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| alan fersht book: Structure and Function of Intrinsically Disordered Proteins Peter Tompa, Alan Fersht, 2009-11-18 The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev |
| alan fersht book: Protein Physics Alexei V. Finkelstein, Oleg Ptitsyn, 2016-06-22 Protein Physics: A Course of Lectures covers the most general problems of protein structure, folding and function. It describes key experimental facts and introduces concepts and theories, dealing with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states. The book systematically summarizes and presents the results of several decades of worldwide fundamental research on protein physics, structure, and folding, describing many physical models that help readers make estimates and predictions of physical processes that occur in proteins. New to this revised edition is the inclusion of novel information on amyloid aggregation, natively disordered proteins, protein folding in vivo, protein motors, misfolding, chameleon proteins, advances in protein engineering & design, and advances in the modeling of protein folding. Further, the book provides problems with solutions, many new and updated references, and physical and mathematical appendices. In addition, new figures (including stereo drawings, with a special appendix showing how to use them) are added, making this an ideal resource for graduate and advanced undergraduate students and researchers in academia in the fields of biophysics, physics, biochemistry, biologists, biotechnology, and chemistry. - Fully revised and expanded new edition based on the latest research developments in protein physics - Written by the world's top expert in the field - Deals with fibrous, membrane, and water-soluble globular proteins, in both their native and denatured states - Summarizes, in a systematic form, the results of several decades of worldwide fundamental research on protein physics and their structure and folding - Examines experimental data on protein structure in the post-genome era |
| alan fersht book: The Selected Papers of Sir Alan Fersht Alan Fersht, 2010 The beginning of Sir Alan Fersht's career coincided with the birth of modern protein science based on structural biology, which started in earnest momentum in the 1960s. He worked in the then Mecca of molecular biology, and was one of the first protein chemists to exploit the new area of structural biology. The papers are interlaced with personal comments on how each article was important in his career and how he each article was important in his career and how he was influenced by the galaxy of legendary scientists in the MRC. --Book Jacket. |
| alan fersht book: Algorithms in Structural Molecular Biology Bruce R. Donald, 2023-08-15 An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins.Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field. |
| alan fersht book: Proteins Thomas E. Creighton, 1993 Organized on a combined basis of chronology and of structural and functional hierarchy, This comprehensive text describes all aspects of proteins--biosynthesis, evolution, dynamics, ligand binding, catalysis, and energy transduction--not just their structures. This edition (first was 1984) is thoroughly updated--especially in the area of protein biosynthesis--and features end-of-chapter exercises and problems, many of which require the student to consult the cited literature in order to obtain the answer. Annotation copyright by Book News, Inc., Portland, OR |
| alan fersht book: Handbook of Glycosyltransferases and Related Genes Naoyuki Taniguchi, Koichi Honke, Minoru Fukuda, 2011-06-28 The so-called postgenomic research era has now been launched, and the field of gly cobiology and glycotechnology has become one of the most important areas in life science because glycosylation is the most common post-translational modification reaction of proteins in vivo. On the basis of Swiss-Prot data, over 50% proteins are known to undergo glycosylation, but in fact the actual functions of most of the sugar chains in the glycoconjugates remain unknown. The complex carbohydrate chains of glycoproteins, glycolipids, and proteoglycans represent the secondary gene products formed through the reactions of glycosyl transferases. The regulation of the biosynthesis of sugar chains is under the control of the expression of glycosyltransferases, their substrate specificity, and their local ization in specific tissue sites. There is a growing body of evidence to suggest that these enzymes play pivotal roles in a variety of important cellular differentiation and developmental events, as well as in disease processes. Over 300 glycosyltransferases appear to exist in mammalian tissues. If the genes that have been purified and cloned from various species such as humans, cattle, pigs, rats and mice are counted as one, approximately 110 glycogenes that encode glycosyltransferases and related genes have been cloned at present, and this number continues to grow each day. However, most of the functions of the glycosyltransferase genes and related genes are unknown. This fact has stimulated numerous new and interesting approaches in molecular biologi cal investigations. |
| alan fersht book: Enzyme Kinetics and Mechanism Paul F. Cook, W. W. Cleland, 2007-03-06 Enzyme Kinetics and Mechanism is a comprehensive textbook on steady-state enzyme kinetics. Organized according to the experimental process, the text covers kinetic mechanism, relative rates of steps along the reaction pathway, and chemical mechanism—including acid-base chemistry and transition state structure. Practical examples taken from the literature demonstrate theory throughout. The book also features numerous general experimental protocols and how-to explanations for interpreting kinetic data. Written in clear, accessible language, the book will enable graduate students well-versed in biochemistry to understand and describe data at the fundamental level. Enzymologists and molecular biologists will find the text a useful reference. |
| alan fersht book: Protein Folding C. M. Dobson, A. R. Fersht, 1995 Discusses the molecular mechanisms controlling protein folding in vivo and in vitro. |
| alan fersht book: A Manual for Biochemistry Protocols Markus R. Wenk, Aaron Zefrin Fernandis, 2007 Biochemistry plays an important role in all areas of the biological and medical sciences. With most of the research or diagnosis involved in these areas being based on biochemically obtained observations, it is essential to have a profile of well standardized protocols.This manual is a basic guide for all students, researchers and experts in biochemistry, designed to help readers in directly starting off their experiments without prior knowledge of the protocol. The book dwells on the concepts used in designing the methodologies, thereby giving ample room for researchers to modify them according to their research requirements. |
| alan fersht book: Introduction to Proteins Amit Kessel, Nir Ben-Tal, 2018-03-22 Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercies, and References. New features in the thoroughly-updated second edition include: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms Animations of protein dynamics and conformational changes, accessible via embedded QR codes Additional features Extensive discussion of the energetics of protein folding, stability and interactions A comprehensive view of membrane proteins, with emphasis on structure-function relationship Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions Exploration of industrial applications of protein engineering and rational drug design Each chapter includes a Summary, Exercies, and References Approximately 300 color images Downloadable solutions manual available at www.crcpress.com For more information, including all presentations, tables, animations, and exercises, as well as a complete teaching course on proteins' structure and function, please visit the author's website: http://ibis.tau.ac.il/wiki/nir_bental/index.php/Introduction_to_Proteins_Book. Praise for the first edition This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins. This is a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure-function relationships. --David Sheehan, ChemBioChem, 2011 Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. This is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field. --Eric Martz, Biochemistry and Molecular Biology Education, 2012 |
| alan fersht book: Modeling Groundwater Flow and Contaminant Transport Jacob Bear, Alexander H.-D. Cheng, 2010-01-18 In many parts of the world, groundwater resources are under increasing threat from growing demands, wasteful use, and contamination. To face the challenge, good planning and management practices are needed. A key to the management of groundwater is the ability to model the movement of fluids and contaminants in the subsurface. The purpose of this book is to construct conceptual and mathematical models that can provide the information required for making decisions associated with the management of groundwater resources, and the remediation of contaminated aquifers. The basic approach of this book is to accurately describe the underlying physics of groundwater flow and solute transport in heterogeneous porous media, starting at the microscopic level, and to rigorously derive their mathematical representation at the macroscopic levels. The well-posed, macroscopic mathematical models are formulated for saturated, single phase flow, as well as for unsaturated and multiphase flow, and for the transport of single and multiple chemical species. Numerical models are presented and computer codes are reviewed, as tools for solving the models. The problem of seawater intrusion into coastal aquifers is examined and modeled. The issues of uncertainty in model input data and output are addressed. The book concludes with a chapter on the management of groundwater resources. Although one of the main objectives of this book is to construct mathematical models, the amount of mathematics required is kept minimal. |
| alan fersht book: Giant Molecules A. I?U. Grosberg, A. R. Khokhlov, Pierre-Gilles de Gennes, 2011 ?? Giant molecules are important in our everyday life. But, as pointed out by the authors, they are also associated with a culture. What Bach did with the harpsichord, Kuhn and Flory did with polymers. We owe a lot of thanks to those who now make this music accessible ??Pierre-Gilles de GennesNobel Prize laureate in Physics(Foreword for the 1st Edition, March 1996)This book describes the basic facts, concepts and ideas of polymer physics in simple, yet scientifically accurate, terms. In both scientific and historic contexts, the book shows how the subject of polymers is fascinating, as it is behind most of the wonders of living cell machinery as well as most of the newly developed materials. No mathematics is used in the book beyond modest high school algebra and a bit of freshman calculus, yet very sophisticated concepts are introduced and explained, ranging from scaling and reptations to protein folding and evolution. The new edition includes an extended section on polymer preparation methods, discusses knots formed by molecular filaments, and presents new and updated materials on such contemporary topics as single molecule experiments with DNA or polymer properties of proteins and their roles in biological evolution. |
| alan fersht book: Bioluminescence: Chemical Principles And Methods (3rd Edition) Osamu Shimomura, Ilia V Yampolsky, 2019-06-06 This book is the bible of bioluminescence and a must-read not only for the students but for those who work in various fields relating to bioluminescence. It summarizes current structural information on all known bioluminescent systems in nature, from well-studied ones to those that have been seldom investigated.This book remains an important source of chemical knowledge on bioluminescence and, since the second edition's publication in 2012, has been revised to include major developments in two systems: earthworm Fridericia and higher fungi whose luciferins have been elucidated and synthesized. These two new luciferins represent an essential addition to seven previously known, with fully rewritten sections covering this new subject matter. |
| alan fersht book: The P53 Family Arnold Jay Levine, David P. Lane, 2010 This volume offers a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, their evolution, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. |
| alan fersht book: Enzymes Robert A. Copeland, 2004-04-07 Fully updated and expanded-a solid foundation for understandingexperimental enzymology. This practical, up-to-date survey is designed for a broadspectrum of biological and chemical scientists who are beginning todelve into modern enzymology. Enzymes, Second Editionexplains the structural complexities of proteins and enzymes andthe mechanisms by which enzymes perform their catalytic functions.The book provides illustrative examples from the contemporaryliterature to guide the reader through concepts and data analysisprocedures. Clear, well-written descriptions simplify the complexmathematical treatment of enzyme kinetic data, and numerouscitations at the end of each chapter enable the reader to accessthe primary literature and more in-depth treatments of specifictopics. This Second Edition of Enzymes: A Practical Introductionto Structure, Mechanism, and Data Analysis features refinedand expanded coverage of many concepts, while retaining theintroductory nature of the book. Important new featuresinclude: A new chapter on protein-ligand binding equilibria Expanded coverage of chemical mechanisms in enzyme catalysisand experimental measurements of enzyme activity Updated and refined discussions of enzyme inhibitors andmultiple substrate reactions Coverage of current practical applications to the study ofenzymology Supplemented with appendices providing contact information forsuppliers of reagents and equipment for enzyme studies, as well asa survey of useful Internet sites and computer software forenzymatic data analysis, Enzymes, Second Edition isthe ultimate practical guide for scientists and students inbiochemical, pharmaceutical, biotechnical, medicinal, andagricultural/food-related research. |
| alan fersht book: Structure and Physics of Viruses Mauricio G. Mateu, 2013-06-04 This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdoctoral researchers with a university degree in biology, chemistry, physics or related scientific disciplines who share an interest or are actually working on viruses. We have aimed also at providing an updated account of many important concepts, techniques, studies and applications in structural and physical virology for established scientists working on viruses, irrespective of their physical, chemical or biological background and their field of expertise. We have not attempted to provide a collection of for-experts-only reviews focused mainly on the latest research in specific topics; we have not generally assumed that the reader knows all of the jargon and all but the most recent and advanced results in each topic dealt with in this book. In short, we have attempted to write a book basic enough to be useful to M.Sc and Ph.D. students, as well as advanced and current enough to be useful to senior scientists with an interest in Structural and/or Physical Virology. |
| alan fersht book: Evaluation of Enzyme Inhibitors in Drug Discovery Robert A. Copeland, 2013-03-18 Offers essential guidance for discovering and optimizing novel drug therapies Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid. This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time. Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers: Reversible modes of inhibitor interactions with enzymes Assay considerations for compound library screening Lead optimization and structure-activity relationships for reversible inhibitors Slow binding and tight binding inhibitors Drug-target residence time Irreversible enzyme inactivators The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development. The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields— from pharmacology to medicinal chemistry to biophysics to clinical medicine. |
| alan fersht book: Boron And Gadolinium Neutron Capture Therapy For Cancer Treatment Narayan S Hosmane, John A Maguire, Yinghuai Zhu, Masao Takagaki, 2012-03-07 The book focuses on two concurrent experimental therapies in cancer treatment known as boron neutron capture therapy (BNCT) and gadolinium neutron capture therapy (GdNCT) using a variety of boron- and gadolinium-based compounds. Some of the gadolinium compounds serve the dual purpose as being MRI contrast agents and GdNCT agents. The book describes why BNCT & GdNCT were not at the forefront of the clinical trials during the past seven to eight decades since the discovery of neutrons by John Chadwick in 1932 and how the latest development in the synthesis of target boron- and gadolinium-based drugs has turned the area into the hottest one worthy of further investigation with the new clinical trials in the USA and elsewhere. |
| alan fersht book: The Meaning of Success Jo Bostock, 2014-03-06 The Meaning of Success: Insights from Women at Cambridge makes a compelling case for a more inclusive definition of success. It argues that in order to recognise, reward and realise the talents of both women and men, a more meaningful definition of success is needed. Practical ways of achieving this are explored through interviews with female role models at the University of Cambridge. First-person stories bring alive the achievements and challenges women experience in their working lives, and the effect gender has on careers. The book stimulates a debate about how to bring about a more inclusive working environment. |
| alan fersht book: Handbook of Food Enzymology John R. Whitaker, Alphons G. J. Voragen, Dominic W.S. Wong, 2002-12-05 Discussing methods of enzyme purification, characterization, isolation, and identification, this book details the chemistry, behavior, and physicochemical properties of enzymes to control, enhance, or inhibit enzymatic activity for improved taste, texture, shelf-life, nutritional value, and process tolerance of foods and food products. The book cov |
| alan fersht book: Pocket Primary Care Meghan M. Kiefer, 2014-03-06 Support your clinical decision making and prepare for everyday challenges in the primary care setting with Pocket Primary Care, a brand new, pocket-sized loose-leaf resource that offers the most current, evidence-based approaches to delivering quality care in the outpatient setting. Representing the efforts of a dedicated team of primary care and specialist physicians at the Massachusetts General Hospital, this practical resource provides the key clinical data you need to manage your patients effectively and quickly. Gain insights into the most up-to-date evidence-based practices, accepted best practices, and expert opinions of physicians at Massachusetts General Hospital, including appropriate workups and when to refer. Quickly find the the information you need through tabs that make it easy to locate topics of interest. Customize the book to meet your specific needs by inserting your own notes into the 6-ring binder's front and back pockets, leaving out pages you don't need, or adding others to it. Get instant access to key clinical information on the most common issues seen in practice, including preventive medicine, cardiology, dermatology, endocrinology, GI, hematology, infectious disease, musculoskeletal complaints, neurology, ophthalmology, ENT, psychiatry, pulmonary, nephrology, women's health, men's health, and geriatrics. |
| alan fersht book: Fuzziness Monika Fuxreiter, Peter Tompa, 2012-03-07 Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions. |
| alan fersht book: Textbook Of Structural Biology (Second Edition) Anders Liljas, Lars Liljas, Goran Lindblom, Poul Nissen, Morten Kjeldgaard, Miriam-rose Ash, 2016-09-27 This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures. |
| alan fersht book: Molecules and Medicine E. J. Corey, Barbara Czakó, László Kürti, 2007-08-31 Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas. |
| alan fersht book: Outline of Crystallography for Biologists David Merwyn Blow, 2002-04-11 X-ray crystallography is the main method used to determine the structure of biological molecules. X-ray crystallography is explained without maths and reading this text allows biologists to assess the quality and accuracy of biological structures. |
| alan fersht book: Allosteric Regulatory Enzymes Thomas W. Traut, 2007-09-11 All enzymes are remarkable since they have the ability to increase the rate of a chemical reaction, often by more than a billion-fold. Allosteric enzymes are even more amazing because the have the additional ability to change their rate in response to cellular activators or inhibitors. This enables them to control the pathway in which they are the regulatory enzyme. Since the effector molecules represent the current status of the cell for a given metabolic pathway, this results in very responsive and balanced metabolic states, and makes it possible for cells and organisms to be appropriately dynamic, and responsive, in a changing environment. This book provides a logical introduction to the limits for enzyme function as dictated by the factors that are limits for life. This book presents a complete description of all the mechanisms used for changing enzyme acticity. Eight enzymes are used as model systems after extensive study of their mechanisms. Wherever possible, the human form of the enzyme is used to illustrate the regulatory features. |
| alan fersht book: Enzymes in Food Processing Gregory A. Tucker, L.F.J. Woods, 2012-12-06 Recent years have seen a rapid increase in the use of enzymes as food processing tools, as an understanding of their means of control has improved. Since publication of the first edition of this book many new products have been commercially produced and the corresponding number of published papers has swollen. This second edition has been fully revised and updated to cover changes in the last five years. It continues to provide food technologists, chemists, biochemists and microbiologists with an authoritative, practical and detailed review of the subject. |
| alan fersht book: Enzymic Catalysis Alan Fersht, David Gani, 1991 Ten papers from all areas of the study of enzymes - including chemistry, biochemistry, biophysics and molecular genetics. They were first presented at an international two-day meeting held at the Royal Society, and they discuss important advances made in all these areas in recent years. |
| alan fersht book: Structural Virology Mavis Agbandje-McKenna, Robert McKenna, 2010-11-11 Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area. |
| alan fersht book: Undeniable Douglas Axe, 2017-06-27 Named A Best Book of the Year by World Magazine Throughout his distinguished and unconventional career, engineer-turned-molecular-biologist Douglas Axe has been asking the questions that much of the scientific community would rather silence. Now, he presents his conclusions in this brave and pioneering book. Axe argues that the key to understanding our origin is the “design intuition”—the innate belief held by all humans that tasks we would need knowledge to accomplish can only be accomplished by someone who has that knowledge. For the ingenious task of inventing life, this knower can only be God. Starting with the hallowed halls of academic science, Axe dismantles the widespread belief that Darwin’s theory of evolution is indisputably true, showing instead that a gaping hole has been at its center from the beginning. He then explains in plain English the science that proves our design intuition scientifically valid. Lastly, he uses everyday experience to empower ordinary people to defend their design intuition, giving them the confidence and courage to explain why it has to be true and the vision to imagine what biology will become when people stand up for this truth. Armed with that confidence, readers will affirm what once seemed obvious to all of us—that living creatures, from single-celled cyanobacteria to orca whales and human beings, are brilliantly conceived, utterly beyond the reach of accident. Our intuition was right all along. |
| alan fersht book: Vintage Chess Sets of the United States Duncan Pohl, 2016-11-23 A detailed record of vintage chess sets produced or designed by American companies, artists and designers. |
| alan fersht book: Clinical Biochemistry John S. Varcoe, 2001 Clinical biochemistry is an analytical and interpretative science. The analytical part involves the determination of the level of chemical components in body fluids and tissues. The interpretative part examines these results and uses them in the diagnosis of disease, the screening for susceptibility to specific diseases, and the monitoring of the progress of treatment. This book is designed to cover the major techniques and analytical instruments used in clinical biochemistry.Each chapter of this book is based on a specific technique, or techniques, with associated instrumentation. These are discussed in some detail. A historical introduction is included for most of the techniques, and the current uses of the techniques are presented. Following that is a series of practical exercises. The first exercises in most of the chapters are a general introduction to the technique, leading to those with a clinical bias. Where applicable, the clinical practical exercises are associated with a case history and/or the discussion of the relevance of the assay to diagnosis and prognosis and to the monitoring of recovery. Each chapter concludes with a selection of appropriate references. |
| alan fersht book: Introduction to Proteins Amit Kessel, Nir Ben-Tal, 2010-12-17 As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online. |
| alan fersht book: Biophysical Chemistry James P. Allen, 2008-09-02 This text presents the subject of physical chemistry using a biological and biochemical approach. The treatment of the material is rigorous, but does not presume unrealistic prior knowledge of math concepts. |
| alan fersht book: Photosynthesis David W. Lawlor, 1993 Provides a simplified description of the partial process of photosynthesis at the molecular, organelle, cell and organ levels of organization in plants, which contribute to the complete process. It surveys effects of global environmental change, carbon dioxide enrichment and ozone depletion. |
| alan fersht book: Harper's Illustrated Biochemistry, 28th Edition Robert K. Murray, Victor W. Rodwell, David Bender, Kathleen M. Botham, P. Anthony Weil, Peter J. Kennelly, 2009-07-03 The biochemistry text that every medical student must own--now in full color! Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease. The Twenty-Eighth Edition has undergone sweeping changes -- including a conversion to full-color artwork and the substantial revision and updating of every chapter -- all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject. Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic. NEW to this edition: Full-color presentation, including 600+ illustrations Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered Two all-new chapters: Free Radicals and Antioxidant Nutrients and Biochemical Case Histories which offers an extensive presentation of 16 clinical conditions A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery |
| alan fersht book: The Aminoacyl-tRNA Synthetases Michael Ibba, 2005-04-01 By virtue of their role as catalysts of the aminoacylation reaction, the aminoacyl-tRNA synthetases ensure that the first step of translation is performed quickly and accurately. In this volume of 36 separate chapters, the many facets of this ancient and ubiquitous family are reviewed, including their surprising structural diversity, enzymology, tRNA interaction properties, and curious alternative functions. These chapters illustrate the degree to which the aminoacyl-tRNA synthetases employ a variety of mechanisms to carry out both the standard functions related to the synthesis of aminoacylated tRNA for protein synthesis, as well as the surprising functions associated with amino acid biosynthesis, cytokine function, and even the processivity of DNA replication. Other chapters explore the regulation of their synthesis, their role in disease, and their prospects as targets for antibacterial therapeutics. This monograph will be a valuable resource for all scientists interested in the fundamentals of protein synthesis from both a basic research and clinical perspective, as well as the relation of translational components to the evolution of the genetic code. |
| alan fersht book: Principles Biochem 7e (International Ed) David Nelson, Michael M. Cox, 2016-11-11 |
| alan fersht book: Structure and Mechanism in Protein Science Alan Fersht, 1999 Includes four new chapters which focus on the repercussions of protein engineering for protein folding and catalysis, this new edition is a more general guide to mechanism in protein science. |
Alan's Universe - YouTube
Alan's Universe is a drama series with powerful moral messages about love, friendships, and standing up for what's right. 📩 CONNECT WITH ME: IG: …
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May 21, 2025 · After decades of touring, Alan Jackson is bidding farewell to life on tour so he can focus on his health following his diagnosis of Charcot-Marie-Tooth (CMT) disease.
Alan (given name) - Wikipedia
Alan is a masculine given name in the English and Breton languages. Its surname form is Aland. [2] There is consensus that in modern English and French, the name is derived from the …
Meaning, origin and history of the name Alan - Behind the Name
May 30, 2025 · It was used in Brittany at least as early as the 6th century, and it could be of Brythonic origin meaning "little rock". Alternatively, it may derive from the tribal name of the …
Alan - Name Meaning, What does Alan mean? - Think Baby Names
Alan as a boys' name is pronounced AL-an. It is of Old German origin, and the meaning of Alan is "precious". From Adal. Also possibly derived from the Gaelic "ailin" meaning "little rock".
Your health partner who prevents, insures, and supports you daily - Alan
Alan enables everyone to take action on their physical and mental health, combining the best of prevention and insurance. More than 640,000 members and 27,000 companies take care of …
Alan - Name Meaning and Origin
The name Alan is of Celtic origin and means "handsome" or "harmony." It is derived from the Gaelic name "Ailin" or "Aluinn," which translates to "little rock" or "noble."
Alan - Meaning of Alan, What does Alan mean? - BabyNamesPedia
Alan is used chiefly in the Breton, English, German, and Scottish languages, and it is derived from Celtic origins. The name is of the meaning little rock; harmony, peace.
Alan - Baby Name Meaning, Origin, and Popularity - Nameberry
4 days ago · The name Alan is a boy's name of Irish origin meaning "handsome, cheerful". In its three most popular spellings -- Alan along with Allen and Allan -- this midcentury favorite has …
Alan Name Meaning, Origin, Popularity, Boy Names Like Alan
The name Alan is derived from the Old Welsh word “alun” which means “fair, bright, white”. In the Middle Ages, the name Alan was very common in England and Scotland, where it was used as …
Alan's Universe - YouTube
Alan's Universe is a drama series with powerful moral messages about love, friendships, and standing up for what's right. 📩 CONNECT WITH ME: IG: …
Alan Jackson Shares Update on Health and Nerve Disease …
May 21, 2025 · After decades of touring, Alan Jackson is bidding farewell to life on tour so he can focus on his health following his diagnosis of Charcot-Marie-Tooth (CMT) disease.
Alan (given name) - Wikipedia
Alan is a masculine given name in the English and Breton languages. Its surname form is Aland. [2] There is consensus that in modern English and French, the name is derived from the …
Meaning, origin and history of the name Alan - Behind the Name
May 30, 2025 · It was used in Brittany at least as early as the 6th century, and it could be of Brythonic origin meaning "little rock". Alternatively, it may derive from the tribal name of the …
Alan - Name Meaning, What does Alan mean? - Think Baby Names
Alan as a boys' name is pronounced AL-an. It is of Old German origin, and the meaning of Alan is "precious". From Adal. Also possibly derived from the Gaelic "ailin" meaning "little rock".
Your health partner who prevents, insures, and supports you daily - Alan
Alan enables everyone to take action on their physical and mental health, combining the best of prevention and insurance. More than 640,000 members and 27,000 companies take care of …
Alan - Name Meaning and Origin
The name Alan is of Celtic origin and means "handsome" or "harmony." It is derived from the Gaelic name "Ailin" or "Aluinn," which translates to "little rock" or "noble."
Alan - Meaning of Alan, What does Alan mean? - BabyNamesPedia
Alan is used chiefly in the Breton, English, German, and Scottish languages, and it is derived from Celtic origins. The name is of the meaning little rock; harmony, peace.
Alan - Baby Name Meaning, Origin, and Popularity - Nameberry
4 days ago · The name Alan is a boy's name of Irish origin meaning "handsome, cheerful". In its three most popular spellings -- Alan along with Allen and Allan -- this midcentury favorite has …
Alan Name Meaning, Origin, Popularity, Boy Names Like Alan
The name Alan is derived from the Old Welsh word “alun” which means “fair, bright, white”. In the Middle Ages, the name Alan was very common in England and Scotland, where it was used as …
