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| albert bendelac death: Environmental Health Perspectives , 1996 |
| albert bendelac death: A Historical Perspective on Evidence-Based Immunology Edward J. Moticka, 2015-11-25 A Historical Perspective on Evidence-Based Immunology focuses on the results of hypothesis-driven, controlled scientific experiments that have led to the current understanding of immunological principles. The text helps beginning students in biomedical disciplines understand the basis of immunologic knowledge, while also helping more advanced students gain further insights. The book serves as a crucial reference for researchers studying the evolution of ideas and scientific methods, including fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, the generation of diversity and mechanism of tolerance of T cells and B cells, the first cytokines, the concept of autoimmunity, the identification of NK cells as a unique cell type, the structure of antibody molecules and identification of Fab and Fc regions, and dendritic cells. - Provides a complete review of the hypothesis-driven, controlled scientific experiments that have led to our current understanding of immunological principles - Explains the types of experiments that were performed and how the interpretation of the experiments altered the understanding of immunology - Presents concepts such as the division of lymphocytes into functionally different populations in their historical context - Includes fundamental insights on immunologic tolerance, interactions of lymphocytes with antigen TCR and BCR, and the generation of diversity and mechanism of tolerance of T and B cells |
| albert bendelac death: Science John Michels (Journalist), 2002 A weekly record of scientific progress. |
| albert bendelac death: The Journal of Immunology , 2008 |
| albert bendelac death: Epidermal Langerhans Cells Gerold Schuler, 1990-12-26 Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells. |
| albert bendelac death: Multiple Sclerosis Institute of Medicine, Board on Neuroscience and Behavioral Health, Committee on Multiple Sclerosis: Current Status and Strategies for the Future, 2001-07-10 Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families. |
| albert bendelac death: Mozart's Grace Scott G. Burnham, 2013 Concentrating on music's effects, this book focuses on the most important elements of Mozart's music. Moving beyond conventional analysis and using the figurative powers of language with skill and imagination, this book engages musical issues such as sonority, texture, line, harmony, dissonance, and timing, and aspects of large-scale form such as thematic returns, retransitions, and endings. |
| albert bendelac death: Cancer Immunology and Immunotherapy Glenn Dranoff, 2011-04-11 The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment. |
| albert bendelac death: Papillomaviruses and Human Disease Kari J. Syrjänen, Lutz Gissmann, Leopold G. Koss, MD, FCRP, 2012-12-06 In recent years, papillomaviruses in general and human papillo maviruses in particular have been recognized as possible agents of important diseases, including some forms of human cancer. The purpose of this book is to present a concise panorama of the pre sent status of knowledge of this topic. This knowledge is as impor tant to molecular biologists and virologists as it is to clinicians and pathologists. To bridge the gap among these diverse groups of investigators, we conceived of a book covering a broad spectrum of the basic scientific, clinical, and pathological aspects of diseases associated with papillomaviruses. Although the principal thrust of this book is directed at human papillomaviruses, fundamental knowledge of animal viruses is essential to the current understand ing of the molecular mechanisms of cell transformation. For this reason, a chapter on animal viruses has also been included. Some of the experimental work having to do with the elucidation of transformation and other aspects of interaction between the virus and the cell cannot be based on human papillomaviruses because of a lack of suitable experimental models. Hence, some of the chapters dealing with fundamental aspects of viral molecular biol ogy are based on animal models. We were very fortunate in having persuaded a number of distin guished colleagues to contribute to this work. |
| albert bendelac death: Skin and Arthropod Vectors Nathalie Boulanger, 2018-01-20 Approx.500 pagesApprox.500 pages |
| albert bendelac death: Progress in Basic and Clinical Immunology Andrzej Mackiewicz, Maciej Kurpisz, Jan Zeromski, 2001-12-31 Progress in Basic and Clinical Immunology is a result of the 14th European Immunology Meeting - EFIS 2000, held in Poznan, Poland, on 23-27 September 2000. EFIS 2000 gathered over 1400 immunologists from all over the world. It was an exceptionally memorable meeting for a number of reasons: 1) it was held in the last year of the century and the millennium, thus provoking conclusions of past achievements of immunology and projections for the future; 2) it was held in Poland, a country that is a symbol of struggle for freedom for a large number of scientists originating from the `Eastern Bloc' countries; and 3) EFIS celebrated its 25th anniversary at this occasion. This comprehensive volume contains 62 chapters grouped into 11 sections: T-cells, Immune Receptors, Antigen Presentation/Dendritic Cells, Cytokines, Immunodeficiencies, Autoimmunity, Allergy/Inflammation, Immunotherapy, Vaccines, Tumor Immunology, and Cancer Immunotherapy. |
| albert bendelac death: Kuby Immunology Jenni Punt, Sharon Stranford, Patricia Jones, Judith A Owen, 2018-06-21 Janis Kuby’s groundbreaking introduction to immunology was the first textbook for the course actually written to be a textbook. Like no other text, it combined an experimental emphasis with extensive pedagogical features to help students grasp basic concepts. Now in a thoroughly updated new edition, Kuby Immunology remains the only undergraduate introduction to immunology written by teachers of the course. In the Kuby tradition, authors Judy Owen, Jenni Punt, and Sharon Stranford present the most current concepts in an experimental context, conveying the excitement of scientific discovery, and highlight important advances, but do so with the focus on the big picture of the study of immune response, enhanced by unsurpassed pedagogical support for the first-time learner. |
| albert bendelac death: Pediatric Hepatology and Liver Transplantation Lorenzo D'Antiga, 2019-04-29 This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers. |
| albert bendelac death: Modification of Radiation Response Carsten Nieder, 2003 This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology are reviewed in depth. The book covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects. |
| albert bendelac death: Surfing Uncertainty Andy Clark, 2015-10-02 How is it that thoroughly physical material beings such as ourselves can think, dream, feel, create and understand ideas, theories and concepts? How does mere matter give rise to all these non-material mental states, including consciousness itself? An answer to this central question of our existence is emerging at the busy intersection of neuroscience, psychology, artificial intelligence, and robotics. In this groundbreaking work, philosopher and cognitive scientist Andy Clark explores exciting new theories from these fields that reveal minds like ours to be prediction machines - devices that have evolved to anticipate the incoming streams of sensory stimulation before they arrive. These predictions then initiate actions that structure our worlds and alter the very things we need to engage and predict. Clark takes us on a journey in discovering the circular causal flows and the self-structuring of the environment that define the predictive brain. What emerges is a bold, new, cutting-edge vision that reveals the brain as our driving force in the daily surf through the waves of sensory stimulation. |
| albert bendelac death: Dicionário Sefaradi de Sobrenomes Guilherme Faiguenboim, Paulo Valadares, Anna Rosa Campagnano, 2009 |
| albert bendelac death: Suddenly Jewish Barbara Kessel, 2000-04 Dramatic personal stories of the unexpected discovery of a Jewish heritage. |
| albert bendelac death: The Diabetes Textbook Joel Rodriguez-Saldana, 2019-06-27 Diabetes has become a worldwide health problem, the global estimated prevalence approaches ten percent and the burden of this disease in terms of morbidity and mortality is unprecedented. The advances acquired through the knowledge of the mechanisms of the disease and the variety of therapeutic approaches contrast with the inability of private and public health systems in underdeveloped and even developed countries to achieve the goals of treatment. This paradox has been described in many sources: the surge of scientific advances contrast with an unprecedented amount of human suffering. Thus, a patient centered and an evidence based approach with the capacity to produce measurable clinical and economic outcomes is required. The purpose of this textbook is multiple: to offer a comprehensive resource covering all aspects of outpatient management; to address diabetes as a health problem from an epidemiological, economic and clinical perspective; to discuss the role of social determinants of health on the worldwide increase in diabetes; to highlight the challenges and obstacles in providing adequate care; and to outline a multidisciplinary approach to management in which medical visits retain their importance as part of a team comprising the patient, his or her family and a multidisciplinary group of health professionals who are able to move beyond the traditional approach of diabetes as a disease and greatly improve outcomes. |
| albert bendelac death: Forensic Neuropathology, Second Edition Jan E. Leestma, 2008-10-14 Over the past 30 years, as both forensic pathology and neuropathology have grown in sophistication, the two specialties have forged a heightened level of interaction. Reflecting the vast increase in knowledge and scientific progress in the past two decades, Forensic Neuropathology, Second Edition examines the new developments that have arisen since the publication of the first volume. New in this Edition: All chapters revised and updated Expanded information on biomechanics of neurotrauma Latest findings on child abuse, impact injuries to the head and spine, and intracranial pressure effects Greater focus on the effects of new Supreme Court rulings on the admissibility of evidence Nearly 300 high-quality color photographs This updated text comprehensively reviews all aspects of neuropathology that may have forensic or medical-legal import. The book presents significant coverage of the role of the neuropathologist in a legal setting before delving into specific forensic aspects of neuropathology, including comprehensive discussions of various syndromes and conditions affecting adults and children. It discusses intracranial equilibria and physical injury to the nervous system and contains entire chapters devoted to neuropathology perspectives on child abuse, gunshot and other penetrating wounds of the nervous system, and the forensic aspects of complex neural functions. This timely revision maintains the breadth and depth of the benchmark first edition while replacing outdated information with the newest developments in these complex areas. Dr. Jan E. Leestma is a world-renowned forensic neuropathologist and is the author of more than a hundred professional publications. He has given expert testimony in more than thirty states, Canada, and the UK. This highly detailed work, which includes the contributions of experts in the fields of biomechanics, neurology, pathology, and the law, is sure to complement the growing literature in this fast-developing area. |
| albert bendelac death: Worldmaking After Empire Adom Getachew, 2020-04-28 Decolonization revolutionized the international order during the twentieth century. Yet standard histories that present the end of colonialism as an inevitable transition from a world of empires to one of nations—a world in which self-determination was synonymous with nation-building—obscure just how radical this change was. Drawing on the political thought of anticolonial intellectuals and statesmen such as Nnamdi Azikiwe, W.E.B Du Bois, George Padmore, Kwame Nkrumah, Eric Williams, Michael Manley, and Julius Nyerere, this important new account of decolonization reveals the full extent of their unprecedented ambition to remake not only nations but the world. Adom Getachew shows that African, African American, and Caribbean anticolonial nationalists were not solely or even primarily nation-builders. Responding to the experience of racialized sovereign inequality, dramatized by interwar Ethiopia and Liberia, Black Atlantic thinkers and politicians challenged international racial hierarchy and articulated alternative visions of worldmaking. Seeking to create an egalitarian postimperial world, they attempted to transcend legal, political, and economic hierarchies by securing a right to self-determination within the newly founded United Nations, constituting regional federations in Africa and the Caribbean, and creating the New International Economic Order. Using archival sources from Barbados, Trinidad, Ghana, Switzerland, and the United Kingdom, Worldmaking after Empire recasts the history of decolonization, reconsiders the failure of anticolonial nationalism, and offers a new perspective on debates about today’s international order. |
| albert bendelac death: Fetal Alcohol Spectrum Disorder Albert E. Chudley, Geoff G. Hicks, 2022-09-08 This volume provides current state-of-the-art methods for screening, diagnosis, management, and prevention of fetal alcohol spectrum disorder (and FASD). Chapters detail animal models, mechanism of ethanol teratogenesis, genetic mechanisms, clinical perspectives, physical traits in children with FASD, managing behavior, FASD and the correction system, nutritional influences aiding FASD prevention, prenatal alcohol screening, the use of dental signatures in FASD diagnosis, the experiences of FASD research and clinical practices in Australia, Canada, UK, USA, adult FASD diagnosis, FASD and children in care, FASD and the healing journey. Authoritative and cutting-edge, Advances in Fetal Alcohol Spectrum Disorder aims to be a useful practical guide to researchers and clinicians to help further their study in this field. |
| albert bendelac death: Imagining Numbers Barry Mazur, 2004-02-01 How the elusive imaginary number was first imagined, and how to imagine it yourself Imagining Numbers (particularly the square root of minus fifteen) is Barry Mazur's invitation to those who take delight in the imaginative work of reading poetry, but may have no background in math, to make a leap of the imagination in mathematics. Imaginary numbers entered into mathematics in sixteenth-century Italy and were used with immediate success, but nevertheless presented an intriguing challenge to the imagination. It took more than two hundred years for mathematicians to discover a satisfactory way of imagining these numbers. With discussions about how we comprehend ideas both in poetry and in mathematics, Mazur reviews some of the writings of the earliest explorers of these elusive figures, such as Rafael Bombelli, an engineer who spent most of his life draining the swamps of Tuscany and who in his spare moments composed his great treatise L'Algebra. Mazur encourages his readers to share the early bafflement of these Renaissance thinkers. Then he shows us, step by step, how to begin imagining, ourselves, imaginary numbers. |
| albert bendelac death: National Institute of Allergy and Infectious Diseases, NIH Vassil St. Georgiev, 2009-07-06 National Institute of Allergy and Infectious Diseases, NIH: Volume 2: Impact on Global Health covers the scientific aspects of the entire portfolio of NIAID, including microbiology and infectious disease, HIV/AIDS, and immunology and vaccines. All major diseases and the relevant immunology and vaccine development are described in detail. In addition, all major NIAID programs, initiatives, and clinical trials are discussed and illustrate the global involvement of NIAID in biomedical research and its impact on public health worldwide. By providing this information, the global scientific community will be able to access and benefit from these programs and initiatives. |
| albert bendelac death: Perilous Times Geoffrey Stone, 2005-09-27 A masterpiece of constitutional history, Perilous Times promises to redefine the national debate on civil liberties and free speech.—Elena Kagan, Harvard Law School Geoffrey Stone's Perilous Times incisively investigates how the First Amendment and other civil liberties have been compromised in America during wartime. Stone delineates the consistent suppression of free speech in six historical periods from the Sedition Act of 1798 to the Vietnam War, and ends with a coda that examines the state of civil liberties in the Bush era. Full of fresh legal and historical insight, Perilous Times magisterially presents a dramatic cast of characters who influenced the course of history over a two-hundred-year period: from the presidents—Adams, Lincoln, Wilson, Roosevelt, and Nixon—to the Supreme Court justices—Taney, Holmes, Brandeis, Black, and Warren—to the resisters—Clement Vallandingham, Emma Goldman, Fred Korematsu, and David Dellinger. Filled with dozens of rare photographs, posters, and historical illustrations, Perilous Times is resonant in its call for a new approach in our response to grave crises. |
| albert bendelac death: Ashcraft's Pediatric Surgery E-Book George W. Holcomb, J. Patrick Murphy, Daniel J Ostlie, 2014-01-31 Acclaimed for its unsurpassed readability and manageable scope, Ashcraft’s Pediatric Surgery presents authoritative, practical guidance on treating the entire range of general surgical and urological problems in infants, children, and adolescents. State-of-the-art, expert coverage equips you to implement all the latest approaches and achieve optimal outcomes for all of your patients. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Make the most effective use of today’s best open and minimally invasive techniques, including single-site umbilical laparoscopic surgery, with guidance from internationally recognized experts in the field. Focus on evidence-based treatments and outcomes to apply today’s best practices. Stay current with timely topics thanks to brand-new chapters on Choledochal Cyst and Gallbladder Disease, Tissue Engineering, and Ethics in Pediatric Surgery, plus comprehensive updates throughout. Hone and expand your surgical skills by watching videos of minimally invasive procedures for recto urethral fistula, biliary atresia, laparoscopic splenectomy, uterine horn, and more. Grasp the visual nuances of surgery from over 1,000 images depicting today’s best surgical practices. |
| albert bendelac death: The Inflammasomes Isabelle Couillin, Virginie Pétrilli, Fabio Martinon, 2011-07-02 The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease. |
| albert bendelac death: Sea turtles in the Mediterranean : Distribution, threats and conservation priorities Paolo Casale, 2010 |
| albert bendelac death: A Rainbow Thread Noam Sienna, 2019 For many queer Jews, Jewish tradition seems like a rich tapestry which at best ignores them and at worst rejects them entirely. In reality, queerness and queer Judaism have been a constant subplot of Jewish history, if only we care to look. Spanning almost two millennia and containing translations from more than a dozen languages, Noam Sienna's new book, A Rainbow Thread: An Anthology of Queer Jewish Texts From the First Century to 1969, collects for the first time more than a hundred sources on the intersection of Jewish and queer identities. Covering poetry, drama, literature, law, midrash, and memoir, this anthology suggests that Jewish texts are not just obstacles to be overcome in the creation of queer Jewish life, but also potential resources waiting to be excavated. Through an unprecedented examination of the histories of gender and sexuality over two millennia of Jewish life around the world, this book inspires and challenges its readers to create a better future through a purposeful reflection on our past. |
| albert bendelac death: Role of CD1- and MR1-restricted T cells in Immunity and Disease Kazuya Iwabuchi, Luc Van Kaer, 2019-10-18 CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes. |
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| albert bendelac death: Telomerase Inhibition Lucy Andrews, Trygve O. Tollefsbol, 2007-11-29 This volume presents a compendium of the most recent and advanced methods applied to the rapidly expanding field of telomerase inhibition. The techniques described provide the researcher with a diverse and comprehensive set of tools for the study of telomerase inhibition. The volume is aimed at biochemists, molecular biologists, cancer researchers, and geneticists. |
| albert bendelac death: Mathematical Modeling of the Immune System in Homeostasis, Infection and Disease Gennady Bocharov, Burkhard Ludewig, Andreas Meyerhans, Vitaly Volpert, 2020-02-24 The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171). |
| albert bendelac death: Thymus Gland Pathology , 2008 |
| albert bendelac death: The Sultan’s Jew Daniel J. Schroeter, 2002 This book examines the Jewish community of Morocco in the late 18th and early 19th centuries through the life of a merchant who was the chief intermediary between the Moroccan sultans and Europe . |
| albert bendelac death: Histamine in Inflammation Robin Thurmond, 2011-06-29 The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors. |
| albert bendelac death: Autoimmune Diseases of the Skin Michael Hertl, 2005-02-24 Autoimmune disorders of the skin remain an enigma for many clinicians and scientists not familiar with these mostly severe and chronic diseases. The book provides an overview and the latest information on the broad spectrum of cutaneous autoimmune disorders for clinicians, scientists and practitioners in dermatology, medicine, rheumatology, ENT, pediatrics and ophthalmology. The book is unique since it presents the state-of-the-art knowledge on pathophysiology, clinical diagnosis and management of these disorders provided by the world experts in the field. The primary intention is to broaden the understanding of the pathophysiology of cutaneous autoimmune disorders and to provide a practical guide to how to identify and handle these conditions. The book is illustrated with many tables, illustrative figures and clinical color photographs. The second edition has been extended by chapters on autoimmune pigmentary disorders (vitiligo), hairloss (alopecia areata) and cutaneous symptoms of rheumatic disorders. |
| albert bendelac death: Transplantation of the Endocrine Pancreas in Diabetes Mellitus Reinout van Schilfgaarde, Mark Adam Hardy, 1988 |
| albert bendelac death: Adoptive Immunotherapy Burkhard Ludewig, Matthias W. Hoffmann, 2008-02-02 An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy. |
| albert bendelac death: A History of the Jews of Tangier in the Nineteenth and Twentieth Centuries M. Mitchell Serels, 1991 The almost two-centuries-long history of the Jews of Tangier was not without antisemitic incidents. Pp. 7-10 narrate the fate of a 17-year-old Jewish girl, Sol Hachuel, who refused to convert to Islam and was executed in 1834. Pp. 27-29 describe humiliations suffered by some Jews from both Moroccan and Spanish authorities in 1863. Pp. 148-151 discuss reactions to the Nazi takeover in Germany. Tangier accepted about 3,000 Jewish refugees from Germany and Italy before 1940; from July 1940 until the end of the war, when the city was under Spanish control, not a single Jew was admitted. Describes, also, the precarious existence of the postwar Jewish community under Moroccan rule, in particular the reaction of the Muslim population to the Six-Day War. |
| albert bendelac death: Cumulated Index Medicus , 1988 |
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Take control of your finances with Albert. Budget, save, spend, and invest, all in one incredibly powerful app. Join 10 million+ people using Albert today.
How much does Albert cost?
Albert plans range from $11.99/mo to $29.99/mo. Try your plan for 30 days before you're charged. The fee will auto-renew until canceled or your Albert account is closed. Cancel in the app.
Albert | Budget and track spending
Budget and track spending with Albert. Monitor bills, track cash flow, and see where every dollar is going. Join 10 million+ people using Albert today.
Albert
Albert plans range from $11.99/mo to $29.99/mo. Try your plan for 30 days before you're charged. The fee will auto-renew until canceled or your Albert account is closed. Cancel in the app.
Automatic savings - Albert
Join 10 million+ people using Albert today. Save automatically based on your income and spending, earn APY with high yield savings, and create custom savings goals. Accounts …
