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| analysis of genes and genomes: Analysis of Genes and Genomes Richard J. Reece, 2004 Analysis of GenesA and Genomes is a clear introduction to the theoretical and practical basis of genetic engineering, gene cloning and molecular biology. All aspects of genetic engineering in the post-genomic era are covered, beginning with the basics of DNA structure and DNA metabolism. Using an example-driven approach, the fundamentals of creating mutations in DNA, cloning in bacteria, yeast, plants and animals are all clearly presented. Newer technologies such as DNA macro and macroarrays, proteomics and bioinformatics are introduced in later chapters helping students to analyse and understand the vast amounts of data that are now available through genome sequence and function projects. Aimed at students with a basic knowledge of the molecular side of biology, this will be invaluable to those looking to better understand the complexities and capabilities of these important new technologies. A modern post-genome era introduction to key techniques used in genetic engineering. An example driven past-to-present approach to allow the experiments of today to be placed in an historical context Beautifully illustrated in full colour throughout. Associated website including updates, additional content and illustrations |
| analysis of genes and genomes: Genetics Daniel L. Hartl, Elizabeth W. Jones, 2005 Biological Sciences |
| analysis of genes and genomes: Genetic Analysis Philip Mark Meneely, 2014 With its unique integration of genetics and molecular biology, this text probes fascinating questions that explore how our understanding of key genetic phenomena can be used to understand biological systems. Opening with a brief overview of key genetic principles, model organisms, and epigenetics, the book goes on to explore the use of gene mutations, the analysis of gene expression and activity, a discussion of the genetic structure of natural populations, and more. |
| analysis of genes and genomes: Genetics Daniel L. Hartl, Maryellen Ruvolo, 2012 |
| analysis of genes and genomes: Computational Genomics with R Altuna Akalin, 2020-12-16 Computational Genomics with R provides a starting point for beginners in genomic data analysis and also guides more advanced practitioners to sophisticated data analysis techniques in genomics. The book covers topics from R programming, to machine learning and statistics, to the latest genomic data analysis techniques. The text provides accessible information and explanations, always with the genomics context in the background. This also contains practical and well-documented examples in R so readers can analyze their data by simply reusing the code presented. As the field of computational genomics is interdisciplinary, it requires different starting points for people with different backgrounds. For example, a biologist might skip sections on basic genome biology and start with R programming, whereas a computer scientist might want to start with genome biology. After reading: You will have the basics of R and be able to dive right into specialized uses of R for computational genomics such as using Bioconductor packages. You will be familiar with statistics, supervised and unsupervised learning techniques that are important in data modeling, and exploratory analysis of high-dimensional data. You will understand genomic intervals and operations on them that are used for tasks such as aligned read counting and genomic feature annotation. You will know the basics of processing and quality checking high-throughput sequencing data. You will be able to do sequence analysis, such as calculating GC content for parts of a genome or finding transcription factor binding sites. You will know about visualization techniques used in genomics, such as heatmaps, meta-gene plots, and genomic track visualization. You will be familiar with analysis of different high-throughput sequencing data sets, such as RNA-seq, ChIP-seq, and BS-seq. You will know basic techniques for integrating and interpreting multi-omics datasets. Altuna Akalin is a group leader and head of the Bioinformatics and Omics Data Science Platform at the Berlin Institute of Medical Systems Biology, Max Delbrück Center, Berlin. He has been developing computational methods for analyzing and integrating large-scale genomics data sets since 2002. He has published an extensive body of work in this area. The framework for this book grew out of the yearly computational genomics courses he has been organizing and teaching since 2015. |
| analysis of genes and genomes: Advances in Animal Genomics Sukanta Mondal, Ram Lakhan Singh, 2020-11-25 Advances in Animal Genomics provides an outstanding collection of integrated strategies involving traditional and modern - omics (structural, functional, comparative and epigenomics) approaches and genomics-assisted breeding methods which animal biotechnologists can utilize to dissect and decode the molecular and gene regulatory networks involved in the complex quantitative yield and stress tolerance traits in livestock. Written by international experts on animal genomics, this book explores the recent advances in high-throughput, next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches which have enabled to produce huge genomic and transcriptomic resources globally on a genome-wide scale. This book is an important resource for researchers, students, educators and professionals in agriculture, veterinary and biotechnology sciences that enables them to solve problems regarding sustainable development with the help of current innovative biotechnologies. - Integrates basic and advanced concepts of animal biotechnology and presents future developments - Describes current high-throughput next-generation whole genome and transcriptome sequencing, array-based genotyping, and modern bioinformatics approaches for sustainable livestock production - Illustrates integrated strategies to dissect and decode the molecular and gene regulatory networks involved in complex quantitative yield and stress tolerance traits in livestock - Ensures readers will gain a strong grasp of biotechnology for sustainable livestock production with its well-illustrated discussion |
| analysis of genes and genomes: Essential Genes and Genomes Ren Zhang, 2021-10-29 This book provides state-of-the-art information on gene essentiality screenings in a wide variety of organisms, i.e. screening for protein-coding genes and other genomic elements that are required by an organism to survive under specific conditions. With a focus on the two techniques that have revolutionized the field, the collection begins with chapters employing CRISPR/Cas9-based approaches followed by Tn-seq-based approaches, but later chapters also delve into other techniques for exploring essential genes, such as bioinformatics methods. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Essential Genes and Genomes: Methods and Protocols is an ideal guide for researchers attempting to strip genetics down to its fundamentals. |
| analysis of genes and genomes: Analysis of Genes and Genomes Richard J. Reece, 2020-06-12 All aspects of genetic engineering in the post-genomic era are covered, beginning with the basics of DNA structure and DNA metabolism. Strong emphasis is placed on the latest, post genomic technologies including DNA macro and microarrays, genome-wide two hybrid analysis, proteomics and bioinformatics. An example driven past-to-present approach to allow the experiments of today to be placed in an historical context Associated website including updates, additional content and illusions |
| analysis of genes and genomes: From Genes to Genomes Jeremy W. Dale, Malcolm von Schantz, 2002-10-08 Rapid advances in our understanding of genetics have required that new books contain topics such as the concept and theory of gene cloning, transgenics, genomics, and various other coverage of traditional and contemporary subjects. Although there is an abundance of textbooks that cover introductory genetics and advanced courses in genetics, there is a noticeable gap at the intermediate (second year) level. In the past gene structure, function and expression were taught at final year /postgraduate level, but the rapid advances in our understanding of genetics has encouraged courses to change considerably. Over recent years these topics have filtered down the curriculum and are currently taught as core topics at second year, with a corresponding change in textbook requirements. Where once second year students were restricted to learning about the concept and theory of gene cloning, now they routinely clone genes for themselves as part of their practical assignments. Genes to Genomics will fill the gap, cover much of the same ground as previous titles, but go further on contemporary topics like transgenics, sequence comparison and analysis of variation. * A concise, up to date textbook that provides a balanced coverage of traditional and contemporary topics taught within intermediate courses in molecular genetics * Jeremy Dale has a proven track record as the successful author of Molecular Genetics of Bacteria * Genes to Genomics will include a series of feature box-outs that will examine some of the topical issues related to the scientific concepts and examples explored within the text * A range of questions and exercises including worked examples and web-based practicals * An accompanying web site will allow the authors to keep their audience up to date in the areas that are prone to date most rapidly between successive editions of the textbook. It will also include the illustrations and images from the textbook, in addition to worked examples, answers to questions within the book, and links to related websites of key interest. |
| analysis of genes and genomes: Genetic Analysis Philip Meneely, 2020 Genetic Analysis applies the combined power of molecular biology, genetics, and genomics to explore how the principles of genetics can be used as analytical tools to solve biological problems. This new edition: Illustrates the conceptual basis of key analytical tools with carefully selected examples from a range of model organisms, and encourages the reader to Look beyond the examples to see how these tools can be used to explore a wide range of biological questions, Covers the latest and most powerful experimental tools to provide a state-of-the-art review of the field, giving insights into gene networks and interactions, Includes extended case studies that enable the reader to fully get to grips with how genetic tools can be used to understand biological systems in the real world. New to This Edition: A new chapter on genome editing with focus on the CRISPR-Cas 9 system, New content on the analysis of gene activity using temperature-sensitive mutations and mosaics, Increased coverage of epigenetics, updated with the latest developments in the field, A new Learning feature called Literature Link, which connects each chapter's content to cutting-edge research. The online resources to accompany Genetic Analysis feature the following material for students and teachers: For students: Practice problems and solutions to test your knowledge of the concepts presented, and help you to master them, Online datasets with which to practise analytic techniques, For registered adopters of the book: Figures from the book in electronic format, ready to download, Journal clubs-suggested papers and discussion questions linked to topics covered in the book. Book jacket. |
| analysis of genes and genomes: From Genes to Genomes Jeremy W. Dale, Malcolm von Schantz, Nicholas Plant, 2011-12-12 The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics. |
| analysis of genes and genomes: Mapping and Sequencing the Human Genome National Research Council, Division on Earth and Life Studies, Commission on Life Sciences, Committee on Mapping and Sequencing the Human Genome, 1988-01-01 There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers. |
| analysis of genes and genomes: Genetics Daniel L. Hartl, Bruce Cochrane, 2017-12 |
| analysis of genes and genomes: Genetics Philip Mark Meneely, Rachel Dawes Hoang, Iruka N. Okeke, Katherine Heston, 2017 Genetics: Genes, Genomes, and Evolution unites evolution, genomics, and genetics in a single narrative approach. It is an approach that provides students with a uniquely flexible and contemporary view of genetics, genomics, and evolution. |
| analysis of genes and genomes: Scientific Frontiers in Developmental Toxicology and Risk Assessment National Research Council, Commission on Life Sciences, Board on Environmental Studies and Toxicology, Committee on Developmental Toxicology, 2000-12-21 Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians. |
| analysis of genes and genomes: Foundations of Comparative Genomics Arcady R. Mushegian, 2010-07-20 This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. - Presents an historic overview of genome biology and its achievements - Includes topics not covered in other books such as minimal and ancestral genomes - Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level - Critically reviews horizontal gene transfer and other contentious issues - Covers comparative virology as a somewhat overlooked foundation of modern genome science |
| analysis of genes and genomes: Genetics Daniel L. Hartl, 1994 |
| analysis of genes and genomes: Pan-genomics: Applications, Challenges, and Future Prospects Debmalya Barh, Siomar C. Soares, Sandeep Tiwari, Vasco Ariston De Car Azevedo, 2020-03-06 Pan-genomics: Applications, Challenges, and Future Prospects covers current approaches, challenges and future prospects of pan-genomics. The book discusses bioinformatics tools and their applications and focuses on bacterial comparative genomics in order to leverage the development of precise drugs and treatments for specific organisms. The book is divided into three sections: the first, an overview of pan-genomics and common approaches, brings the main concepts and current approaches on pan-genomics research; the second, case studies in pan-genomics, thoroughly discusses twelve case, and the last, current approaches and future prospects in pan-multiomics, encompasses the developments on omics studies to be applied on bacteria related studies. This book is a valuable source for bioinformaticians, genomics researchers and several members of biomedical field interested in understanding further bacterial organisms and their relationship to human health. - Covers the entire spectrum of pangenomics, highlighting the use of specific approaches, case studies and future perspectives - Discusses current bioinformatics tools and strategies for exploiting pangenomics data - Presents twelve case studies with different organisms in order to provide the audience with real examples of pangenomics applicability |
| analysis of genes and genomes: An Introduction to Human Molecular Genetics Jack J. Pasternak, 2005-06-03 An Introduction to Human Molecular Genetics Second Edition Jack J. Pasternak The Second Edition of this internationally acclaimed text expands its coverage of the molecular genetics of inherited human diseases with the latest research findings and discoveries. Using a unique, systems-based approach, the text offers readers a thorough explanation of the gene discovery process and how defective genes are linked to inherited disease states in major organ and tissue systems. All the latest developments in functional genomics, proteomics, and microarray technology have been thoroughly incorporated into the text. The first part of the text introduces readers to the fundamentals of cytogenetics and Mendelian genetics. Next, techniques and strategies for gene manipulation, mapping, and isolation are examined. Readers will particularly appreciate the text's exceptionally thorough and clear explanation of genetic mapping. The final part features unique coverage of the molecular genetics of distinct biological systems, covering muscle, neurological, eye, cancer, and mitochondrial disorders. Throughout the text, helpful figures and diagrams illustrate and clarify complex material. Readers familiar with the first edition will recognize the text's same lucid and engaging style, and will find a wealth of new and expanded material that brings them fully up to date with a current understanding of the field, including: * New chapters on complex genetic disorders, genomic imprinting, and human population genetics * Expanded and fully revised section on clinical genetics, covering diagnostic testing, molecular screening, and various treatments This text is targeted at upper-level undergraduate students, graduate students, and medical students. It is also an excellent reference for researchers and physicians who need a clinically relevant reference for the molecular genetics of inherited human diseases. |
| analysis of genes and genomes: Medical and Health Genomics Dhavendra Kumar, Stylianos Antonarakis, 2016-06-04 Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. - Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management - Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study - Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management - Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems |
| analysis of genes and genomes: Principles of Biology Lisa Bartee, Walter Shiner, Catherine Creech, 2017 The Principles of Biology sequence (BI 211, 212 and 213) introduces biology as a scientific discipline for students planning to major in biology and other science disciplines. Laboratories and classroom activities introduce techniques used to study biological processes and provide opportunities for students to develop their ability to conduct research. |
| analysis of genes and genomes: Genetics Daniel L. Hartl, Elizabeth W. Jones, 1998 |
| analysis of genes and genomes: Molecular Biology of the Cell , 2002 |
| analysis of genes and genomes: Making Sense of Genes Kostas Kampourakis, 2017-03-30 What are genes? What do genes do? These seemingly simple questions are in fact challenging to answer accurately. As a result, there are widespread misunderstandings and over-simplistic answers, which lead to common conceptions widely portrayed in the media, such as the existence of a gene 'for' a particular characteristic or disease. In reality, the DNA we inherit interacts continuously with the environment and functions differently as we age. What our parents hand down to us is just the beginning of our life story. This comprehensive book analyses and explains the gene concept, combining philosophical, historical, psychological and educational perspectives with current research in genetics and genomics. It summarises what we currently know and do not know about genes and the potential impact of genetics on all our lives. Making Sense of Genes is an accessible but rigorous introduction to contemporary genetics concepts for non-experts, undergraduate students, teachers and healthcare professionals. |
| analysis of genes and genomes: Genomics in Aquaculture Simon A MacKenzie, Sissel Jentoft, 2016-07-29 Genomics in Aquaculture is a concise, must-have reference that describes current advances within the field of genomics and their applications to aquaculture. Written in an accessible manner for anyone—non-specialists to experts alike—this book provides in-depth coverage of genomics spanning from genome sequencing, to transcriptomics and proteomics. It provides, for ease of learning, examples from key species most relevant to current intensive aquaculture practice. Its coverage of minority species that have a specific biological interest (e.g., Pleuronectiformes) makes this book useful for countries that are developing such species. It is a robust, practical resource that covers foundational, functional, and applied aspects of genomics in aquaculture, presenting the most current information in a field of research that is rapidly growing. - Provides the latest scientific methods and technologies to maximize efficiencies for healthy fish production, with summary tables for quick reference - Offers an extended glossary of technical and methodological terms to help readers better understand key biological concepts - Describes state-of-the-art technologies, such as transcriptomics and epigenomics, currently under development for future perspective of the field - Covers minority species that have a specific biological interest (e.g., Pleuronectiformes), making the book useful to countries developing such species |
| analysis of genes and genomes: Genome Data Analysis Ju Han Kim, 2019-04-30 This textbook describes recent advances in genomics and bioinformatics and provides numerous examples of genome data analysis that illustrate its relevance to real world problems and will improve the reader’s bioinformatics skills. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine learning algorithms using R and Python are demonstrated for gene-expression microarrays, genotyping microarrays, next-generation sequencing data, epigenomic data, and biological network and semantic analyses. In addition, detailed attention is devoted to integrative genomic data analysis, including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases. The textbook is primarily intended for life scientists, medical scientists, statisticians, data processing researchers, engineers, and other beginners in bioinformatics who are experiencing difficulty in approaching the field. However, it will also serve as a simple guideline for experts unfamiliar with the new, developing subfield of genomic analysis within bioinformatics. |
| analysis of genes and genomes: Human Genes and Genomes Leon E. Rosenberg, Diane Drobnis Rosenberg, 2012-05-21 In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor's office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines. - Bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease - Includes the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more - Explores ethical, legal, regulatory and economic aspects of genomics in medicine - Integrates historical (classical) genetics approach with the latest discoveries in structural and functional genomics |
| analysis of genes and genomes: The Barley Genome Nils Stein, Gary J. Muehlbauer, 2018-08-18 This book presents an overview of the state-of-the-art in barley genome analysis, covering all aspects of sequencing the genome and translating this important information into new knowledge in basic and applied crop plant biology and new tools for research and crop improvement. Unlimited access to a high-quality reference sequence is removing one of the major constraints in basic and applied research. This book summarizes the advanced knowledge of the composition of the barley genome, its genes and the much larger non-coding part of the genome, and how this information facilitates studying the specific characteristics of barley. One of the oldest domesticated crops, barley is the small grain cereal species that is best adapted to the highest altitudes and latitudes, and it exhibits the greatest tolerance to most abiotic stresses. With comprehensive access to the genome sequence, barley’s importance as a genetic model in comparative studies on crop species like wheat, rye, oats and even rice is likely to increase. |
| analysis of genes and genomes: The Grape Genome Dario Cantu, M. Andrew Walker, 2019-11-13 This book describes the current state of international grape genomics, with a focus on the latest findings, tools and strategies employed in genome sequencing and analysis, and genetic mapping of important agronomic traits. It also discusses how these are having a direct impact on outcomes for grape breeders and the international grape research community. While V. vinifera is a model species, it is not always appreciated that its cultivation usually requires the use of other Vitis species as rootstocks. The book discusses genetic diversity within the Vitis genus, the available genetic resources for breeding, and the available genomic resources for other Vitis species. Grapes (Vitis vinifera spp. vinifera) have been a source of food and wine since their domestication from their wild progenitor (Vitis vinifera ssp. sylvestris) around 8,000 years ago, and they are now the world’s most valuable horticultural crop. In addition to being economically important, V. vinifera is also a model organism for the study of perennial fruit crops for two reasons: Firstly, its ability to be transformed and micropropagated via somatic embryogenesis, and secondly its relatively small genome size of 500 Mb. The economic importance of grapes made V. vinifera an obvious early candidate for genomic sequencing, and accordingly, two draft genomes were reported in 2007. Remarkably, these were the first genomes of any fruiting crop to be sequenced and only the fourth for flowering plants. Although riddled with gaps and potentially omitting large regions of repetitive sequences, the two genomes have provided valuable insights into grape genomes. Cited in over 2,000 articles, the genome has served as a reference in more than 3,000 genome-wide transcriptional analyses. Further, recent advances in DNA sequencing and bioinformatics are enabling the assembly of reference-grade genome references for more grape genotypes revealing the exceptional extent of structural variation in the species. |
| analysis of genes and genomes: The Rye Genome M. Timothy Rabanus-Wallace, Nils Stein, 2021-10-25 This book celebrates the dawn of the rye genomics era with concise, comprehensive, and accessible reviews on the current state of rye genomic research, written by experts in the field for students, researchers and growers. To most, rye is the key ingredient in a flavoursome bread or their favourite American whisky. To a farmer, rye is the remarkable grain that tolerates the harshest winters and the most unforgiving soils, befitting its legacy as the life-giving seed that fed the ancient civilisations of northern Eurasia. Since the mid-1900s, scientists have employed genetic approaches to better understand and utilize rye, but only since the technological advances of the mid-2010s has the possibility of addressing questions using rye genome assemblies become a reality. Alongside the secret of its unique survival abilities, rye genomics has accelerated research on a host of intriguing topics such as the complex history of rye’s domestication by humans, the nature of genes that switch fertility on and off, the function and origin of accessory chromosomes, and the evolution of selfish DNA. |
| analysis of genes and genomes: Essential Genetics Daniel L. Hartl, Elizabeth W. Jones, 2006 Completely updated to reflect new discoveries and current thinking in the field, the Fourth Edition of Essential Genetics is designed for the shorter, less comprehensive introductory course in genetics. The text is written in a clear, lively, and concise manner and includes many special features that make the book user friendly. Topics were carefully chosen to provide a solid foundation for understanding the basic processes of gene transmission, mutation, expression, and regulation. The text also helps students develop skills in problem solving, achieve a sense of the social and historical context in which genetics has developed, and become aware of the genetic resources and information available through the Internet. |
| analysis of genes and genomes: Plant Genomes J. -N. Volff, M. Schmid, 2008-04-14 Recent major advances in the field of comparative genomics and cytogenomics of plants, particularly associated with the completion of ambitious genome projects, have uncovered astonishing facets of the architecture and evolutionary history of plant genomes. The aim of this book was to review these recent developments as well as their implications in our understanding of the mechanisms which drive plant diversity. New insights into the evolution of gene functions, gene families and genome size are presented, with particular emphasis on the evolutionary impact of polyploidization and transposable elements. Knowledge on the structure and evolution of plant sex chromosomes, centromeres and microRNAs is reviewed and updated. Taken together, the contributions by internationally recognized experts present a panoramic overview of the structural features and evolutionary dynamics of plant genomes. This volume of Genome Dynamics will provide researchers, teachers and students in the fields of biology and agronomy with a valuable source of current knowledge on plant genomes. |
| analysis of genes and genomes: Atlas of Mammalian Chromosomes Stephen J. O'Brien, Alexander S. Graphodatsky, Polina L. Perelman, 2020-04-02 THE UPDATED NEW EDITION OF THE POPULAR COLLECTION OF HIGH-RESOLUTION CHROMOSOME PHOTOGRAPHS FOR GENETICISTS, MAMMOLOGISTS, AND BIOLOGISTS INTERESTED IN COMPARATIVE GENOMICS, SYSTEMATICS, AND CHROMOSOME STRUCTURE Filled with a visually exquisite collection of the banded metaphase chromosome karyotypes from some 1,000 species of mammals, the Atlas of Mammalian Chromosomes offers an unabridged compendium of the state of this genomic art form. The Atlas??contains the best karyotype produced, the common and Latin name of the species, the published citation, and identifies the contributing authors. Nearly all karyotypes are G-banded, revealing the chromosomal bar codes of homologous segments among related species. The Atlas brings together information from a range of cytogenetic literature and features high-quality karyotype images for nearly every mammal studied to date. When the Atlas was first published, only three mammals were sequenced. Today, that number is over 300. Now in its second edition, this book contains extensive revisions and major additions such as new karyotypes that employ G- and C- banding to represent euchromatin and heterochromatin genome composition, new phylogenetic trees for each order, homology segment chromosome information on published aligned chromosome painting. Summaries of the painting data for some species indicate conserved homology segments among compared species. An invaluable resource for today's comparative genomics era, this comprehensive collection of high-resolution chromosome photographs: Assembles information previously scattered throughout the cytogenetics literature in one comprehensive volume Provides chromosome information and illustrations for the karyotypes of 300 new species Addresses the mandate of the Human Genome Project to annotate the genomes of other organisms Serves as a basis for chromosome-level genome assemblies Offers a detailed summation of three decades of ZooFish (chromosome painting) Presents high-resolution photos of karyotypes that represent more than 1,000 mammal species Written for geneticists, mammalogists, and biologists, the Atlas of Mammalian Chromosomes offers a step forward for an understanding of species formation, of genome organization, and of DNA script for natural selection. |
| analysis of genes and genomes: The Pangenome Hervé Tettelin, Duccio Medini, 2020-04-30 This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics. |
| analysis of genes and genomes: Clinical Genome Sequencing Aad Tibben, Barbara B. Biesecker, 2019-04-03 Clinical Genome Sequencing: Psychological Aspects thoroughly details key psychological factors to consider while implementing genome sequencing in clinical practice, taking into account the subtleties of genetic risk assessment, patient consent and best practices for sharing genomic findings. Chapter contributions from leading international researchers and practitioners cover topics ranging from the current state of genomic testing, to patient consent, patient responses to sequencing data, common uncertainties, direct-to-consumer genomics, the role of genome sequencing in precision medicine, genetic counseling and genome sequencing, genome sequencing in pediatrics, genome sequencing in prenatal testing, and ethical issues in genome sequencing. Applied clinical case studies support concept illustration, making this an invaluable, practical reference for this important and multifaceted topic area within genomic medicine. |
| analysis of genes and genomes: Nonmammalian Genomic Analysis Eric Hon Cheong Lai, 1996-01-01 Offering detailed protocols for those needing to construct a variety of maps and isolate genes, this unique book is intended to popularize the new techniques of genome analysis derived from the Human Genome Project. The power of these new methods is often most striking when applied to problems outside of human genetics, particularly the nonmammalian systems on which many researchers focus. Many of these organisms are economically important and biologically rich. Nonmammalian Genomic Analysis: A Practical Guide covers the how to aspects of preparation, handling, cloning, and analysis of large DNA and the creation of chromosome and genome maps. This lab manual facilitates the transfer of these technologies to small low tech environments and allows them to be used by those with no background in genome mapping or large-fragment cloning. Like having a local expert, this collection provides procedures for anyone, anywhere, and allows the replication of others' success. Key Features * Includes detailed and clearly-written step-by-step protocols * Evinces expected results and offers trouble shooting advice * Provides techniques appropriate for small laboratories as well as those with limited resources * Covers a broad variety of cloning systems, including single copy vectors * Discusses a diverse range of organisms, from prokaryotes to eukaryotes, from single-celled organisms to highly complex organisms |
| analysis of genes and genomes: Bioinformatics for Beginners Supratim Choudhuri, 2018-10-30 Bioinformatics for Beginners: Genes, Genomes, Molecular Evolution, Databases and Analytical Tools provides a coherent and friendly treatment of bioinformatics for any student or scientist within biology who has not routinely performed bioinformatic analysis. The book discusses the relevant principles needed to understand the theoretical underpinnings of bioinformatic analysis and demonstrates, with examples, targeted analysis using freely available web-based software and publicly available databases. Eschewing non-essential information, the work focuses on principles and hands-on analysis, also pointing to further study options. |
| analysis of genes and genomes: Genetic Variation Michael R. Barnes, Gerome Breen, 2014-10-20 “Your genome is an email attachment” What a difference a few years can make? In 2001, to a global fanfare, the completion of the frst draft sequence of the human genome was announced. This had been a Herculean effort, involving thousands of researchers and millions of dollars. Today, a project to re-sequence 1,000 genomes is well underway, and within a year or two, your own “personal genome” is likely to be available for a few thousand pounds, a price that will undoubtedly decrease further. We are fast approaching the day when your genome will be available as an email attachment (about 4 Mb). The key to this feat is the fact that any two human genomes are more than 99% identical, so rather than representing every base, there is really only a requirement to store the 1% of variable sequence judged against a common reference genome. This brings us directly to the focus of this edition of Methods in Molecular Biology, Genetic Variation. The human genome was once the focus of biology, but now individual genome var- tion is taking the center stage. This new focus on individual variation ultimately democ- tizes biology, offering individuals insight into their own phenotype. But these advances also raise huge concerns of data misuse, misinterpretation, and misunderstanding. The immediacy of individual genomes also serves to highlight our relative ignorance of human genetic variation, underlining the need for more studies of the nature and impact of genetic variation on human phenotypes. |
| analysis of genes and genomes: Ecological Genomics Christian R Landry, Nadia Aubin-Horth, 2013-11-30 Researchers in the field of ecological genomics aim to determine how a genome or a population of genomes interacts with its environment across ecological and evolutionary timescales. Ecological genomics is trans-disciplinary by nature. Ecologists have turned to genomics to be able to elucidate the mechanistic bases of the biodiversity their research tries to understand. Genomicists have turned to ecology in order to better explain the functional cellular and molecular variation they observed in their model organisms. We provide an advanced-level book that covers this recent research and proposes future development for this field. A synthesis of the field of ecological genomics emerges from this volume. Ecological Genomics covers a wide array of organisms (microbes, plants and animals) in order to be able to identify central concepts that motivate and derive from recent investigations in different branches of the tree of life. Ecological Genomics covers 3 fields of research that have most benefited from the recent technological and conceptual developments in the field of ecological genomics: the study of life-history evolution and its impact of genome architectures; the study of the genomic bases of phenotypic plasticity and the study of the genomic bases of adaptation and speciation. |
| analysis of genes and genomes: Cereal Genomics Robert J. Henry, Agnelo Furtado, 2013-11-16 In Cereal Genomics: Methods and Protocols, expert researchers provides modern protocols for the analysis and manipulation of cereal genomes. Techniques for isolation and analysis of DNA and RNA from both the vegetative tissues and from the more challenging seeds of cereals are described. Tools for the isolation, characterization and functional analysis of cereal genes and their transcripts are detailed. Methods for molecular screening of cereals and for their genetic transformation are also covered. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cereal Genomics: Methods and Protocols provides a comprehensive resource for those studying cereal genomes. |
analysis 与 analyses 有什么区别? - 知乎
也就是说，当analysis 在具体语境中表示抽象概念时，它就成为了不可数名词，本身就没有analyses这个复数形式，二者怎么能互换呢？ 当analysis 在具体语境中表示可数名词概念时（ …
Geopolitics: Geopolitical news, analysis, & discussion - Reddit
Geopolitics is focused on the relationship between politics and territory. Through geopolitics we attempt to analyze and predict the actions and decisions of nations, or other forms of political …
为什么很多人认为TPAMI是人工智能所有领域的顶刊？ - 知乎
Dec 15, 2024 · TPAMI全称是IEEE Transactions on Pattern Analysis and Machine Intelligence，从名字就能看出来，它关注的是"模式分析"和"机器智能"这两个大方向。这两个 …
Alternate Recipes In-Depth Analysis - An Objective Follow-up
Sep 14, 2021 · This analysis in the spreadsheet is completely objective. The post illustrates only one of the many playing styles, the criteria of which are clearly defined in the post - a middle of …
What is the limit for number of files and data analysis for ... - Reddit
Jun 19, 2024 · Number of Files: You can upload up to 25 files concurrently for analysis. This includes a mix of different types, such as documents, images, and spreadsheets. Data …
r/StockMarket - Reddit's Front Page of the Stock Market
Welcome to /r/StockMarket! Our objective is to provide short and mid term trade ideas, market analysis & commentary for active traders and investors. Posts about equities, options, forex, …
Is the Google data analytics certificate worth it? : r/analytics - Reddit
Aug 9, 2021 · This is a place to discuss and post about data analysis. Rules: - Comments should remain civil and courteous. - All reddit-wide rules apply here. - Do not post personal …
Rank the math courses you took in terms of difficulty
Math. Analysis 2 Numerical Analysis Signals and Systems Math. Analysis 1 Linear Algebra and Geometry Funnily enough here in Italy we dont really take specific diff eq or statistics courses.. …
I took and passed the PL-300 Microsoft Power BI Data Analyst
Using built on optimization analysis features Finally, like I mentioned earlier, at least 20% of the exam is focusing on Microsoft specific products, such as Understanding how Azure and both …
Are CFI certificates worth getting? : r/CFA - Reddit
Dec 7, 2021 · Additionally, it is mostly theoretical and doesn’t use applications such as Excel. While the FMVA® Course topics range from how to build a financial model to advanced …
Comparative analysis and phylogeny of mitochondrial …
The mitochondrial genomes contained 37 genes, including 13 protein-coding genes, two rRNA genes, 22 tRNA genes, and a control ... detailed analysis to date, which examined the phylogenetic
Comparative analysis of the chloroplast genomes of eight Piper
In phylogenetic analysis, barcodes or markers, including certain genes or certain fragments of genome sequences, are used to reconstruct relationships (de Vere et al., 2015; Liu et al.,
Comparative Analysis of Period Genes in Teleost Fish …
comparative analysis of per genes in the teleost fish. Here, interrogation of these five teleost genomes uncovered 19 fish per genes. Phylogenetic, splice site, and syntenic analyses were …
Metacaspase gene family in Rosaceae genomes: Comparative …
Microsynteny analysis of MC genes in Rosaceae genomes The microsynteny analysis of each MC gene was carried out using Microsyn software and MCScanX pipeline [43, 44], based on the …
Analysis of genes contributing to plant-beneficial functions in …
genomes), endophytes/symbionts (9 of 59 genomes) and animal pathogens (4 of 135 genomes), but were absent in plant pathogens. The distribution of certain PBFC genes according to bacterial
Comparative Analysis of Mitochondrial Genomes between the …
22 transfer RNA genes (tRNAs), and 3 ribosomal RNA genes (rRNAs) [23,29]. An explana- tion for this could be that the vast majority of mtDNA is composed of non-coding sequences
Genomes of Epinephelidae (Perciformes) - ResearchGate
Genes 2022, 13, 660 2 of 15 Molecular biology has been applied to the studies on the classification and phylogeny of fishes and has solved some taxonomic problems [13].
Genome-wide identification, characterization, and comparative …
Feb 3, 2022 · Phylogenetic analysis demonstrated orthologous NLRs shared between C. arabica and the parental genomes and those that were possibly lost. The NLR family members in coffee …
Comparative Analysis of the Complete Mitochondrial …
Alexander Kenechukwu et al. Mitochondrial Genomes for Development Application with other species. We also reconstructed phylogenetic tree based on PCG sequences for the purpose of …
Comparative and phylogenetic analysis of the complete
Osmanthus species. The chloroplast genomes of 15 Osmanthus species were 155,155 to 155,570 bp in length, which showed a typical quadripartite structure with high conservation of gene order …
KEGG: Kyoto Encyclopedia of Genes and Genomes - Kanehisa
Molecular network-based analysis of diseases, drugs, and environmental compounds Perturbants Perturbed system Molecular interaction network Molecular reaction network Environmental ...
Comparative analysis of codon usage patterns in …
Neutrality analysis showed that these cp genomes had a ... Effective number of codons (ENc)-plot analysis showed that most genes followed the parabolic line of trajectory, but
Comparative Analysis the Complete Chloroplast Genomes of …
from 167,975 to 172,653 bp, including 113 distinct genes comprising 79 protein-coding genes, 30 transfer RNA (tRNA) genes and four ribosomal RNA (rRNA) genes. In comparative analysis, we …
Comparative analysis of the chloroplast genomes of Rosa
The chloroplast genomes of R. rubiginosa, R. hybrida, and R. acicularis were conserved and contained 115 unique genes, of which 80 were protein-coding genes, 31 were transfer RNA …
Genome-wide analysis of the basic leucine zipper (bZIP) …
Keywords: bZIP gene family, Legume genomes, Evolution, Expression analysis * Correspondence: leiyong@caas.cn; lboshou@hotmail.com Key Laboratory of Biology and Genetic Improvement of …
Genomic analysis of almost 8,000 Salmonella genomes
Genomic analysis of almost 8,000 Salmonella genomes reveals ... resistance genes positive Salmonella isolates out of 7,997 isolates. We further uncov ... of 2,610 genomes, accounting for …
A snakemake toolkit for the batch assembly, annotation, and ...
Apr 3, 2024 · phylogenetic analysis of mitochondrial genomes and nuclear ribosomal genes, respectively, from low-coverage genome skims. The third pipeline gene2phylo takes a set of …
OPEN High throughput ANI analysis of 90K prokaryotic …
identity of all orthologous genes shared between any two genomes and offers robust resolution between strains of the same or closely related species (i.e., showing 80 100% ANI).
Sisoridae Sisoridae (Osteichthyes, Siluriformes) and the …
Pa ge 1/ 15 Comparative analysis of the complete mitochondrial genomes of three Sisoridae (Osteichthyes, Siluriformes) and the phylogenetic relationships of
Pan-cancer analysis of whole genomes - bioRxiv
Jul 12, 2017 · research to define the catalogue of genes and mutations that can drive cancer. This has been accelerated by technological advances in genomic analysis, from gross descriptions of …
Genomes and Their Evolution - Central Bucks School District
The more similar in sequence the genes and genomes of two species, the more closely related those ... Molecular analysis has shown that these genes all include a 180-nucleotide sequence …
In Silico Analysis of CCGAC and CATGTG Cis-regulatory
Functional analysis on stress-regulated genes for saline, osmotic, and heat stress clearly shows that these motif frequencies with inter motif distance (0-30) in the promoter region of Arabi-
Comparative Analysis of the Small Heat Shock Proteins in …
phylogenetic analysis has identified four additional plant sHSP subfamilies and thus has increased the number of plant sHSP subfamilies from 7 to 11. We have also identified a number of novel …
Analysis of synonymous codon usage patterns in …
mitochondrial coding genes obtained were further screened, and those with sequences less than 100 coding amino acids were excluded from downstream analysis (Bu et al., 2021). Finally, we …
Citrus sucrose transporter genes: genome-wide identification …
ORIGINAL ARTICLE Citrus sucrose transporter genes: genome-wide identification and transcript analysis in ripening and ABA-injected fruits Mohammad Zahidul Islam 1,2,3 & Long-Fei Jin1,2 & …
Forecasting the dissemination of antibiotic resistance genes …
representing 7 phyla and ~40% of the genomes in the database (Fig. 1c). These genomes contained a median of four resistance genes predicted with high confidence to be horizontally transferred ...
Environmental genes and genomes: understanding the …
Environmental genes and genomes: understanding the differences and challenges in the approaches and software for their analyses Marie Lisandra Zepeda Mendoza, Thomas Sicheritz …
Comparative analysis of mitochondrial genomes of two alpine …
A homologous comparison was carried out to predict the genes of genomes. The protein sequences of the NCBI mitochondrial reference genome were compared to genomes of the samples using …
Presence of elsinochrome and other putative effectors in select …
spp. genomes, with considerable variation between species. Ontology analysis revealed putative genes related to toxin activity, detoxification, and carbohydrate binding in Elsinoë. Furthermore, …
Comprehensive analysis of Mycobacterium tuberculosis …
Oct 28, 2024 · Article Comprehensive analysis of Mycobacterium tuberculosis genomes reveals genetic variations in bacterial virulence Wittawin Worakitchanon,1 Hideki Yanai,2 Pundharika …
comprehensive Analysis of sialyltransferases in Vertebrate …
in Vertebrate Genomes ... comprehensive finding and analysis of glycosyltrans-ferase genes.1,3,5–7 Vertebrate sialyltransferase genes represent a multigene super-family of homologous
Comparative Analysis of Chloroplast Genomes: Functional …
tion of the arrangement or order of genes in genomes by gene-cluster analysis history (Stoebe and Kowallik 1999). However, such analysis are usually carried out with some par-ticular sets of …
Comparative analysis of chloroplast genomes on Meliaceae …
These cp genomes contained a total of 135 unique genes, comprising 90 protein-coding, 8 rRNA, and 37 tRNA genes. Divergence time estimation revealed that the Meliaceae family diverged into …
Analysis of six chloroplast genomes provides insight into
genomes, plus four Saxifragaceae chloroplast genomes from GenBank. Then, we constructed a phylogeny of Chrysosplenium using chloroplast genomes of 29 species within Saxifragales and …
Comparative Chloroplast Genome Analysis of Suaeda …
circular genomes are about 120-160 kb in size [5] and are highly conserved in higher plants [3]. ... Genome comparison was conducted by sequence analysis of genes as well as the determination …
The complete chloroplast genomes and phylogenetic analysis …
In this study, the complete chloroplast genomes of E. longipe-tala and E. populnea were reported for the first time. Both chloroplast genomes contained 114 unique genes, including 80 protein …
Analysis of 10,478 cancer genomes identifies candidate …
Analysis of Whole Genomes analysis12, the 100kGP cohort was better powered to identify a driver mutation for 19 cancers, notably for breast, colorectal, esophageal and uterine cancer, lung ...
Genome-wide analysis of luhya and maasai genomes reveals …
Feb 20, 2017 · Citation: Ngeno K. Genome-wide analysis of luhya and maasai genomes reveals signatures of selection for fertility, prostate cancer, prostatitis and vein disease. J Cancer Prev …
Characterization and Comparative Analysis of Mitochondrial …
genes’ (PCGs’) sequence conservatism has become a powerful marker for phylogenetic relationships, evolutionary biology, specimen identification, and comparative genomics analysis
Analyses of pig genomes provide insight into porcine ... - Nature
Because many immune genes were not included in the analysis of 1:1 orthologues, we examined a randomly selected subset of 158 immunity-related pig proteins for evidence of accelerated …
Genes and Genomes. By Maxine Singer and Paul Berg.
Genes and Genomes. By MAXIN SINGEE anR PAUd L BERG. Blackwell Scientific Publications Ltd. 1991. 929 pages. £27.50. ISB 0N 632 02879 3. Genes and Genomes is one of those large and …
Pan-Genome-Wide Identification and Transcriptome-Wide …
Transcriptome-Wide Analysis of DREB Genes That Respond to Biotic and Abiotic Stresses in Cucumber. ... In this study, we identified 55 CsDREBs from the cucumber pan-genomes of 13 …
The 1000 Genomes Project - National Human Genome …
– Pilot 3: 1000 genes in 1000 people – Test multiple platforms/protocols – Develop and evaluate methods for data collection and analysis Started Feb 2008, ~ 300 Gb data already CEU trio …
How many single-copy orthologous genes from whole …
release of high-quality genomes, orthologous genes can be better identified and serve as powerful candidates for phylogenetic analysis. The question is, given the current limitations on the taxon …
Comparative Analysis of Six Lagerstroemia Complete …
Xu et al. Comparative Analysis - Lagerstroemia. cp Genomes FIGURE 1 | Gene map of. Lagerstroemia. chloroplast genome. The genes inside and outside of the circle are transcribed in …
KEGG: Kyoto Encyclopedia of Genes and Genomes
Sequence Analysis BLAST / FASTA - Sequence similarity search MOTIF - Sequence motif search CLUSTALW / MAFFT / PRRN - Multiple alignment ... Genomes Genes Genes with KO KO …
Comparative analysis of codon usage patterns in chloroplast …
more than 2000 plants chloroplast genomes have been published on NCBI, such as EuphorbiaJatropha [12], [13] and Ricinus [14]. ere are three dierent types of chloroplast genes: …
Comparative analysis of chloroplast genomes in Commiphora …
Comparative analysis of chloroplast genomes in Commiphora gileadensis from Saudi Arabia and Oman reveal evolutionary genetic divergence abeer l-aandal department of Biology, College of …
RESEARCH Open Access Comparative analysis of the …
A total of 31 protein-coding genes, 20 tRNAs and 4 rRNA genes, including one pseudogene (rpl16), were annotated in the mitogenome (Table 1). ere were eight genes contain introns and the …
Network-based microsynteny analysis identifies major …
A comprehensive analysis of relative gene order, or microsynteny, can provide valuable information for understanding the evolu-tionary history of genes and genomes, and ultimately traits and …
