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| archean biologics: Ecosystem Dynamics in a Polar Desert , 1998 Presents information from the primary abiotic forces defining the system, and from the present hydrology, biogeochemistry and physics of major sites of organic carbon production of the McMurdo Dry Valleys. Additionally, research on the physical, chemical, and biological properties of the dry valley soils is included. The role of environmental management in long-term ecological studies is also addressed. The accompanying CDROM provides details and scale to visualize the McMurdo Dry Valleys from an ecosystem perspective. |
| archean biologics: Rare Earth Peter D. Ward, Donald Brownlee, 2007-05-08 In November 12, 2002, Dr. John Chambers of the NASA Ames Research Center gave a seminar to the Astrobiology Group at the University of Washington. The audience of about 100 listened with rapt attention as Chambers described results from a computer study of how planetary systems form. The goal of his research was to answer a deceptively simple question: How often would newly forming planetary systems produce Earth-like planets, given a star the size of our own sun? By “Earth-like” Chambers meant a rocky planet with water on its surface, orbiting within a star’s “habitable zone. ” This not-too-hot and not-too-cold inner region, relatively close to the star, supports the presence of liquid water on a planet surface for hundreds of million of years—the time-span probably necessary for the evolution of life. To answer the question of just how many Earth-like planets might be spawned in such a planetary system, Chambers had spent thousands of hours running highly sophisticated modeling programs through arrays of powerful computers. The results presented at the meeting were startling. The simulations showed that rocky planets orbiting at the “right” distances from the central star are easily formed, but they can end up with a wide range of water content. Earth seems to be quite a gem—a rocky planet where not only can liquid water exist for long periods of time, but where water can be found as a heathy oceanful—not too little and not too much. Our planet seems to reside in a benign region of the Galaxy, where comet and asteroid bombardment is tolerable and habitable-zone planets can commonly grow to Earth size. Such real estate in our galaxy—perhaps in any galaxy—is prime for life. And rare as well. |
| archean biologics: Government Reports Announcements & Index , 1984 |
| archean biologics: Encyclopedia of Biology Don Rittner, Timothy Lee McCabe, 2004-01 Contains approximately eight hundred alphabetical entries, prose essays on important topics, line illustrations, and black-and-white photographs. |
| archean biologics: Chemical, Mineralogical and Isotopic Studies of Diagenesis of Carbonate and Clastic Sediments Ihsan Al-Aasm, Howri Mansurbeg, 2021-06-10 Diagenesis of carbonates and clastic sediments encompasses the biochemical, mechanical, and chemical changes that occur in sediments subsequent to deposition and prior to low-grade metamorphism. These parameters which, to a large extent, control diagenesis in carbonates and clastic sediments include primary composition of the sediments, depositional facies, pore water chemistry, burial–thermal and tectonic evolution of the basin, and paleo-climatic conditions. Diagenetic processes involve widespread chemical, mineralogical, and isotopic modifications affected by the original mineralogy of carbonate and clastic sediments. These diagenetic alterations will impose a major control on porosity and permeability and hence on hydrocarbon reservoirs, water aquifers, and the presence of other important economic minerals. In this Special Issue, we have submissions focusing on understanding the interplay between the mineralogical and chemical changes in carbonates and clastic sediments and the diagenetic processes, fluid flow, tectonics, and mineral reactions at variable scales and environments from a verity of sedimentary basins. Quantitative analyses of diagenetic reactions in these sediments using a variety of techniques are essential for understanding the pathways of these reactions in different diagenetic environments. |
| archean biologics: Prebiotic Chemistry Peter Walde, 2005-10-13 |
| archean biologics: Microstructural Geochronology Desmond E. Moser, Fernando Corfu, James R. Darling, Steven M. Reddy, Kimberly Tait, 2017-11-23 Microstructural Geochronology Geochronology techniques enable the study of geological evolution and environmental change over time. This volume integrates two aspects of geochronology: one based on classical methods of orientation and spatial patterns, and the other on ratios of radioactive isotopes and their decay products. The chapters illustrate how material science techniques are taking this field to the atomic scale, enabling us to image the chemical and structural record of mineral lattice growth and deformation, and sometimes the patterns of radioactive parent and daughter atoms themselves, to generate a microstructural geochronology from some of the most resilient materials in the solar system. First compilation of research focusing on the crystal structure, material properties, and chemical zoning of the geochronology mineral archive down to nanoscale Novel comparisons of mineral time archives from different rocky planets and asteroids and their shock metamorphic histories Fundamentals on how to reconstruct and date radiogenic isotope distributions using atom probe tomography Microstructural Geochronology will be a valuable resource for graduate students, academics, and researchers in the fields of petrology, geochronology, mineralogy, geochemistry, planetary geology, astrobiology, chemistry, and material science. It will also appeal to philosophers and historians of science from other disciplines. |
| archean biologics: When Did Plate Tectonics Begin on Planet Earth? Kent C. Condie, Victoria Pease, 2008-01-01 Inspired by a GSA Penrose Conference held in Lander, Wyoming, June 14-18, 2006, this volume discusses the beginning and evolution of plate tectonics on Earth, and gives readers an introduction to some of the uncertainties and controversies related to the evolution of the planet. In the first three sections of the book, which cover isotopic, geochemical, metamorphic, mineralization, and mantle geodynamic constraints, a variety of papers address the question of when modern-style plate tectonics began on planet Earth. The next set of papers focuses on the geodynamic or geophysical constraints for the beginning of plate tectonics. The volume's final section synthesizes a broad range of evidence, from planetary analogues and geodynamic modeling, to Earth's preserved geologic record. This work provides an excellent graduate level text summarizing the current state of knowledge and will be of interest to a wide range of earth and planetary scientists.--Publisher's website. |
| archean biologics: Deep-Sea Sediments H. Huneke, T. Mulder, 2011-02-08 'Deep-Sea Sediments' focuses on the sedimentary processes operating within the various modern and ancient deep-sea environments. The chapters track the way of sedimentary particles from continental erosion or production in the marine realm, to transport into the deep sea, to final deposition on the sea floor. |
| archean biologics: Applications of Microanalytical Techniques to Understanding Mineralizing Processes Michael A. McKibben, 1998 |
| archean biologics: Atlas of Microbial Mat Features Preserved Within the Siliciclastic Rock Record Juergen Schieber, 2007 This book illustrates a wide geographic and stratigraphic range of the features and structures to be seen within the modern and preserved rock record which can be ascribed to the presence and/or influence of microbials mats; with an accent on the Precambrian record. It restricts to the siliciclastic rock record and equivalent modern settings. Much work by individuals and teams has been done on these features in the past decade but the general sedimentologist and geologist are not well informed or even aware of the range and importance of these structures. This book illustrates and fully describes all the relevant features, to accoutn for their genesis and to place their occurrence within a conceptual-process-related, and time-palaeoenvironmental context, as well considering their implications for sequence architecture. * The first full compilation of microbial mat features/structures preserved in the sliciclastic rock record * High quality, full color photographs fully support the text * Modern and ancient examples connect the formative processes and utilization of mat-related features in the interpretation of sedimentary rocks |
| archean biologics: Mantle Xenoliths Peter H. Nixon, 1987 The eruption of deep-seated xenoliths in basaltic, alnoitic, kimberlitic, etc volcanoes provides the geologist with an important direct means of examining the fragments of the earth's mantle and lower crust. |
| archean biologics: The Origin and Early Evolution of Life: Prebiotic Chemistry of Biomolecules Michele Fiore, 2019-10-29 Studying the origin of life is one of man’s greatest achievements over the last sixty years. The fields of interest encompassed by this quest are multiple and interdisciplinary: chemistry, physics, biology, biochemistry, mathematics, geology but also statistics, atmospheric science, meteorology, oceanography, and astrophysics. Recent scientific discoveries, such as water on Mars and the existence of super-Earths with atmospheres similar to primordial Earth, have pushed researchers to simulate prebiotic conditions in explaining the abiotic formation of molecules essential to life. This collection of articles offers an overview of recent discoveries in the field of prebiotic chemistry of biomolecules, their formation and selection, and the evolution of complex chemical systems. |
| archean biologics: Bibliography of Agriculture with Subject Index , 1995 |
| archean biologics: Microbial Biomass Process Technologies and Management Basanta Kumara Behera, Ajit Varma, 2017-07-12 This book describes how microbes can be used as effective and sustainable resources to meet the current challenge of finding suitable and economical solutions for biopharmaceuticals, enzymes, food additives, nutraceuticals, value added biochemicals and microbial fuels, and discusses various aspects of microbial regulatory activity and its applications. It particularly focuses on the design, layout and other relevant issues in industrial microbe applications. Moreover, it discusses the entire microbial-product supply chain, from manufacturing sites to end users, both in domestic and international markets, providing insights into the global marketing of microbes and microbial biomass-derived products. Further, it includes topics concerning the effective production and utilization of eco-friendly biotechnology industries. It offers a valuable, ready-to-use guide for technologists and policymakers developing new biotechnologies. |
| archean biologics: Altered Volcanic Rocks Cathryn Gifkins, Walter Herrmann, Ross R. Large, 2005-01-01 This book is about the processes and products of alteration in submarine volcanic successions. Its emphasis is on hydrothermal alteration associated with volcanic hosted massive sulfide deposits. |
| archean biologics: Life in the Solar System and Beyond Barrie W. Jones, 2013-11-27 In Life in the Solar System and Beyond, Professor Jones has written a broad introduction to the subject, addressing important topics such as, what is life?, the origins of life and where to look for extraterrestrial life. The chapters are arranged as follows: Chapter 1 is a broad introduction to the cosmos, with an emphasis on where we might find life. In Chapters 2 and 3 Professor Jones discusses life on Earth, the one place we know to be inhabited. Chapter 4 is a brief tour of the Solar system, leading us in Chapters 5 and 6 to two promising potential habitats, Mars and Europa. In Chapter 7 the author discusses the fate of life in the Solar system, which gives us extra reason to consider life further afield. Chapter 8 focuses on the types of stars that might host habitable planets, and where in the Galaxy these might be concentrated. Chapters 9 and 10 describe the instruments and techniques being employed to discover planets around other stars (exoplanetary systems), and those that will be employed in the near future. Chapter 11 summarizes the known exoplanetary systems, together with an outline of the systems we expect to discover soon, particularly habitable planets. Chapter 12 describes how we will attempt to find life on these planets, and the final chapter brings us to the search for extraterrestrial intelligence, and the question as to whether we are alone. |
| archean biologics: Protein Therapeutics, 2 Volume Set Tristan Vaughan, Jane Osbourn, Bahija Jallal, 2017-12-04 Branchenführende Big-Pharma-Unternehmen und erstklassige Forscher präsentieren grundlegende Konzepte und Herausforderungen bei proteinbasierten Pharmazeutika. Beinhaltet auch eine Einführung in die aus Sicht der Arzneimittelentwicklung fünf wesentlichen Anwendungsbereiche. |
| archean biologics: Subduction Zone Magmatism Yashiyuki Tatsumi, Stephen Eggins, 1995-06-15 Subduction zones are major sites of volcanism on the Earth. As one crustal plate sinks or is pushed beneath another, hot magma is produced and the resultant magma flux is fundamental to both the thermal evolution and chemical differentiation of the mantle and the Earth itself. To understand these evolutionary processes, we need to understand the physical and chemical consequences of all aspects of the subduction process. In this book, the authors present a simple, current and comprehensive model that explains the dominant geological processes at work in subduction zones. Structuring the book around the model, the authors describe the physical characteristics and geochemical dynamics of subduction zones, arc magma generation, and the dynamics and flow in the mantle. Students and researchers alike will find this book of immense value in understanding this most complex of subjects. |
| archean biologics: Preservation of Cultural Heritage and Resources Threatened by Climate Change Chiara Bertolin, 2019-08-13 With its wide spectrum of data, case studies, monitoring, and experimental and numerical simulation techniques, the multidisciplinary approach of material, environmental, and computer science applied to the conservation of cultural heritage offers several opportunities for the heritage science and conservation community to map and monitor state-of-the-art knowledge on natural and human-induced climate change impacts on cultural heritage—mainly constituted by the built environment—in Europe and Latin America. Geosciences’ Special Issue titled “Preservation of Cultural Heritage and Resources Threatened by Climate Change” was launched to take stock of the existing but still fragmentary knowledge on this challenge, and to enable the community to respond to the implementation of the Paris agreement. These 10 papers exploit a broad range of data derived from preventive conservation monitoring conducted indoors in museums, churches, historical buildings, or outdoors in archeological sites and city centers. Case studies presented in the papers focus on a well-assorted sample of decay phenomena occurring on heritage materials (e.g., surface recession and biomass accumulation on limestone, depositions of pollutant on marble, salt weathering on inorganic building materials, and weathering processes on mortars in many local- to regional-scale study areas in the Scandinavian Peninsula, the United Kingdom, Belgium, France, Italy, Greece, and Panama). Besides monitoring, the methodological approaches showcased include, but are not limited to, original material characterization, decay product characterization, and climate and numerical modelling on material components for assessing environmental impact and climate change effects. |
| archean biologics: The Ecology of Cyanobacteria B.A. Whitton, M. Potts, 2007-05-08 Cyanobacteria make a major contribution to world photosynthesis and nitrogen fixation, but are also notorious for causing nuisances such as dense and often toxic `blooms' in lakes and the ocean. The Ecology of Cyanobacteria: Their Diversity in Time and Space is the first book to focus solely on ecological aspects of these organisms. Its twenty-two chapters are written by some thirty authors, who are leading experts in their particular subject. The book begins with an overview of the cyanobacteria - or blue-green algae, for those who are not specialists - then looks at their diversity in the geological record and goes on to describe their ecology in present environments where they play important roles. Why is one of the key groups of organisms in the Precambrian still one of the most important groups of phototrophs today? The importance of ecological information for rational management and exploitation of these organisms for commercial and other practical purposes is also assessed. Accounts are provided of nuisances as well as the ecology of the commercially successful Spirulina and the role of cyanobacteria in ecosystem recovery from oil pollution. Many chapters include aspects of physiology, biochemistry, geochemistry and molecular biology where these help general understanding of the subject. In addition there are three chapters dealing specifically with molecular ecology. Thirty-two pages of colour photos incorporate about seventy views and light micrographs. These features make the book valuable to a wide readership, including biologists, microbiologists, geologists, water managers and environmental consultants. The book complements the highly successful The Molecular Biology of Cyanobacteria already published by Kluwer. |
| archean biologics: The Archaean Geology of the Kaapvaal Craton, Southern Africa Alfred Kröner, Axel Hofmann, 2019 This book provides a comprehensive overview of the evolution of one of the oldest and best-exposed Archaean cratons on this planet. There is currently a renewed interest in the early Earth, and the Kaapvaal craton has long served as a model for early crustal evolution. This unique multidisciplinary resource features information on geology, tectonics, geochemistry, and geochronology. It offers a wealth of new data on various aspects of the craton as well as contributions on the various crustal units by international specialists. |
| archean biologics: Handbook of Crystal Growth Tatau Nishinaga, 2014-11-04 Volume IAHandbook of Crystal Growth, 2nd Edition (Fundamentals: Thermodynamics and Kinetics) Volume IA addresses the present status of crystal growth science, and provides scientific tools for the following volumes: Volume II (Bulk Crystal Growth) and III (Thin Film Growth and Epitaxy). Volume IA highlights thermodynamics and kinetics. After historical introduction of the crystal growth, phase equilibria, defect thermodynamics, stoichiometry, and shape of crystal and structure of melt are described. Then, the most fundamental and basic aspects of crystal growth are presented, along with the theories of nucleation and growth kinetics. In addition, the simulations of crystal growth by Monte Carlo, ab initio-based approach and colloidal assembly are thoroughly investigated. Volume IBHandbook of Crystal Growth, 2nd Edition (Fundamentals: Transport and Stability) Volume IB discusses pattern formation, a typical problem in crystal growth. In addition, an introduction to morphological stability is given and the phase-field model is explained with comparison to experiments. The field of nanocrystal growth is rapidly expanding and here the growth from vapor is presented as an example. For the advancement of life science, the crystal growth of protein and other biological molecules is indispensable and biological crystallization in nature gives many hints for their crystal growth. Another subject discussed is pharmaceutical crystal growth. To understand the crystal growth, in situ observation is extremely powerful. The observation techniques are demonstrated. Volume IA - Explores phase equilibria, defect thermodynamics of Si, stoichiometry of oxides and atomistic structure of melt and alloys - Explains basic ideas to understand crystal growth, equilibrium shape of crystal, rough-smooth transition of step and surface, nucleation and growth mechanisms - Focuses on simulation of crystal growth by classical Monte Carlo, ab-initio based quantum mechanical approach, kinetic Monte Carlo and phase field model. Controlled colloidal assembly is presented as an experimental model for crystal growth. Volume IIB - Describes morphological stability theory and phase-field model and comparison to experiments of dendritic growth - Presents nanocrystal growth in vapor as well as protein crystal growth and biological crystallization - Interprets mass production of pharmaceutical crystals to be understood as ordinary crystal growth and explains crystallization of chiral molecules - Demonstrates in situ observation of crystal growth in vapor, solution and melt on the ground and in space |
| archean biologics: Iron Geochemistry: An Isotopic Perspective Clark Johnson, Brian Beard, Stefan Weyer, 2020-01-30 This book provides a comprehensive summary of research to date in the field of stable iron isotope geochemistry. Since research began in this field 20 years ago, the field has grown to become one of the major research fields in non-traditional stable isotope geochemistry. This book reviews all aspects of the field, from low-temperature to high-temperature processes, biological processes, and cosmochemical processes. It provides a detailed history and state-of-the art summary about analytical methods to determine Fe-isotope ratios and discusses analytical and sample prospects. |
| archean biologics: Etching of Crystals K. Sangwal, 2012-12-02 Defects in Solids, Volume 15: Etching of Crystals: Theory, Experiment, and Application focuses on the processes, reactions, and methodologies involved in the etching of crystals, including thermodynamics and diffusion. The publication first underscores the defects in crystals, detection of defects, and growth and dissolution of crystals. Discussions focus on thermodynamic theories, nature of pit sites, surface roughening during diffusion-controlled dissolution, growth controlled by simultaneous mass transfer and surface reactions, and chemical and thermal etching. The text then examines the theories of dissolution and etch-pit formation and the chemical aspects of the dissolution process, including catalytic reactions, dissolution of semiconductors, topochemical adsorption theories, and diffusion theories. The book tackles the solubility of crystals and complexes in solution and the kinetics and mechanism of dissolution. Topics include metallic crystals, semiconductors, stability of complexes, relationship between solubility, surface energy, and hardness of crystals, and solvents for crystals and estimation of crystal solubility in solvents other than water. The publication is a dependable source of data for readers interested in the etching of crystals. |
| archean biologics: Mineralogy of Noble Metals and “Invisible” Speciations of These Elements in Natural Systems, Volume II. Galina Palyanova, 2021 This Special Issue book includes one review and eleven research articles. This review presents the results of studies on the noble metal forms in pyrite, arsenopyrite, chalcopyrite, sphalerite, and greenockite and summarizes the distribution and speciations of noble metals in base metal sulfides of Au and Au-bearing deposits of the Urals (Russia). Nine research articles are devoted to studying gold mineralization at different types of gold deposits and the characterization of the conditions of its formation. The typomorphism of placer gold and its distribution mechanisms in the east of the Siberian Platform were studied, and the diagnostic method and morphogenetic criteria for identifying the genesis of placers and different sources in the platform areas were proposed in other research articles. One research article presents an experimental study of Pt solubility in a CO-CO2-rich fluid. These studies contribute to a better understanding of the behavior of Au, Ag, and other noble metals; their forms in ore-forming systems; and the genesis of ore deposits. I sincerely appreciate the efforts and contributions of the Authors and Reviewers and would also like to express gratitude to the Editor-in-Chief, other Editors, and Assistant Editors of Minerals for their help. |
| archean biologics: Biomedical Applications of Metals Mahendra Rai, Avinash P. Ingle, Serenella Medici, 2019-01-26 Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers. |
| archean biologics: Laser-ablation-ICPMS in the Earth Sciences Paul Joseph Sylvester, 2001 Accompanying CD-ROM titled: Short course volume 29, 2001 (to accompany Short course 40, 2008). |
| archean biologics: Arctic Hydrology, Permafrost and Ecosystems Daqing Yang, Douglas L. Kane, 2021 This book provides a comprehensive, up-to-date assessment of the key terrestrial components of the Arctic system, i.e., its hydrology, permafrost, and ecology, drawing on the latest research results from across the circumpolar regions. The Arctic is an integrated system, the elements of which are closely linked by the atmosphere, ocean, and land. Using an integrated system approach, the book's 30 chapters, written by a diverse team of leading scholars, carefully examine Arctic climate variability/change, large river hydrology, lakes and wetlands, snow cover and ice processes, permafrost characteristics, vegetation/landscape changes, and the future trajectory of Arctic system evolution. The discussions cover the fundamental features of and processes in the Arctic system, with a special focus on critical knowledge gaps, i.e., the interactions and feedbacks between water, permafrost, and ecosystem, such as snow pack and permafrost changes and their impacts on basin hydrology and ecology, river flow, geochemistry, and energy fluxes to the Arctic Ocean, and the structure and function of the Arctic ecosystem in response to past/future changes in climate, hydrology, and permafrost conditions. Given its scope, the book offers a valuable resource for researchers, graduate students, environmentalists, managers, and administrators who are concerned with the northern environment and resources. |
| archean biologics: Environmental Tracers Trevor Elliot, 2018-10-08 This book is a printed edition of the Special Issue Environmental Tracers that was published in Water |
| archean biologics: Radon: A Tracer for Geological, Geophysical and Geochemical Studies Mark Baskaran, 2016-08-19 This book reviews all the major research accomplishments and summarizes the different applications of radon. It serves as a solid reference book for researchers who are interested in the U-series radionuclides and noble gases as tracers and chronometers. Radon has been widely utilized as a powerful tracer to quantify a number of processes that include gas exchange rates between air and water, submarine groundwater discharge in coastal waters, water exchange between rivers and lakes, ocean circulation, hydrocarbon and uranium exploration. It is also used as an atmospheric tracer for the identification and quantification of air masses and as a tool for earthquake prediction, etc. A significant portion of the book presents state-of-the knowledge on indoor-radon-related health issues. Applications of the decay-series of Rn-222 are presented in a chapter. It serves as a reference and a state-of-the-art resource for researchers who want to learn the different applications of radon in Earth systems. |
| archean biologics: Biologics, Biosimilars, and Biobetters Iqbal Ramzan, 2021-02-03 A comprehensive primer and reference, this book provides pharmacists and health practitioners the relevant science and policy concepts behind biologics, biosimilars, and biobetters from a practical and clinical perspective. Explains what pharmacists need to discuss the equivalence, efficacy, safety, and risks of biosimilars with physicians, health practitioners, and patients about Guides regulators on pragmatic approaches to dealing with these drugs in the context of rapidly evolving scientific and clinical evidence Balances scientific information on complex drugs with practical information, such as a checklist for pharmacists |
| archean biologics: Marine Mineral Exploration H. Kunzendorf, 1986 Front Cover; Marine Mineral Exploration; Copyright Page; List of Contributors; Preface; Contents; CHAPTER 1. INTRODUCTION; CHAPTER 2. MARINE HARD MINERAL RESOURCES; CHAPTER 3. RESEARCH VESSELS AND SUBMERSIBLES; CHAPTER 4. MARINE GEOPHYSICAL EXPLORATION TECHNIQUES; CHAPTER 5. MARINE GEOCHEMICAL EXPLORATION METHODS; CHAPTER 6. DATA EVALUATION OF EXPLORATION SURVEYS; CHAPTER 7. MARINE MINERAL EXPLORATION EXAMPLES; CHAPTER 8. LEGAL ASPECTS OF MARINE MINERAL EXPLORATION. |
| archean biologics: Biologics and Biosimilars Xiaodong Feng, Hong-Guang Xie, Ashim Malhotra, Catherine F. Yang, 2022-06-13 Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs. |
| archean biologics: Biologics in General Medicine W.-H. Boehncke, H.H. Radeke, 2007-05-08 This is the first book to cover every angle in the clinical application of biologics. Readers will not only find that all of the biologics currently approved for clinical use are delineated in a standardized way, but also the differential therapy with biologics in fields including dermatology and neurology is described in detail and summarized in treatment algorithms. Shorter sections on biologic biotechnology as well as safety and regulatory issues complement the more clinically-oriented central chapters. |
| archean biologics: Infections Related to Biologics An Issue of Infectious Disease Clinics of North America Aruna K. Subramanian, Dora Ho, 2020-06-04 In collaboration with Consulting Editor Dr. Helen Boucher, Drs. Aruna Subramanian and Dora Yuk-Wai Ho have created an extremely timely and relevant issue for infectious disease physcians, as the field of biologics is exploding. These new agents are being used in rheumatologic diseases, hematologic malignancies, solid tumors, and other conditions; there is a lack of guidance in the literature on how to address their infectious risks. The first 9 articles explain the mechanisms of action of the biologic agents and the infectious disease risks associated with their immune system targets. The last few articles go into more depth on the viral, fungal, and mycobacterial infections that are potentiated by biologics, and discuss recommended prophylaxis and preventative strategies, including vaccinations. Specifically, articles are devoted to the following: TNF inhibitors; Agents targeting B cells; Agents targeting T cell activation; Direct T cell inhibition and agents targeting T cell migration and chemotaxis; IL-1 and IL-6 and other interleukin and IgE inhibition; Check-point inhibitors; Tyrosine kinase inhibitors for heme malignancies; EGFR inhibitors and other Tyrosine kinase inhibitors for solid tumors; Targeting JAK-STAT signaling and complement pathway for inflammatory diseases; Viral infections Potentiated by Biologics (and Prophylaxis); Endemic Fungal Infections Potentiated by Biologics (and prophylaxis); Mycobacterial Infections Potentiated by Biologics; and Vaccinations for patients on biologics. Readers will come away with the clinical overviews of these topics to improve prevention and management of patients treated with biologics. |
| archean biologics: Introduction to Biologic and Biosimilar Product Development and Analysis Karen M. Nagel, 2018-09-27 The purpose of this book is to give a concise introduction to development and analysis of pharmaceutical biologics for those in the pharmaceutical industry who are switching focus from small molecules to biologics processing, analysis, and delivery. In order to maintain a limited focus, Introduction to Biologic and Biosimilar Product Development and Analysis, will deal only with peptides, proteins and monoclonal antibodies. |
| archean biologics: Biosimilars Shein-Chung Chow, 2013-07-29 As many biological products face losing their patents in the next decade, the pharmaceutical industry needs an abbreviated regulatory pathway for approval of biosimilar drug products, which are cost-effective, follow-on/subsequent versions of the innovator’s biologic products. But scientific challenges remain due to the complexity of both the manufacturing process and the structures of biosimilar products. Written by a top biostatistics researcher, Biosimilars: Design and Analysis of Follow-on Biologics is the first book entirely devoted to the statistical design and analysis of biosimilarity and interchangeability of biosimilar products. It includes comparability tests of important quality attributes at critical stages of the manufacturing processes of biologic products. Connecting the pharmaceutical/biotechnology industry, government regulatory agencies, and academia, this state-of-the-art book focuses on the scientific factors and practical issues related to the design and analysis of biosimilar studies. It covers most of the statistical questions encountered in various study designs at different stages of research and development of biological products. |
| archean biologics: Biologics, A History of Agents Made From Living Organisms in the Twentieth Century Alexander von Schwerin, Heiko Stoff, Bettina Wahrig, 2015-10-06 The use of biologics – drugs made from living organisms – has raised specific scientific, industrial, medical and legal issues. The essays contained in this collection each deal with a case study of a biologic substance, or group of biologics, and its use during the twentieth century. |
| archean biologics: Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics Lisa M. Plitnick, Danuta Herzyk, 2013-06-27 Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics. - Provides in-depth coverage of the process of nonclinical safety assessment and comprehensive reviews of each type of biopharmaceutical - Contains the most pertinent international regulatory guidance documents for nonclinical evaluation - Covers early de-risking strategies and designs of safety assessment programs for novel biopharmaceuticals and vaccines, as well as follow-on biologics or biosimilars - A multi-authored book with chapters written by qualified experts in their respective fields |
Archean - Wikipedia
The Archean (IPA: / ɑːr ˈ k iː ə n / ar-KEE-ən, also spelled Archaean or Archæan), in older sources sometimes called the Archaeozoic, is the second of the four geologic eons of Earth's history, …
Archean Eon | Atmosphere, Timeline, and Facts | Britannica
The Archean Eon was preceded by the Hadean Eon, an informal division of geologic time spanning from about 4.6 billion to 4 billion years ago and characterized by Earth’s initial …
Archean - New World Encyclopedia
The Archean (or Archaean) eon is an interval of geologic time of about 1.4 billion years, beginning with the formation of Earth's crust and the oldest Earth rocks 3,960-3,800 million years ago …
What Happened in the Archean Eon? [4.0 to 2.5 billion years ago]
During the Archean Eon, which spanned from approximately 4 billion to 2.5 billion years ago, significant geological and biological events unfolded on Earth. Notably, this eon witnessed the …
What is Archean? - Earth.com
The Archean (formerly Archaeozoic) is a geologic eon between the Hadean and Proterozoic eons. The Archean Eon begins at roughly 3.8 billion years ago (Ga) and ends at about 2.5 Ga. But …
8.4: Archean Eon - Geosciences LibreTexts
The Archean Eon, which lasted from 4.0–2.5 billion years ago, is named after the Greek word for beginning. This eon represents the beginning of the rock record. Although there is current …
Introduction to the Archean Eon: Earth’s formative years
Sep 21, 2023 · Welcome to a journey back in time, where we explore the remarkable epoch known as the Archean Eon. This era, which spans roughly from 4 billion to 2.5 billion years …
Archean Eon summary | Britannica
Archean Eon, or Archaean Eon or Archeozoic Eon, Older of the two divisions of Precambrian time. The Archean begins with the formation of the Earth’s crust 4 billion years ago and …
The Archean Eon and the Hadean - University of California …
The Archean eon, which preceded the Proterozoic eon, spanned about 1.5 billion years and is subdivided into four eras: the Neoarchean (2.8 to 2.5 billion years ago), Mesoarchean (3.2 to …
The Archean Eon - Smithsonian Institution
The Archean Eon (4 to 2.5 billion years ago) During the Archean Eon, methane droplets in the air shrouded the young Earth in a global haze. There was no oxygen gas on Earth. Oxygen was …
Archean - Wikipedia
The Archean (IPA: / ɑːr ˈ k iː ə n / ar-KEE-ən, also spelled Archaean or Archæan), in older sources sometimes called the Archaeozoic, is the second of the four geologic eons of Earth's history, …
Archean Eon | Atmosphere, Timeline, and Facts | Britannica
The Archean Eon was preceded by the Hadean Eon, an informal division of geologic time spanning from about 4.6 billion to 4 billion years ago and characterized by Earth’s initial …
Archean - New World Encyclopedia
The Archean (or Archaean) eon is an interval of geologic time of about 1.4 billion years, beginning with the formation of Earth's crust and the oldest Earth rocks 3,960-3,800 million years ago …
What Happened in the Archean Eon? [4.0 to 2.5 billion years ago]
During the Archean Eon, which spanned from approximately 4 billion to 2.5 billion years ago, significant geological and biological events unfolded on Earth. Notably, this eon witnessed the …
What is Archean? - Earth.com
The Archean (formerly Archaeozoic) is a geologic eon between the Hadean and Proterozoic eons. The Archean Eon begins at roughly 3.8 billion years ago (Ga) and ends at about 2.5 Ga. But …
8.4: Archean Eon - Geosciences LibreTexts
The Archean Eon, which lasted from 4.0–2.5 billion years ago, is named after the Greek word for beginning. This eon represents the beginning of the rock record. Although there is current …
Introduction to the Archean Eon: Earth’s formative years
Sep 21, 2023 · Welcome to a journey back in time, where we explore the remarkable epoch known as the Archean Eon. This era, which spans roughly from 4 billion to 2.5 billion years …
Archean Eon summary | Britannica
Archean Eon, or Archaean Eon or Archeozoic Eon, Older of the two divisions of Precambrian time. The Archean begins with the formation of the Earth’s crust 4 billion years ago and …
The Archean Eon and the Hadean - University of California …
The Archean eon, which preceded the Proterozoic eon, spanned about 1.5 billion years and is subdivided into four eras: the Neoarchean (2.8 to 2.5 billion years ago), Mesoarchean (3.2 to …
The Archean Eon - Smithsonian Institution
The Archean Eon (4 to 2.5 billion years ago) During the Archean Eon, methane droplets in the air shrouded the young Earth in a global haze. There was no oxygen gas on Earth. Oxygen was …
