Advertisement
| bmc shapiro: Management and Control of Foreign Exchange Risk Laurent L. Jacque, 2013-12-01 Since I first published Management of Foreign Exchange Risk (Lexington Books, 1978), financial innovation-spurred, in part, by exploding volatility in currency prices-has revolutionized the theory and praxis of foreign exchange risk management. Old-fashioned forward contracts have surrendered market share to currency swaps and options as well as to their perpetually multiplying derivatives. Interestingly, forex derivatives now provide a low cost and highly efficient method of transferring risk from the firms that are exposed to risk but which would rather not be (i. e. , risk-hedgers) to those which are not exposed but which-in exchange for a fee-would assume some exposure to risk (i. e. , risk bearers). Perhaps more importantly, foreign exchange risk management, which was once a fairly mechanical task confmed to the international treasury function, is now permeating global strategic management. Indeed, since the demise of the Bretton Woods system of pegged exchange rates, the cost of forex hedging instruments has fallen so dramatically that firms can readily avail themselves of hedging products which can reduce unwanted risk, thereby potentially gaining a competitive advantage over rivals that do not. Management and Control of Foreign Exchange Risk has grown out of a fundamental revision of my earlier work published almost 20 years ago. In the process, my thinking about risk and its mathematics has greatly benefitted from my association with John Cozzolino and Charles Tapiero. |
| bmc shapiro: Mental Health in the Digital Age Elias Aboujaoude, Vladan Starcevic, 2015 Mental Health in the Digital Age, written by distinguished international experts, comprehensively examines the intersection between digital technology and mental health. It provides a state-of-the-art, evidence-based, and well-balanced review and is a valuable guide to an area often shrouded in controversy. |
| bmc shapiro: Evidence-Based Neurology Livia Candelise, Richard A. C. Hughes, Alessandro Liberati, Bernard M. J. Uitdehaag, Charles P. Warlow, 2008-04-15 In Evidence-based Neurology: Management of Neurological Disorders a carefully selected group of clinically experienced collaborators use the best available evidence to answer more than 100 clinical questions about the treatment and management of neurological disorders. Divided into three sections and 24 chapters, this book fills the gap between guidelines and primary studies as well as between primary and secondary scientific medical literature summarizes the most recent and important findings on treatments for neurological patients measures the benefit and, when applicable, the risk of harm inherent in specific neurological interventions. This unique, evidence-based text, edited by members of the Cochrane Neurological Network will be an essential resource for all general neurologists, from the novice to the most experienced, in their everyday clinical practice. |
| bmc shapiro: RNA Structure and Folding Dagmar Klostermeier, Christian Hammann, 2013-10-14 While structure-function relationships of proteins have been studied for a long time, structural studies of RNA face additional challenges. Nevertheless, with the continuous discovery of novel RNA molecules with key cellular functions and of novel pathways and interaction networks, the need for structural information of RNA is still increasing. This volume provides an introduction into techniques to assess structure and folding of RNA. Each chapter explains the theoretical background of one technique, and illustrates possibilities and limitations in selected application examples. |
| bmc shapiro: Essentials of Regenerative Medicine in Interventional Pain Management Annu Navani, Sairam Atluri, Mahendra Sanapati, 2024-05-02 Regenerative medicine is an emerging and integral part of interventional pain management and meets definitions of interventional pain management and interventional techniques. Interventional techniques are defined as minimally invasive procedures including, percutaneous precision needle placement, with placement of drugs in targeted areas or ablation of targeted nerves; and some surgical techniques such as laser or endoscopic diskectomy, intrathecal infusion pumps, and spinal cord stimulators, for the diagnosis and management of chronic, persistent, or intractable pain. On the same token, interventional pain management is defined as the discipline of medicine devoted to the diagnosis and treatment of pain related disorders principally with the application of interventional techniques in managing subacute, chronic, persistent, and intractable pain, independently or in conjunction with other modalities of treatment. This new edition brings a wide array of information for interventional pain physicians and other physicians practicing regenerative medicine with its applications in managing chronic pain and other disorders. The structure of the book begins with an introduction of the subject, followed by sections on historical context, pathophysiology, applicability of regenerative medicine with its evidence base, anatomy, technical aspects, complications, and precautions for each topic when available and applicable. From across the globe, leading experts in their respective fields contributed chapters on specific topics to present a cogent and integrative understanding of the field of regenerative medicine as applicable for interventional pain physicians. This comprehensive text achieves its goal of providing an evidence-based approach to application of principles of regenerative medicine in managing chronic pain of spinal, neurological, and musculoskeletal origins. |
| bmc shapiro: Ecological Genomics Christian R. Landry, Nadia Aubin-Horth, 2013-11-25 Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation. |
| bmc shapiro: Endurance Sports Medicine Timothy L. Miller, 2023-05-17 Providing a fresh update of this continuously evolving branch of sports medicine, this comprehensive yet practical guide focuses specifically on the treatment of athletes who train for and participate in endurance sporting events, including not only traditional endurance athletes such as runners, swimmers, bikers and triathletes, but also rowers, adventure racers, military personnel and cross-fit athletes. Detailing strategies for not only treating and preventing injuries and conditions but also for optimizing an athlete’s performance, this book is divided into three thematic sections. The first section covers common medical conditions faced by the endurance athlete, including cardiovascular conditions, asthma, and heat- and altitude-related illnesses, while also discussing gender differences, pregnancy and the pediatric and masters endurance athlete. Section two focuses on the management of common musculoskeletal conditions, such as stress fractures, overuse injuries of the soft tissue, shoulder and hip injuries, and exercise and osteoarthritis; this section now includes discussion of the use of cutting-edge orthobiologics. The last section presents performance optimization and event coverage, including gait and swim-stroke analysis, bike fitting, resistance training, mental preparation, optimizing nutrition, and how to organize medical coverage for events, as well as decision-making for return to play. Completely updated and including brand new chapters, Endurance Sports Medicine, Second Edition remains a valuable guide for sports medicine physicians, orthopedists, athletic trainers, physical therapists, coaches, officials, and athletes in understanding the needs of the determined individuals who participate in endurance sports. |
| bmc shapiro: Multinational Financial Management Alan C. Shapiro, 1989 Throughout the text, a variety of real-life cases and examples, including new mini-cases in most chapters, demonstrate how to use financial analysis and reasoning to solve real international financial problems. |
| bmc shapiro: Chocolate and Health Philip K. Wilson, W. Jeffrey Hurst, 2015-05-18 Following on from their previous volume on Chocolate as Medicine, Philip K. Wilson and W. Jeffrey Hurst edit this companion volume, Chocolate and Health, providing a comprehensive overview of the chemistry, nutrition and bioavailability of cacao and chocolate. The book begins with a brief historical introduction to the topic, outlining the current and historical medical uses of chocolate and chocolate derivatives. The remainder of the text is arranged into three sections, taking the reader through various aspects of the nutritional and health aspects of cacoa. The first section covers the cultivation, chemistry and genome analysis of cacao. The second section discusses the biochemistry and nutritional components of cacao in relation to health, covering bioavailabilty and the metabolism and metabolomics of cacao. The final section provides an overview of the potential use of chocolate in health and medical care. Each section is written and prepared by experts within each field, providing a global perspective of the current and ongoing research in this area. This text provides the reader with a complete overview of the field and is of interest to food and biomedical scientists, as well as nutritionists, medicinal chemists and anyone with an interest in chocolate. |
| bmc shapiro: Maine Composers and Their Music Frances Turgeon Wiggin, 1959 |
| bmc shapiro: Street Vendors in the Global Urban Economy Sharit Bhowmik, 2012-04-27 This volume looks at the living and working conditions of street vendors in different cities of the world. It examines the legal guidelines regarding control of public space and the rights of the working poor to earn their livelihood, and the civic authorities' constant regulation of this space. |
| bmc shapiro: United States Court of International Trade Reports United States. Court of International Trade, 2007 |
| bmc shapiro: Virus Bioinformatics Manja Marz, Bashar Ibrahim, Franziska Hufsky, David L. Robertson, 2020-02-21 Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics. |
| bmc shapiro: Comprehensive Toxicology , 2017-12-01 Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts |
| bmc shapiro: BoogarLists | Directory of Accounting Firms , |
| bmc shapiro: Systems Biology Aleš Prokop, Béla Csukás, 2013-08-28 Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory. |
| bmc shapiro: BoogarLists | Directory of Financial Services , |
| bmc shapiro: Computational Intelligence and Pattern Analysis in Biology Informatics Ujjwal Maulik, Sanghamitra Bandyopadhyay, Jason T. Wang, 2011-03-21 An invaluable tool in Bioinformatics, this unique volume provides both theoretical and experimental results, and describes basic principles of computational intelligence and pattern analysis while deepening the reader's understanding of the ways in which these principles can be used for analyzing biological data in an efficient manner. This book synthesizes current research in the integration of computational intelligence and pattern analysis techniques, either individually or in a hybridized manner. The purpose is to analyze biological data and enable extraction of more meaningful information and insight from it. Biological data for analysis include sequence data, secondary and tertiary structure data, and microarray data. These data types are complex and advanced methods are required, including the use of domain-specific knowledge for reducing search space, dealing with uncertainty, partial truth and imprecision, efficient linear and/or sub-linear scalability, incremental approaches to knowledge discovery, and increased level and intelligence of interactivity with human experts and decision makers Chapters authored by leading researchers in CI in biology informatics. Covers highly relevant topics: rational drug design; analysis of microRNAs and their involvement in human diseases. Supplementary material included: program code and relevant data sets correspond to chapters. |
| bmc shapiro: High-Performance Computational Solutions in Protein Bioinformatics Dariusz Mrozek, 2014-06-04 Recent developments in computer science enable algorithms previously perceived as too time-consuming to now be efficiently used for applications in bioinformatics and life sciences. This work focuses on proteins and their structures, protein structure similarity searching at main representation levels and various techniques that can be used to accelerate similarity searches. Divided into four parts, the first part provides a formal model of 3D protein structures for functional genomics, comparative bioinformatics and molecular modeling. The second part focuses on the use of multithreading for efficient approximate searching on protein secondary structures. The third and fourth parts concentrate on finding 3D protein structure similarities with the support of GPUs and cloud computing. Parts three and four both describe the acceleration of different methods. The text will be of interest to researchers and software developers working in the field of structural bioinformatics and biomedical databases. |
| bmc shapiro: Infrastructural Lives Stephen Graham, Colin McFarlane, 2014-10-10 Infrastructural Lives is the first book to describe the everyday experience and politics of urban infrastructures. It focuses on a range of infrastructures in both the global South and North. The book examines how day-to-day experience and perception of infrastructure provides a new and powerful lens to view urban sustainability, politics, economics, cultures and ecologies. An interdisciplinary group of leading and emerging urban researchers examine critical questions about urban infrastructure in different global contexts. The chapters address water, sanitation, and waste politics in Mumbai, Kampala and Tyneside, analyse the use of infrastructure in the dispossession of Palestinian communities, explore the pacification of Rio’s favelas in the run-up to the 2014 World Cup, describe how people’s bodies and lives effectively operate as ‘infrastructure’ in many major cities, and also explores tentative experiments with low-carbon infrastructures. These diverse cases and perspectives are connected by a shared sense of infrastructure not just as a ‘thing’, a ‘system’, or an ‘output,’ but as a complex social and technological process that enables – or disables – particular kinds of action in the city. Infrastructural Lives is crucial reading for academics, researchers, students and practitioners in urban studies globally. |
| bmc shapiro: New Accountant , 2007 |
| bmc shapiro: G Protein-Coupled Receptors Sandra Siehler, Graeme Milligan, 2010-09-30 Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field. |
| bmc shapiro: Integrative Omics Manish Kumar Gupta, Pramod Katara, Sukanta Mondal, Ram Lakhan Singh, 2024-05-03 Integrative Omics: Concepts, Methodology and Applications provides a holistic and integrated view of defining and applying network approaches, integrative tools, and methods to solve problems for the rationalization of genotype to phenotype relationships. The reference includes a range of chapters in a systemic 'step by step' manner, which begins with the basic concepts from Omic to Multi Integrative Omics approaches, followed by their full range of approaches, applications, emerging trends, and future trends. All key areas of Omics are covered including biological databases, sequence alignment, pharmacogenomics, nutrigenomics and microbial omics, integrated omics for Food Science and Identification of genes associated with disease, clinical data integration and data warehousing, translational omics as well as omics technology policy and society research. Integrative Omics: Concepts, Methodology and Applications highlights the recent concepts, methodologies, advancements in technologies and is also well-suited for researchers from both academic and industry background, undergraduate and graduate students who are mainly working in the area of computational systems biology, integrative omics and translational science. The book bridges the gap between biological sciences, physical sciences, computer science, statistics, data science, information technology and mathematics by presenting content specifically dedicated to mathematical models of biological systems. - Provides a holistic, integrated view of a defining and applying network approach, integrative tools, and methods to solve problems for rationalization of genotype to phenotype relationships - Offers an interdisciplinary approach to Databases, data analytics techniques, biological tools, network construction, analysis, modeling, prediction and simulation of biological systems leading to 'translational research', i.e., drug discovery, drug target prediction, and precision medicine - Covers worldwide methods, concepts, databases, and tools used in the construction of integrated pathways |
| bmc shapiro: Urban Health and Planning in the 21st Century: Bridging Across the Formal and Informal Using an Eco-Social Lens Ritu Priya, Jose Siri, John Porter, Carolyn Stephens, Unnikrishnan Payyappallimana , Mathew George, Sayan Das, 2024-03-22 Modern urban planning emerged in response to public health challenges in the post-industrial revolution period in Europe. It has since evolved through the colonial and post-colonial phases of the 19th and 20th centuries with international, national, and local specificities. In the 21st century, human societies are rapidly urbanizing, even in LMICs where half or more of the population still live in rural areas. Therefore public policies that shape the nature of urbanization and urban habitats will become ever more critical to human and planetary health and wellbeing. |
| bmc shapiro: Evolution of Radiation Oncology at Massachusetts General Hospital Herman D. Suit, Jay S. Loeffler, 2011-02-04 The Massachusetts General Hospital (MGH) has a history of excellence and is internationally recognized as a world class medical center, providing quality medical care, advancing medicine through clinical and laboratory research and facilitating the education of exceptional health care professionals. The Massachusetts General Hospital Radiation Oncology Department, staff, residents and fellows, past and present, concur that MGH stands for Man’s Greatest Hospital. This decidedly immodest assessment is widely viewed amongst this group as being manifestly true, and that perception is clearly reflected in a marvelous esprit de corp. Such an unequivocally positive attitude is solidly based on the judgment that the best possible care is provided to each MGH patient, i.e. the patient is, in fact, Number One. There is a deep sense of pride in the contributions made by this department to the scientific advancement of oncology, and to progressively and substantially increasing the proportion of patients who are free of tumor and of treatment related morbidity. Evolution of Radiation of Oncology at Massachusetts General Hospital is the work of the former Chair of the Department, Herman D. Suit. From 1970 – 2000, his guidance and management of this Department brought it to recognition as a world class center. Dr. Suit was key in the development and building of the Department that now includes The Northeast Proton Therapy Center at the MGH. His passion for the science of radiation therapy and its evolving growth through the years is evident in this book. He has assembled a fascinating chronicle, beginning with the creation of MGH in 1811 followed by personal experiences that culminated with his leadership of the Radiation Oncology Department. |
| bmc shapiro: Symbiosis: Cellular, Molecular, Medical and Evolutionary Aspects Malgorzata Kloc, 2020-12-02 This volume presents a comprehensive overview of the latest developments in symbiosis research. It covers molecular, organellar, cellular, immunologic, genetic and evolutionary aspects of symbiotic interactions in humans and other model systems. The book also highlights new approaches to interdisciplinary research and therapeutic applications. Symbiosis refers to any mutually beneficial interaction between different organisms. The symbiotic origin of cellular organelles and the exchange of genetic material between hosts and their bacterial and viral symbionts have helped shaped the current diversity of life. Recently, symbiosis has gained a new level of recognition, due to the realization that all organisms function as a holobiome and that any kind of interference with the hosts influences their symbionts and vice versa, and can have profound consequences for the survival of both. For example, in humans, the microbiome, i.e., the entirety of all the microorganisms living in association with the intestines, oral cavity, urogenital system and skin, is partially inherited during pregnancy and influences the maturation and functioning of the human immune system, protects against pathogens and regulates metabolism. Symbionts also regulate cancer development, wound healing, tissue regeneration and stem cell function. The medical applications of this new realization are vast and largely uncharted. The composition and robustness of human symbionts could make them a valuable diagnostic tool for predicting impending diseases, and the manipulation of symbionts could yield new strategies for the treatment of incurable diseases. |
| bmc shapiro: Bone Health Justyna J. Miszkiewicz, Sharon L. Brennan-Olsen, Jose A. Riancho, 2019-06-29 This multidisciplinary book addresses three lines of evidence (medieval, contemporary, and epigenetic) regarding the effect of human socio-economic status on bone health. It provides an overview of the extent to which human social background affects adult bone quality and quantity, and makes recommendations for future skeletal biology research into lifestyle-related musculoskeletal disorders. The book is divided into three major parts, the first of which discusses bone and dental health in medieval human skeletal remains from distinct socio-economic status groups. In turn, Part 2 reviews bone health in contemporary human populations with a range of social backgrounds; in addition, a conceptual model proposing a social gradient of osteoporosis and fracture risk related to biological mechanisms and cumulative stressors throughout the human lifecycle is presented. Lastly, Part 3 highlights the role of epigenetics in socially patterned risk factors for skeletal disorders, and discusses how epigenetic mechanisms transduce the psychosocial environment and increase the risk of developing conditions such as osteoporosis. Overall, the book highlights the importance of considering the social-biological nexus in future skeletal biology research and future treatment of bone disease. Increased awareness of this nexus can potentially improve individual and population-level bone health interventions, reducing the social inequities observed in fracture risk. Given its scope, the book offers a valuable resource for researchers, academics, and students in the fields of medicine, epidemiology, the health sciences, biological anthropology, human anatomy and adaptation, developmental studies of human societies, human biology, and any field concerning musculoskeletal disorders and health. It will also benefit clinical practitioners evaluating osteoporosis, osteopenia, fracture risk, bone quality and quantity. |
| bmc shapiro: A Decade of the Berkeley Math Circle Zvezdelina Stankova, Tom Rike, 2008-11-26 Many mathematicians have been drawn to mathematics through their experience with math circles: extracurricular programs exposing teenage students to advanced mathematical topics and a myriad of problem solving techniques and inspiring in them a lifelong love for mathematics. Founded in 1998, the Berkeley Math Circle (BMC) is a pioneering model of a U.S. math circle, aspiring to prepare our best young minds for their future roles as mathematics leaders. Over the last decade, 50 instructors--from university professors to high school teachers to business tycoons--have shared their passion for mathematics by delivering more than 320 BMC sessions full of mathematical challenges and wonders. Based on a dozen of these sessions, this book encompasses a wide variety of enticing mathematical topics: from inversion in the plane to circle geometry; from combinatorics to Rubik's cube and abstract algebra; from number theory to mass point theory; from complex numbers to game theory via invariants and monovariants. The treatments of these subjects encompass every significant method of proof and emphasize ways of thinking and reasoning via 100 problem solving techniques. Also featured are 300 problems, ranging from beginner to intermediate level, with occasional peaks of advanced problems and even some open questions. The book presents possible paths to studying mathematics and inevitably falling in love with it, via teaching two important skills: thinking creatively while still ``obeying the rules,'' and making connections between problems, ideas, and theories. The book encourages you to apply the newly acquired knowledge to problems and guides you along the way, but rarely gives you ready answers. ``Learning from our own mistakes'' often occurs through discussions of non-proofs and common problem solving pitfalls. The reader has to commit to mastering the new theories and techniques by ``getting your hands dirty'' with the problems, going back and reviewing necessary problem solving techniques and theory, and persistently moving forward in the book. The mathematical world is huge: you'll never know everything, but you'll learn where to find things, how to connect and use them. The rewards will be substantial. In the interest of fostering a greater awareness and appreciation of mathematics and its connections to other disciplines and everyday life, MSRI and the AMS are publishing books in the Mathematical Circles Library series as a service to young people, their parents and teachers, and the mathematics profession. |
| bmc shapiro: Cancer Genomics Graham Dellaire, Jason N Berman, Robert J. Arceci, 2013-11-21 Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with Future Directions, examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. - Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. - Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature. |
| bmc shapiro: The Use of Routine Health Data in Low- and Middle-Income Countries Jim Todd, Michael Johnson Mahande, 2020-12-11 This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact. |
| bmc shapiro: Comprehensive Analysis of Parasite Biology Sylke Müller, Rachel Cerdan, Ovidiu Radulescu, 2016-07-11 Dieses Buch, geschrieben von Fachexperten auf dem Gebiet, fasst den aktuellen Stand der Wissenschaft im Hinblick auf phänotypische und zielorientierte Ansätze der Entwicklung von Arzneistoffen gegen pathogene Protozoen zusammen. Der Schwerpunkt liegt dabei vor allem auf virtuellen Substanzen und dem Hochdurchsatz-Screening, auf Naturprodukten, dem computergestützten Design von Arzneistoffen, dem strukturgestützten Design von Arzneistoffen, der Identifizierung von Wirkmechanismen und dem Pathway-Modelling. Weiterhin werden moderne omik-Technologien sowie enzymatische Drug Targets erörtert. Mathematische, auf der Systembiologie basierende Ansätze werden als neue Methoden für die Auflösung komplexer Mechanismen, die Pathogene überleben lassen, und für die Target-Identifizierung vorgestellt. Präsentiert werden darüber hinaus neu entwickelte Wirkstoffe, die über bestimmte Pathways Parasiten abtöten und als Leitsubstanzen für weitere Arzneimittelentwicklungen dienen. |
| bmc shapiro: The OMICs Giovanni Coppola, 2014 The OMICs:Applications in Neuroscience summarizes the state of the art in OMICs applications in neurology and neuroscience, attracting neurologists who are interested in the progress of this field towards clinical applications, and neuroscientists who may be not familiar with the most recent advances in this ever-changing field. The book will include an overview of most relevant high-throughput approaches (collectively known as 'OMICs') and how they relate to neurology and neuroscience. The explosion of high-throughput assays has introduced large datasets, computational servers, and bioinformatics approaches to neuroscience and medicine in general. The reader will be provided with an overview of the application or method, a perspective on the current and future applications in neurology and neuroscience, and a few published examples illustrating possible practical use. Emerging topics such as ethical issues related to personal genome sequencing, epigenetics, network analysis, and role of peripheral biomarkers in disease diagnosis and follow-up will be covered as well. |
| bmc shapiro: Biological Knowledge Discovery Handbook Mourad Elloumi, Albert Y. Zomaya, 2015-02-04 The first comprehensive overview of preprocessing, mining, and postprocessing of biological data Molecular biology is undergoing exponential growth in both the volume and complexity of biological data and knowledge discovery offers the capacity to automate complex search and data analysis tasks. This book presents a vast overview of the most recent developments on techniques and approaches in the field of biological knowledge discovery and data mining (KDD) providing in-depth fundamental and technical field information on the most important topics encountered. Written by top experts, Biological Knowledge Discovery Handbook: Preprocessing, Mining, and Postprocessing of Biological Data covers the three main phases of knowledge discovery (data preprocessing, data processing also known as data mining and data postprocessing) and analyzes both verification systems and discovery systems. BIOLOGICAL DATA PREPROCESSING Part A: Biological Data Management Part B: Biological Data Modeling Part C: Biological Feature Extraction Part D Biological Feature Selection BIOLOGICAL DATA MINING Part E: Regression Analysis of Biological Data Part F Biological Data Clustering Part G: Biological Data Classification Part H: Association Rules Learning from Biological Data Part I: Text Mining and Application to Biological Data Part J: High-Performance Computing for Biological Data Mining Combining sound theory with practical applications in molecular biology, Biological Knowledge Discovery Handbook is ideal for courses in bioinformatics and biological KDD as well as for practitioners and professional researchers in computer science, life science, and mathematics. |
| bmc shapiro: Structural Bioinformatics Jenny Gu, Philip E. Bourne, 2011-09-20 Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins. This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more. Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields. Praise for the previous edition: This book is a gold mine of fundamental and practical information in an area not previously well represented in book form. —Biochemistry and Molecular Education ... destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students. —BAMBED ...a useful and timely summary of a rapidly expanding field. —Nature Structural Biology ...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue. —Briefings in Bioinformatics |
| bmc shapiro: Atlas of Interventional Orthopedics Procedures, E-Book Christopher J. Williams, Walter Sussman, John Pitts, 2022-02-25 The field of interventional orthopedics is changing the landscape of orthopedic care as patients seek less invasive options for the treatment of common conditions like arthritis, rotator cuff tears, and degenerative disc disease. Offering easy-to-follow, step-by-step guidance on both peripheral joint and spinal procedures, Atlas of Interventional Orthopedics Procedures is the first reference to provide this practical content in one authoritative, user-friendly text. Abundantly illustrated and easy to read, it presents simple to advanced injection skills covering all orthopedic and physical medicine procedures using up-to-date imaging techniques. - Presents foundational knowledge for interventional orthopedics as well as ultrasound and x-ray guided techniques for both peripheral joint and spinal procedures. - Features nearly 1,000 high-quality images including fluoroscopy, MRIs, procedural images, and unique anatomical illustrations drawn by a physical medicine and rehabilitation physician. - Covers need-to-know topics such as autologous orthobiologics, allogenic tissue grafts, prolotherapy, and principles of fluoroscopy and ultrasound injection techniques. - Offers several ultrasound and fluoroscopy images for each procedure, as well as step-by-step descriptions and the authors' preferred technique. - Walks you through general injection techniques such as interventional spine procedures, peripheral joint injections, and spinal and peripheral ligament, tendon, and nerve techniques; advanced techniques include intraosseous injections, needle arthroscopy, perineural hydrodissection, and emerging interventional techniques. - Provides an up-to-date review on regenerative medicine for musculoskeletal pathology from editors and authors who are leading physicians in the field. - Follows the core tenets of interventional orthopedics, including injectates that can facilitate healing of musculoskeletal tissues, precise placement of those injectates into damaged structures using imaging guidance, and the eventual development of new tools to facilitate percutaneous tissue manipulation. |
| bmc shapiro: Bioinformatics Database Systems Kevin Byron, Katherine G. Herbert, Jason T. L. Wang, 2016-12-19 Modern biological databases comprise not only data, but also sophisticated query facilities and bioinformatics data analysis tools. This book provides an exploration through the world of Bioinformatics Database Systems. The book summarizes the popular and innovative bioinformatics repositories currently available, including popular primary genetic and protein sequence databases, phylogenetic databases, structure and pathway databases, microarray databases and boutique databases. It also explores the data quality and information integration issues currently involved with managing bioinformatics databases, including data quality issues that have been observed, and efforts in the data cleaning field. Biological data integration issues are also covered in-depth, and the book demonstrates how data integration can create new repositories to address the needs of the biological communities. It also presents typical data integration architectures employed in current bioinformatics databases. The latter part of the book covers biological data mining and biological data processing approaches using cloud-based technologies. General data mining approaches are discussed, as well as specific data mining methodologies that have been successfully deployed in biological data mining applications. Two biological data mining case studies are also included to illustrate how data, query, and analysis methods are integrated into user-friendly systems. Aimed at researchers and developers of bioinformatics database systems, the book is also useful as a supplementary textbook for a one-semester upper-level undergraduate course, or an introductory graduate bioinformatics course. About the Authors Kevin Byron is a PhD candidate in the Department of Computer Science at the New Jersey Institute of Technology. Katherine G. Herbert is Associate Professor of Computer Science at Montclair State University. Jason T.L. Wang is Professor of Bioinformatics and Computer Science at the New Jersey Institute of Technology. |
| bmc shapiro: Pathogen Genomics: Empowering Infectious Disease Surveillance and Outbreak Investigations Marc Jean Struelens, Vitali Sintchenko, 2020-07-03 |
| bmc shapiro: Cumulative List of Organizations Described in Section 170 (c) of the Internal Revenue Code of 1954 , 2003 |
| bmc shapiro: Bioinformatics David Edwards, Jason Stajich, David Hansen, 2009-09-03 Bioinformatics is a relatively new field of research. It evolved from the requirement to process, characterize, and apply the information being produced by DNA sequencing technology. The production of DNA sequence data continues to grow exponentially. At the same time, improved bioinformatics such as faster DNA sequence search methods have been combined with increasingly powerful computer systems to process this information. Methods are being developed for the ever more detailed quantification of gene expression, providing an insight into the function of the newly discovered genes, while molecular genetic tools provide a link between these genes and heritable traits. Genetic tests are now available to determine the likelihood of suffering specific ailments and can predict how plant cultivars may respond to the environment. The steps in the translation of the genetic blueprint to the observed phenotype is being increasingly understood through proteome, metabolome and phenome analysis, all underpinned by advances in bioinformatics. Bioinformatics is becoming increasingly central to the study of biology, and a day at a computer can often save a year or more in the laboratory. The volume is intended for graduate-level biology students as well as researchers who wish to gain a better understanding of applied bioinformatics and who wish to use bioinformatics technologies to assist in their research. The volume would also be of value to bioinformatics developers, particularly those from a computing background, who would like to understand the application of computational tools for biological research. Each chapter would include a comprehensive introduction giving an overview of the fundamentals, aimed at introducing graduate students and researchers from diverse backgrounds to the field and bring them up-to-date on the current state of knowledge. To accommodate the broad range of topics in applied bioinformatics, chapters have been grouped into themes: gene and genome analysis, molecular genetic analysis, gene expression analysis, protein and proteome analysis, metabolome analysis, phenome data analysis, literature mining and bioinformatics tool development. Each chapter and theme provides an introduction to the biology behind the data describes the requirements for data processing and details some of the methods applied to the data to enhance biological understanding. |
| bmc shapiro: Ethical Considerations When Preparing a Clinical Research Protocol Evan DeRenzo, Eric A. Singer, Joel Moss, 2020-06-12 Ethical Considerations When Preparing a Clinical Research Protocol, Second Edition, provides a foundation for improving skills in the understanding of ethical requirements in the design and conduct of clinical research. It includes practical information on ethical principles in clinical research, how to design appropriate research studies, how to consent and assent documents, how to get protocols approved, special populations, confidentiality issues, and the reporting of adverse events. The book's valuable appendix includes a listing of web resources about research ethics, along with a glossary, making it an invaluable resource for scientists collaborating in clinical trials, physician investigators, clinical research fellows, and more. - Walks investigators and trainees through the identification of the ethical aspects of each section of a clinical research protocol - Includes case histories that illustrate key points - Contains information on conducting clinical research within the pharmaceutical industry - Includes internet resources and worldwide web addresses for important research ethics documents and regulations - Contains a chapter on Study Design and Methodology that is purposely expanded to explicitly address biostatistical considerations |
Automation, ITSM, ITOM, Observability, Mainframe – B…
Optimize technology and accelerate digital transformation with BMC’s solutions for automation, operations, service management, …
About BMC - BMC Software
BMC Cares Keeping sight of what really matters Our core values drive a desire to give back to the community through volunteer efforts, financial investments, and community partnerships that …
Leadership Team - BMC Software
BMC Leadership Meet the BMC leadership teams that are charting the path forward.
Software & Solutions - BMC Software
BMC solutions enable high-speed innovation, optimized infrastructure and cost, and a friction-free user …
Careers - BMC Software
It is the policy of BMC Software to afford equal opportunity for employment to all individuals regardless of race, color, sex, age, national origin, physical or mental …
Automation, ITSM, ITOM, Observability, Mainframe – BMC Software
Optimize technology and accelerate digital transformation with BMC’s solutions for automation, operations, service management, and enterprise-scale AI
About BMC - BMC Software
BMC Cares Keeping sight of what really matters Our core values drive a desire to give back to the community through volunteer efforts, financial investments, and community partnerships that …
Leadership Team - BMC Software
BMC Leadership Meet the BMC leadership teams that are charting the path forward.
Software & Solutions - BMC Software
BMC solutions enable high-speed innovation, optimized infrastructure and cost, and a friction-free user experience to help you succeed.
Careers - BMC Software
It is the policy of BMC Software to afford equal opportunity for employment to all individuals regardless of race, color, sex, age, national origin, physical or mental disability, history of …
BMC Announces the Creation of Two Independent Companies
Oct 9, 2024 · Both companies to build on industry-leading offerings to deliver even greater customer value and accelerate growth. HOUSTON - October 9, 2024 – BMC, a global leader in …
BMC Community Home - BMC Software
Connect. Learn. Grow. Connect with like-minded individuals, grow through shared experiences, and learn new skills that empower you to succeed.
IT Support Levels Clearly Explained: L1, L2, L3 & More
Oct 23, 2024 · As BMC and BMC Helix, we are committed to a shared purpose for customers in every industry and around the globe. BMC empowers 86% of the Forbes Global 50 to …
Artificial Intelligence - BMC Software
Accelerate business value, faster than humanly possible, with AI. BMC’s comprehensive portfolio of solutions enables organizations to drive business value by maximizing their data, keeping …
Product Trials and Demos - BMC Software
BMC helps customers run and reinvent their businesses with open, scalable, and modular solutions to complex IT problems.
