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| a primer of molecular population genetics: A Primer of Molecular Population Genetics Asher D. Cutter, 2019-06-06 What are the genomic signatures of adaptations in DNA? How often does natural selection dictate changes to DNA? How does the ebb and flow in the abundance of individuals over time get marked onto chromosomes to record genetic history? Molecular population genetics seeks to answer such questions by explaining genetic variation and molecular evolution from micro-evolutionary principles. It provides a way to learn about how evolution works and how it shapes species by incorporating molecular details of DNA as the heritable material. It enables us to understand the logic of how mutations originate, change in abundance in populations, and become fixed as DNA sequence divergence between species. With the revolutionary advances in genomic data acquisition, understanding molecular population genetics is now a fundamental requirement for today's life scientists. These concepts apply in analysis of personal genomics, genome-wide association studies, landscape and conservation genetics, forensics, molecular anthropology, and selection scans. This book introduces, in an accessible way, the bare essentials of the theory and practice of molecular population genetics. |
| a primer of molecular population genetics: A Primer of Population Genetics Daniel L. Hartl, 1988 The use of molecular methods to study genetic polymorphisms has made a familiarity with population genetics essential for any biologist whose work is at the population level. A Primer of Population Genetics, Third Edition provides a concise but comprehensive introduction to population genetics. The four chapters of the book address genetic variation, the causes of evolution, molecular population genetics, and the genetic architecture of complex traits. Chapter-end problems reinforce ideas and, while there are some equations, the emphasis is on explanation rather than derivation. |
| a primer of molecular population genetics: A Primer of Population Genetics Daniel L. Hartl, 1981 The use of molecular methods to study genetic polymorphisms has made a familiarity with population genetics essential for any biologist whose work is at the population level. A Primer of Population Genetics, Third Edition provides a concise but comprehensive introduction to population genetics. The four chapters of the book address genetic variation, the causes of evolution, molecular population genetics, and the genetic architecture of complex traits. Chapter-end problems reinforce ideas and, while there are some equations, the emphasis is on explanation rather than derivation. |
| a primer of molecular population genetics: Molecular Population Genetics Matthew W. Hahn, 2018 |
| a primer of molecular population genetics: A Primer of Molecular Population Genetics Asher D. Cutter, Provides a concise, accessible introduction to the principle ideas, methods, and caveats for understanding evolution at the molecular level. |
| a primer of molecular population genetics: A Primer of Ecological Genetics Jeffrey K. Conner, Daniel L. Hartl, 2004-01 This book covers basic concepts in population and quantitative genetics, including measuring selection on phenotypic traits. The emphasis is on material applicable to field studies of evolution focusing on ecologically important traits. Topics addressed are critical for training students in ecology, evolution, conservation biology, agriculture, forestry, and wildlife management. Many texts in this field are too complex and mathematical to allow the average beginning student to readily grasp the key concepts. A Primer of Ecological Genetics, in contrast, employs mathematics and statistics-fully explained, but at a less advanced level-as tools to improve understanding of biological principles. The main goal is to enable students to understand the concepts well enough that they can gain entry into the primary literature. Integration of the different chapters of the book shows students how diverse concepts relate to each other. |
| a primer of molecular population genetics: Population Genetics John H. Gillespie, 2004-08-06 Publisher Description |
| a primer of molecular population genetics: Evolutionary Genetics Glenn-Peter Sætre, Mark Ravinet, 2019 With recent technological advances, vast quantities of genetic and genomic data are being generated at an ever-increasing pace. The explosion in access to data has transformed the field of evolutionary genetics. A thorough understanding of evolutionary principles is essential for making sense of this, but new skill sets are also needed to handle and analyze big data. This contemporary textbook covers all the major components of modern evolutionary genetics, carefully explaining fundamental processes such as mutation, natural selection, genetic drift, and speciation. It also draws on a rich literature of exciting and inspiring examples to demonstrate the diversity of evolutionary research, including an emphasis on how evolution and selection has shaped our own species. Practical experience is essential for developing an understanding of how to use genetic and genomic data to analyze and interpret results in meaningful ways. In addition to the main text, a series of online tutorials using the R language serves as an introduction to programming, statistics, and analysis. Indeed the R environment stands out as an ideal all-purpose source platform to handle and analyze such data. The book and its online materials take full advantage of the authors' own experience in working in a post-genomic revolution world, and introduces readers to the plethora of molecular and analytical methods that have only recently become available. Evolutionary Genetics is an advanced but accessible textbook aimed principally at students of various levels (from undergraduate to postgraduate) but also for researchers looking for an updated introduction to modern evolutionary biology and genetics. |
| a primer of molecular population genetics: A Primer of Conservation Genetics Richard Frankham, Jonathan D. Ballou, David A. Briscoe, 2004-02-12 This concise, entry level text provides an introduction to the importance of genetic studies in conservation and presents the essentials of the discipline in an easy-to-follow format, with main points and terms clearly highlighted. The authors assume only a basic knowledge of Mendelian genetics and simple statistics, making the book accessible to those with a limited background in these areas. Connections between conservation genetics and the wider field of conservation biology are interwoven throughout the book. Worked examples are provided throughout to help illustrate key equations and glossary and suggestions for further reading provide additional support for the reader. Many beautiful pen and ink portraits of endangered species are included to enhance the text. Written for short, introductory level courses in genetics, conservation genetics and conservation biology, this book will also be suitable for practising conservation biologists, zoo biologists and wildlife managers. |
| a primer of molecular population genetics: An Introduction to Population Genetics Rasmus Nielsen, Montgomery Slatkin, 2013-07-18 This book covers both classical population genetics theory developed in terms of allele and haplotype frequencies and modern population genetics theory developed in terms of coalescent theory. It features applications of theory to problems that arise in the study of human and other populations and assumes little prior knowledge of mathematics. |
| a primer of molecular population genetics: Evolution and Selection of Quantitative Traits Bruce Walsh, Michael Lynch, 2018-06-21 Quantitative traits-be they morphological or physiological characters, aspects of behavior, or genome-level features such as the amount of RNA or protein expression for a specific gene-usually show considerable variation within and among populations. Quantitative genetics, also referred to as the genetics of complex traits, is the study of such characters and is based on mathematical models of evolution in which many genes influence the trait and in which non-genetic factors may also be important. Evolution and Selection of Quantitative Traits presents a holistic treatment of the subject, showing the interplay between theory and data with extensive discussions on statistical issues relating to the estimation of the biologically relevant parameters for these models. Quantitative genetics is viewed as the bridge between complex mathematical models of trait evolution and real-world data, and the authors have clearly framed their treatment as such. This is the second volume in a planned trilogy that summarizes the modern field of quantitative genetics, informed by empirical observations from wide-ranging fields (agriculture, evolution, ecology, and human biology) as well as population genetics, statistical theory, mathematical modeling, genetics, and genomics. Whilst volume 1 (1998) dealt with the genetics of such traits, the main focus of volume 2 is on their evolution, with a special emphasis on detecting selection (ranging from the use of genomic and historical data through to ecological field data) and examining its consequences. |
| a primer of molecular population genetics: A Mathematical Primer of Molecular Phylogenetics Xuhua Xia, 2020-04-13 This volume, A Mathematical Primer of Molecular Phylogenetics, offers a unique perspective on a number of phylogenetic issues that have not been covered in detail in previous publications. The volume provides sufficient mathematical background for young mathematicians and computational scientists, as well as mathematically inclined biology students, to make a smooth entry into the expanding field of molecular phylogenetics. The book will also provide sufficient details for researchers in phylogenetics to understand the workings of existing software packages used. The volume offers comprehensive but detailed numerical illustrations to render difficult mathematical and computational concepts in molecular phylogenetics accessible to a variety of readers with different academic background. The text includes examples of solved problems after each chapter, which will be particularly helpful for fourth-year undergraduates, postgraduates, and postdoctoral students in biology, mathematics and computer sciences. Researchers in molecular biology and evolution will find it very informative as well. |
| a primer of molecular population genetics: Molecular and Genome Evolution Dan Graur, 2015-01-01 This book describes the driving forces behind the evolutionary process at the molecular and genome levels, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes, the methodology and the analytical tools involved in dealing with molecular data from an evolutionary perspective, and the logic of evolutionary hypothesis testing. Evolutionary phenomena at the molecular level are detailed in a way that can be understood without much prerequisite knowledge of molecular biology, evolution, or mathematics. Numerous examples that support and clarify the theoretical arguments and methodological discussions are included. |
| a primer of molecular population genetics: Primer of Genetic Analysis James N. Thompson, Jr, Jenna J. Hellack, Gerald Braver, David S. Durica, 2007-10-01 This third edition of a student-tested primer provides guided instruction in the analysis and interpretation of genetic principles and problem solving. All core areas of genetics are covered. Each section is introduced with a summary of key concepts and terms. A series of problems, graded from simple to more complex, then allows students to test their understanding of the material. Each question is accompanied by a detailed explanation. This new edition includes additional problems, extensively expanded coverage of molecular biology throughout, new overview chapters, and an expanded glossary. |
| a primer of molecular population genetics: Principles of Population Genetics Daniel L. Hartl, Andrew G. Clark, 1997-01-01 Principles of Population Genetics, Third Edition gives a balanced presentation of theory and observation for students at the undergraduate and graduate levels. Applications of the principles discussed are illustrated by numerous worked examples. |
| a primer of molecular population genetics: Population Genetics Matthew Hamilton, 2009-04-08 This book aims to make population genetics approachable, logical and easily understood. To achieve these goals, the book’s design emphasizes well explained introductions to key principles and predictions. These are augmented with case studies as well as illustrations along with introductions to classical hypotheses and debates. Pedagogical features in the text include: Interact boxes that guide readers step-by-step through computer simulations using public domain software. Math boxes that fully explain mathematical derivations. Methods boxes that give insight into the use of actual genetic data. Numerous Problem boxes are integrated into the text to reinforce concepts as they are encountered. Dedicated website at www.wiley.com/go/hamiltongenetics This text also offers a highly accessible introduction to coalescent theory, the major conceptual advance in population genetics of the last two decades. |
| a primer of molecular population genetics: Introduction to Conservation Genetics Richard Frankham, David A. Briscoe, Jonathan D. Ballou, 2002-03-14 Genetic diversity, biodiversity, population management. |
| a primer of molecular population genetics: Epigenetic Inheritance and Evolution Eva Jablonka, Marion J. Lamb, 1995 Does the inheritance of acquired characteristics play a significant role in evolution? In this book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original, provocative exploration of the nature and origin of hereditary variations. Starting with a historical account of Lamarck's ideas and the reasons they have fallen in disrepute, the authors go on to challenge the prevailing assumption that all heritable variation is random and the result of variation in DNA base sequences. They also detail recent breakthroughs in our understanding of the molecular mechanisms underlying inheritance--including several pathways not envisioned by classical population genetics--and argue that these advances need to be more fully incorporated into mainstream evolutionary theory. Throughout, the book offers a new look at the evidence for and against the hereditability of environmentally induced changes, and addresses timely questions about the importance of non-Mendelian inheritance. A glossary and extensive list of references round out the book. Urging a reconsideration of the present DNA-centric view prevalent in the field, Epigentic Inheritance and Evolution will make fascinating and important reading for students and researchers in evolution, genetics, ecology, molecular biology, developmental biology, and the history and philosophy of science. |
| a primer of molecular population genetics: Statistical Population Genomics Julien Y Dutheil, 2020-10-08 This open access volume presents state-of-the-art inference methods in population genomics, focusing on data analysis based on rigorous statistical techniques. After introducing general concepts related to the biology of genomes and their evolution, the book covers state-of-the-art methods for the analysis of genomes in populations, including demography inference, population structure analysis and detection of selection, using both model-based inference and simulation procedures. Last but not least, it offers an overview of the current knowledge acquired by applying such methods to a large variety of eukaryotic organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, pointers to the relevant literature, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Statistical Population Genomics aims to promote and ensure successful applications of population genomic methods to an increasing number of model systems and biological questions. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors. |
| a primer of molecular population genetics: Introduction to Evolutionary Genomics Naruya Saitou, 2014-01-22 This book is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies. Features: introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection; presents a brief evolutionary history of life from the primordial seas to the emergence of humans; describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans; reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building; discusses databases of genome sequences and related information, evolutionary distances, and population genomics; provides supplementary material at an associated website. |
| a primer of molecular population genetics: Darwinian Populations and Natural Selection Peter Godfrey-Smith, 2009-03-26 In 1859 Darwin described a deceptively simple mechanism that he called natural selection, a combination of variation, inheritance, and reproductive success. He argued that this mechanism was the key to explaining the most puzzling features of the natural world, and science and philosophy were changed forever as a result. The exact nature of the Darwinian process has been controversial ever since, however. Godfrey-Smith draws on new developments in biology, philosophy of science, and other fields to give a new analysis and extension of Darwin's idea. The central concept used is that of a Darwinian population, a collection of things with the capacity to undergo change by natural selection. From this starting point, new analyses of the role of genes in evolution, the application of Darwinian ideas to cultural change, and evolutionary transitions that produce complex organisms and societies are developed. Darwinian Populations and Natural Selection will be essential reading for anyone interested in evolutionary theory |
| a primer of molecular population genetics: Gene Genealogies, Variation and Evolution: A primer in coalescent theory Jotun Hein, Mikkel Schierup, Carsten Wiuf, 2004-12-09 Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. Rich in examples and illustrations it is ideal for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine, and for students studying the evolution of human population and disease. It is also an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;Coalescent theory is a central concept in the study of genetic sequence variation that probabilistically describes the genealogy relating the sampled sequences. In this text, besides fulfilling the glaring need for such a book, the authors present this theory in a straightforward and elementary manner and describe the statistical and computational methods used in modelling and analyzing genetic sequence variation. Rich in examples and illustrations the book covers basic concepts, complications arising from geographical structure and recombination before considering aspects of statistical inference based on these models. The book ends with chapters on Gene Mapping, which combines sequence variation data with phenotypic data (such as disease) to define areas of the genome where genes are responsible for the trait, and Human Evolution, a research area that is experiencing a renaissance due to the enormous amounts of data produced in molecular studies. Authored by leading experts, this seminal text presents a straightforward and elementary account of coalescent theory, which is a central concept in the study of genetic sequence variation observed in a population. It is highly suitable for a graduate course in statistics, population, molecular and medical genetics, bioscience and medicine and students studying the evolution of human population and disease, and will be an invaluable reference for bioscientists and statisticians in the pharmaceutical industry and academia - ;an excellent and timely book that should appeal to a variety of people in genetics and applied mathematics. - Professor Montgomery Slatkin (Berkeley);the authors are outstanding experts in the field, and the book is topical and timely. - Professor David Balding (Imperial College);Hein, Schierup and Wiuf have written the first general book on the coalescent. It is an engaging combination of clear mathematical derivation and real data examples. - Professor Joe Felsenstein (University of Washington) |
| a primer of molecular population genetics: Computational Molecular Evolution Ziheng Yang, 2006-10-05 This book describes the models, methods and algorithms that are most useful for analysing the ever-increasing supply of molecular sequence data, with a view to furthering our understanding of the evolution of genes and genomes. |
| a primer of molecular population genetics: Molecular Tools and Infectious Disease Epidemiology Betsy Foxman, 2010-12-28 Molecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies. - Presents the key points of consideration when integrating molecular biology and epidemiology - Discusses how using molecular tools in epidemiologic research affects program design and conduct - Considers the ethical concerns that arise in molecular epidemiologic studies - Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field |
| a primer of molecular population genetics: Clinical Precision Medicine Judy S. Crabtree, 2019-11-15 Clinical Precision Medicine: A Primer offers clinicians, researchers and students a practical, up-to-date resource on precision medicine, its evolving technologies, and pathways towards clinical implementation. Early chapters address the fundamentals of molecular biology and gene regulation as they relate to precision medicine, as well as the foundations of heredity and epigenetics. Oncology, an early adopter of precision approaches, is considered with its relationship to genetic variation in drug metabolism, along with tumor immunology and the impact of DNA variation in clinical care. Contributions by Stephanie Kramer, a Clinical Genetic Counselor, also provide current information on prenatal diagnostics and adult genetics that highlight the critical role of genetic counselors in the era of precision medicine. - Includes applied discussions of chromosomes and chromosomal abnormalities, molecular genetics, epigenetic regulation, heredity, clinical genetics, pharmacogenomics and immunogenomics - Features chapter contributions from leaders in the field - Consolidates fundamental concepts and current practices of precision medicine in one convenient resource |
| a primer of molecular population genetics: An Introduction to Genetic Epidemiology Palmer, Lyle J., Burton, Paul R., George Davey Smith, 2011-05-31 This book brings together leading experts to provide an introduction to genetic epidemiology that begins with a primer in human molecular genetics through all the standard methods in population genetics and genetic epidemiology required for an adequate grounding in the field. |
| a primer of molecular population genetics: Molecular Evolution Roderick D.M. Page, Edward C. Holmes, 2009-07-14 The study of evolution at the molecular level has given the subject of evolutionary biology a new significance. Phylogenetic 'trees' of gene sequences are a powerful tool for recovering evolutionary relationships among species, and can be used to answer a broad range of evolutionary and ecological questions. They are also beginning to permeate the medical sciences. In this book, the authors approach the study of molecular evolution with the phylogenetic tree as a central metaphor. This will equip students and professionals with the ability to see both the evolutionary relevance of molecular data, and the significance evolutionary theory has for molecular studies. The book is accessible yet sufficiently detailed and explicit so that the student can learn the mechanics of the procedures discussed. The book is intended for senior undergraduate and graduate students taking courses in molecular evolution/phylogenetic reconstruction. It will also be a useful supplement for students taking wider courses in evolution, as well as a valuable resource for professionals. First student textbook of phylogenetic reconstruction which uses the tree as a central metaphor of evolution. Chapter summaries and annotated suggestions for further reading. Worked examples facilitate understanding of some of the more complex issues. Emphasis on clarity and accessibility. |
| a primer of molecular population genetics: Molecular Epidemiology Paul A. Schulte, Frederica P. Perera, 2012-12-02 This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators. |
| a primer of molecular population genetics: Molecular Ecology and Evolution: Approaches and Applications B. Schierwater, B. Streit, G.P. Wagner, R. DeSalle, 2013-06-29 The past 25 years have witnessed a revolution in the way ecologists and evolutionary biologists approach their disciplines. Modern molecular techniques are now reshaping the spectrum of questions that can be addressed while studying the mechanisms and consequences of the ecology and evolution of living organisms. Molecular Ecology and Evolution: Approaches and Applications describes, from a molecular perspective, several methodological and technical approaches used in the fields of ecology, evolution, population biology, molecular systematics, conservation genetics, and development. Modern techniques are introduced, and older, more classic ones refined. The advantages, limitations, and potentials of each are discussed in detail, and thereby illustrate the widening range of cross-field research and applications which this modern technology is stimulating. This book will serve as an important textbook for graduate and advanced undergraduate students, and as a key reference work for researchers |
| a primer of molecular population genetics: Genetic Management of Fragmented Animal and Plant Populations Richard Frankham, Jonathan D. Ballou, Katherine Ralls, Mark Eldridge, Michele R. Dudash, Charles B. Fenster, Robert C. Lacy, Paul Sunnucks, 2017-07-04 One of the greatest unmet challenges in conservation biology is the genetic management of fragmented populations of threatened animal and plant species. More than a million small, isolated, population fragments of threatened species are likely suffering inbreeding depression and loss of evolutionary potential, resulting in elevated extinction risks. Although these effects can often be reversed by re-establishing gene flow between population fragments, managers very rarely do this. On the contrary, genetic methods are used mainly to document genetic differentiation among populations, with most studies concluding that genetically differentiated populations should be managed separately, thereby isolating them yet further and dooming many to eventual extinction! Many small population fragments are going extinct principally for genetic reasons. Although the rapidly advancing field of molecular genetics is continually providing new tools to measure the extent of population fragmentation and its genetic consequences, adequate guidance on how to use these data for effective conservation is still lacking. This accessible, authoritative text is aimed at senior undergraduate and graduate students interested in conservation biology, conservation genetics, and wildlife management. It will also be of particular relevance to conservation practitioners and natural resource managers, as well as a broader academic audience of conservation biologists and evolutionary ecologists. |
| a primer of molecular population genetics: Population Genetics and Microevolutionary Theory Alan R. Templeton, 2006-09-29 The advances made possible by the development of molecular techniques have in recent years revolutionized quantitative genetics and its relevance for population genetics. Population Genetics and Microevolutionary Theory takes a modern approach to population genetics, incorporating modern molecular biology, species-level evolutionary biology, and a thorough acknowledgment of quantitative genetics as the theoretical basis for population genetics. Logically organized into three main sections on population structure and history, genotype-phenotype interactions, and selection/adaptation Extensive use of real examples to illustrate concepts Written in a clear and accessible manner and devoid of complex mathematical equations Includes the author's introduction to background material as well as a conclusion for a handy overview of the field and its modern applications Each chapter ends with a set of review questions and answers Offers helpful general references and Internet links |
| a primer of molecular population genetics: Genomics John M. Archibald, 2018-03-12 Genomics has transformed the biological sciences. From epidemiology and medicine to evolution and forensics, the ability to determine an organism's complete genetic makeup has changed the way science is done and the questions that can be asked of it. Its most celebrated achievement was the Human Genome Project, a technologically challenging endeavor that took thousands of scientists around the world 13 years and over 3 billion US dollars to complete. In this Very Short Introduction John Archibald explores the science of genomics and its rapidly expanding toolbox. Sequencing a human genome now takes only a few days and costs as little as $1,000. The genomes of simple bacteria and viruses can be sequenced in a matter of hours on a device that fits in the palm of your hand. The resulting sequences can be used to better understand our biology in health and disease and to 'personalize' medicine. Archibald shows how the field of genomics is on the cusp of another quantum leap; the implications for science and society are profound. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable. |
| a primer of molecular population genetics: Marine Genetics Antonio M. Solé-Cava, Claudia A.M. Russo, John P. Thorpe, 2013-03-09 Our current knowledge of marine organisms and the factors affecting their ecology, distribution and evolution has been revolutionised by the use, in the last 20 years, of molecular population genetics tools. This book is the result of a meeting of world-leading experts, in Rio de Janeiro, where the state of the art of this field was reviewed. Topics covered include the molecular analysis of bio-invasions, the recent developments in marine biotechnology, the factors affecting levels of genetic variation and population structure in marine organisms and their application to conservation biology, fisheries and aquaculture. This is the first book dedicated to the genetic study of marine organisms. It will be very useful to biology students, scientists and anyone working or simply interested in areas such as marine biology, zoology, ecology, and population and molecular genetics. |
| a primer of molecular population genetics: Frontiers in Cancer Research Carlo C. Maley, Mel Greaves, 2016-11-21 This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans. This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention. |
| a primer of molecular population genetics: The Origins of Genome Architecture Michael Lynch, 2007-06 The availability of genomic blueprints for hundreds of species has led to a transformation in biology, encouraging the proliferation of adaptive arguments for the evolution of genomic features. This text explains why the details matter and presents a framework for how the architectural diversity of eukaryotic genomes and genes came to arise. |
| a primer of molecular population genetics: Insect Molecular Genetics Marjorie A. Hoy, 2013-10-22 Developed as an introduction to new molecular genetic techniques, Insect Molecular Genetics also provides literature, terminology, and additional sources of information to students, researchers, and professional entomologists. Although most molecular genetics studies have employed Drosophila, this book applies the same techniques to other insects, including pest insects of economic importance. As a text, as a reference, as a primer, and as a review of a vast and growing literature, Insect Molecular Genetics is a valuable addition to the libraries of entomologists, geneticists, and molecular biologists. - Features offered by this unique reference source: Detailed illustrations - Suggested readings at the end of each chapter - Glossary of molecular genetic terms |
| a primer of molecular population genetics: Decoding the Language of Genetics David Botstein, 2015 This is a book about the conceptual language of genetics. There is a need for special words and terms to deal with some of the essential abstractions in genetics; these are the focus of this book. It is intended to help readers with diverse interests and experience to think about genetic analysis in a more sophisticated and creative way.--Publisher information. |
| a primer of molecular population genetics: Bioinformatics and Molecular Evolution Paul G. Higgs, Teresa K. Attwood, 2005 In the current era of complete genome sequencing, Bioinformatics and Molecular Evolution provides an up-to-date and comprehensive introduction to bioinformatics in the context of evolutionary biology. This accessible text: provides a thorough examination of sequence analysis, biological databases, pattern recognition, and applications to genomics, microarrays, and proteomics emphasizes the theoretical and statistical methods used in bioinformatics programs in a way that is accessible to biological science students places bioinformatics in the context of evolutionary biology, including population genetics, molecular evolution, molecular phylogenetics, and their applications features end-of-chapter problems and self-tests to help students synthesize the materials and apply their understanding is accompanied by a dedicated website - www.blackwellpublishing.com/higgs - containing downloadable sequences, links to web resources, answers to self-test questions, and all artwork in downloadable format (artwork also available to instructors on CD-ROM). This important textbook will equip readers with a thorough understanding of the quantitative methods used in the analysis of molecular evolution, and will be essential reading for advanced undergraduates, graduates, and researchers in molecular biology, genetics, genomics, computational biology, and bioinformatics courses. |
| a primer of molecular population genetics: The Northern Elephant Seal Charles Haskins Townsend, 2018-10-15 This work has been selected by scholars as being culturally important and is part of the knowledge base of civilization as we know it. This work is in the public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. To ensure a quality reading experience, this work has been proofread and republished using a format that seamlessly blends the original graphical elements with text in an easy-to-read typeface. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. |
| a primer of molecular population genetics: Molecular Biology of the Cell , 2002 |
Primer designing tool - National Center for Biotechnology Informati…
Enable search for primer pairs specific to the intended PCR template Help. With this option on, the program will search the primers against the selected database and determine …
Basic Local Alignment Search Tool - BLAST
The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to …
Brief guide to RT-qPCR - PMC
Here, we provide an overview of RT-qPCR, focusing on essential reagents, the importance of primer design, the detailed workflow, and data analysis methods. This guide will be …
Primer designing tool - National Center for Biotechnology Informati…
Enable search for primer pairs specific to the intended PCR template Help. With this option on, the program will search the primers against the selected database and determine …
Electronic-PCR (e-PCR) is retiring, use Primer-BLAST instead
Jun 28, 2017 · Our current supported primer search tool is Primer-BLAST https://www.ncbi.nlm.nih.gov/tools/primer-blast/ You can search BLAST databases …
Primer designing tool - National Center for Biotechnology Information
Enable search for primer pairs specific to the intended PCR template Help. With this option on, the program will search the primers against the selected database and determine whether a primer …
Basic Local Alignment Search Tool - BLAST
The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. The program compares nucleotide or protein sequences to sequence databases and calculates …
Brief guide to RT-qPCR - PMC
Here, we provide an overview of RT-qPCR, focusing on essential reagents, the importance of primer design, the detailed workflow, and data analysis methods. This guide will be useful for scientists …
Primer designing tool - National Center for Biotechnology Information
Enable search for primer pairs specific to the intended PCR template Help. With this option on, the program will search the primers against the selected database and determine whether a primer …
Electronic-PCR (e-PCR) is retiring, use Primer-BLAST instead
Jun 28, 2017 · Our current supported primer search tool is Primer-BLAST https://www.ncbi.nlm.nih.gov/tools/primer-blast/ You can search BLAST databases with primer …
National Center for Biotechnology Information
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
Primer-BLAST: A tool to design target-specific primers for …
We describe a robust and fully implemented general purpose primer design tool that designs target-specific PCR primers. Primer-BLAST offers flexible options to adjust the specificity threshold and …
Methods to Disseminate Research: A Primer - PMC
Decisions in healthcare, policy, education and other fields use data to drive action and change (Ruiz et al., 2022).Hence, communicating research findings is essential to ensure knowledge acquired …
National Center for Biotechnology Information
See Primer specificity stringency under Primer Pair Specificity Checking Parameters for more details. Increase the value for the "Max primer pairs to screen" option.
qPCR primer design revisited - PubMed
Nov 22, 2017 · We present an overview of the main steps in the primer design workflow, with data that illustrate some of the unexpected variability that often occurs when theory is translated into …
