrochemicals. These volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs. |
| biomarker guide: New Approaches to Drug Discovery Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch, 2016-03-30 This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase. |
| biomarker guide: Basics of Petroleum Geochemistry Majid Alipour, 2025-04-24 This book provides a concise summary about fundamental aspects of petroleum geology and geochemistry for graduate students, primarily from non-English-speaking countries. These fundamentals constitute about 40% of the book, while the remaining 60% deals with regional examples from petroleum geology of the Zagros basin of Iran. The regional examples are prepared using both published and unpublished (proprietary) data. The aim is to familiarize readers with the fundamental aspects of petroleum geochemistry and then provide typical examples from one of the world’s most prolific petroleum provinces. |
| biomarker guide: Handbook on the Toxicology of Metals: Volume I: General Considerations Gunnar F. Nordberg, Max Costa, 2021-11-30 Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. - Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems - Includes information on sources, transport and the transformation of metals in the environment - Covers the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health - Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment and prevention of metallic elements and compounds |
| biomarker guide: Clinical Trials Tom Brody, 2016-02-19 Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. - Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more - Extensively covers the study schema and related features of study design - Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials - Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers |
| biomarker guide: Oil Spill Environmental Forensics Case Studies Scott Stout, Zhendi Wang, 2017-10-22 Oil Spill Environmental Forensics Case Studies includes 34 chapters that serve to present various aspects of environmental forensics in relation to real-world oil spill case studies from around the globe. Authors representing academic, government, and private researcher groups from 14 countries bring a diverse and global perspective to this volume. Oil Spill Environmental Forensics Case Studies addresses releases of natural gas/methane, automotive gasoline and other petroleum fuels, lubricants, vegetable oils, paraffin waxes, bitumen, manufactured gas plant residues, urban runoff, and, of course, crude oil, the latter ranging from light Bakken shale oil to heavy Canadian oil sands oil. New challenges surrounding forensic investigations of stray gas in the shallow subsurface, volatiles in air, dissolved chemicals in water (including passive samplers), and biological tissues associated with oil spills are included, as are the effects and long-term oil weathering, long-term monitoring in urbanized and non-urbanized environments, fate and transport, forensic historical research, new analytical and chemical data processing and interpretation methods. - Presents cases in each chapter on the application of specific oil spill environmental forensic techniques - Features chapters written by international experts from both academia and industry - Includes relevant concepts and theories elucidated for each theme |
| biomarker guide: Oil Spill Monitoring Handbook Sharon Hook, Graeme Batley, Michael Holloway, Andrew Ross, Paul Irving, 2016-10-03 Oil spills can be difficult to manage, with reporting frequently delayed. Too often, by the time responders arrive at the scene, the slick has moved, dissolved, dispersed or sunk. This Oil Spill Monitoring Handbook provides practical advice on what information is likely required following the accidental release of oil or other petroleum-based products into the marine environment. The book focuses on response phase monitoring for maritime spills, otherwise known as Type I or operational monitoring. Response phase monitoring tries to address the questions – what? where? when? how? how much? – that assist responders to find, track, predict and clean up spills, and to assess their efforts. Oil spills often occur in remote, sensitive and logistically difficult locations, often in adverse weather, and the oil can change character and location over time. An effective response requires robust information provided by monitoring, observation, sampling and science. The Oil Spill Monitoring Handbook completely updates the Australian Maritime Safety Authority’s 2003 edition of the same name, taking into account the latest scientific advances in physical, chemical and biological monitoring, many of which have evolved as a consequence of major oil spill disasters in the last decade. It includes sections on the chemical properties of oil, the toxicological impacts of oil exposure, and the impacts of oil exposure on different marine habitats with relevance to Australia and elsewhere. An overview is provided on how monitoring integrates with the oil spill response process, the response organisation, the use of decision-support tools such as net environmental benefit analysis, and some of the most commonly used response technologies. Throughout the text, examples are given of lessons learned from previous oil spill incidents and responses, both local and international. General guidance of spill monitoring approaches and technologies is augmented with in-depth discussion on both response phase and post-response phase monitoring design and delivery. Finally, a set of appendices delivers detailed standard operating procedures for practical observation, sample and data collection. The Oil Spill Monitoring Handbook is essential reading for scientists within the oil industry and environmental and government agencies; individuals with responder roles in industry and government; environmental and ecological monitoring agencies and consultants; and members of the maritime sector in Australia and abroad, including officers in ports, shipping and terminals. |
| biomarker guide: Geochemistry Dionisios Panagiotaras, 2012-05-02 This book brings together the knowledge from a variety of topics within the field of geochemistry. The audience for this book consists of a multitude of scientists such as physicists, geologists, technologists, petroleum engineers, volcanologists, geochemists and government agencies. The topics represented facilitate as establishing a starting point for new ideas and further contributions. An effective management of geological and environmental issues requires the understanding of recent research in minerals, soil, ores, rocks, water, sediments. The use of geostatistical and geochemical methods relies heavily on the extraction of this book. The research presented was carried out by experts and is therefore highly recommended to scientists, under- and post-graduate students who want to gain knowledge about the recent developments in geochemistry and benefit from an enhanced understanding of the dynamics of the earth's system processes. |
| biomarker guide: Quantifying the Evolution of Early Life Marc Laflamme, James D. Schiffbauer, Stephen Q. Dornbos, 2011-02-28 This volume provides a detailed description of a wide range of numerical, statistical or modeling techniques and novel instrumentation separated into individual chapters written by paleontologists with expertise in the given methodology. Each chapter outlines the strengths and limitations of specific numerical or technological approaches, and ultimately applies the chosen method to a real fossil dataset or sample type. A unifying theme throughout the book is the evaluation of fossils during the prologue and epilogue of one of the most exciting events in Earth History: the Cambrian radiation. |
| biomarker guide: Marine Organic Matter: Biomarkers, Isotopes and DNA J. K. Volkman, 2006-02-09 The oceans contain a great biodiversity of marine organisms. They include a rich variety of unusual genes and biochemistries and hence a diverse array of organic compounds ranging from colourful carotenoids and chlorophylls to lipids with structures ranging from the simple to the complex. This volume brings together ten chapters on the occurrence and identification of the lipid biomarkers and of pigments in marine waters. It describes how they can be used in conjunction with stable isotopes and molecular biology to ascertain the sources and fate of organic matter (both natural and pollutant) in the sea and underlying sediments. The authors are each experts in their field and the chapters provide both an overview of the state-of-the-art and knowledge gaps together with abundant detail to satisfy the needs of specialists and non-specialists alike. |
Home page | Biomarker Research
Biomarker Research is an open access, peer-reviewed journal that encompasses all aspects of biomarker investigation. Biomarker Research aims to publish original discoveries, novel …
Targeting the chemokine receptor CXCR4 for cancer therapies
May 1, 2025 · The C-X-C chemokine receptor type 4 (CXCR4) has emerged as a key molecular biomarker for cancer therapies due to its critical role in tumor progression and metastases by …
Articles | Biomarker Research - BioMed Central
Jun 10, 2025 · The C-X-C chemokine receptor type 4 (CXCR4) has emerged as a key molecular biomarker for cancer therapies due to its critical role in tumor progression and metastases by …
RNA epigenetic modifications as dynamic biomarkers in cancer: …
Jun 7, 2025 · Some studies demonstrated that the level of ADAR1 in ESCC and the level of ADAR2 in HCC are correlated with patient survival, highlighting the potential of A-to-I editing …
The evolving landscape of biomarkers for systemic therapy in …
Apr 12, 2025 · The main biomarkers for systemic therapy in hepatocellular carcinoma are derived from peripheral blood, tissues, and imaging. Currently, the understanding of the clinical …
Decoding tumor angiogenesis: pathways, mechanisms, and future ...
Apr 18, 2025 · Angiogenesis, a crucial process in tumor growth and metastasis, necessitates targeted therapeutic intervention. This review reviews the latest knowledge of anti …
The multifaceted roles of cathepsins in immune and inflammatory ...
Dec 31, 2024 · High CTSA expression correlates with increased M2 macrophage infiltration in tumors, making it a potential biomarker for glioma risk, progression, and prognosis . Recent …
About | Biomarker Research - BioMed Central
Biomarker Research is an open access, peer-reviewed journal that encompasses all aspects of biomarker investigation. Biomarker Research aims to publish original discoveries, novel …
LRG1, a novel serum biomarker for iMCD disease activity
Apr 7, 2025 · Additionally, serum CRP/LRG1 ratio differed across iMCD subtypes, suggesting potential variations in inflammatory pathways. These findings support serum LRG1 as a …
Submission guidelines | Biomarker Research - BioMed Central
Biomarker Research encompasses every aspect of biomarker investigation from all biomedical disciplines. The journal recognizes that the study of biomarkers ...
Home page | Biomarker Research
Biomarker Research is an open access, peer-reviewed journal that encompasses all aspects of …
Targeting the chemokine receptor CXCR4 for cancer the…
May 1, 2025 · The C-X-C chemokine receptor type 4 (CXCR4) has emerged as a key molecular biomarker for …
Articles | Biomarker Research - BioMed Central
Jun 10, 2025 · The C-X-C chemokine receptor type 4 (CXCR4) has emerged as a key molecular biomarker for …
RNA epigenetic modifications as dynamic biomarkers in can…
Jun 7, 2025 · Some studies demonstrated that the level of ADAR1 in ESCC and the level of ADAR2 in HCC …
The evolving landscape of biomarkers for systemic ther…
Apr 12, 2025 · The main biomarkers for systemic therapy in hepatocellular carcinoma are derived from …
